Mineralocorticoid receptor interaction with SP1 generates a new response element for pathophysiologically relevant gene expression.

PubWeight™: 0.76‹?›

🔗 View Article (PMC 3783164)

Published in Nucleic Acids Res on July 01, 2013

Authors

Sandra Meinel1, Stefanie Ruhs, Katja Schumann, Nicole Strätz, Kay Trenkmann, Barbara Schreier, Ivo Grosse, Jens Keilwagen, Michael Gekle, Claudia Grossmann

Author Affiliations

1: Julius-Bernstein-Institut für Physiologie, Universität Halle-Wittenberg, 06112 Halle/Saale, Germany, Institut für Informatik, Universität Halle-Wittenberg, 06120 Halle/Saale, Germany and Abteilung Molekulare Genetik, Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), 06466 Gatersleben, Germany.

Articles cited by this

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med (1999) 29.32

The steroid and thyroid hormone receptor superfamily. Science (1988) 25.68

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med (2003) 13.25

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (2000) 7.03

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science (1995) 6.58

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature (1996) 5.40

Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A (1999) 3.19

ErbB receptors: directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol (2004) 3.18

Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med (1992) 2.54

Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int (2003) 2.13

The epidermal growth factor receptor: from development to tumorigenesis. Differentiation (2007) 2.07

Functional synergy between the transcription factor Sp1 and the estrogen receptor. Mol Endocrinol (1997) 1.87

Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem (1998) 1.83

Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor. Kidney Int (2000) 1.71

Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction. Hypertension (2007) 1.68

The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice. J Clin Invest (2009) 1.65

Aldosterone and vascular inflammation. Hypertension (2008) 1.65

Development of a panel of monoclonal antibodies against the mineralocorticoid receptor. Endocrinology (2005) 1.61

Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension (2011) 1.57

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension (2012) 1.54

Mineralocorticoids, hypertension, and cardiac fibrosis. J Clin Invest (1994) 1.48

The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. Mol Biol Cell (2008) 1.40

Sp1 binding sites and an estrogen response element half-site are involved in regulation of the human progesterone receptor A promoter. Mol Endocrinol (2000) 1.35

Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells. Circulation (2004) 1.32

Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis. J Cell Biol (2010) 1.30

Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development. J Clin Invest (2000) 1.25

Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting enzyme inhibitor therapy, with or without an angiotensin II receptor blocker. Clin J Am Soc Nephrol (2006) 1.19

Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. FASEB J (2004) 1.13

Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation (2002) 1.13

Estrogen regulates KiSS1 gene expression through estrogen receptor alpha and SP protein complexes. Endocrinology (2007) 1.11

Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. Am J Physiol Regul Integr Comp Physiol (2001) 1.11

Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways. Hypertension (2010) 1.10

Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1). J Biol Chem (2009) 1.06

Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells. Mol Cell Biochem (2010) 1.01

Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am J Physiol Endocrinol Metab (2007) 1.01

Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats. Hypertens Res (2005) 1.00

Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B. Mol Pharmacol (2010) 0.98

Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol Endocrinol (2005) 0.96

Identification, cloning, and developmental expression of hepatoma-derived growth factor in the developing rat heart. Dev Dyn (2001) 0.96

Influence of heart failure on nucleocytoplasmic transport in human cardiomyocytes. Cardiovasc Res (2009) 0.95

Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J (2002) 0.93

Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target. J Mol Signal (2011) 0.93

Heat shock protein 90 is important for Sp1 stability during mitosis. J Mol Biol (2009) 0.93

Cell surface heparan sulfates mediate internalization of the PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signalling processes involved in fibroblast cell migration. Biochem J (2011) 0.89

EF domains are sufficient for nongenomic mineralocorticoid receptor actions. J Biol Chem (2008) 0.88

Transcriptional regulation of the human Na/K ATPase via the human mineralocorticoid receptor. Mol Cell Biochem (2000) 0.87

Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes. Mol Cell Endocrinol (2005) 0.87

Mineralocorticoids upregulate arterial contraction to epidermal growth factor. Am J Physiol Regul Integr Comp Physiol (2001) 0.84

Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. Oncogene (2011) 0.83

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. Arterioscler Thromb Vasc Biol (2011) 0.80

Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor binding sites in vivo. BMC Res Notes (2012) 0.77

Articles by these authors

A 1,000-loci transcript map of the barley genome: new anchoring points for integrative grass genomics. Theor Appl Genet (2007) 2.44

Functional microRNA targets in protein coding sequences. Bioinformatics (2012) 2.40

miRGen 2.0: a database of microRNA genomic information and regulation. Nucleic Acids Res (2009) 1.78

OakContigDF159.1, a reference library for studying differential gene expression in Quercus robur during controlled biotic interactions: use for quantitative transcriptomic profiling of oak roots in ectomycorrhizal symbiosis. New Phytol (2013) 1.57

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension (2012) 1.54

SNP2CAPS: a SNP and INDEL analysis tool for CAPS marker development. Nucleic Acids Res (2004) 1.52

Nuclear shuttling precedes dimerization in mineralocorticoid receptor signaling. Chem Biol (2012) 1.50

Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders. Pflugers Arch (2003) 1.47

Ca2+ but not H2O2 modulates GRE-element activation by the human mineralocorticoid receptor in HEK cells. Mol Cell Endocrinol (2006) 1.46

A transcriptomic hourglass in plant embryogenesis. Nature (2012) 1.40

Applications of recursive segmentation to the analysis of DNA sequences. Comput Chem (2002) 1.25

Toward the identification and regulation of the Arabidopsis thaliana ABI3 regulon. Nucleic Acids Res (2012) 1.25

Nephrotoxicity of platinum complexes is related to basolateral organic cation transport. Kidney Int (2004) 1.24

Transcriptional dynamics of two seed compartments with opposing roles in Arabidopsis seed germination. Plant Physiol (2013) 1.23

Evidence and evolutionary analysis of ancient whole-genome duplication in barley predating the divergence from rice. BMC Evol Biol (2009) 1.19

Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension. Am J Hypertens (2002) 1.19

A general approach for discriminative de novo motif discovery from high-throughput data. Nucleic Acids Res (2013) 1.18

Elongation-related functions of LEAFY COTYLEDON1 during the development of Arabidopsis thaliana. Plant J (2012) 1.14

De-novo discovery of differentially abundant transcription factor binding sites including their positional preference. PLoS Comput Biol (2011) 1.11

Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways. Hypertension (2010) 1.10

Reporting science and conflicts of interest in the lay press. PLoS One (2007) 1.08

Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide. J Nucl Med (2005) 1.07

Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs. Neoplasia (2006) 1.02

Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38. Int J Cancer (2008) 1.02

Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am J Physiol Endocrinol Metab (2007) 1.01

Natural variation of transcriptional auxin response networks in Arabidopsis thaliana. Plant Cell (2010) 1.01

Analysis of sequence, map position, and gene expression reveals conserved essential genes for iron uptake in Arabidopsis and tomato. Plant Physiol (2004) 0.99

Fractionally integrated process with power-law correlations in variables and magnitudes. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 0.98

Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1). Cell Physiol Biochem (2002) 0.97

Aldosterone stimulates epidermal growth factor receptor expression. J Biol Chem (2003) 0.96

Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol Endocrinol (2005) 0.96

Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts. Am J Physiol Regul Integr Comp Physiol (2007) 0.95

Repeats and correlations in human DNA sequences. Phys Rev E Stat Nonlin Soft Matter Phys (2003) 0.94

Meta-All: a system for managing metabolic pathway information. BMC Bioinformatics (2006) 0.94

Acidic environment leads to ROS-induced MAPK signaling in cancer cells. PLoS One (2011) 0.94

Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome. FASEB J (2013) 0.94

Implementation of an in vitro model system for investigation of reperfusion damage after renal ischemia. Cell Physiol Biochem (2009) 0.94

Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly? Pflugers Arch (2008) 0.92

Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology (2009) 0.92

Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na+ reabsorption. Am J Physiol Renal Physiol (2004) 0.91

Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains. J Physiol (2013) 0.90

Human epidermal growth factor receptor-1 expression renders Chinese hamster ovary cells sensitive to alternative aldosterone signaling. J Biol Chem (2002) 0.88

EF domains are sufficient for nongenomic mineralocorticoid receptor actions. J Biol Chem (2008) 0.88

Mineralocorticoid receptor inhibits CREB signaling by calcineurin activation. FASEB J (2010) 0.88

Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance. Steroids (2007) 0.87

Hypoxia-induced extracellular acidosis increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway. Adv Exp Med Biol (2011) 0.86

Evaluation as part of operations: reconciling the common rule and continuous improvement. Commentary. Hastings Cent Rep (2013) 0.86

Apples and oranges: avoiding different priors in Bayesian DNA sequence analysis. BMC Bioinformatics (2010) 0.85

Cisplatin-induced apoptosis is enhanced by hypoxia and by inhibition of mitochondria in renal collecting duct cells. Toxicol Sci (2005) 0.85

Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells. Oncol Rep (2007) 0.85

Phylogenetic footprints in fern spore- and seed-specific gene promoters. Plant J (2007) 0.84

Activity of drug efflux transporters in tumor cells under hypoxic conditions. Adv Exp Med Biol (2008) 0.84

Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem (2006) 0.84

Protein uptake disturbs collagen homeostasis in proximal tubule-derived cells. Kidney Int Suppl (2003) 0.84

Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3. J Am Soc Nephrol (2005) 0.84

Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC). Cell Physiol Biochem (2006) 0.84

Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture. Toxicology (2006) 0.83

Parsimonious higher-order hidden Markov models for improved array-CGH analysis with applications to Arabidopsis thaliana. PLoS Comput Biol (2012) 0.83

Short-term regulation of basolateral organic anion uptake in proximal tubular opossum kidney cells: prostaglandin E2 acts via receptor-mediated activation of protein kinase A. J Am Soc Nephrol (2003) 0.83

VOMBAT: prediction of transcription factor binding sites using variable order Bayesian trees. Nucleic Acids Res (2006) 0.82

Role of epidermal growth factor receptor in vascular structure and function. Curr Opin Nephrol Hypertens (2014) 0.82

Colocalization of mineralocorticoid and EGF receptor at the plasma membrane. Biochim Biophys Acta (2010) 0.82

Exploiting prior knowledge and gene distances in the analysis of tumor expression profiles with extended Hidden Markov Models. Bioinformatics (2011) 0.82

Effects of the mycotoxin deoxynivalenol on human primary hepatocytes. Mol Nutr Food Res (2008) 0.82

Genetic analysis of bolting after winter in sugar beet (Beta vulgaris L.). Theor Appl Genet (2014) 0.81

Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells. Hypertens Res (2011) 0.81

Activation of cell migration with fibroblast growth factor-2 requires calcium-sensitive potassium channels. Pflugers Arch (2008) 0.81

Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells. Pediatr Nephrol (2005) 0.81

Non-classical actions of the mineralocorticoid receptor: misuse of EGF receptors? Mol Cell Endocrinol (2007) 0.81

The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells. Cell Physiol Biochem (2005) 0.81

Impact of hypoxic and acidic extracellular conditions on cytotoxicity of chemotherapeutic drugs. Adv Exp Med Biol (2007) 0.81

Utilizing gene pair orientations for HMM-based analysis of promoter array ChIP-chip data. Bioinformatics (2009) 0.81

Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity. Kidney Int (2005) 0.81

Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells. Pediatr Nephrol (2007) 0.81

Losartan reduces mortality in a genetic model of heart failure. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.80

Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. Toxicology (2007) 0.80

Mechanism of cell death of rat cardiac fibroblasts induced by serum depletion. Mol Cell Biochem (2003) 0.80

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. Arterioscler Thromb Vasc Biol (2011) 0.80

Differential reduction of HCN channel activity by various types of lipopolysaccharide. J Mol Cell Cardiol (2011) 0.80

Air pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts. Biol Chem (2006) 0.80