Published in Proc Natl Acad Sci U S A on July 22, 2013
The role of Ca2+ in the pathophysiology of pancreatitis. J Physiol (2013) 1.05
Acute Pancreatitis-Progress and Challenges: A Report on an International Symposium. Pancreas (2015) 1.01
Ca(2+) signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca(2+) channel blockade. J Physiol (2015) 0.96
Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology (2015) 0.91
Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol (2016) 0.88
Calcium and ATP control multiple vital functions. Philos Trans R Soc Lond B Biol Sci (2016) 0.86
A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway. J Biol Chem (2014) 0.85
Endoplasmic reticulum-plasma membrane junctions: structure, function and dynamics. J Physiol (2016) 0.84
Store-Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression. J Am Soc Nephrol (2015) 0.83
The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function. Cell Calcium (2015) 0.83
Ca(2+) tunnelling through the ER lumen as a mechanism for delivering Ca(2+) entering via store-operated Ca(2+) channels to specific target sites. J Physiol (2017) 0.83
CRAC channel gating and its modulation by STIM1 and 2-aminoethoxydiphenyl borate. J Physiol (2016) 0.83
The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells. Biochem J (2015) 0.82
High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells. Am J Physiol Renal Physiol (2014) 0.82
Blockade of calcium entry provides a therapeutic window in acute pancreatitis. J Physiol (2016) 0.82
Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview. Philos Trans R Soc Lond B Biol Sci (2016) 0.80
Alcoholic pancreatitis: New insights into the pathogenesis and treatment. World J Gastrointest Pathophysiol (2016) 0.80
Store-operated CRAC channel inhibitors: opportunities and challenges. Future Med Chem (2016) 0.79
CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis. Rev Physiol Biochem Pharmacol (2016) 0.78
Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release. Gut (2015) 0.78
Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction. Am J Physiol Cell Physiol (2016) 0.78
Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca(2+) oscillations in mouse pancreatic acinar cells. Sci Rep (2016) 0.77
Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Philos Trans R Soc Lond B Biol Sci (2016) 0.77
From moderately severe to severe hypertriglyceridemia induced acute pancreatitis: circulating miRNAs play role as potential biomarkers. PLoS One (2014) 0.77
New insights into the pathways initiating and driving pancreatitis. Curr Opin Gastroenterol (2016) 0.77
BH3 mimetic-elicited Ca(2+) signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca(2+)-like peptides. Cell Death Dis (2017) 0.75
Identifying risk factors for progression to critical care admission and death among individuals with acute pancreatitis: a record linkage analysis of Scottish healthcare databases. BMJ Open (2016) 0.75
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
Store-operated calcium channels. Physiol Rev (2005) 11.95
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature (1983) 10.90
Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature (1992) 10.22
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol Rev (2006) 4.87
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
Acute pancreatitis: bench to the bedside. Gastroenterology (2007) 2.78
Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals. EMBO J (1999) 2.67
Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology (1997) 2.54
Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proc Natl Acad Sci U S A (2000) 2.34
Stimulus-secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J Physiol (1992) 2.31
Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology (2006) 2.23
Pancreatic acinar cells: the role of calcium in stimulus-secretion coupling. J Physiol (1976) 2.04
Polarized calcium signaling in exocrine gland cells. Annu Rev Physiol (2008) 1.94
Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]. J Cell Biol (1998) 1.91
Termination of cytosolic Ca2+ signals: Ca2+ reuptake into intracellular stores is regulated by the free Ca2+ concentration in the store lumen. EMBO J (1998) 1.88
Store-operated CRAC channels: function in health and disease. Nat Rev Drug Discov (2010) 1.82
The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. Am J Pathol (2000) 1.74
Ca2+ flow via tunnels in polarized cells: recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch. Cell (1997) 1.70
Calcium uptake via endocytosis with rapid release from acidifying endosomes. Curr Biol (1998) 1.68
Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science (1986) 1.58
Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels. J Biol Chem (2008) 1.44
Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci U S A (2007) 1.43
Isolation and culture of adult mouse hepatocytes. Methods Mol Biol (2010) 1.43
Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proc Natl Acad Sci U S A (2004) 1.42
Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. J Biol Chem (1993) 1.41
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37
Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. J Biol Chem (2006) 1.35
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc Natl Acad Sci U S A (2009) 1.34
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci (2006) 1.30
Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore. J Cell Sci (2002) 1.29
The acinar-ductal tango in the pathogenesis of acute pancreatitis. Gut (2010) 1.29
Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends Pharmacol Sci (2006) 1.27
Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors. Curr Biol (2009) 1.26
Calcium ion uptake in isolated pancreas cells induced by secretagogues. Biochim Biophys Acta (1976) 1.25
Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities. Pflugers Arch (2012) 1.23
Generation of specific Ca(2+) signals from Ca(2+) stores and endocytosis by differential coupling to messengers. Curr Biol (2006) 1.17
Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and pancreatitis. Cell Calcium (2009) 1.12
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger. Proc Natl Acad Sci U S A (2000) 1.05
Voltage-dependent Ba2+ permeation through store-operated CRAC channels: implications for channel selectivity. Cell Calcium (2007) 1.03
The action of selective CRAC channel blockers is affected by the Orai pore geometry. Cell Calcium (2012) 1.02
Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proc Natl Acad Sci U S A (2011) 0.99
Mast cell CRAC channel as a novel therapeutic target in allergy. Curr Opin Allergy Clin Immunol (2011) 0.99
Depletion of intracellular calcium stores activates a calcium conducting nonselective cation current in mouse pancreatic acinar cells. J Biol Chem (1996) 0.97
CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol (2012) 0.96
The relationship between acetylcholine-evoked Ca(2+)-dependent current and the Ca2+ concentrations in the cytosol and the lumen of the endoplasmic reticulum in pancreatic acinar cells. Pflugers Arch (1999) 0.93
Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol (2013) 0.92
Ca(2+) -permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochim Biophys Acta (2008) 0.89
Slow depletion of endoplasmic reticulum Ca(2+) stores and block of store-operated Ca(2+) channels by 2-aminoethoxydiphenyl borate in mouse pancreatic acinar cells. Naunyn Schmiedebergs Arch Pharmacol (2002) 0.87
Substance P and bombesin elevate cytosolic Ca2+ by different molecular mechanisms in a rat pancreatic acinar cell line. J Physiol (1990) 0.86
Effects of ethanol metabolites on exocytosis of pancreatic acinar cells in rats. Gastroenterology (2012) 0.85
A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr Biol (2012) 0.84
Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells. Pflugers Arch (2012) 0.84
Antithrombotic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb Vasc Biol (2012) 0.78
Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology (2006) 2.23
Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology (2011) 2.06
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol (2003) 1.95
Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology (2008) 1.89
Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. J Biol Chem (2006) 1.84
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J Biol Chem (2006) 1.82
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol (2003) 1.80
Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium (2005) 1.68
Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci U S A (2007) 1.43
Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proc Natl Acad Sci U S A (2004) 1.42
Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO J (2006) 1.40
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem J (2009) 1.38
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO J (2002) 1.35
Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. J Biol Chem (2006) 1.35
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc Natl Acad Sci U S A (2009) 1.34
Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons. J Biol Chem (2002) 1.34
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci (2006) 1.30
Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore. J Cell Sci (2002) 1.29
The NAADP receptor: new receptors or new regulation? Mol Interv (2005) 1.26
Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors. Curr Biol (2009) 1.26
Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. J Physiol (2002) 1.23
Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia. Circ Res (2012) 1.23
The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Rev Physiol Biochem Pharmacol (2013) 1.22
Dynamic association of the ULK1 complex with omegasomes during autophagy induction. J Cell Sci (2013) 1.18
Generation of specific Ca(2+) signals from Ca(2+) stores and endocytosis by differential coupling to messengers. Curr Biol (2006) 1.17
Signal transduction, calcium and acute pancreatitis. Pancreatology (2003) 1.12
Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem (2009) 1.11
Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim. J Biol Chem (2004) 1.11
The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death. Eur J Pharmacol (2002) 1.09
Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am J Physiol Gastrointest Liver Physiol (2007) 1.07
Bernd Nilius: the bard of ion channels. Congratulations on 65th birthday. Pflugers Arch (2010) 1.06
The role of Ca2+ in the pathophysiology of pancreatitis. J Physiol (2013) 1.05
Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology (2010) 1.04
Stable Golgi-mitochondria complexes and formation of Golgi Ca(2+) gradients in pancreatic acinar cells. J Biol Chem (2005) 1.03
Arthroscopic assessment and classification of Kienbock's disease. Tech Hand Up Extrem Surg (2006) 1.02
Modulation of calcium signalling by mitochondria. Biochim Biophys Acta (2009) 1.02
The action of selective CRAC channel blockers is affected by the Orai pore geometry. Cell Calcium (2012) 1.02
Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proc Natl Acad Sci U S A (2011) 0.99
Decoding of short-lived Ca2+ influx signals into long term substrate phosphorylation through activation of two distinct classes of protein kinase C. J Biol Chem (2003) 0.98
The pancreas misled: signals to pancreatitis. Pancreatology (2007) 0.97
CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol (2012) 0.96
Pancreatitis and calcium signalling: report of an international workshop. Pancreas (2008) 0.95
The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist (2007) 0.94
Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations. Biochem J (2004) 0.93
Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. J Cell Biol (2002) 0.93
ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflugers Arch (2007) 0.93
Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol (2013) 0.92
ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Arch (2008) 0.92
Role of Ca2+ in pancreatic cell death induced by alcohol metabolites. J Gastroenterol Hepatol (2006) 0.89
InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. Biochem J (2011) 0.89
Twenty years of calcium imaging: cell physiology to dye for. Mol Interv (2005) 0.88
Non-uniform distribution of mitochondria in pancreatic acinar cells. Cell Tissue Res (2003) 0.88
Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochem J (2003) 0.85
Sensitive and convenient detection of microRNAs based on cascade amplification by catalytic DNAzymes. Chemistry (2012) 0.85
Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. J Biol Chem (2004) 0.85
Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. J Biol Chem (2003) 0.84
Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol (2009) 0.84
A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr Biol (2012) 0.84
Morphological and functional changes of dissociated single pancreatic acinar cells: testing the suitability of the single cell as a model for exocytosis and calcium signaling. Cell Calcium (2004) 0.83
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. J Med Chem (2013) 0.82
Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Med Rep (2011) 0.82
High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells. Am J Physiol Renal Physiol (2014) 0.82
The endoplasmic reticulum is a focal point for co-ordination of cellular activity. Cell Calcium (2003) 0.81
CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in CD8 cells from COPD patients. Clin Sci (Lond) (2014) 0.81
An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. J Biol Chem (2002) 0.80
5-Methyldeoxycytidine enhances the substrate activity of DNA polymerase. Chem Commun (Camb) (2013) 0.80
What can we learn about cell signalling by combining optical imaging and patch clamp techniques? Pflugers Arch (2002) 0.80
Simultaneously sensitive detection of multiple miRNAs based on a strand displacement amplification. Chem Commun (Camb) (2012) 0.79
From Galvani to patch clamp: the development of electrophysiology. Pflugers Arch (2006) 0.79
Regulation of intracellular Ca2+ stores by multiple Ca2+-releasing messengers. Diabetes (2002) 0.79
Co-ordination of Ca(2+) signalling in mammalian cells by the new Ca(2+)-releasing messenger NAADP. Pflugers Arch (2003) 0.79
Live cell imaging of early autophagy events: omegasomes and beyond. J Vis Exp (2013) 0.78
Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. Am J Physiol Gastrointest Liver Physiol (2007) 0.78
In vitro characterisation of the duration of action of the histamine-1 receptor antagonist azelastine. Eur J Pharmacol (2011) 0.78