Published in Oncotarget on September 01, 2013
miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. Cell Death Dis (2013) 1.08
KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress. Cell Death Differ (2014) 0.89
The 26S proteasome is a multifaceted target for anti-cancer therapies. Oncotarget (2015) 0.88
DNA damage modulates interactions between microRNAs and the 26S proteasome. Oncotarget (2014) 0.83
KMT Set7/9 affects genotoxic stress response via the Mdm2 axis. Oncotarget (2015) 0.82
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis. Oncotarget (2013) 0.80
Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair. PLoS One (2014) 0.80
Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene (2016) 0.79
Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma. Dig Dis Sci (2015) 0.78
Polypharmacology of small molecules targeting the ubiquitin-proteasome and ubiquitin-like systems. Oncotarget (2015) 0.78
A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression. Oncotarget (2014) 0.77
No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes. Immunogenetics (2014) 0.76
Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice. EMBO J (2016) 0.75
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget (2016) 0.75
E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells. Genes Cancer (2016) 0.75
One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy. Oncotarget (2017) 0.75
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Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol (2001) 6.96
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell (2008) 5.38
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Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol (2007) 3.54
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Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell (2004) 2.17
A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature (2005) 2.03
Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. J Biol Chem (2001) 1.97
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Neuronal induction of the immunoproteasome in Huntington's disease. J Neurosci (2003) 1.83
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Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol (2000) 1.31
Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon. Biochem J (2004) 1.30
Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML. Cell Cycle (2006) 1.21
Transformation of the proteasome with age-related macular degeneration. FEBS Lett (2007) 1.18
A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome. Am J Physiol Heart Circ Physiol (2008) 1.15
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N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome. Arch Biochem Biophys (2003) 1.09
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Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage. Mol Cell Biol (2011) 1.00
Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes. J Biol Chem (2006) 0.99
Therapeutic targeting of cancer cell cycle using proteasome inhibitors. Cell Div (2012) 0.98
Dependence of phospholipase D1 multi-monoubiquitination on its enzymatic activity and palmitoylation. J Biol Chem (2010) 0.97
The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity. J Neurochem (2007) 0.94
The ubiquitin proteasome system and its involvement in cell death pathways. Cell Death Differ (2010) 0.94
Mapping and structural dissection of human 20 S proteasome using proteomic approaches. Mol Cell Proteomics (2002) 0.93
Role of proteasomes in transcription and their regulation by covalent modifications. Front Biosci (2008) 0.92
Development of phosphopeptide enrichment techniques for phosphoproteome analysis. Analyst (2008) 0.90
Carfilzomib: in relapsed, or relapsed and refractory, multiple myeloma. Drugs (2012) 0.89
The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene (2012) 0.85
Identification of the Xenopus 20S proteasome alpha4 subunit which is modified in the meiotic cell cycle. Gene (1999) 0.84
Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction. Cell Cycle (2012) 0.84
Correlation between nuclear action of anthracycline anticancer agents and their binding affinity to the proteasome. Int J Oncol (2002) 0.84
Identification of alpha-type subunits of the Xenopus 20S proteasome and analysis of their changes during the meiotic cell cycle. BMC Biochem (2004) 0.82
Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Biochem Biophys Res Commun (2011) 0.82
Involvement of proteasomal subunits zeta and iota in RNA degradation. Biochem J (1997) 0.82
Inhibition of the p53-hdm2 interaction with low molecular weight compounds. Cell Cycle (2004) 0.79
Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells. Amino Acids (2010) 0.78
[Recombinant proteasomal alpha-type subunits exhibit endoribonuclease activity]. Tsitologiia (2010) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell (2008) 3.35
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med (2009) 2.03
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90
MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle (2011) 1.89
Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology (2011) 1.85
TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84
The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol (2008) 1.76
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A (2007) 1.70
microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A (2011) 1.58
Regulation of the apoptosis-necrosis switch. Oncogene (2004) 1.54
FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. Cell Cycle (2008) 1.52
p63, a story of mice and men. J Invest Dermatol (2011) 1.50
New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J (2006) 1.50
26S proteasome exhibits endoribonuclease activity controlled by extra-cellular stimuli. Cell Cycle (2010) 1.48
Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc Natl Acad Sci U S A (2003) 1.48
Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity. Cancer Res (2011) 1.47
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun (2005) 1.42
One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat (2007) 1.41
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code. J Biol Chem (2010) 1.40
Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proc Natl Acad Sci U S A (2008) 1.39
A novel recessive connexin 31 (GJB3) mutation in a case of erythrokeratodermia variabilis. J Invest Dermatol (2004) 1.39
Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol (2008) 1.38
p63 is upstream of IKK alpha in epidermal development. J Cell Sci (2006) 1.35
TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A (2009) 1.34
The twin-arginine translocation pathway is a major route of protein export in Streptomyces coelicolor. Proc Natl Acad Sci U S A (2006) 1.34
A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am J Hum Genet (2005) 1.33
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol Cell Biol (2004) 1.33
p73 in Cancer. Genes Cancer (2011) 1.33
GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation. Cell Cycle (2013) 1.32
p53 is cleaved by caspases generating fragments localizing to mitochondria. J Biol Chem (2006) 1.30
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev (2013) 1.30
miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro. Biochem Biophys Res Commun (2010) 1.29
Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells. J Biol Chem (2006) 1.27
p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun (2010) 1.25
Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24
Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice. J Exp Med (2011) 1.23
Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux. J Cell Sci (2009) 1.20
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc Natl Acad Sci U S A (2007) 1.19
Roles for p53 and p73 during oligodendrocyte development. Development (2004) 1.18
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Res (2002) 1.16
The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A (2010) 1.15
A novel RGD-independent cel adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis. J Biol Chem (2003) 1.14
miR-146a is modulated in human endothelial cell with aging. Atherosclerosis (2011) 1.14
E1A activates transcription of p73 and Noxa to induce apoptosis. J Biol Chem (2004) 1.14
Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells. J Immunol (2009) 1.13
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun (2011) 1.13
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias. J Cell Sci (2011) 1.11
Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB J (2002) 1.11
Itch self-polyubiquitylation occurs through lysine-63 linkages. Biochem Pharmacol (2008) 1.09
The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway. Proc Natl Acad Sci U S A (2010) 1.09
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells. Neurosci Lett (2007) 1.08
Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc Natl Acad Sci U S A (2010) 1.08
p73: a multifunctional protein in neurobiology. Mol Neurobiol (2011) 1.07
Identification of NCF2/p67phox as a novel p53 target gene. Cell Cycle (2012) 1.07
Transglutaminase type II plays a protective role in hepatic injury. Am J Pathol (2003) 1.06
Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer (2010) 1.05
miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J Cell Biol (2012) 1.04
Cell death pathology: cross-talk with autophagy and its clinical implications. Biochem Biophys Res Commun (2011) 1.04
Expression of transglutaminase 5 in normal and pathologic human epidermis. J Invest Dermatol (2002) 1.04
NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2. Proc Natl Acad Sci U S A (2010) 1.03
Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03
Cell death pathology: perspective for human diseases. Biochem Biophys Res Commun (2011) 1.03
New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun (2005) 1.02
p73-alpha is capable of inducing scotin and ER stress. Oncogene (2004) 1.02
Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma. J Cell Biochem (2003) 1.01
Regulation of the p73 protein stability and degradation. Biochem Biophys Res Commun (2005) 1.00
TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation. FASEB J (2008) 1.00
Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation. Exp Dermatol (2011) 1.00
Expression of GATA-3 in epidermis and hair follicle: relationship to p63. Biochem Biophys Res Commun (2007) 0.99
Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs. Nucleic Acids Res (2011) 0.99
Calpain cleavage regulates the protein stability of p73. Biochem Biophys Res Commun (2005) 0.99
Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci U S A (2011) 0.99
Identification of a MAP65 isoform involved in directional expansion of plant cells. FEBS Lett (2003) 0.99
Dominant negative (DeltaN) p63alpha induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways. Biochem Biophys Res Commun (2010) 0.99
p63 the guardian of human reproduction. Cell Cycle (2012) 0.98
NRF2 and p53: Januses in cancer? Oncotarget (2012) 0.98
How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat (2014) 0.97
Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma protein. J Biol Chem (2007) 0.96
Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. Biochem J (2002) 0.96
TAp73 is required for spermatogenesis and the maintenance of male fertility. Proc Natl Acad Sci U S A (2014) 0.95
p73 and p63 protein stability: the way to regulate function? Biochem Pharmacol (2003) 0.95
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A (2014) 0.94
Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers. Oncotarget (2013) 0.94