Published in Science on August 01, 2013
Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv (2015) 1.49
A practical and catalytic reductive olefin coupling. J Am Chem Soc (2014) 1.46
Academia-industry symbiosis in organic chemistry. Acc Chem Res (2015) 1.15
Two-phase synthesis of (-)-taxuyunnanine D. J Am Chem Soc (2014) 1.12
Cancer wars: natural products strike back. Front Chem (2014) 1.11
Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling. AIDS (2014) 1.05
Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One (2014) 0.99
Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters. Plant Cell (2014) 0.94
A unified approach to ent-atisane diterpenes and related alkaloids: synthesis of (-)-methyl atisenoate, (-)-isoatisine, and the hetidine skeleton. J Am Chem Soc (2014) 0.92
Improving physical properties via C-H oxidation: chemical and enzymatic approaches. Angew Chem Int Ed Engl (2014) 0.89
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. Chem Rev (2016) 0.88
Radicals: Reactive Intermediates with Translational Potential. J Am Chem Soc (2016) 0.83
Nineteen-step total synthesis of (+)-phorbol. Nature (2016) 0.82
Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology. J Am Chem Soc (2014) 0.81
Natural product synthesis at the interface of chemistry and biology. Chemistry (2014) 0.81
Short, Enantioselective Total Synthesis of Highly Oxidized Taxanes. Angew Chem Int Ed Engl (2016) 0.80
A biocompatible alkene hydrogenation merges organic synthesis with microbial metabolism. Angew Chem Int Ed Engl (2014) 0.80
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products. Chem Rev (2017) 0.78
Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L. Proc Natl Acad Sci U S A (2016) 0.77
Evolutionary prediction of medicinal properties in the genus Euphorbia L. Sci Rep (2016) 0.76
Scalable Synthesis of (-)-Thapsigargin. ACS Cent Sci (2016) 0.76
Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast. Nat Commun (2016) 0.75
Fe-Catalyzed C-C Bond Construction from Olefins via Radicals. J Am Chem Soc (2017) 0.75
Oxidative Entry into the Illicium Sesquiterpenes: Enantiospecific Synthesis of (+)-Pseudoanisatin. J Am Chem Soc (2016) 0.75
Tumor-Preferential Induction of Immune Responses and Epidermal Cell Death in Actinic Keratoses by Ingenol Mebutate. PLoS One (2016) 0.75
Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery. Future Med Chem (2014) 0.75
Mechanism, reactivity, and selectivity of nickel-catalyzed [4 + 4 + 2] cycloadditions of dienes and alkynes. J Org Chem (2014) 0.75
Enantioselective total synthesis of (-)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids. Chem Sci (2017) 0.75
Aiming for the ideal synthesis. J Org Chem (2010) 3.44
Redox economy in organic synthesis. Angew Chem Int Ed Engl (2009) 2.74
Total synthesis of eudesmane terpenes by site-selective C-H oxidations. Nature (2009) 2.65
Total synthesis of palau'amine. Angew Chem Int Ed Engl (2010) 2.62
Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A (2011) 2.52
The economies of synthesis. Chem Soc Rev (2009) 2.15
Protecting-group-free synthesis as an opportunity for invention. Nat Chem (2009) 2.11
Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach. J Am Chem Soc (2008) 2.10
If C-H bonds could talk: selective C-H bond oxidation. Angew Chem Int Ed Engl (2011) 2.09
C-H functionalization logic in total synthesis. Chem Soc Rev (2011) 2.00
The pursuit of palau'amine. Angew Chem Int Ed Engl (2007) 2.00
Innate and guided C-H functionalization logic. Acc Chem Res (2011) 1.94
Practical and innate carbon-hydrogen functionalization of heterocycles. Nature (2012) 1.83
A concise approach to vinigrol. Angew Chem Int Ed Engl (2008) 1.78
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc (2010) 1.71
A new reagent for direct difluoromethylation. J Am Chem Soc (2012) 1.70
Modern synthetic efforts toward biologically active terpenes. Nat Chem Biol (2007) 1.68
Intermolecular enolate heterocoupling: scope, mechanism, and application. J Am Chem Soc (2008) 1.66
Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton. J Am Chem Soc (2007) 1.65
Synthesis of (+)-cortistatin A. J Am Chem Soc (2008) 1.48
A practical and catalytic reductive olefin coupling. J Am Chem Soc (2014) 1.46
Chemoselectivity: the mother of invention in total synthesis. Acc Chem Res (2009) 1.44
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl (2008) 1.44
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc (2011) 1.41
Total synthesis of (+/-)-psychotrimine. J Am Chem Soc (2008) 1.41
Scalable enantioselective total synthesis of taxanes. Nat Chem (2011) 1.40
Carbon-fluorine bond formation. Curr Opin Drug Discov Devel (2008) 1.40
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl (2008) 1.39
Emerging classes of protein-protein interaction inhibitors and new tools for their development. Curr Opin Chem Biol (2004) 1.38
Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide. Science (2013) 1.35
Scalable synthesis of cortistatin A and related structures. J Am Chem Soc (2011) 1.30
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc (2008) 1.26
Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc (2011) 1.25
Syntheses and antiproliferative evaluation of oxyphenisatin derivatives. Bioorg Med Chem Lett (2007) 1.22
A synthesis of the carbon skeleton of maoecrystal V. Org Lett (2009) 1.22
1,3-Diol synthesis via controlled, radical-mediated C-H functionalization. J Am Chem Soc (2008) 1.21
Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B. J Am Chem Soc (2011) 1.19
Synthesis: A constructive debate. Nature (2012) 1.19
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A (2012) 1.19
Massadine chloride: a biosynthetic precursor of massadine and stylissadine. Angew Chem Int Ed Engl (2007) 1.19
Enantiospecific total syntheses of kapakahines B and F. J Am Chem Soc (2009) 1.17
Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F. J Am Chem Soc (2010) 1.15
Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E. Angew Chem Int Ed Engl (2006) 1.15
Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylation. J Am Chem Soc (2011) 1.13
Two-phase synthesis of (-)-taxuyunnanine D. J Am Chem Soc (2014) 1.12
Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues. Angew Chem Int Ed Engl (2009) 1.09
Scope and mechanism of direct indole and pyrrole couplings adjacent to carbonyl compounds: total synthesis of acremoauxin A and oxazinin 3. J Am Chem Soc (2007) 1.07
Natural product synthesis in the age of scalability. Nat Prod Rep (2013) 1.07
Total synthesis of vinigrol. J Am Chem Soc (2009) 1.06
Sequential C(sp3)-H arylation and olefination: total synthesis of the proposed structure of pipercyclobutanamide A. Angew Chem Int Ed Engl (2012) 1.06
Total synthesis guided structure elucidation of (+)-psychotetramine. Angew Chem Int Ed Engl (2011) 1.06
Practical radical cyclizations with arylboronic acids and trifluoroborates. Org Lett (2011) 1.04
HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones. Angew Chem Int Ed Engl (2002) 1.03
Total synthesis of dixiamycin B by electrochemical oxidation. J Am Chem Soc (2014) 1.03
Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability. J Am Chem Soc (2013) 1.02
On the origin of the haouamine alkaloids. Angew Chem Int Ed Engl (2008) 1.02
Intermolecular Ritter-type C-H amination of unactivated sp3 carbons. J Am Chem Soc (2012) 1.02
Scalable, enantioselective synthesis of germacrenes and related sesquiterpenes inspired by terpene cyclase phase logic. Angew Chem Int Ed Engl (2012) 1.01
Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides. J Nat Prod (2010) 0.99
Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds. Angew Chem Int Ed Engl (2002) 0.99
Synthesis of ent-kaurane and beyerane diterpenoids by controlled fragmentations of overbred intermediates. Angew Chem Int Ed Engl (2013) 0.99
Guided desaturation of unactivated aliphatics. Nat Chem (2012) 0.99
Strain release in C-H bond activation? Angew Chem Int Ed Engl (2009) 0.98
Direct synthesis of fluorinated heteroarylether bioisosteres. Angew Chem Int Ed Engl (2013) 0.97
Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide". J Am Chem Soc (2012) 0.96
Bioconjugation by native chemical tagging of C-H bonds. J Am Chem Soc (2013) 0.95
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines. ACS Chem Biol (2010) 0.94
C-H methylation of heteroarenes inspired by radical SAM methyl transferase. J Am Chem Soc (2014) 0.92
Scalable total synthesis and biological evaluation of haouamine A and its atropisomer. J Am Chem Soc (2009) 0.92
A unified approach to ent-atisane diterpenes and related alkaloids: synthesis of (-)-methyl atisenoate, (-)-isoatisine, and the hetidine skeleton. J Am Chem Soc (2014) 0.92
A simple litmus test for aldehyde oxidase metabolism of heteroarenes. J Med Chem (2014) 0.91
Development of a concise synthesis of (+)-ingenol. J Am Chem Soc (2014) 0.91
Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues. J Am Chem Soc (2015) 0.90
Regioselective bromination of fused heterocyclic N-oxides. Org Lett (2013) 0.90
Direct, chemoselective N-tert-prenylation of indoles by C-H functionalization. Angew Chem Int Ed Engl (2009) 0.89
Improving physical properties via C-H oxidation: chemical and enzymatic approaches. Angew Chem Int Ed Engl (2014) 0.89
Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental study. J Org Chem (2013) 0.89
Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation. Angew Chem Int Ed Engl (2014) 0.88
Radical C-H functionalization of heteroarenes under electrochemical control. Angew Chem Int Ed Engl (2014) 0.87
A mild, ferrocene-catalyzed C-H imidation of (hetero)arenes. J Am Chem Soc (2014) 0.87
Activity-linked labeling of enzymes by self-immolative polymers. Bioconjug Chem (2009) 0.87
C-H functionalization logic enables synthesis of (+)-hongoquercin A and related compounds. Angew Chem Int Ed Engl (2013) 0.86
Strained cyclophane natural products: macrocyclization at its limits. Nat Prod Rep (2012) 0.86
An approach to mimicking the sesquiterpene cyclase phase by nickel-promoted diene/alkyne cooligomerization. J Org Chem (2012) 0.86
Why a proximity-induced Diels-Alder reaction is so fast. Org Lett (2012) 0.86
"Donor-two-acceptor" dye design: a distinct gateway to NIR fluorescence. J Am Chem Soc (2012) 0.86
Sulfhydryl-based dendritic chain reaction. Chem Commun (Camb) (2010) 0.86
Palau'chlor: a practical and reactive chlorinating reagent. J Am Chem Soc (2014) 0.85
Applications of C-H functionalization logic to cyclobutane synthesis. J Org Chem (2014) 0.84
Preparation and purification of zinc sulfinate reagents for drug discovery. Nat Protoc (2013) 0.84
The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis. Angew Chem Int Ed Engl (2002) 0.83
Ring opening of pymisyl-protected aziridines with organocuprates. Chemistry (2010) 0.82
Synthesis of enantiopure 3-substituted morpholines. J Org Chem (2010) 0.82
Synthesis-guided structure revision of the sarcodonin, sarcoviolin, and hydnellin natural product family. J Org Chem (2011) 0.82
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome. J Nat Prod (2012) 0.81
Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology. J Am Chem Soc (2014) 0.81
Exploring the pharmacology and action spectra of photochromic open-channel blockers. Chembiochem (2012) 0.81