Published in Nature on November 28, 2012
Organic chemistry. Strain-release amination. Science (2016) 1.49
Academia-industry symbiosis in organic chemistry. Acc Chem Res (2015) 1.15
Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability. J Am Chem Soc (2013) 1.02
Visible light-promoted metal-free C-H activation: diarylketone-catalyzed selective benzylic mono- and difluorination. J Am Chem Soc (2013) 1.01
Direct synthesis of fluorinated heteroarylether bioisosteres. Angew Chem Int Ed Engl (2013) 0.97
Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method. ACS Cent Sci (2016) 0.97
Late-stage deoxyfluorination of alcohols with PhenoFluor. J Am Chem Soc (2013) 0.95
Bioconjugation by native chemical tagging of C-H bonds. J Am Chem Soc (2013) 0.95
Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides. Org Lett (2014) 0.93
Direct α-arylation of ethers through the combination of photoredox-mediated C-H functionalization and the Minisci reaction. Angew Chem Int Ed Engl (2014) 0.93
C-H methylation of heteroarenes inspired by radical SAM methyl transferase. J Am Chem Soc (2014) 0.92
Meta-selective C-H functionalization using a nitrile-based directing group and cleavable Si-tether. J Am Chem Soc (2013) 0.88
Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation. Angew Chem Int Ed Engl (2014) 0.88
Amine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway. Chem Sci (2014) 0.87
A mild, ferrocene-catalyzed C-H imidation of (hetero)arenes. J Am Chem Soc (2014) 0.87
Radical C-H functionalization of heteroarenes under electrochemical control. Angew Chem Int Ed Engl (2014) 0.87
A scalable and operationally simple radical trifluoromethylation. Nat Commun (2015) 0.85
Preparation and purification of zinc sulfinate reagents for drug discovery. Nat Protoc (2013) 0.84
Radicals: Reactive Intermediates with Translational Potential. J Am Chem Soc (2016) 0.83
Stereoselectively fluorinated N-heterocycles: a brief survey. Beilstein J Org Chem (2013) 0.83
Metal-free trifluoromethylation of aromatic and heteroaromatic aldehydes and ketones. J Org Chem (2014) 0.83
Chemo- and site-selective derivatizations of natural products enabling biological studies. Nat Prod Rep (2014) 0.83
Palladium-catalyzed intramolecular C-H difluoroalkylation: synthesis of substituted 3,3-difluoro-2-oxindoles. Angew Chem Int Ed Engl (2014) 0.81
Mild silver-mediated geminal difluorination of styrenes using an air- and moisture-stable fluoroiodane reagent. Angew Chem Int Ed Engl (2014) 0.80
Photoredox-mediated Minisci C-H alkylation of N-heteroarenes using boronic acids and hypervalent iodine. Chem Sci (2016) 0.78
Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on a Kilogram Scale. Chem (2016) 0.78
Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols. Chemistry (2015) 0.78
Metal-free C-H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation. Chem Sci (2017) 0.77
Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution. J Am Chem Soc (2014) 0.76
Biocatalytic trifluoromethylation of unprotected phenols. Nat Commun (2016) 0.75
Copper-catalyzed direct alkylation of heteroarenes. Chem Sci (2017) 0.75
Copper-Catalyzed Aerobic C-H Trifluoromethylation of Phenanthrolines. Synlett (2016) 0.75
Organic chemistry: Toolkit of reagents to aid drug discovery. Nature (2012) 0.75
4-Trifluoromethyl-p-quinols as dielectrophiles: three-component, double nucleophilic addition/aromatization reactions. Sci Rep (2016) 0.75
Photoredox radical conjugate addition of dithiane-2-carboxylate promoted by an iridium(iii) phenyl-tetrazole complex: a formal radical methylation of Michael acceptors. Chem Sci (2016) 0.75
Photo-driven redox-neutral decarboxylative carbon-hydrogen trifluoromethylation of (hetero)arenes with trifluoroacetic acid. Nat Commun (2017) 0.75
Visible-light-induced oxidant and metal-free dehydrogenative cascade trifluoromethylation and oxidation of 1,6-enynes with water. Chem Sci (2017) 0.75
Laser-initiated Radical Trifluoromethylation of Peptides and Proteins and Its Application to Mass Spectrometry-Based Protein Footprinting. Angew Chem Int Ed Engl (2017) 0.75
Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides. Chem Sci (2017) 0.75
Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew Chem Int Ed Engl (2001) 19.25
Fluorine in pharmaceuticals: looking beyond intuition. Science (2007) 8.98
Fluorine in medicinal chemistry. Chem Soc Rev (2007) 6.99
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl (2010) 4.17
Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem (2011) 3.31
The palladium-catalyzed trifluoromethylation of aryl chlorides. Science (2010) 2.85
Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A (2011) 2.52
Pd(II)-catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter. J Am Chem Soc (2010) 2.37
Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. Nature (2011) 2.30
Innate and guided C-H functionalization logic. Acc Chem Res (2011) 1.94
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc (2010) 1.71
A new reagent for direct difluoromethylation. J Am Chem Soc (2012) 1.70
A broadly applicable copper reagent for trifluoromethylations and perfluoroalkylations of aryl iodides and bromides. Angew Chem Int Ed Engl (2011) 1.68
Direct alkylation of heteroaryls using potassium alkyl- and alkoxymethyltrifluoroborates. Org Lett (2011) 1.58
Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides. J Am Chem Soc (2009) 1.53
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc (2011) 1.41
Selective difluoromethylation and monofluoromethylation reactions. Chem Commun (Camb) (2009) 1.18
Copper-mediated difluoromethylation of aryl and vinyl iodides. J Am Chem Soc (2012) 1.16
Stereoselective nucleophilic monofluoromethylation of N-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone. Org Lett (2006) 1.00
Palladium-catalyzed 2,2,2-trifluoroethylation of organoboronic acids and esters. Angew Chem Int Ed Engl (2011) 0.99
Aiming for the ideal synthesis. J Org Chem (2010) 3.44
Redox economy in organic synthesis. Angew Chem Int Ed Engl (2009) 2.74
Total synthesis of eudesmane terpenes by site-selective C-H oxidations. Nature (2009) 2.65
Total synthesis of palau'amine. Angew Chem Int Ed Engl (2010) 2.62
Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A (2011) 2.52
The economies of synthesis. Chem Soc Rev (2009) 2.15
Protecting-group-free synthesis as an opportunity for invention. Nat Chem (2009) 2.11
Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach. J Am Chem Soc (2008) 2.10
If C-H bonds could talk: selective C-H bond oxidation. Angew Chem Int Ed Engl (2011) 2.09
C-H functionalization logic in total synthesis. Chem Soc Rev (2011) 2.00
The pursuit of palau'amine. Angew Chem Int Ed Engl (2007) 2.00
Innate and guided C-H functionalization logic. Acc Chem Res (2011) 1.94
A concise approach to vinigrol. Angew Chem Int Ed Engl (2008) 1.78
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc (2010) 1.71
A new reagent for direct difluoromethylation. J Am Chem Soc (2012) 1.70
Modern synthetic efforts toward biologically active terpenes. Nat Chem Biol (2007) 1.68
Intermolecular enolate heterocoupling: scope, mechanism, and application. J Am Chem Soc (2008) 1.66
Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton. J Am Chem Soc (2007) 1.65
Recent developments in natural product synthesis using metal-catalysed C-H bond functionalisation. Chem Soc Rev (2011) 1.58
Synthesis of (+)-cortistatin A. J Am Chem Soc (2008) 1.48
A practical and catalytic reductive olefin coupling. J Am Chem Soc (2014) 1.46
Chemoselectivity: the mother of invention in total synthesis. Acc Chem Res (2009) 1.44
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl (2008) 1.44
Total synthesis of (+/-)-psychotrimine. J Am Chem Soc (2008) 1.41
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc (2011) 1.41
Scalable enantioselective total synthesis of taxanes. Nat Chem (2011) 1.40
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl (2008) 1.39
Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide. Science (2013) 1.35
Scalable synthesis of cortistatin A and related structures. J Am Chem Soc (2011) 1.30
14-step synthesis of (+)-ingenol from (+)-3-carene. Science (2013) 1.26
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc (2008) 1.26
Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc (2011) 1.25
A synthesis of the carbon skeleton of maoecrystal V. Org Lett (2009) 1.22
1,3-Diol synthesis via controlled, radical-mediated C-H functionalization. J Am Chem Soc (2008) 1.21
Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B. J Am Chem Soc (2011) 1.19
Synthesis: A constructive debate. Nature (2012) 1.19
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A (2012) 1.19
Massadine chloride: a biosynthetic precursor of massadine and stylissadine. Angew Chem Int Ed Engl (2007) 1.19
Enantiospecific total syntheses of kapakahines B and F. J Am Chem Soc (2009) 1.17
Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F. J Am Chem Soc (2010) 1.15
Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E. Angew Chem Int Ed Engl (2006) 1.15
Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylation. J Am Chem Soc (2011) 1.13
Two-phase synthesis of (-)-taxuyunnanine D. J Am Chem Soc (2014) 1.12
Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues. Angew Chem Int Ed Engl (2009) 1.09
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem (2014) 1.07
Scope and mechanism of direct indole and pyrrole couplings adjacent to carbonyl compounds: total synthesis of acremoauxin A and oxazinin 3. J Am Chem Soc (2007) 1.07
Natural product synthesis in the age of scalability. Nat Prod Rep (2013) 1.07
Total synthesis of vinigrol. J Am Chem Soc (2009) 1.06
Total synthesis guided structure elucidation of (+)-psychotetramine. Angew Chem Int Ed Engl (2011) 1.06
Sequential C(sp3)-H arylation and olefination: total synthesis of the proposed structure of pipercyclobutanamide A. Angew Chem Int Ed Engl (2012) 1.06
An enantioselective organocatalytic oxidative dearomatization strategy. J Am Chem Soc (2008) 1.06
Practical radical cyclizations with arylboronic acids and trifluoroborates. Org Lett (2011) 1.04
HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones. Angew Chem Int Ed Engl (2002) 1.03
Total synthesis of dixiamycin B by electrochemical oxidation. J Am Chem Soc (2014) 1.03
Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability. J Am Chem Soc (2013) 1.02
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90. ACS Med Chem Lett (2010) 1.02
On the origin of the haouamine alkaloids. Angew Chem Int Ed Engl (2008) 1.02
Intermolecular Ritter-type C-H amination of unactivated sp3 carbons. J Am Chem Soc (2012) 1.02
Scalable, enantioselective synthesis of germacrenes and related sesquiterpenes inspired by terpene cyclase phase logic. Angew Chem Int Ed Engl (2012) 1.01
Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides. J Nat Prod (2010) 0.99
Synthesis of ent-kaurane and beyerane diterpenoids by controlled fragmentations of overbred intermediates. Angew Chem Int Ed Engl (2013) 0.99
Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds. Angew Chem Int Ed Engl (2002) 0.99
Guided desaturation of unactivated aliphatics. Nat Chem (2012) 0.99
Strain release in C-H bond activation? Angew Chem Int Ed Engl (2009) 0.98
Direct synthesis of fluorinated heteroarylether bioisosteres. Angew Chem Int Ed Engl (2013) 0.97
Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide". J Am Chem Soc (2012) 0.96
Bioconjugation by native chemical tagging of C-H bonds. J Am Chem Soc (2013) 0.95
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines. ACS Chem Biol (2010) 0.94
C-H methylation of heteroarenes inspired by radical SAM methyl transferase. J Am Chem Soc (2014) 0.92
Scalable total synthesis and biological evaluation of haouamine A and its atropisomer. J Am Chem Soc (2009) 0.92
A unified approach to ent-atisane diterpenes and related alkaloids: synthesis of (-)-methyl atisenoate, (-)-isoatisine, and the hetidine skeleton. J Am Chem Soc (2014) 0.92
A Simple Procedure for C-C Bond Cleavage of Aromatic and Aliphatic Epoxides with Aqueous Sodium Periodate Under Ambient Conditions. Tetrahedron Lett (2008) 0.91
Development of a concise synthesis of (+)-ingenol. J Am Chem Soc (2014) 0.91
A simple litmus test for aldehyde oxidase metabolism of heteroarenes. J Med Chem (2014) 0.91
Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues. J Am Chem Soc (2015) 0.90
Regioselective bromination of fused heterocyclic N-oxides. Org Lett (2013) 0.90
Improving physical properties via C-H oxidation: chemical and enzymatic approaches. Angew Chem Int Ed Engl (2014) 0.89
Direct, chemoselective N-tert-prenylation of indoles by C-H functionalization. Angew Chem Int Ed Engl (2009) 0.89
Synthesis and cytotoxicity of a new class of potent decapeptide macrocycles. Org Lett (2007) 0.89
Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental study. J Org Chem (2013) 0.89