Published in Mol Biol Cell on August 07, 2013
Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell (2014) 1.14
The role of molecular remodeling in differential regulation of tight junction permeability. Semin Cell Dev Biol (2014) 1.02
Claudins and the kidney. J Am Soc Nephrol (2014) 0.87
Claudin-2-dependent paracellular channels are dynamically gated. Elife (2015) 0.85
A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction. Mol Biol Cell (2015) 0.83
PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function. J Biol Chem (2015) 0.82
Molecular aspects of tight junction barrier function. Curr Opin Pharmacol (2014) 0.81
Junctional proteins of the blood-brain barrier: New insights into function and dysfunction. Tissue Barriers (2016) 0.80
Scaffolding protein GOPC regulates tight junction structure. Cell Tissue Res (2015) 0.79
Active and passive involvement of claudins in the pathophysiology of intestinal inflammatory diseases. Pflugers Arch (2016) 0.79
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79
Conceptual barriers to understanding physical barriers. Semin Cell Dev Biol (2015) 0.78
The intestinal epithelial barrier: a therapeutic target? Nat Rev Gastroenterol Hepatol (2016) 0.78
Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology (2016) 0.77
Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport. Am J Physiol Cell Physiol (2015) 0.76
ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. J Cell Sci (2016) 0.76
Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease. Mucosal Immunol (2017) 0.76
Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol (2017) 0.76
The mucosal barrier at a glance. J Cell Sci (2017) 0.75
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. Tissue Barriers (2015) 0.75
Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability. J Cell Biochem (2015) 0.75
Celiac Disease: Role of the Epithelial Barrier. Cell Mol Gastroenterol Hepatol (2017) 0.75
Filtration, diffusion, and molecular sieving through porous cellulose membranes. J Gen Physiol (1954) 11.50
Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol (1993) 10.65
Intestinal mucosal barrier function in health and disease. Nat Rev Immunol (2009) 7.15
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem (1998) 5.34
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol (1994) 5.01
Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69
A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol (1997) 3.86
Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol (2002) 3.59
Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol (1987) 3.40
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest (2001) 3.28
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol (2005) 3.22
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest (2005) 3.15
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol (1997) 3.07
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol (2002) 2.94
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells. Am J Physiol Cell Physiol (2005) 2.92
COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol (1997) 2.71
Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem (1999) 2.68
Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol (2011) 2.67
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology (2002) 2.66
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci (2006) 2.59
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol (2010) 2.47
Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol (2005) 2.45
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell (2005) 2.29
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell (2009) 2.10
Occludin confers adhesiveness when expressed in fibroblasts. J Cell Sci (1997) 2.10
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci (2009) 1.96
Setting up a selective barrier at the apical junction complex. Curr Opin Cell Biol (2004) 1.93
Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol (2009) 1.91
IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology (2006) 1.89
Epithelial transport and barrier function in occludin-deficient mice. Biochim Biophys Acta (2005) 1.88
Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterology (1998) 1.84
Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem (2009) 1.81
Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am J Physiol (1997) 1.80
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem (2010) 1.74
MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A (2010) 1.70
LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology (2007) 1.70
Multiple domains of occludin are involved in the regulation of paracellular permeability. J Cell Biochem (2000) 1.65
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem (2004) 1.64
Ion transport through cell membrane. J Theor Biol (1964) 1.58
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol (2011) 1.58
Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem (2008) 1.55
Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell (2010) 1.51
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction. J Biol Chem (2000) 1.50
Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol (2011) 1.48
Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell (2009) 1.46
MicroRNA regulation of intestinal epithelial tight junction permeability. Gastroenterology (2011) 1.41
Loss of occludin affects tricellular localization of tricellulin. Mol Biol Cell (2008) 1.40
Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface. J Mol Biol (2005) 1.39
Occludin is required for cytokine-induced regulation of tight junction barriers. J Cell Sci (2010) 1.26
TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology (2013) 1.24
A dominant mutant of occludin disrupts tight junction structure and function. J Cell Sci (1999) 1.18
Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes (2012) 1.13
Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition. Gastroenterology (2012) 1.09
Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin. Mol Biol Cell (2005) 1.07
Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach. J Proteome Res (2009) 1.05
The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a. Nat Struct Mol Biol (2007) 1.01
A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase. Pharm Res (2005) 0.97
The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability. Proc Natl Acad Sci U S A (2012) 0.93
Occludin regulates actin cytoskeleton in endothelial cells. Cell Struct Funct (2001) 0.83
Occludin modulates organization of perijunctional circumferential actin in rat endothelial cells. Med Electron Microsc (1999) 0.77
Multiple myeloma. N Engl J Med (2011) 10.38
Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host Microbe (2007) 3.34
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A (2004) 3.27
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol (2005) 3.22
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest (2005) 3.15
Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. N Engl J Med (2014) 2.99
Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86
Recognition of host immune activation by Pseudomonas aeruginosa. Science (2005) 2.84
Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol (2008) 2.84
A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest (2004) 2.75
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest (2006) 2.67
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology (2002) 2.66
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci (2006) 2.59
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol (2010) 2.47
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell (2005) 2.46
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology (2008) 2.42
The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol (2008) 2.42
CD95 promotes tumour growth. Nature (2010) 2.42
Molecular ordering of the initial signaling events of CD95. Mol Cell Biol (2002) 2.36
Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell (2005) 2.29
Epithelial barriers in homeostasis and disease. Annu Rev Pathol (2010) 2.28
Latest advances and current challenges in the treatment of multiple myeloma. Nat Rev Clin Oncol (2012) 2.25
American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma. J Clin Oncol (2007) 2.09
Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma. Leuk Lymphoma (2008) 2.09
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09
Probing the structure of single-molecule surface-enhanced Raman scattering hot spots. J Am Chem Soc (2008) 2.06
Continuing attrition of physician-scientists (CAPS): a preventable syndrome? Gastroenterology (2012) 2.00
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00
IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology (2006) 1.89
Muscle force and activation under stable and unstable conditions. J Strength Cond Res (2002) 1.89
Trends in utilization and outcomes of autologous transplantation as early therapy for multiple myeloma. Biol Blood Marrow Transplant (2013) 1.88
New drugs for myeloma. Oncologist (2007) 1.84
Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol (2008) 1.76
Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology (2015) 1.76
Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients. Clin Cancer Res (2013) 1.75
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem (2010) 1.74
Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. J Clin Invest (2007) 1.72
MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A (2010) 1.70
LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology (2007) 1.70
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem (2004) 1.64
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest (2008) 1.64
Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog (2007) 1.60
Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem (2006) 1.59
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol (2011) 1.58
Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology (2010) 1.57
Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem (2008) 1.55
The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology (2011) 1.54
Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell (2010) 1.51
PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proc Natl Acad Sci U S A (2008) 1.51
Characterization of epithelial cell shedding from human small intestine. Lab Invest (2006) 1.45
Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity. Mayo Clin Proc (2004) 1.43
Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology (2005) 1.42
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology (2008) 1.41
The tight junction in inflammatory disease: communication breakdown. Curr Opin Pharmacol (2009) 1.37
Safety of prolonged therapy with bortezomib in relapsed or refractory multiple myeloma. Cancer (2005) 1.36
Evaluation of diffusion-weighted MR imaging for detection of bowel inflammation in patients with Crohn's disease. Acad Radiol (2009) 1.34
Racial and ethnic composition of volunteer cord blood donors: comparison with volunteer unrelated marrow donors. Transfusion (2002) 1.33
Multiple myeloma. Annu Rev Med (2011) 1.33
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo. Lab Invest (2005) 1.32
CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells. J Immunol (2005) 1.31
Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit Care Med (2003) 1.30
Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol (2006) 1.30
Anti-inflammatory effects of phosphatidylcholine. J Biol Chem (2007) 1.29
Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest (2004) 1.28