Occludin: a novel integral membrane protein localizing at tight junctions.

PubWeight™: 10.65‹?› | Rank: Top 0.1%

🔗 View Article (PMC 2290891)

Published in J Cell Biol on December 01, 1993

Authors

M Furuse1, T Hirase, M Itoh, A Nagafuchi, S Yonemura, S Tsukita, S Tsukita

Author Affiliations

1: Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan.

Articles citing this

(truncated to the top 100)

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol (1998) 7.78

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A (1999) 5.54

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol (2002) 5.51

Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol (1998) 5.32

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol (2001) 5.17

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol (1996) 5.06

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol (1999) 5.06

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol (1994) 5.01

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta (2007) 4.74

Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69

A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol (1998) 4.64

Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27

Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol (1997) 4.00

A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol (1997) 3.86

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol (1999) 3.78

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut (2006) 3.70

Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol (2001) 3.66

Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol (1998) 3.62

Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol (1999) 3.57

Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A (1999) 3.49

The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci U S A (2001) 3.46

Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol (1997) 3.35

Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol (2005) 3.05

Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol (1999) 3.02

Breaking through the tight junction barrier. J Cell Biol (1993) 3.01

ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol (1998) 2.99

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol (1996) 2.94

Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J Cell Biol (1998) 2.75

alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol (1998) 2.74

Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest Ophthalmol Vis Sci (2006) 2.74

COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol (1997) 2.71

Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol (2011) 2.67

Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 2.63

Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol (2000) 2.62

Symplekin, a novel type of tight junction plaque protein. J Cell Biol (1996) 2.58

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience (2008) 2.55

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest (1999) 2.53

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol (2001) 2.51

Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. Ultrasound Med Biol (2008) 2.47

Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Proc Natl Acad Sci U S A (1998) 2.45

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol (2008) 2.42

Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol (1999) 2.40

Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut (2003) 2.37

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. J Cell Biol (1996) 2.37

Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J Cell Biol (2002) 2.35

Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell (2005) 2.29

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J (2001) 2.28

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci U S A (2009) 2.25

Androgens regulate the permeability of the blood-testis barrier. Proc Natl Acad Sci U S A (2005) 2.25

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J Cell Biol (2002) 2.18

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest (1995) 2.14

Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol (2008) 2.13

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol (2009) 2.12

Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol (1999) 2.07

Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions. J Cell Biol (1998) 2.06

Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol (2001) 2.06

Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet (2006) 2.05

E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci U S A (1999) 2.05

Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes. Mol Biol Cell (2001) 2.04

Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol (1999) 1.96

Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem (2011) 1.92

Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol (2010) 1.87

Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins. Infect Immun (2001) 1.85

Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem (2009) 1.81

Xenopus laevis actin-depolymerizing factor/cofilin: a phosphorylation-regulated protein essential for development. J Cell Biol (1996) 1.81

Tight junctions of the blood-brain barrier. Cell Mol Neurobiol (2000) 1.81

Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell (2000) 1.76

Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J Cell Biol (2000) 1.76

X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif. EMBO J (2001) 1.75

Loss of the tight junction MAGUK ZO-1 in breast cancer: relationship to glandular differentiation and loss of heterozygosity. Am J Pathol (1998) 1.71

Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol (2005) 1.69

Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM). J Exp Med (1999) 1.68

Claudin association with CD81 defines hepatitis C virus entry. J Biol Chem (2010) 1.67

The neurovascular unit in the setting of stroke. J Intern Med (2010) 1.66

Dynamic behavior of paired claudin strands within apposing plasma membranes. Proc Natl Acad Sci U S A (2003) 1.66

The actin cytoskeleton in endothelial cell phenotypes. Microvasc Res (2008) 1.65

Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells. Brain Res (2006) 1.65

Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock (2009) 1.63

Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner. Infect Immun (2002) 1.63

ELL2, a new member of an ELL family of RNA polymerase II elongation factors. Proc Natl Acad Sci U S A (1997) 1.62

Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol (1999) 1.62

Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells. Infect Immun (1997) 1.61

Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. J Cell Biol (2002) 1.60

Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin. J Cell Biol (1999) 1.59

Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57

Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J Physiol (2012) 1.56

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55

Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem (2008) 1.55

Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells. Am J Pathol (2007) 1.54

Occludin: one protein, many forms. Mol Cell Biol (2011) 1.53

Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell (2010) 1.51

Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Mol Biol Cell (2001) 1.51

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol (2011) 1.48

Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell (2009) 1.46

Carbohydrate-mediated Golgi to cell surface transport and apical targeting of membrane proteins. EMBO J (1998) 1.45

Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat (2002) 1.44

Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV. J Virol (2006) 1.44

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS (2012) 1.44

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19

An efficient mRNA-dependent translation system from reticulocyte lysates. Eur J Biochem (1976) 46.42

Junctional complexes in various epithelia. J Cell Biol (1963) 31.83

The scanning model for translation: an update. J Cell Biol (1989) 31.23

Cadherin cell adhesion receptors as a morphogenetic regulator. Science (1991) 13.78

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol (1986) 8.74

Immunochemistry on ultrathin frozen sections. Histochem J (1980) 8.61

Structure and function of intercellular junctions. Int Rev Cytol (1974) 8.14

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature (1987) 7.23

The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell (1991) 5.27

Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family. J Cell Biol (1988) 4.71

Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol (1986) 4.69

Further observations on the fine structure of freeze-cleaved tight junctions. J Cell Sci (1973) 4.66

Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol (1987) 4.58

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol (1993) 4.22

Structure, function, and regulation of cellular tight junctions. Am J Physiol (1992) 4.20

The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. EMBO J (1987) 4.00

Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM. Proc Natl Acad Sci U S A (1987) 3.86

Cingulin, a new peripheral component of tight junctions. Nature (1988) 3.81

Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr Opin Cell Biol (1992) 3.61

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc Natl Acad Sci U S A (1991) 3.60

Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells. J Cell Biol (1988) 3.47

A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites. J Cell Biol (1991) 3.31

Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein. J Cell Biol (1986) 3.03

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. J Cell Biol (1989) 2.84

Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur J Cell Biol (1990) 2.77

Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules. EMBO J (1987) 2.64

Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am J Physiol (1987) 2.58

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J Cell Biol (1993) 2.56

Radixin is a novel member of the band 4.1 family. J Cell Biol (1991) 2.40

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul (1991) 2.38

Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization. J Cell Biol (1984) 2.35

The epithelial tight junction: structure, function and preliminary biochemical characterization. Mol Cell Biochem (1988) 2.33

Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures. J Biol Chem (1987) 2.30

Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations. EMBO J (1988) 2.26

Isolation of cell-to-cell adherens junctions from rat liver. J Cell Biol (1989) 2.22

Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature. J Cell Biol (1975) 2.22

On tight-junction structure. Cell (1982) 2.22

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Cell (1985) 2.10

ZO-1 and cingulin: tight junction proteins with distinct identities and localizations. Am J Physiol (1989) 1.96

Evidence for the lipidic nature of tight junction strands. Nature (1982) 1.96

Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA. EMBO J (1987) 1.93

The molecular organization of tight junctions. J Cell Biol (1993) 1.81

Nomenclature of the desmosomal cadherins. J Cell Biol (1993) 1.65

A new 400-kD protein from isolated adherens junctions: its localization at the undercoat of adherens junctions and at microfilament bundles such as stress fibers and circumferential bundles. J Cell Biol (1989) 1.61

The diversity of connexin genes encoding gap junctional proteins. Eur J Cell Biol (1991) 1.57

The cell-to-cell channel of gap junctions. Cell (1987) 1.41

Desmosomal glycoproteins 2 and 3 (desmocollins) show N-terminal similarity to calcium-dependent cell-cell adhesion molecules. J Cell Sci (1990) 1.32

The molecular constituents of intercellular junctions. Curr Opin Cell Biol (1989) 1.29

Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid. FEBS Lett (1985) 1.29

Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions. Lab Invest (1984) 1.24

Major Myelin proteolipid: the 4-alpha-helix topology. J Membr Biol (1991) 1.23

Membrane topology and quaternary structure of cardiac gap junction ion channels. J Mol Biol (1992) 1.22

Gap junctional intercellular communication and the regulation of connexin expression and function. Curr Opin Cell Biol (1990) 1.19

Segmental differentiations of cell junctions in the vascular endothelium. Arteries and veins. J Cell Biol (1976) 1.19

Isolated rat brain capillaries possess intact, structurally complex, interendothelial tight junctions; freeze-fracture verification of tight junction integrity. Brain Res (1984) 0.97

Articles by these authors

The transcriptional landscape of the mammalian genome. Science (2005) 37.63

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol (1998) 11.26

Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol (2001) 9.62

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol (1998) 7.78

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev (2001) 7.60

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature (1987) 7.23

Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays. Proc Natl Acad Sci U S A (2001) 6.07

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A (1999) 5.54

The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell (1991) 5.27

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol (1998) 5.15

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol (1999) 5.06

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol (1994) 5.01

Expressed recombinant cadherins mediate cell sorting in model systems. Cell (1988) 4.97

Thermostabilization and thermoactivation of thermolabile enzymes by trehalose and its application for the synthesis of full length cDNA. Proc Natl Acad Sci U S A (1998) 4.95

Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family. J Cell Biol (1988) 4.71

Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69

A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol (1998) 4.64

High-efficiency full-length cDNA cloning by biotinylated CAP trapper. Genomics (1996) 4.41

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol (1993) 4.22

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J Cell Biol (1992) 4.12

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol (1994) 4.09

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06

Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol (1997) 4.00

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr Biol (2000) 3.98

Occludin is a functional component of the tight junction. J Cell Sci (1996) 3.90

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol (1999) 3.78

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res (2000) 3.78

Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol (2001) 3.66

Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol (1998) 3.62

Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr Opin Cell Biol (1992) 3.61

Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol (1999) 3.57

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J Cell Biol (1994) 3.43

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol (1998) 3.39

Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol (1997) 3.35

The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules. J Cell Biol (1994) 3.31

A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites. J Cell Biol (1991) 3.31

Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. J Cell Sci (1995) 3.27

Real-time imaging of cell-cell adherens junctions reveals that Drosophila mesoderm invagination begins with two phases of apical constriction of cells. J Cell Sci (2001) 3.25

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci (1998) 3.24

Cytoplasmic regulation of the movement of E-cadherin on the free cell surface as studied by optical tweezers and single particle tracking: corralling and tethering by the membrane skeleton. J Cell Biol (1998) 3.23

The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles. J Cell Biol (1980) 3.08

Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem (1997) 3.08

A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci (1992) 3.04

Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol (1999) 3.02

Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci (1997) 2.97

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol (1996) 2.94

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol (1994) 2.93

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness. Cancer Res (1992) 2.89

Submembranous junctional plaque proteins include potential tumor suppressor molecules. J Cell Biol (1993) 2.87

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. J Cell Biol (1989) 2.84

Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82

alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol (1998) 2.74

Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics (1995) 2.65

Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules. EMBO J (1987) 2.64

Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J Biol Chem (1999) 2.60