Published in Proc Natl Acad Sci U S A on August 19, 2013
Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins. Mol Biosyst (2014) 0.79
Validity of the MPTP-Treated Mouse as a Model for Parkinson's Disease. Mol Neurobiol (2015) 0.77
Moment based gene set tests. BMC Bioinformatics (2015) 0.76
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol (2007) 4.60
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics (1998) 4.42
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc Natl Acad Sci U S A (2005) 4.22
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Genetics of Parkinson's disease and parkinsonism. Ann Neurol (2006) 3.60
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (2013) 3.60
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17
Aberrations of EZH2 in cancer. Clin Cancer Res (2011) 3.13
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun (2008) 3.06
Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ (2006) 2.67
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A (2008) 2.64
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry (2009) 2.38
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
Parkin stabilizes PINK1 through direct interaction. Biochem Biophys Res Commun (2009) 1.89
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal (2011) 1.82
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. J Biol Chem (2010) 1.75
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A (2011) 1.70
The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites. Development (1998) 1.59
Structural basis of EZH2 recognition by EED. Structure (2007) 1.58
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. J Neurosci (2007) 1.54
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem (2009) 1.52
Epigenetic regulation by histone methylation and histone variants. Mol Endocrinol (2005) 1.42
High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid. Stem Cells (2007) 1.32
Role of mendelian genes in "sporadic" Parkinson's disease. Parkinsonism Relat Disord (2012) 1.31
RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J (2001) 1.27
Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein. Mol Cell Biol (1997) 1.19
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). J Neurochem (2008) 1.18
Differentiation and survival influences of growth factors in human neuroblastoma. Eur J Cancer (1995) 1.13
The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function. Connect Tissue Res (2008) 1.13
Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease. Acta Neuropathol (2011) 1.13
Polycomb proteins in mammalian cell differentiation and plasticity. FEBS Lett (2011) 1.12
Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci (2008) 1.10
HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Mol Cell (2004) 1.07
PRC2 during vertebrate organogenesis: a complex in transition. Dev Biol (2012) 1.04
The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. J Biol Chem (1998) 1.00
Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. J Mol Biol (2007) 0.94
The N-terminus of Drosophila ESC mediates its phosphorylation and dimerization. Biochem Biophys Res Commun (2005) 0.92
PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells. Hum Pathol (2010) 0.90
Enhancer of zeste homolog 2: A potential target for tumor therapy. Int J Biochem Cell Biol (2011) 0.87
Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus. Cell Signal (2011) 0.85
Expression of PINK1 in the brain, eye and ear of mouse during embryonic development. J Chem Neuroanat (2010) 0.77
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. J Biol Chem (2005) 1.60
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes. Hum Mol Genet (2011) 1.48
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell (2006) 1.38
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions. J Biol Chem (2003) 1.19
Protein tyrosine phosphatases in health and disease. FEBS J (2012) 1.08
PTEN regulation, a novel function for the p85 subunit of phosphoinositide 3-kinase. Sci STKE (2006) 1.03
Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities. Biochim Biophys Acta (2013) 0.98
Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester. J Biol Chem (2010) 0.95
Dual-specificity MAP kinase phosphatases as targets of cancer treatment. Anticancer Agents Med Chem (2011) 0.94
PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells. Hum Pathol (2010) 0.90
A novel loss-of-function mutation (N48K) in the PTEN gene in a Spanish patient with Cowden disease. J Invest Dermatol (2003) 0.89
Dual-specificity phosphatases as molecular targets for inhibition in human disease. Antioxid Redox Signal (2014) 0.88
Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP. J Biol Chem (2001) 0.88
In vivo functional analysis of the counterbalance of hyperactive phosphatidylinositol 3-kinase p110 catalytic oncoproteins by the tumor suppressor PTEN. Cancer Res (2007) 0.87
A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. J Mol Biol (2007) 0.87
Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus. Cell Signal (2011) 0.85
Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations. J Biol Chem (2009) 0.85
A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains. J Cell Biochem (2012) 0.85
Protein tyrosine phosphatases as novel targets in breast cancer therapy. Biochim Biophys Acta (2013) 0.84
Functional definition of relevant epitopes on the tumor suppressor PTEN protein. Cancer Lett (2004) 0.84
ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1. J Biol Chem (2005) 0.83
Functional assignment of MAPK phosphatase domains. Proteins (2007) 0.83
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease. Hum Mol Genet (2013) 0.83
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. J Biol Chem (2011) 0.82
Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR. Mol Cell Neurosci (2004) 0.81
Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7. FEBS J (2006) 0.80
Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Mol Genet Genomics (2011) 0.79
Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity. Biochim Biophys Acta (2007) 0.79
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. J Biol Chem (2011) 0.78
A one-step method to identify MAP kinase residues involved in inactivation by tyrosine- and dual-specificity protein phosphatases. Anal Biochem (2009) 0.77
Studying the regulation of MAP Kinase by MAP Kinase phosphatases in vitro and in cell systems. Methods Mol Biol (2010) 0.77
Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function. J Mol Biol (2012) 0.76
Regulation of MAPK cascades by protein tyrosine phosphatases. Methods Mol Biol (2004) 0.75