Published in Cell Cycle on August 05, 2013
Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Mol Cell Biol (2015) 0.91
Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology. Lab Invest (2013) 0.83
Modulation of osteoclast differentiation and bone resorption by Rho GTPases. Small GTPases (2014) 0.80
Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts. Sci Rep (2015) 0.79
Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report. J Med Case Rep (2015) 0.75
New targets for old diseases: lessons from mucolipidosis type II. EMBO Mol Med (2013) 0.75
Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells. Front Aging Neurosci (2017) 0.75
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
Bone resorption by osteoclasts. Science (2000) 11.68
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87
Genetic regulation of osteoclast development and function. Nat Rev Genet (2003) 7.94
A gene network regulating lysosomal biogenesis and function. Science (2009) 7.17
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science (1994) 5.97
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med (1997) 5.72
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med (2006) 5.33
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell (2001) 4.36
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science (1996) 4.22
The osteoblast: a sophisticated fibroblast under central surveillance. Science (2000) 3.93
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A (1998) 3.60
PPAR-gamma regulates osteoclastogenesis in mice. Nat Med (2007) 3.59
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal (2012) 3.40
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat Genet (2000) 3.12
Genetic control of bone formation. Annu Rev Cell Dev Biol (2009) 3.06
Osteopetrosis. N Engl J Med (2004) 2.95
Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 2.84
Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol (1999) 2.78
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol (2013) 2.62
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes. Nature (2008) 2.43
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature (1997) 2.31
Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat Med (2003) 2.17
Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity. Nat Genet (2011) 2.16
Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene. Hum Mol Genet (2001) 2.15
Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. J Clin Invest (2013) 2.08
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science (2010) 2.03
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration. EMBO J (2005) 1.96
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. Nature (2006) 1.91
TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family. Genes Dev (1991) 1.90
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development (1996) 1.88
Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. Nat Genet (2011) 1.84
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2013) 1.81
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A (2002) 1.70
An SNX10 mutation causes malignant osteopetrosis of infancy. J Med Genet (2012) 1.58
The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants. Bone (2000) 1.55
Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med (2009) 1.52
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. Proc Natl Acad Sci U S A (2000) 1.48
ZKSCAN3 is a master transcriptional repressor of autophagy. Mol Cell (2013) 1.40
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell (2008) 1.38
Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood (2010) 1.37
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. J Biol Chem (2001) 1.33
Whole-exome sequencing identifies mutations in the nucleoside transporter gene SLC29A3 in dysosteosclerosis, a form of osteopetrosis. Hum Mol Genet (2012) 1.31
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest (2007) 1.29
Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. J Exp Med (2012) 1.28
Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res (2006) 1.28
Vesicular trafficking in osteoclasts. Semin Cell Dev Biol (2008) 1.19
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. Development (2001) 1.19
The osteoclast and its unique cytoskeleton. Ann N Y Acad Sci (2011) 1.15
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev (2013) 1.15
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts. Biochem J (2009) 1.12
Chloride channel 7 (ClCN7) gene mutations and autosomal dominant osteopetrosis, type II. J Bone Miner Res (2003) 1.10
Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain. Mol Biol Cell (2010) 1.10
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol (2005) 1.08
Advances in osteoclast biology resulting from the study of osteopetrotic mutations. Hum Genet (2008) 1.06
Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis. Science (2011) 1.06
Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem (2005) 1.05
Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins. Proc Natl Acad Sci U S A (2008) 1.05
Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption. J Bone Miner Res (2009) 1.04
Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts. J Biol Chem (2005) 1.01
Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement. J Bone Miner Res (2006) 1.01
Clinical and cellular manifestations of OSTM1-related infantile osteopetrosis. J Bone Miner Res (2008) 1.01
Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia. Am J Hum Genet (2009) 0.98
Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts. J Bone Miner Res (2012) 0.96
Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis. Traffic (2011) 0.94
Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase. Exp Cell Res (2009) 0.94
SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity. J Bone Miner Res (2013) 0.93
V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption. J Bone Miner Res (2012) 0.93
LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS One (2011) 0.92
Intracellular ClC-3 chloride channels promote bone resorption in vitro through organelle acidification in mouse osteoclasts. Am J Physiol Cell Physiol (2008) 0.91
A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Res (2011) 0.90
Participation of protein kinase C beta in osteoclast differentiation and function. Bone (2003) 0.90
A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts. J Bone Miner Res (2008) 0.89
Ultrastructural localization of a tartrate-resistant acid ATPase in bone. J Bone Miner Res (1990) 0.89
SNX10 is required for osteoclast formation and resorption activity. J Cell Biochem (2012) 0.87
Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption. J Bone Miner Res (2013) 0.87
Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification. J Bone Miner Res (2005) 0.86
Novel insights into V-ATPase functioning: distinct roles for its accessory subunits ATP6AP1/Ac45 and ATP6AP2/(pro) renin receptor. Curr Protein Pept Sci (2012) 0.86
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Mol Cell Biol (2011) 0.86
Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Mol Cell Biol (2011) 0.85
Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia. Eur J Med Genet (2012) 0.85
Mechanisms of osteoclastic secretion. Ann N Y Acad Sci (2007) 0.85
Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption. BMC Musculoskelet Disord (2010) 0.83
The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis. J Bone Miner Res (2013) 0.82
OSTM1 bone defect reveals an intercellular hematopoietic crosstalk. J Biol Chem (2008) 0.81
Differential effects of calmodulin and protein kinase C antagonists on bone resorption and acid transport activity. Calcif Tissue Int (2003) 0.80
Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function. Small GTPases (2011) 0.78
Role of osteoclasts in the hematopoietic stem cell niche formation. Cell Cycle (2012) 0.77
Endocrine regulation of energy metabolism by the skeleton. Cell (2007) 10.41
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev Dyn (2002) 4.01
Endocrine regulation of male fertility by the skeleton. Cell (2011) 3.20
Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat Med (2003) 2.17
The contribution of bone to whole-organism physiology. Nature (2012) 2.03
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol (2003) 1.99
Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J Bone Miner Res (2011) 1.89
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2013) 1.81
Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone (2011) 1.75
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest (2009) 1.73
Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO Rep (2004) 1.37
Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab (2013) 1.19
Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual. J Exp Med (2011) 1.16
Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest (2014) 1.13
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol (2004) 1.12
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem (2012) 1.01
Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Mol Cell Biol (2014) 0.96
In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice. Mol Metab (2013) 0.94
A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues. Cell Tissue Res (2006) 0.91
Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice. Am J Physiol Endocrinol Metab (2013) 0.90
FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice. Endocrinology (2014) 0.88
Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice. J Endocrinol (2013) 0.86
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab (2017) 0.75
[Neural control of bone remodeling: crucial role of leptin]. Med Sci (Paris) (2005) 0.75
[Serotonin, two faces of a unique molecule in the regulation of bone mass]. Med Sci (Paris) (2010) 0.75
[Intestinal serotonin and regulation of bone mass]. Med Sci (Paris) (2009) 0.75
[Diabetes is buried under a bone]. Med Sci (Paris) (2008) 0.75
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2015) 0.75