c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling.

PubWeight™: 5.97‹?› | Rank: Top 1%

🔗 View Article (PMID 7939685)

Published in Science on October 21, 1994

Authors

A E Grigoriadis1, Z Q Wang, M G Cecchini, W Hofstetter, R Felix, H A Fleisch, E F Wagner

Author Affiliations

1: Research Institute of Molecular Pathology (IMP), Vienna, Austria.

Articles citing this

(truncated to the top 100)

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93

RANK is essential for osteoclast and lymph node development. Genes Dev (1999) 5.85

TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest (2000) 5.78

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A (1999) 5.78

Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev (1997) 5.65

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med (2005) 4.02

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70

Osteoprotection by semaphorin 3A. Nature (2012) 3.40

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A (1996) 3.34

Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med (1999) 3.07

Osteoclasts: what do they do and how do they do it? Am J Pathol (2007) 2.93

Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol (2000) 2.87

Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest (2002) 2.85

Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun (1996) 2.44

Cellular and molecular mechanisms of bone remodeling. J Biol Chem (2010) 2.39

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest (2004) 2.31

Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol Cell Biol (1998) 2.22

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med (2005) 2.21

c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation. J Clin Invest (2003) 2.19

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest (2006) 2.11

Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res (2008) 2.09

Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A (1999) 2.04

Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92

Paget disease of bone. J Clin Invest (2005) 1.92

Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov (2012) 1.91

Functions of c-Jun in liver and heart development. J Cell Biol (1999) 1.85

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79

PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab (2010) 1.77

Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol (2004) 1.77

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol (2008) 1.70

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A (1998) 1.66

Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood (2010) 1.66

A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev (2006) 1.56

Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med (2005) 1.56

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis. Cell Rep (2015) 1.54

Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem (2008) 1.53

Parathyroid hormone-related protein is required for tooth eruption. Proc Natl Acad Sci U S A (1998) 1.52

Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. Mol Cell Biol (1995) 1.47

The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J (2004) 1.46

AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44. Mol Cell Biol (1997) 1.46

Role of NF-κB in the skeleton. Cell Res (2010) 1.45

The intracellular domain of CD44 promotes the fusion of macrophages. Blood (2005) 1.45

Osteoclasts; culprits in inflammatory osteolysis. Arthritis Res Ther (2005) 1.43

Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem (2009) 1.39

Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J Exp Med (1998) 1.35

Fra-1 replaces c-Fos-dependent functions in mice. Genes Dev (2000) 1.33

Functions of AP1 (Fos/Jun) in bone development. Ann Rheum Dis (2002) 1.33

Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus. BMC Cell Biol (2007) 1.32

RANKing the importance of measles virus in Paget's disease. J Clin Invest (2000) 1.30

Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond. Front Immunol (2014) 1.29

Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J Bone Miner Metab (2006) 1.29

Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell (1998) 1.28

Regulation of gene expression in osteoblasts. Biofactors (2010) 1.23

Adenosine A(2A) receptor ligation inhibits osteoclast formation. Am J Pathol (2011) 1.21

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts. Blood (2007) 1.21

Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts. Arthritis Res Ther (2006) 1.20

Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest (2010) 1.19

Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1). Mol Cell Biol (1996) 1.18

Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J Cell Biol (2009) 1.15

A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev (2013) 1.15

Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res (2002) 1.13

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech (2010) 1.13

Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding. Mol Cell Biol (2003) 1.11

Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J Biol Chem (2009) 1.11

Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11

Study of the cell biology and biochemistry of cherubism. J Clin Pathol (1998) 1.09

c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs. J Clin Invest (2006) 1.08

Cadmium osteotoxicity in experimental animals: mechanisms and relationship to human exposures. Toxicol Appl Pharmacol (2009) 1.06

The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J (1997) 1.06

Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. Am J Pathol (1999) 1.05

Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J Clin Invest (2005) 1.05

IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. J Bone Miner Res (2010) 1.02

RANKing c-Jun in osteoclast development. J Clin Invest (2004) 1.01

Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation. J Cell Sci (2007) 1.00

C/EBPα regulates osteoclast lineage commitment. Proc Natl Acad Sci U S A (2013) 0.99

RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro. J Bone Miner Res (2007) 0.98

The requirement for and changing composition of the activating protein-1 transcription factor during differentiation of human leukemia HL60 cells induced by 1,25-dihydroxyvitamin D3. Cancer Res (2006) 0.97

Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo. Clin Dev Immunol (2013) 0.96

The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells. J Leukoc Biol (2008) 0.95

Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells. J Cell Physiol (1998) 0.95

The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. J Biol Chem (2010) 0.95

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. J Biol Chem (2012) 0.94

M-CSF potently augments RANKL-induced resorption activation in mature human osteoclasts. PLoS One (2011) 0.94

Signaling Pathways in Osteoclast Differentiation. Chonnam Med J (2016) 0.94

Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. Mol Cell Biol (1996) 0.93

Transforming growth factor-beta enables NFATc1 expression during osteoclastogenesis. Biochem Biophys Res Commun (2007) 0.91

Signalling in osteoclasts and the role of Fos/AP1 proteins. Ann Rheum Dis (2003) 0.91

Mild osteopetrosis in the microphthalmia-oak ridge mouse. A model for intermediate autosomal recessive osteopetrosis in humans. Am J Pathol (1995) 0.90

The role of osteoprotegerin in arthritis. Arthritis Res Ther (2003) 0.90

Activated T lymphocytes suppress osteoclastogenesis by diverting early monocyte/macrophage progenitor lineage commitment towards dendritic cell differentiation through down-regulation of receptor activator of nuclear factor-kappaB and c-Fos. Clin Exp Immunol (2006) 0.90

PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts. Blood (2008) 0.90

Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling. Purinergic Signal (2012) 0.89

Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets. Pathol Res Pract (2008) 0.89

Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway. Cell Commun Signal (2013) 0.88

Origin, development, and homeostasis of tissue-resident macrophages. Immunol Rev (2014) 0.88

Bone remodeling: new aspects of a key process that controls skeletal maintenance and repair. Osteoporos Int (2004) 0.87

Articles by these authors

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature (1988) 13.21

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature (1985) 7.54

Strain-dependent epithelial defects in mice lacking the EGF receptor. Science (1995) 5.22

Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature (1997) 5.08

Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med (1997) 4.57

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev (1995) 4.54

Hyperthermia in combined treatment of cancer. Lancet Oncol (2002) 4.41

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12

Bone and haematopoietic defects in mice lacking c-fos. Nature (1993) 4.07

AP-1 in mouse development and tumorigenesis. Oncogene (2001) 3.93

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell (1994) 3.91

Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development (1994) 3.86

Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature (1996) 3.83

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci U S A (1986) 3.68

Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51

c-jun is essential for normal mouse development and hepatogenesis. Nature (1993) 3.43

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet (1999) 3.42

The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. Nat Genet (1998) 3.31

Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol (1999) 3.29

PARP is important for genomic stability but dispensable in apoptosis. Genes Dev (1997) 3.20

The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci U S A (1981) 2.93

Bisphosphonates: mechanisms of action. J Clin Invest (1996) 2.83

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell (1990) 2.77

Cigarette smoking, major depression, and other psychiatric disorders among adolescents. J Am Acad Child Adolesc Psychiatry (1996) 2.69

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science (1999) 2.68

Transfer of genes into embryonal carcinoma cells by retrovirus infection: efficient expression from an internal promoter. EMBO J (1985) 2.60

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol (1999) 2.60

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev (1999) 2.56

Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol (1996) 2.55

Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development (2000) 2.43

Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med (2000) 2.36

Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene. Cell (1988) 2.36

Anomalous origin of the right vertebral artery: review of the literature and case report of right vertebral artery origin distal to the left subclavian artery. AJNR Am J Neuroradiol (1999) 2.34

Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes. Nature (1984) 2.34

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab (1997) 2.31

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell (2000) 2.22

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21

Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J (1987) 2.16

Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell (1989) 2.14

Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone (1996) 2.11

Analysis of the differentiation-promoting potential of inducible c-fos genes introduced into embryonal carcinoma cells. EMBO J (1985) 2.11

A universal retroviral vector for efficient constitutive expression of exogenous genes. Nucleic Acids Res (1987) 2.11

Intraaneurysmal flow: evaluation with Doppler guidewires. AJNR Am J Neuroradiol (1996) 2.09

The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res (1996) 2.09

Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature (1987) 2.08

The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med (1997) 2.07

JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. EMBO J (2000) 2.05

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature (1994) 2.03

Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology (1990) 2.02

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med (1999) 1.98

Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse. J Bone Miner Res (1990) 1.97

Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol (2000) 1.97

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Nat Genet (2000) 1.96

Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement. Osteoarthritis Cartilage (2003) 1.91

Magnetic resonance cholangiopancreatography-guided unilateral endoscopic stent placement for Klatskin tumors. Gastrointest Endosc (2001) 1.90

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A (1999) 1.88

Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. 1993. Int J Hyperthermia (2009) 1.87

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J (1998) 1.86

Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology (1996) 1.86

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res (2001) 1.85

Cancer incidence and risk estimation among medical x-ray workers in China, 1950-1995. Health Phys (2002) 1.85

Functions of c-Jun in liver and heart development. J Cell Biol (1999) 1.85

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell (2000) 1.81

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med (2001) 1.81

Clustered homeo boxes are differentially expressed during murine development. Cell (1985) 1.80

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem (1998) 1.79

Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell (2001) 1.79

Drug smuggling by ingested cocaine-filled packages: conventional x-ray and ultrasound. Abdom Imaging (1995) 1.79

Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension (1997) 1.77

Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. Int J Hyperthermia (1993) 1.77

New approaches to understanding p53 gene tumor mutation spectra. Mutat Res (1999) 1.75

Fos is an essential component of the mammalian UV response. EMBO J (1995) 1.73

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.71

Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J (1997) 1.70

Osteoblasts are target cells for transformation in c-fos transgenic mice. J Cell Biol (1993) 1.70

Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection. Mech Dev (1997) 1.69

Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo. Int J Hyperthermia (1998) 1.67

Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fields in vitro. Int J Hyperthermia (1997) 1.66

Efficacy of interpersonal psychotherapy as a maintenance treatment of recurrent depression. Contributing factors. Arch Gen Psychiatry (1991) 1.65

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J (1994) 1.64

Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell (1983) 1.63

NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. J Neurosci (2000) 1.61

Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet (2001) 1.60

The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening. J Clin Pathol (2004) 1.59

Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia. Acta Radiol (2006) 1.59

Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells. Proc Natl Acad Sci U S A (1980) 1.58

JunB is essential for mammalian placentation. EMBO J (1999) 1.57

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Oncogene (2001) 1.57

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet (1999) 1.56

Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem (1995) 1.56

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet (1997) 1.52