Published in Mol Cell Biol on October 01, 1990
The hy3 Long Hypocotyl Mutant of Arabidopsis Is Deficient in Phytochrome B. Plant Cell (1991) 10.72
mRNA stability in mammalian cells. Microbiol Rev (1995) 8.78
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA (1995) 5.76
Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J (1998) 3.79
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol (1993) 3.48
A splicing-dependent regulatory mechanism that detects translation signals. EMBO J (1996) 3.07
Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci U S A (1993) 2.98
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol (1993) 2.85
At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol (1998) 2.79
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Mol Cell Biol (1995) 2.55
Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51
The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm. Mol Biol Cell (1995) 2.46
Nonsense codons within the Rous sarcoma virus gag gene decrease the stability of unspliced viral RNA. Mol Cell Biol (1991) 2.42
Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance. Mol Cell Biol (1994) 2.42
The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J (2001) 2.37
Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol Cell Biol (1995) 2.31
Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA. EMBO J (1998) 2.24
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol (1994) 2.13
Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol Cell Biol (1994) 2.09
Fifteen novel FBN1 mutations causing Marfan syndrome detected by heteroduplex analysis of genomic amplicons. Am J Hum Genet (1995) 2.01
p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts. Mol Cell Biol (1991) 1.69
T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: a nuclear-associated translation-like mechanism. J Exp Med (1997) 1.67
Sequences within the last intron function in RNA 3'-end formation in cultured cells. Mol Cell Biol (1993) 1.67
Premature chain termination is a unifying mechanism for COL1A1 null alleles in osteogenesis imperfecta type I cell strains. Am J Hum Genet (1996) 1.59
Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. J Clin Invest (1991) 1.56
A GFP-based reporter system to monitor nonsense-mediated mRNA decay. Nucleic Acids Res (2005) 1.49
The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon. Am J Hum Genet (1997) 1.48
T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J (2002) 1.43
A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII. Proc Natl Acad Sci U S A (1993) 1.40
Determination of mRNA fate by different RNA polymerase II promoters. Proc Natl Acad Sci U S A (1993) 1.39
Molecular analysis of Hurler syndrome in Druze and Muslim Arab patients in Israel: multiple allelic mutations of the IDUA gene in a small geographic area. Am J Hum Genet (1993) 1.38
Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junction. Mol Cell Biol (1994) 1.34
Translation termination is involved in histone mRNA degradation when DNA replication is inhibited. Mol Cell Biol (2005) 1.30
Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution. Mol Cell Biol (2003) 1.27
Regulation of asparagine synthetase gene expression by amino acid starvation. Mol Cell Biol (1991) 1.22
Compound heterozygosity for a dominant glycine substitution and a recessive internal duplication mutation in the type XVII collagen gene results in junctional epidermolysis bullosa and abnormal dentition. Am J Pathol (1996) 1.19
Expression of a mutant human fibrillin allele upon a normal human or murine genetic background recapitulates a Marfan cellular phenotype. J Clin Invest (1995) 1.07
Defective splicing of mRNA from one COL1A1 allele of type I collagen in nondeforming (type I) osteogenesis imperfecta. J Clin Invest (1993) 1.06
Initiation of translation can occur only in a restricted region of the CYC1 mRNA of Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.05
A compound-heterozygous Marfan patient: two defective fibrillin alleles result in a lethal phenotype. Am J Hum Genet (1994) 1.05
Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. Am J Hum Genet (1993) 1.04
Nuclear retention of COL1A1 messenger RNA identifies null alleles causing mild osteogenesis imperfecta. J Clin Invest (1996) 1.04
Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells. Mol Cell Biol (1995) 1.03
X rays induce interallelic homologous recombination at the human thymidine kinase gene. Mol Cell Biol (1992) 1.02
Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila. Genetics (1994) 1.01
The familial hypercholesterolemia (FH)-North Karelia mutation of the low density lipoprotein receptor gene deletes seven nucleotides of exon 6 and is a common cause of FH in Finland. J Clin Invest (1992) 1.00
Succinyl CoA: 3-oxoacid CoA transferase (SCOT): human cDNA cloning, human chromosomal mapping to 5p13, and mutation detection in a SCOT-deficient patient. Am J Hum Genet (1996) 0.99
U1 small nuclear RNAs with altered specificity can be stably expressed in mammalian cells and promote permanent changes in pre-mRNA splicing. Mol Cell Biol (1993) 0.98
Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes. Am J Hum Genet (1993) 0.96
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
Constant splice-isoform ratios in human lymphoblastoid cells support the concept of a splico-stat. Genetics (2011) 0.88
Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency. J Clin Invest (1994) 0.86
PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs). Am J Hum Genet (1993) 0.84
Extent of laminin-5 assembly and secretion effect junctional epidermolysis bullosa phenotype. J Exp Med (1998) 0.82
The molecular basis of HEXA mRNA deficiency caused by the most common Tay-Sachs disease mutation. Am J Hum Genet (1995) 0.81
PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. Infect Immun (1993) 0.81
A nonsense mutation in the erythrocyte band 3 gene associated with decreased mRNA accumulation in a kindred with dominant hereditary spherocytosis. J Clin Invest (1996) 0.78
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay. Org Biomol Chem (2016) 0.77
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01
Genomic sequencing. Proc Natl Acad Sci U S A (1984) 92.36
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc Natl Acad Sci U S A (1977) 41.76
Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol Cell Biol (1990) 8.17
Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev (1988) 5.97
Interference of nonsense mutations with eukaryotic messenger RNA stability. Proc Natl Acad Sci U S A (1979) 5.70
A survey on intron and exon lengths. Nucleic Acids Res (1988) 5.55
Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1990) 5.47
Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol Cell Biol (1989) 5.19
Premature translation termination mediates triosephosphate isomerase mRNA degradation. Mol Cell Biol (1988) 4.09
Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia. Cell (1981) 3.80
In vivo splicing products of the rabbit beta-globin pre-mRNA. Cell (1984) 3.35
Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse. EMBO J (1985) 3.25
Nonsense mutations in the human beta-globin gene affect mRNA metabolism. Proc Natl Acad Sci U S A (1988) 2.88
Structure and expression of a cloned beta o thalassaemic globin gene. Nucleic Acids Res (1981) 2.71
Effect of premature termination of translation on mRNA stability depends on the site of ribosome release. Proc Natl Acad Sci U S A (1987) 2.24
Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon. Blood (1984) 2.20
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. Blood (1984) 2.17
Codon replacement in the PGK1 gene of Saccharomyces cerevisiae: experimental approach to study the role of biased codon usage in gene expression. Mol Cell Biol (1987) 2.06
Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes. J Biol Chem (1981) 2.02
Sequence-independent autoregulation of the adenovirus type 5 E1A transcription unit. Mol Cell Biol (1985) 1.90
mRNA-deficient beta o-thalassemia results from a single nucleotide deletion. Nucleic Acids Res (1982) 1.78
Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. EMBO J (1989) 1.68
New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo. J Clin Invest (1988) 1.36
A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells. Nucleic Acids Res (1985) 1.28
Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase. J Biol Chem (1989) 1.11
Delayed processing of dihydrofolate reductase heterogeneous nuclear RNA in amino acid-starved mouse fibroblasts. Mol Cell Biol (1983) 0.99
Analysis of gene expression using episomal mouse dihydrofolate reductase minigenes. Nucleic Acids Res (1988) 0.97
Delayed processing/export of messenger RNA under conditions of reduced protein synthesis. J Cell Physiol (1988) 0.96
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem Sci (1998) 9.06
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J (2000) 7.54
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell (2001) 4.92
In vitro analysis of the Escherichia coli RNA polymerase interaction with wild-type and mutant lactose promoters. J Mol Biol (1978) 4.15
Premature translation termination mediates triosephosphate isomerase mRNA degradation. Mol Cell Biol (1988) 4.09
Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev (2000) 3.74
Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci U S A (1993) 2.98
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. Proc Natl Acad Sci U S A (1998) 2.87
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol (1993) 2.85
At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol (1998) 2.79
Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol Cell Biol (2001) 2.61
Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51
Defects in RNA splicing and the consequence of shortened translational reading frames. Am J Hum Genet (1996) 2.45
Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance. Mol Cell Biol (1994) 2.42
Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol (1998) 2.24
Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation. Genes Dev (1994) 2.13
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol (1994) 2.13
Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol Cell Biol (1994) 2.09
Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol (1985) 1.97
Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man. J Biol Chem (1985) 1.90
lac Promoter mutations located downstream from the transcription start site. J Mol Biol (1980) 1.82
Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. EMBO J (1997) 1.79
mRNA-deficient beta o-thalassemia results from a single nucleotide deletion. Nucleic Acids Res (1982) 1.78
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem (2001) 1.74
Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia. Proc Natl Acad Sci U S A (1980) 1.72
Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. EMBO J (1989) 1.68
Sequences within the last intron function in RNA 3'-end formation in cultured cells. Mol Cell Biol (1993) 1.67
Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position. EMBO J (2000) 1.40
Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene. Mol Cell Biol (1986) 1.40
lac Promoter mutation Pr115 generates a new transcription initiation point. J Mol Biol (1980) 1.32
A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells. Nucleic Acids Res (1985) 1.28
New ways of initiating translation in eukaryotes. Mol Cell Biol (2001) 1.20
Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues. Mol Biol Cell (2001) 1.18
Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme. Proc Natl Acad Sci U S A (1986) 1.14
mRNA surveillance in mammalian cells: the relationship between introns and translation termination. RNA (2000) 1.12
Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase. J Biol Chem (1989) 1.11
Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes. Biochimie (1996) 1.08
Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. Am J Hum Genet (1993) 1.04
Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells. Mol Cell Biol (1995) 1.03
Nucleotide sequence of murine triosephosphate isomerase cDNA. Nucleic Acids Res (1990) 0.99
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells. Cancer Res (1997) 0.94
Influence of A-T content on the fractionation of DNA restriction fragments by RPC-5 column chromatography. J Biol Chem (1979) 0.93
The power of point mutations. Nat Genet (2001) 0.93
Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter. J Biol Chem (1990) 0.90
Modulation of human triosephosphate isomerase gene transcription by serum. J Biol Chem (1991) 0.77