Published in Mol Cell Biol on January 01, 1990
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Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol (2001) 4.10
Biased chromatin signatures around polyadenylation sites and exons. Mol Cell (2009) 3.74
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol (1993) 3.48
Role of polyadenylation in nucleocytoplasmic transport of mRNA. Mol Cell Biol (1996) 3.26
Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Res (2003) 3.21
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A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol (1995) 3.18
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16
Polypurine sequences within a downstream exon function as a splicing enhancer. Mol Cell Biol (1994) 3.15
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA. Mol Cell Biol (1990) 3.10
Selection of splice sites in pre-mRNAs with short internal exons. Mol Cell Biol (1991) 3.02
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol Cell Biol (1992) 2.99
Effect of 5' splice site mutations on splicing of the preceding intron. Mol Cell Biol (1990) 2.75
Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol Cell Biol (1999) 2.72
Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors. Mol Cell Biol (1995) 2.51
Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions. Mol Cell Biol (1994) 2.49
Sequence information for the splicing of human pre-mRNA identified by support vector machine classification. Genome Res (2003) 2.42
Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae. RNA (2003) 2.36
Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1. Mol Cell Biol (1994) 2.35
Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1995) 2.34
Architectural limits on split genes. Proc Natl Acad Sci U S A (1996) 2.29
Intron definition in splicing of small Drosophila introns. Mol Cell Biol (1994) 2.27
The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing. Genes Dev (2000) 2.27
Selection of novel exon recognition elements from a pool of random sequences. Mol Cell Biol (1995) 2.27
Nuclear pre-mRNA introns: analysis and comparison of intron sequences from Tetrahymena thermophila and other eukaryotes. Nucleic Acids Res (1990) 2.25
Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet (2014) 2.17
Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins. Proc Natl Acad Sci U S A (1998) 2.16
Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5' splice site. Mol Cell Biol (1993) 2.10
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Intron self-complementarity enforces exon inclusion in a yeast pre-mRNA. Proc Natl Acad Sci U S A (1997) 2.08
Nuclear export and retention signals in the RS domain of SR proteins. Mol Cell Biol (2002) 2.04
Exon inclusion is dependent on predictable exonic splicing enhancers. Mol Cell Biol (2005) 2.02
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An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1. Mol Cell Biol (1997) 2.00
A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon. Mol Cell Biol (1995) 1.92
Insertion of a 5' truncated L1 element into the 3' end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy. J Clin Invest (1993) 1.92
Transcriptional and posttranscriptional regulation of HIV-1 gene expression. Cold Spring Harb Perspect Med (2012) 1.88
Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J (1994) 1.87
Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol (1993) 1.85
Circular RNA is expressed across the eukaryotic tree of life. PLoS One (2014) 1.84
The splicing of U12-type introns can be a rate-limiting step in gene expression. EMBO J (2002) 1.84
Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene. Nucleic Acids Res (1992) 1.83
Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1997) 1.83
Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol (1996) 1.81
Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications. RNA (2007) 1.78
Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol Cell Biol (1993) 1.76
Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol (1995) 1.75
Human genomic sequences that inhibit splicing. Mol Cell Biol (2000) 1.73
Cooperation of pre-mRNA sequence elements in splice site selection. Mol Cell Biol (1992) 1.70
Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure for enhancer display. Mol Cell Biol (1999) 1.69
Sequences within the last intron function in RNA 3'-end formation in cultured cells. Mol Cell Biol (1993) 1.67
Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Res (2003) 1.66
An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol (1998) 1.64
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In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit. Mol Cell Biol (1993) 1.60
The exon sequence TAGG can inhibit splicing. Nucleic Acids Res (1996) 1.60
Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1993) 1.58
Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps. Proc Natl Acad Sci U S A (1995) 1.58
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene. Mol Cell Biol (1993) 1.57
Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing. J Virol (1995) 1.57
Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. J Clin Invest (1991) 1.56
A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA (2001) 1.55
Mutations in the conserved loop of human U5 snRNA generate use of novel cryptic 5' splice sites in vivo. EMBO J (1993) 1.55
Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol Cell Biol (1994) 1.54
Coevolutionary networks of splicing cis-regulatory elements. Proc Natl Acad Sci U S A (2007) 1.54
Elements regulating an alternatively spliced exon of the rat fibronectin gene. Mol Cell Biol (1993) 1.54
Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation. Mol Cell Biol (1999) 1.52
A sequence compilation and comparison of exons that are alternatively spliced in neurons. Nucleic Acids Res (1994) 1.50
Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA. EMBO J (2004) 1.50
Utilization of splicing elements and polyadenylation signal elements in the coupling of polyadenylation and last-intron removal. Mol Cell Biol (1999) 1.48
Participation of the C-terminal domain of RNA polymerase II in exon definition during pre-mRNA splicing. Mol Cell Biol (2000) 1.48
Point mutations in the dystrophin gene. Proc Natl Acad Sci U S A (1992) 1.46
Genomic sequence, splicing, and gene annotation. Am J Hum Genet (2000) 1.46
Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site. Mol Cell Biol (1993) 1.44
Dichotomous splicing signals in exon flanks. Genome Res (2005) 1.42
Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA (2001) 1.42
RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. J Virol (2001) 1.41
Simian virus 40 late mRNA leader sequences involved in augmenting mRNA accumulation via multiple mechanisms, including increased polyadenylation efficiency. J Virol (1991) 1.39
Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene. Proc Natl Acad Sci U S A (2003) 1.36
Alternative splicing of a human alpha-tropomyosin muscle-specific exon: identification of determining sequences. Mol Cell Biol (1992) 1.36
Regulated immunoglobulin (Ig) RNA processing does not require specific cis-acting sequences: non-Ig RNA can be alternatively processed in B cells and plasma cells. Mol Cell Biol (1994) 1.36
Cross-kingdom patterns of alternative splicing and splice recognition. Genome Biol (2008) 1.36
Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein. J Clin Invest (1997) 1.36
A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression. J Virol (2004) 1.35
Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe. Mol Cell Biol (2000) 1.34
Calpainopathy-a survey of mutations and polymorphisms. Am J Hum Genet (1999) 1.31
Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA. Mol Cell Biol (1996) 1.31
Consensus sequence Zen. Appl Bioinformatics (2002) 1.31
Influence of intron length on alternative splicing of CD44. Mol Cell Biol (1998) 1.30
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A compensatory base change in U1 snRNA suppresses a 5' splice site mutation. Cell (1986) 9.65
The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro. Cell (1983) 9.00
U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell (1985) 8.85
Speculations on RNA splicing. Cell (1981) 8.28
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28
Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell (1986) 8.06
Splicing of messenger RNA precursors. Science (1987) 7.61
Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences. Cell (1985) 7.49
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell (1987) 7.44
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts. Cell (1983) 6.48
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
A multicomponent complex is involved in the splicing of messenger RNA precursors. Cell (1985) 6.27
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A survey on intron and exon lengths. Nucleic Acids Res (1988) 5.55
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes. Nature (1987) 5.13
A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein. Cell (1986) 4.57
The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Science (1985) 4.56
An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly. EMBO J (1987) 4.52
A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNA. Cell (1986) 4.44
A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell (1982) 4.22
Alternative splicing caused by RNA secondary structure. Cell (1985) 4.21
An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly. Science (1988) 4.16
Affinity chromatography of splicing complexes: U2, U5, and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome. Science (1986) 4.01
Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediate. Cell (1984) 4.00
Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing. Cell (1985) 3.59
Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles. Mol Cell Biol (1988) 3.56
mRNA splicing efficiency in yeast and the contribution of nonconserved sequences. Cell (1985) 3.42
Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants. Cell (1985) 3.25
Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol Cell Biol (1987) 3.00
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Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing. Genes Dev (1988) 2.62
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A gene chimaera of SV40 and mouse beta-globin is transcribed and properly spliced. Nature (1981) 2.35
The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA. Nature (1987) 2.33
Exon mutations that affect the choice of splice sites used in processing the SV40 late transcripts. Nucleic Acids Res (1985) 2.28
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U1 small nuclear ribonucleoproteins are required early during spliceosome assembly. Mol Cell Biol (1987) 1.83
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Evidence for nuclear factors involved in recognition of 5' splice sites. Nucleic Acids Res (1989) 1.58
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