Published in J Clin Invest on October 01, 1975
Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation. J Cell Biol (1983) 5.73
The origin of the chemiluminescence of phagocytosing granulocytes. J Clin Invest (1976) 2.92
Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system. J Clin Invest (1978) 2.66
The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst. J Clin Invest (1976) 2.43
Energy metabolism of human neutrophils during phagocytosis. J Clin Invest (1982) 2.37
Macrophage activation selectively enhances expression of Fc receptors for IgG2a. J Exp Med (1983) 1.63
Down-regulation of mannosyl receptor-mediated endocytosis and antigen F4/80 in bacillus Calmette-Guérin-activated mouse macrophages. Role of T lymphocytes and lymphokines. J Exp Med (1982) 1.61
The requirement for membrane sialic acid in the stimulation of superoxide production during phagocytosis by human polymorphonuclear leukocytes. J Exp Med (1976) 1.35
NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate. J Clin Invest (1980) 1.26
Enhancement of platelet function by superoxide anion. J Clin Invest (1977) 1.04
Electron and proton transport by NADPH oxidases. Philos Trans R Soc Lond B Biol Sci (2005) 0.97
Variation in hydrogen peroxide sensitivity between different strains of Neisseria gonorrhoeae is dependent on factors in addition to catalase activity. Infect Immun (1994) 0.90
Monoclonal antibodies to a particulate superoxide-forming system stimulate a respiratory burst in intact guinea pig neutrophils. Proc Natl Acad Sci U S A (1986) 0.81
Allosteric transformation of reduced nicotinamide adenine dinucleotide (phosphate) oxidase induced by phagocytosis in human polymorphonuclear leukocytes. Infect Immun (1978) 0.81
Role of oxygen in phagocyte microbicidal action. Environ Health Perspect (1994) 0.79
Platelet-derived growth factor stimulates phagocytosis and blocks agonist-induced activation of the neutrophil oxidative burst: a possible cellular mechanism to protect against oxygen radical damage. Proc Natl Acad Sci U S A (1987) 0.79
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J Biol Chem (1959) 17.39
Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest (1967) 9.01
The role of the phagocyte in host-parasite interactions. 13. The direct quantitative estimation of H2O2 in phagocytizing cells. Biochim Biophys Acta (1968) 5.12
Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes. J Reticuloendothel Soc (1972) 4.60
Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N Engl J Med (1974) 4.21
Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes. J Clin Invest (1974) 3.78
Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes. J Lab Clin Med (1975) 3.24
Respiration and glucose oxidation in human and guinea pig leukocytes: comparative studies. J Clin Invest (1970) 2.83
Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med (1975) 2.65
NADPH oxidase deficiency in X-linked chronic granulomatous disease. J Clin Invest (1975) 2.62
Role of the superoxide anion in the myeloperoxidase-mediated antimicrobial system. J Biol Chem (1974) 2.61
Deficiency of reduced nicotinamide-adenine dinucleotide oxidase in chronic granulomatous disease. Science (1968) 2.56
The superoxide anion and singlet molecular oxygen: their role in the microbicidal activity of the polymorphonuclear leukocyte. Biochem Biophys Res Commun (1974) 2.50
ENZYMATIC BASIS OF THE RESPIRATORY STIMULATION DURING PHAGOCYTOSIS. Nature (1964) 2.50
Phagocytosis (third of three parts). N Engl J Med (1974) 2.41
Disorders of phagocytic cell function. Prog Hematol (1971) 2.37
Enzymatic basis of metabolic stimulation in leucocytes during phagocytosis: the role of activated NADPH oxidase. Arch Biochem Biophys (1971) 2.27
Failure of nitro blue tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease. J Clin Invest (1969) 2.11
Chronic granulomatous disease--pieces of a cellular and molecular puzzle. Fed Proc (1973) 2.08
Oxygen metabolism in Lactobacillus plantarum. J Bacteriol (1974) 2.03
Effects of anaerobiosis and inhibitors on O2-production by human granulocytes. Blood (1975) 1.85
Abnormal kinetics of degranulation in chronic granulomatous disease. N Engl J Med (1974) 1.04
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med (1978) 11.45
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature (1986) 6.34
Oxygen-dependent microbial killing by phagocytes (second of two parts). N Engl J Med (1978) 4.31
Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest (1994) 4.28
Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N Engl J Med (1974) 4.21
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
The respiratory burst of phagocytes. J Clin Invest (1984) 3.86
Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes. J Clin Invest (1974) 3.78
Oxidants from phagocytes: agents of defense and destruction. Blood (1984) 3.20
Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion. J Clin Invest (1984) 3.01
The origin of the chemiluminescence of phagocytosing granulocytes. J Clin Invest (1976) 2.92
Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med (1975) 2.65
Molecular basis of chronic granulomatous disease. Blood (1991) 2.60
The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst. J Clin Invest (1976) 2.43
Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558. J Clin Invest (1991) 2.38
Subcellular localization of the superoxide-forming enzyme in human neutrophils. J Clin Invest (1979) 2.33
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med (1980) 2.32
The respiratory burst oxidase. J Biol Chem (1994) 2.29
Evidence for hydroxyl radical production by human neutrophils. J Clin Invest (1977) 2.15
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke (1997) 2.14
Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense. J Infect Dis (1994) 2.12
Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system. J Clin Invest (1985) 2.06
Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease. N Engl J Med (1975) 2.05
Aromatization of cyclohexanecarboxylic acid. J Biol Chem (1966) 2.04
Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein. J Pediatr (1982) 2.03
Measurement of O2- production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils. Methods Enzymol (1984) 1.97
Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system. N Engl J Med (1989) 1.93
Neutrophils and host defense. Ann Intern Med (1988) 1.92
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest (1990) 1.91
The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J Biol Chem (1994) 1.90
Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils. Blood (1999) 1.88
Effects of anaerobiosis and inhibitors on O2-production by human granulocytes. Blood (1975) 1.85
Termination of the respiratory burst in human neutrophils. J Clin Invest (1978) 1.80
cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. J Biol Chem (1981) 1.75
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem (1994) 1.74
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem (1992) 1.69
Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process. J Biol Chem (1987) 1.68
Cloning and expression of a human muscle phosphofructokinase cDNA. Gene (1989) 1.66
Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci U S A (1996) 1.66
Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J Clin Invest (1998) 1.58
Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. J Biol Chem (1984) 1.57
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet (1998) 1.54
Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch Biochem Biophys (1996) 1.54
Role of C5a in multiorgan failure during sepsis. J Immunol (2001) 1.53
Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase. J Biol Chem (1996) 1.48
Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase. Proc Natl Acad Sci U S A (1995) 1.48
Chronic granulomatous disease. Adv Hum Genet (1987) 1.48
Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease. Blood (1989) 1.47
Loss of function of cytochrome c in Jurkat cells undergoing fas-mediated apoptosis. J Biol Chem (1996) 1.47
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. J Clin Invest (1989) 1.47
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol (1995) 1.46
A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease. J Biol Chem (1986) 1.45
Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood (1979) 1.42
Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement. Blood (1977) 1.42
Endogenous protein phosphorylation by resting and activated human neutrophils. Blood (1983) 1.41
The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme. J Biol Chem (1979) 1.36
The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis. J Clin Invest (1995) 1.34
Studies on the interaction between GP-18-0-deficient neutrophils and vascular endothelium. Blood (1982) 1.34
Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells. Methods Enzymol (1990) 1.34
Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J Biol Chem (1997) 1.33
Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium. J Biol Chem (1990) 1.31
The O2--producing enzyme of human neutrophils. Further properties. J Biol Chem (1981) 1.31
A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease. J Clin Invest (1997) 1.30
Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity. J Biol Chem (1998) 1.30
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A (1991) 1.29
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304. J Biol Chem (1998) 1.29
Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. Mol Biol Cell (1993) 1.28
Spontaneous activation of NADPH oxidase in a cell-free system: unexpected multiple effects of magnesium ion concentrations. Biochem J (1999) 1.24
Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process. J Clin Invest (1979) 1.23
Activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem (1987) 1.22
Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. J Biol Chem (1984) 1.22
The oxidative killing mechanisms of the neutrophil. Prog Clin Immunol (1977) 1.21
Kinetics of activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem (1988) 1.21
Hematologically important mutations: X-linked chronic granulomatous disease (second update). Blood Cells Mol Dis (2001) 1.19
Induction of gp91-phox, a component of the phagocyte NADPH oxidase, in microglial cells during central nervous system inflammation. J Cereb Blood Flow Metab (2001) 1.16
Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst. FASEB J (1993) 1.15
Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phox. J Biol Chem (1995) 1.15
The respiratory burst oxidase of human neutrophils. Further studies of the purified enzyme. J Biol Chem (1986) 1.14
Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. J Clin Invest (1976) 1.14
JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. J Biol Chem (2001) 1.14