Published in J Clin Invest on October 01, 1976
Increased superoxide anion production by immunologically activated and chemically elicited macrophages. J Exp Med (1978) 6.50
Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol (1982) 4.38
Bactericidal activity of a superoxide anion-generating system. A model for the polymorphonuclear leukocyte. J Exp Med (1979) 3.19
H2O2 release from human granulocytes during phagocytosis. Relationship to superoxide anion formation and cellular catabolism of H2O2: studies with normal and cytochalasin B-treated cells. J Clin Invest (1977) 2.71
Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system. J Clin Invest (1978) 2.66
Subcellular localization of the superoxide-forming enzyme in human neutrophils. J Clin Invest (1979) 2.33
Evidence for hydroxyl radical production by human neutrophils. J Clin Invest (1977) 2.15
Host responses in tissue repair and fibrosis. Annu Rev Pathol (2012) 2.10
Use of lipophilic probes of membrane potential to assess human neutrophil activation. Abnormality in chronic granulomatous disease. J Clin Invest (1980) 1.97
Termination of the respiratory burst in human neutrophils. J Clin Invest (1978) 1.80
Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH. Biochem J (1985) 1.73
Modulation of human neutrophil function by monohydroxy-eicosatetraenoic acids. Immunology (1980) 1.60
Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. J Clin Invest (1983) 1.54
Role of cell surface contact in the kinetics of superoxide production by granulocytes. J Clin Invest (1983) 1.48
Human neutrophil-mediated nonoxidative antifungal activity against Cryptococcus neoformans. Infect Immun (2000) 1.38
Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst. J Clin Invest (1984) 1.35
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem J (1991) 1.34
Generation of chemiluminescence by a particulate fraction isolated from human neutrophils. Analysis of molecular events. J Clin Invest (1979) 1.26
NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate. J Clin Invest (1980) 1.26
Superoxide-forming NADPH oxidase preparation of pig polymorphonuclear leucocyte. Biochem J (1982) 1.22
Intracellular pH modulates the generation of superoxide radicals by human neutrophils. J Clin Invest (1985) 1.20
The pH dependence of NADPH oxidase in human eosinophils. J Physiol (2005) 1.19
Hydrogen peroxide-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels. Heart Vessels (1998) 1.17
Arrangement of the respiratory burst oxidase in the plasma membrane of the neutrophil. J Clin Invest (1981) 1.10
Respiratory burst oxidase from human neutrophils: purification and some properties. Proc Natl Acad Sci U S A (1985) 1.06
Oxidation of methionine by human polymorphonuclear leukocytes. J Clin Invest (1980) 1.05
Respiratory burst enzyme in human neutrophils. Evidence for multiple mechanisms of activation. J Clin Invest (1981) 1.03
A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans reveals novel roles for yeast AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis. Eukaryot Cell (2009) 1.03
Effect of calcium on superoxide production by phagocytic vesicles from rabbit alveolar macrophages. J Clin Invest (1981) 1.03
Hydrogen peroxide production in chronic granulomatous disease. A cytochemical study of reduced pyridine nucleotide oxidases. J Clin Invest (1977) 1.01
Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. Infect Immun (2014) 0.96
Differential alterations in host peripheral polymorphonuclear leukocyte chemiluminescence during the course of bacterial and viral infections. Infect Immun (1980) 0.95
Applications of electron spin resonance spectrometry for reactive oxygen species and reactive nitrogen species research. J Clin Biochem Nutr (2010) 0.92
Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation. MBio (2015) 0.92
Neutrophils and mononuclear cells from patients with chronic granulomatous disease release nitric oxide. Br J Clin Pharmacol (1993) 0.89
Composition of partially purified NADPH oxidase from pig neutrophils. Biochem J (1984) 0.86
Phagocytes, toxic oxygen metabolites and inflammatory bowel disease: implications for treatment. Ann R Coll Surg Engl (1990) 0.82
Ether link cleavage is the major pathway of iodothyronine metabolism in the phagocytosing human leukocyte and also occurs in vivo in the rat. J Clin Invest (1983) 0.80
2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. Toxicol Appl Pharmacol (2007) 0.79
L-triiodothyronine and L-reverse-triiodothyronine generation in the human polymorphonuclear leukocyte. J Clin Invest (1978) 0.79
Consequences of dimerization of the voltage-gated proton channel. Prog Mol Biol Transl Sci (2013) 0.78
Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem (2016) 0.77
Production of oxygen-centered radicals by neutrophils and macrophages as studied by electron spin resonance (ESR). Environ Health Perspect (1985) 0.77
NADPH-binding protein of the neutrophil superoxide-generating oxidase of guinea pigs. Proc Natl Acad Sci U S A (1994) 0.77
Inhibition of human neutrophil oxidative metabolism and degranulation in vitro by nitroblue tetrazolium and vitamin E. Am J Pathol (1978) 0.76
NADPH oxidase of guinea-pig macrophages catalyses the reduction of ubiquinone-1 under anaerobic conditions. Biochem J (1986) 0.75
Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model. Med Sci Monit (2016) 0.75
Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des (2015) 0.75
Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system. Redox Biol (2017) 0.75
The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev (2016) 0.75
Superoxide production by phagocytic leukocytes: the scientific legacy of Bernard Babior. J Clin Invest (2004) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J Biol Chem (1959) 17.39
The statistical analysis of enzyme kinetic data. Adv Enzymol Relat Areas Mol Biol (1967) 9.95
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. J Clin Invest (1975) 7.40
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis. J Clin Invest (1975) 6.25
Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes. Semin Hematol (1975) 6.19
H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors. J Clin Invest (1975) 5.90
Spectrum of horse-heart cytochrome c. Biochem J (1959) 5.37
Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N Engl J Med (1974) 4.21
Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes. J Clin Invest (1974) 3.78
Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system. J Biol Chem (1975) 3.53
Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes. J Lab Clin Med (1975) 3.24
Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med (1975) 2.65
NADPH oxidase deficiency in X-linked chronic granulomatous disease. J Clin Invest (1975) 2.62
The superoxide anion and singlet molecular oxygen: their role in the microbicidal activity of the polymorphonuclear leukocyte. Biochem Biophys Res Commun (1974) 2.50
NADPH and NADH oxidation by guinea pig polymorphonuclear leucocytes. Can J Biochem Physiol (1963) 2.43
Enzymatic basis of metabolic stimulation in leucocytes during phagocytosis: the role of activated NADPH oxidase. Arch Biochem Biophys (1971) 2.27
Chronic granulomatous disease--pieces of a cellular and molecular puzzle. Fed Proc (1973) 2.08
Production of hydrogen peroxide by phagocytizing human granulocytes. J Lab Clin Med (1975) 2.05
Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease. N Engl J Med (1975) 2.05
Effects of anaerobiosis and inhibitors on O2-production by human granulocytes. Blood (1975) 1.85
Mechanism of phagocytosis-associated oxidative metabolism in polymorphonuclear leucocytes and macrophages. J Reticuloendothel Soc (1972) 1.64
Pyridine nucleotide-dependent superoxide production by a cell-free system from human granulocytes. J Clin Invest (1975) 1.57
Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. J Clin Invest (1976) 1.14
Singlet oxygen: a unique microbicidal agent in cells. Science (1973) 1.01
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med (1978) 11.45
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature (1986) 6.34
Oxygen-dependent microbial killing by phagocytes (second of two parts). N Engl J Med (1978) 4.31
Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest (1994) 4.28
Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N Engl J Med (1974) 4.21
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
The respiratory burst of phagocytes. J Clin Invest (1984) 3.86
Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes. J Clin Invest (1974) 3.78
Oxidants from phagocytes: agents of defense and destruction. Blood (1984) 3.20
Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion. J Clin Invest (1984) 3.01
The origin of the chemiluminescence of phagocytosing granulocytes. J Clin Invest (1976) 2.92
Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med (1975) 2.65
Molecular basis of chronic granulomatous disease. Blood (1991) 2.60
Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558. J Clin Invest (1991) 2.38
Subcellular localization of the superoxide-forming enzyme in human neutrophils. J Clin Invest (1979) 2.33
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med (1980) 2.32
The respiratory burst oxidase. J Biol Chem (1994) 2.29
Evidence for hydroxyl radical production by human neutrophils. J Clin Invest (1977) 2.15
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke (1997) 2.14
Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense. J Infect Dis (1994) 2.12
Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system. J Clin Invest (1985) 2.06
Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease. N Engl J Med (1975) 2.05
Aromatization of cyclohexanecarboxylic acid. J Biol Chem (1966) 2.04
Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein. J Pediatr (1982) 2.03
Measurement of O2- production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils. Methods Enzymol (1984) 1.97
Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system. N Engl J Med (1989) 1.93
Neutrophils and host defense. Ann Intern Med (1988) 1.92
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest (1990) 1.91
The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J Biol Chem (1994) 1.90
Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils. Blood (1999) 1.88
Effects of anaerobiosis and inhibitors on O2-production by human granulocytes. Blood (1975) 1.85
Termination of the respiratory burst in human neutrophils. J Clin Invest (1978) 1.80
cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. J Biol Chem (1981) 1.75
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem (1994) 1.74
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem (1992) 1.69
Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process. J Biol Chem (1987) 1.68
Cloning and expression of a human muscle phosphofructokinase cDNA. Gene (1989) 1.66
Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci U S A (1996) 1.66
Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J Clin Invest (1998) 1.58
Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. J Biol Chem (1984) 1.57
Pyridine nucleotide-dependent superoxide production by a cell-free system from human granulocytes. J Clin Invest (1975) 1.57
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet (1998) 1.54
Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch Biochem Biophys (1996) 1.54
Role of C5a in multiorgan failure during sepsis. J Immunol (2001) 1.53
Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase. J Biol Chem (1996) 1.48
Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase. Proc Natl Acad Sci U S A (1995) 1.48
Chronic granulomatous disease. Adv Hum Genet (1987) 1.48
Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease. Blood (1989) 1.47
Loss of function of cytochrome c in Jurkat cells undergoing fas-mediated apoptosis. J Biol Chem (1996) 1.47
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. J Clin Invest (1989) 1.47
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol (1995) 1.46
A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease. J Biol Chem (1986) 1.45
Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood (1979) 1.42
Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement. Blood (1977) 1.42
Endogenous protein phosphorylation by resting and activated human neutrophils. Blood (1983) 1.41
The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme. J Biol Chem (1979) 1.36
The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis. J Clin Invest (1995) 1.34
Studies on the interaction between GP-18-0-deficient neutrophils and vascular endothelium. Blood (1982) 1.34
Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells. Methods Enzymol (1990) 1.34
Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J Biol Chem (1997) 1.33
Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium. J Biol Chem (1990) 1.31
The O2--producing enzyme of human neutrophils. Further properties. J Biol Chem (1981) 1.31
A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease. J Clin Invest (1997) 1.30
Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity. J Biol Chem (1998) 1.30
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A (1991) 1.29
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304. J Biol Chem (1998) 1.29
Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. Mol Biol Cell (1993) 1.28
Spontaneous activation of NADPH oxidase in a cell-free system: unexpected multiple effects of magnesium ion concentrations. Biochem J (1999) 1.24
Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process. J Clin Invest (1979) 1.23
Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. J Biol Chem (1984) 1.22
Activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem (1987) 1.22
Kinetics of activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem (1988) 1.21
The oxidative killing mechanisms of the neutrophil. Prog Clin Immunol (1977) 1.21
Hematologically important mutations: X-linked chronic granulomatous disease (second update). Blood Cells Mol Dis (2001) 1.19
Induction of gp91-phox, a component of the phagocyte NADPH oxidase, in microglial cells during central nervous system inflammation. J Cereb Blood Flow Metab (2001) 1.16
Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst. FASEB J (1993) 1.15
Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phox. J Biol Chem (1995) 1.15
Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. J Clin Invest (1976) 1.14
The respiratory burst oxidase of human neutrophils. Further studies of the purified enzyme. J Biol Chem (1986) 1.14