Published in J Physiol on September 02, 2013
Irisin ERKs the fat. Diabetes (2014) 2.05
Low brown adipose tissue activity in endurance-trained compared with lean sedentary men. Int J Obes (Lond) (2015) 1.66
Irisin - a myth rather than an exercise-inducible myokine. Sci Rep (2015) 1.39
The brain and brown fat. Ann Med (2014) 1.02
The many roles of PGC-1α in muscle--recent developments. Metabolism (2014) 1.01
Thermogenic capacity is antagonistically regulated in classical brown and white subcutaneous fat depots by high fat diet and endurance training in rats: impact on whole-body energy expenditure. J Biol Chem (2014) 1.01
Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise. Int J Biol Sci (2014) 0.99
Irisin, two years later. Int J Endocrinol (2013) 0.97
The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. J Biol Chem (2013) 0.95
Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PLoS One (2014) 0.93
Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. Eur J Appl Physiol (2014) 0.91
Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men. Korean J Physiol Pharmacol (2014) 0.88
Association of circulating irisin and cardiopulmonary exercise capacity in healthy volunteers: results of the Study of Health in Pomerania. BMC Pulm Med (2015) 0.85
Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk. J Diabetes Res (2015) 0.84
Greek goddess or Greek myth: the effects of exercise on irisin/FNDC5 in humans. J Physiol (2013) 0.83
Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle? PLoS One (2014) 0.82
Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol (2017) 0.82
Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. PLoS One (2015) 0.81
Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One (2015) 0.81
Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile. J Diabetes Metab Disord (2016) 0.80
Resistance exercise with low glycogen increases p53 phosphorylation and PGC-1α mRNA in skeletal muscle. Eur J Appl Physiol (2015) 0.79
FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs. Age (Dordr) (2014) 0.78
Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression. Physiol Rep (2015) 0.78
Does IRISIN Have a BRITE Future as a Therapeutic Agent in Humans? Curr Obes Rep (2014) 0.77
Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators Inflamm (2015) 0.77
Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans. Appetite (2015) 0.76
Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics. BMC Cancer (2015) 0.76
Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population. PLoS One (2016) 0.75
The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion. Endocrine (2016) 0.75
Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review. F1000Res (2017) 0.75
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects. Diabetes Metab J (2016) 0.75
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females. PLoS One (2017) 0.75
Can Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats? Asian J Sports Med (2016) 0.75
Irisin: A Potential Link between Physical Exercise and Metabolism-An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People. J Diabetes Res (2017) 0.75
Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver. Sci Rep (2017) 0.75
Irisin and Fibronectin Type III Domain-Containing 5 Responses to Exercise in Different Environmental Conditions. Int J Exerc Sci (2017) 0.75
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett (2007) 3.65
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism (2012) 3.61
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab (2013) 2.64
Is irisin a human exercise gene? Nature (2012) 2.46
FNDC5/irisin is not only a myokine but also an adipokine. PLoS One (2013) 2.30
Role of N-glycosylation in trafficking of apical membrane proteins in epithelia. Am J Physiol Renal Physiol (2008) 1.55
Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids (2008) 1.31
Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines. Nutr Metab (Lond) (2012) 1.22
Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats. Metabolism (2013) 1.19
Protein N-glycosylation, protein folding, and protein quality control. Mol Cells (2010) 1.13
Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol (1985) (2009) 1.06
Effects of combined endurance and strength training on muscle strength, power and hypertrophy in 40-67-year-old men. Scand J Med Sci Sports (2009) 0.93
The effects of whey protein on myostatin and cell cycle-related gene expression responses to a single heavy resistance exercise bout in trained older men. Eur J Appl Physiol (2007) 0.93
Strength, [corrected] endurance or combined training elicit diverse skeletal muscle myosin heavy chain isoform proportion but unaltered androgen receptor concentration in older men. Int J Sports Med (2009) 0.87
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting. Eur Heart J (2007) 1.94
Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One (2012) 1.84
Long-term leisure-time physical activity and serum metabolome. Circulation (2012) 1.81
Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs. J Appl Physiol (1985) (2009) 1.74
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains. J Appl Physiol (1985) (2009) 1.58
Relationship of sex hormones to bone geometric properties and mineral density in early pubertal girls. J Clin Endocrinol Metab (2004) 1.57
Gender-based analysis of the 3-year outcome of bioactive stents versus paclitaxel-eluting stents in patients with acute myocardial infarction: an insight from the TITAX-AMI trial. J Invasive Cardiol (2012) 1.50
Serum osteocalcin is not associated with glucose but is inversely associated with leptin across generations of nondiabetic women. J Clin Endocrinol Metab (2012) 1.49
Are glycoprotein inhibitors safe during percutaneous coronary intervention in patients on chronic warfarin treatment? Thromb Haemost (2009) 1.42
Vegetarian diet alters the assessment of exocrine pancreatic function with the use of fecal tests. J Pediatr Gastroenterol Nutr (2004) 1.40
Aging, muscle fiber type, and contractile function in sprint-trained athletes. J Appl Physiol (1985) (2006) 1.34
Assessing body composition with DXA and bioimpedance: effects of obesity, physical activity, and age. Obesity (Silver Spring) (2008) 1.32
Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids (2008) 1.31
Physical fitness profiles in young Finnish men during the years 1975-2004. Med Sci Sports Exerc (2006) 1.30
Venous obstruction after pacemaker implantation. Pacing Clin Electrophysiol (2007) 1.28
The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention. Clin Physiol Funct Imaging (2005) 1.21
Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial. Am J Clin Nutr (2005) 1.21
Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle. FASEB J (2006) 1.20
Relationship between the number of repetitions and selected percentages of one repetition maximum in free weight exercises in trained and untrained men. J Strength Cond Res (2006) 1.20
Vitamin D and living in northern latitudes--an endemic risk area for vitamin D deficiency. Int J Circumpolar Health (2008) 1.18
The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors. J Biol Chem (2006) 1.18
Determination of functional strength imbalance of the lower extremities. J Strength Cond Res (2006) 1.16
Differential effects of strength training leading to failure versus not to failure on hormonal responses, strength, and muscle power gains. J Appl Physiol (1985) (2006) 1.16
Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J Mol Biol (2007) 1.16
Individual responses to combined endurance and strength training in older adults. Med Sci Sports Exerc (2011) 1.15
Muscle hypertrophy, hormonal adaptations and strength development during strength training in strength-trained and untrained men. Eur J Appl Physiol (2003) 1.15
The dibenzodioxocin lignin substructure is abundant in the inner part of the secondary wall in Norway spruce and silver birch xylem. Planta (2003) 1.13
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing. Autophagy (2011) 1.12
Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans. J Nutr (2009) 1.12
Effects of long-term training specificity on maximal strength and power of the upper and lower extremities in athletes from different sports. Eur J Appl Physiol (2002) 1.11
Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J (2010) 1.09
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med (2014) 1.08
Panoramic ultrasonography is a valid method to measure changes in skeletal muscle cross-sectional area. Eur J Appl Physiol (2009) 1.08
Strategies to improve vitamin D status in northern European children: exploring the merits of vitamin D fortification and supplementation. J Nutr (2006) 1.08
Fecal pyruvate kinase (M2-PK): a new predictor for inflammation and severity of pouchitis. Scand J Gastroenterol (2005) 1.08
Acute heavy-resistance exercise-induced pain and neuromuscular fatigue in elderly women with fibromyalgia and in healthy controls: effects of strength training. Arthritis Rheum (2006) 1.07
Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice. Cardiovasc Diabetol (2008) 1.06
Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol (1985) (2009) 1.06
A novel human glycosyltransferase: primary structure and characterization of the gene and transcripts. Biochem Biophys Res Commun (2003) 1.05
Clinical and laboratory risk factors of thrombotic complications after pacemaker implantation: a prospective study. Europace (2010) 1.04
Association of physical fitness with health-related quality of life in Finnish young men. Health Qual Life Outcomes (2010) 1.03
Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol (2010) 1.02
Cytokine and hormone responses to resistance training. Eur J Appl Physiol (2009) 1.02
Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs. PLoS One (2010) 1.02
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet (2014) 1.02
Changes in exercise performance and hormonal concentrations over a big ten soccer season in starters and nonstarters. J Strength Cond Res (2004) 1.02
Bone and muscle development during puberty in girls: a seven-year longitudinal study. J Bone Miner Res (2009) 1.01
Biomechanical and skeletal muscle determinants of maximum running speed with aging. Med Sci Sports Exerc (2009) 1.01
Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy. Am J Physiol Endocrinol Metab (2011) 1.01
Guided ultrasonic waves in long bones: modelling, experiment and in vivo application. Physiol Meas (2002) 1.01
Changing incidence of acute appendicitis and nonspecific abdominal pain between 1987 and 2007 in Finland. World J Surg (2011) 1.00
Body composition, fitness, and metabolic health during strength and endurance training and their combination in middle-aged and older women. Eur J Appl Physiol (2009) 0.99
Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D₃ via the NF-κB pathway. FASEB J (2012) 0.99
A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. J Nutr (2010) 0.98
Assessment of the cortical bone thickness using ultrasonic guided waves: modelling and in vitro study. Ultrasound Med Biol (2007) 0.97
Effects of combined resistance and cardiovascular training on strength, power, muscle cross-sectional area, and endurance markers in middle-aged men. Eur J Appl Physiol (2004) 0.97
Expression of functional prolactin and its receptor in human colorectal cancer. Int J Colorectal Dis (2002) 0.97
Postexercise myostatin and activin IIb mRNA levels: effects of strength training. Med Sci Sports Exerc (2007) 0.96
Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor alpha2. J Clin Invest (2003) 0.96
Aquatic training and detraining on fitness and quality of life in fibromyalgia. Med Sci Sports Exerc (2007) 0.96
Improvements of muscle strength predicted benefits in HRQOL and postural balance in women with fibromyalgia: an 8-month randomized controlled trial. Rheumatology (Oxford) (2009) 0.96
Effects of amino acids supplement on physiological adaptations to resistance training. Med Sci Sports Exerc (2009) 0.96
Muscle activity and inactivity periods during normal daily life. PLoS One (2013) 0.96
Differential effects of sex hormones on peri- and endocortical bone surfaces in pubertal girls. J Clin Endocrinol Metab (2005) 0.95
Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation. J Nutr Metab (2011) 0.95
Endogenous hormones, muscle strength, and risk of fall-related fractures in older women. J Gerontol A Biol Sci Med Sci (2006) 0.95
Heart rate dynamics after combined endurance and strength training in older men. Med Sci Sports Exerc (2009) 0.95
Association between exercise and pubertal BMD is modulated by estrogen receptor alpha genotype. J Bone Miner Res (2004) 0.95
Strength and power profiles of the lower and upper extremities in master throwers at different ages. J Strength Cond Res (2007) 0.95
Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations. J Clin Endocrinol Metab (2008) 0.95
The effects of amino acid supplementation on hormonal responses to resistance training overreaching. Metabolism (2006) 0.95
Contribution of genetic and environmental factors to individual differences in maximal walking speed with and without second task in older women. J Gerontol A Biol Sci Med Sci (2005) 0.94
Functional characterization of B class MADS-box transcription factors in Gerbera hybrida. J Exp Bot (2010) 0.94
Premorbid personality factors in schizophrenia and bipolar disorder: results from a large cohort study of male conscripts. J Abnorm Psychol (2009) 0.94
Fatigue in a simulated cross-country skiing sprint competition. J Sports Sci (2009) 0.93
Parasympathetic innervation and function of endocrine pancreas requires the glial cell line-derived factor family receptor alpha2 (GFRalpha2). Diabetes (2005) 0.93
Effects of streptozotocin-induced diabetes and physical training on gene expression of extracellular matrix proteins in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2005) 0.93
Serum TRACP 5b is a useful marker for monitoring alendronate treatment: comparison with other markers of bone turnover. J Bone Miner Res (2005) 0.93
The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol (2003) 0.93
Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins. Am J Physiol Endocrinol Metab (2012) 0.93