Drug repurposing: a better approach for infectious disease drug discovery?

PubWeight™: 0.86‹?›

🔗 View Article (PMC 4015799)

Published in Curr Opin Immunol on September 05, 2013

Authors

G Lynn Law1, Jennifer Tisoncik-Go, Marcus J Korth, Michael G Katze

Author Affiliations

1: Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Articles cited by this

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68

Network biology: understanding the cell's functional organization. Nat Rev Genet (2004) 36.62

NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res (2012) 15.84

Network medicine: a network-based approach to human disease. Nat Rev Genet (2011) 14.07

Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov (2004) 7.57

Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30

The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer (2007) 4.40

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. Pharmacol Ther (2013) 2.64

Drug Repurposing from an Academic Perspective. Drug Discov Today Ther Strateg (2011) 1.68

Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. MBio (2013) 1.41

Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One (2010) 1.41

Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism (2008) 1.37

The French paradox: lessons for other countries. Heart (2004) 1.28

A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm. MBio (2011) 1.18

Drug repositioning: re-investigating existing drugs for new therapeutic indications. J Postgrad Med (2011) 1.17

The emergence of genome-based drug repositioning. Sci Transl Med (2011) 1.07

Network-based drug repositioning. Mol Biosyst (2013) 1.07

Gene expression signature-based screening identifies new broadly effective influenza a antivirals. PLoS One (2010) 1.04

Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase. Cancer Res (2010) 1.04

Systems virology: host-directed approaches to viral pathogenesis and drug targeting. Nat Rev Microbiol (2013) 1.02

Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms. Genome Biol (2012) 0.98

Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett (2010) 0.96

Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis. BMC Syst Biol (2012) 0.94

Drug repositioning through incomplete bi-cliques in an integrated drug-target-disease network. Integr Biol (Camb) (2012) 0.93

Network pharmacology for cancer drug discovery: are we there yet? Future Med Chem (2012) 0.88

A multi-omic systems approach to elucidating Yersinia virulence mechanisms. Mol Biosyst (2012) 0.86

Opportunities in systems biology to discover mechanisms and repurpose drugs for CNS diseases. Drug Discov Today (2012) 0.83

Articles by these authors

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature (2006) 6.46

Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91

Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc Natl Acad Sci U S A (2002) 4.26

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12

Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog (2009) 3.35

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93

Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J Virol (2004) 2.67

Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol (2007) 2.59

Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54

Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes (2005) 2.46

Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4(+)-T-cell lines. J Virol (2003) 2.46

Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog (2009) 2.44

The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway. J Virol (2004) 2.37

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A (2013) 2.29

The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20

Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence. J Virol (2006) 2.14

Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. BMC Genomics (2009) 2.02

Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS Pathog (2009) 1.99

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med (2013) 1.98

Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation. Hepatology (2012) 1.82

Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates. Proc Natl Acad Sci U S A (2013) 1.81

Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers. Hepatology (2003) 1.80

Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. MBio (2010) 1.79

Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina). J Virol (2004) 1.77

Compression of next-generation sequencing reads aided by highly efficient de novo assembly. Nucleic Acids Res (2012) 1.76

Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74

Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes. PLoS Pathog (2009) 1.73

Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis. Virol J (2006) 1.58

A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice. J Virol (2009) 1.56

Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol (2003) 1.56

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses. Nat Med (2013) 1.55

MicroRNA expression and virulence in pandemic influenza virus-infected mice. J Virol (2010) 1.54

Systems biology and the host response to viral infection. Nat Biotechnol (2007) 1.53

Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific host response and responses intermediate between avian (H5N1 and H7N7) and human (H3N2) viruses and implications for treatment options. MBio (2014) 1.52

Innate immune modulation by RNA viruses: emerging insights from functional genomics. Nat Rev Immunol (2008) 1.51

Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques. J Virol (2010) 1.47

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol (2002) 1.44

A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo. J Virol (2010) 1.44

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog (2013) 1.43

Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J Virol (2006) 1.42

Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. MBio (2013) 1.41

HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS Pathog (2009) 1.40

Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection. J Virol (2010) 1.40

Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma. Cancer Res (2003) 1.40

Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients. Gastroenterology (2006) 1.38

Dynamic host energetics and cytoskeletal proteomes in human immunodeficiency virus type 1-infected human primary CD4 cells: analysis by multiplexed label-free mass spectrometry. J Virol (2009) 1.35

Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice. G3 (Bethesda) (2012) 1.35

Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection. J Virol (2009) 1.33

Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol (2011) 1.30

The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. J Virol (2009) 1.29

Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients. J Virol (2005) 1.29

The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. J Virol (2006) 1.28

To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon. Viral Immunol (2002) 1.26

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. Cell Host Microbe (2012) 1.24

Virus-host interactions: from systems biology to translational research. Curr Opin Microbiol (2009) 1.23

Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production. J Virol (2007) 1.22

Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response. J Virol (2006) 1.21

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Genome Biol (2005) 1.20

Next-generation sequencing reveals HIV-1-mediated suppression of T cell activation and RNA processing and regulation of noncoding RNA expression in a CD4+ T cell line. MBio (2011) 1.20

A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm. MBio (2011) 1.18

Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction. Hepatology (2007) 1.18

High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein. J Virol (2004) 1.16

Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. PLoS Pathog (2007) 1.16

The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins. J Gen Virol (2003) 1.14

A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes. PLoS Pathog (2013) 1.14

The non-human primate reference transcriptome resource (NHPRTR) for comparative functional genomics. Nucleic Acids Res (2012) 1.13

Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients. Hepatology (2012) 1.13

2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models. BMC Genomics (2012) 1.13

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol (2014) 1.10

Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response. PLoS Pathog (2006) 1.09

System-based proteomic analysis of the interferon response in human liver cells. Genome Biol (2004) 1.09

Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol (2010) 1.09

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol (2013) 1.08

The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling. J Virol (2009) 1.07