Published in Science on September 13, 2013
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Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem (2014) 0.96
Cancer biomarker discovery and validation. Transl Cancer Res (2015) 0.96
Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade. Sci Rep (2014) 0.95
The role of microRNA-200 in progression of human colorectal and breast cancer. PLoS One (2013) 0.92
The isolation and characterization of CTC subsets related to breast cancer dormancy. Sci Rep (2015) 0.92
The architecture and biological function of dual antibody-coated dendrimers: enhanced control of circulating tumor cells and their hetero-adhesion to endothelial cells for metastasis prevention. Theranostics (2014) 0.88
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In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis. Breast Cancer Res (2016) 0.84
Evolving Personalized Therapy for Castration-Resistant Prostate Cancer. Biomedicine (Taipei) (2014) 0.84
Phosphatidylinositol Phosphate 5-Kinase Iγ and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth. J Biol Chem (2015) 0.83
CD133+CD54+CD44+ circulating tumor cells as a biomarker of treatment selection and liver metastasis in patients with colorectal cancer. Oncotarget (2016) 0.83
A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy. Eur J Cancer (2014) 0.83
Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies. Mediators Inflamm (2016) 0.83
Label-free enumeration, collection and downstream cytological and cytogenetic analysis of circulating tumor cells. Sci Rep (2016) 0.82
Multi-Phenotypic subtyping of circulating tumor cells using sequential fluorescent quenching and restaining. Sci Rep (2016) 0.80
Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial. J Nanobiotechnology (2015) 0.80
Integrated analysis of multiple biomarkers from circulating tumor cells enabled by exclusion-based analyte isolation. Clin Cancer Res (2016) 0.79
Tumor cell intravasation. Am J Physiol Cell Physiol (2016) 0.78
Circulating Tumor Cells Enriched by the Depletion of Leukocytes with Bi-Antibodies in Non-Small Cell Lung Cancer: Potential Clinical Application. PLoS One (2015) 0.78
Circulating tumor cell isolation: the assets of filtration methods with polycarbonate track-etched filters. Chin J Cancer Res (2015) 0.78
Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer. Sci Rep (2016) 0.78
Sampling circulating tumor cells for clinical benefits: how frequent? J Hematol Oncol (2015) 0.78
Combined cell surface carbonic anhydrase 9 and CD147 antigens enable high-efficiency capture of circulating tumor cells in clear cell renal cell carcinoma patients. Oncotarget (2016) 0.78
Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions. Cancer Epidemiol Biomarkers Prev (2016) 0.77
Molecular prognostic prediction in liver cirrhosis. World J Gastroenterol (2015) 0.77
Enrichment of circulating head and neck tumour cells using spiral microfluidic technology. Sci Rep (2017) 0.77
Role of TGF-β receptor III localization in polarity and breast cancer progression. Mol Biol Cell (2014) 0.76
Microfluidic Strategies for Understanding the Mechanics of Cells and Cell-Mimetic Systems. Annu Rev Chem Biomol Eng (2015) 0.76
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Circulating Tumor Cells and Circulating Tumor DNA Provide New Insights into Pancreatic Cancer. Int J Med Sci (2016) 0.75
Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response. Oncotarget (2016) 0.75
Multifunctional Magnetic Particles for Combined Circulating Tumor Cells Isolation and Cellular Metabolism Detection. Adv Funct Mater (2016) 0.75
Clinical Significance of Folate Receptor-positive Circulating Tumor Cells Detected by Ligand-targeted Polymerase Chain Reaction in Lung Cancer. J Cancer (2017) 0.75
TTF-1- and/or CD56-positive Circulating Tumor Cells in patients with small cell lung cancer (SCLC). Sci Rep (2017) 0.75
Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging. Oncol Lett (2016) 0.75
Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis. Sci Rep (2016) 0.75
Circulating tumor cell clusters: What we know and what we expect (Review). Int J Oncol (2016) 0.75
In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications. Biomicrofluidics (2016) 0.75
DNA methylation as a potential diagnosis indicator for rapid discrimination of rare cancer cells and normal cells. Sci Rep (2015) 0.75
Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application. Oncotarget (2016) 0.75
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients. Oncol Lett (2015) 0.75
Investigation of Tumor Cell Behaviors on a Vascular Microenvironment-Mimicking Microfluidic Chip. Sci Rep (2015) 0.75
In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells. Sci Rep (2016) 0.75
Ultrasonic scattering measurements of a live single cell at 86 MHz. IEEE Trans Ultrason Ferroelectr Freq Control (2015) 0.75
A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis). Oncol Lett (2016) 0.75
Tumor-Initiating Cells: Emerging Biophysical Methods of Isolation. Curr Stem Cell Rep (2016) 0.75
Biomarkers for early diagnosis, prognosis, prediction, and recurrence monitoring of non-small cell lung cancer. Onco Targets Ther (2017) 0.75
The Role of BEAMing and Digital PCR for Multiplexed Analysis in Molecular Oncology in the Era of Next-Generation Sequencing. Mol Diagn Ther (2017) 0.75
Androgen receptor expression on circulating tumor cells in metastatic breast cancer. PLoS One (2017) 0.75
Mouse models of metastasis: progress and prospects. Dis Model Mech (2017) 0.75
NanoVelcro-captured CTC number concomitant with enhanced serum levels of MMP7 and MMP9 enables accurate prediction of metastasis and poor prognosis in patients with lung adenocarcinoma. Int J Nanomedicine (2017) 0.75
Zebrafish Xenograft: An Evolutionary Experiment in Tumour Biology. Genes (Basel) (2017) 0.75
Evaluation of a simple method for storage of blood samples that enables isolation of circulating tumor cells 96 h after sample collection. J Biol Res (Thessalon) (2017) 0.75
Selective Adhesive Cell Capture without Molecular Specificity: New Surfaces Exploiting Nanoscopic Polycationic Features as Discrete Adhesive Units. RSC Adv (2017) 0.75
Circulating Tumor Cells: Moving Biological Insights into Detection. Theranostics (2017) 0.75
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Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res (2008) 14.37
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Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87
EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol (2008) 8.72
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol (2013) 4.11
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Circulating epithelial cells in patients with benign colon diseases. Clin Chem (2011) 2.57
Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res (2013) 2.50
Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer. Int J Clin Oncol (2011) 1.11
Comparison of three molecular assays for the detection and molecular characterization of circulating tumor cells in breast cancer. Breast Cancer Res (2013) 0.99
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New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer (2002) 24.71
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Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol (2007) 10.17
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med (2009) 6.72
The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Stromal effects on mammary gland development and breast cancer. Science (2002) 5.22
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell (2006) 4.98
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol (2005) 4.57
Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell (2008) 4.18
Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol (2004) 4.16
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00
Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell (2003) 3.68
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell (2008) 3.44
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest (2012) 3.09
Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem (2002) 2.86
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol (2002) 2.83
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell (2003) 2.70
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61
Hormonal and local control of mammary branching morphogenesis. Differentiation (2006) 2.60
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res (2007) 2.41
Altered fracture repair in the absence of MMP9. Development (2003) 2.41
Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J (2003) 2.34
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech (2008) 2.34
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell (2008) 2.24
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci (2002) 2.21
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A (2012) 2.20
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev (2007) 2.14
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol (2008) 2.13
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem (2006) 2.09
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn (2006) 2.03
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol (2013) 2.03
Patterning mechanisms of branched organs. Science (2008) 2.00
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol (2002) 1.99
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia (2005) 1.98
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Dev Biol (2008) 1.97
Matrix remodeling during endochondral ossification. Trends Cell Biol (2004) 1.97
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell (2012) 1.95
Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harb Protoc (2011) 1.95
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med (2005) 1.93
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A (2005) 1.90
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol (2002) 1.88
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell (2013) 1.86
Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development (2005) 1.84
Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J Cell Sci (2002) 1.80
GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol (2010) 1.80
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep (2013) 1.78
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J (2007) 1.74
Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res (2004) 1.71
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Curr Opin Hematol (2003) 1.71
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest (2009) 1.68
GATA-3 and the regulation of the mammary luminal cell fate. Curr Opin Cell Biol (2008) 1.68
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J (2004) 1.64
Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell (2007) 1.62
Location, location, location: the cancer stem cell niche. Cell Stem Cell (2007) 1.62
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res (2010) 1.60
Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res (2003) 1.59
New functional roles for non-collagenous domains of basement membrane collagens. J Cell Sci (2002) 1.58
Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci (2006) 1.58
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med (2006) 1.54
Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell (2005) 1.53
Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harb Protoc (2011) 1.50
Coevolution of cancer and stromal cellular responses. Cancer Cell (2005) 1.50
Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harb Protoc (2011) 1.50
In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol (2013) 1.47
How proteases regulate bone morphogenesis. Ann N Y Acad Sci (2003) 1.47
Shedding light on sheddases: role in growth and development. Bioessays (2002) 1.47
Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol (2003) 1.43
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J (2006) 1.42
MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J (2003) 1.42
Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39
Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev (2011) 1.36
Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol (2006) 1.36
Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech (2010) 1.35
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev Dyn (2007) 1.35
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J (2004) 1.34
Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci (2012) 1.32
Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am J Pathol (2002) 1.31
Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One (2007) 1.29
Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J Immunol (2006) 1.27
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A (2012) 1.26
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J Clin Invest (2005) 1.25
Role of c-kit/Kit ligand signaling in regulating vasculogenesis. Thromb Haemost (2003) 1.25
Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem (2004) 1.24
Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci (2008) 1.23
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. J Biol Chem (2007) 1.21