PubRank

David D Moore

Author PubWeight™ 127.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006 5.52
2 Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004 4.65
3 A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 2011 4.44
4 Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2002 3.51
5 Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006 3.44
6 Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 2007 3.37
7 The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol 2011 2.81
8 Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 2002 2.66
9 Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology 2007 2.53
10 Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A 2003 2.44
11 Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol 2005 2.03
12 A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 2002 1.99
13 Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology 2004 1.89
14 Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab 2011 1.89
15 The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab 2005 1.89
16 Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology 2008 1.83
17 Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology 2005 1.82
18 Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol 2005 1.79
19 Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A 2009 1.77
20 A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest 2004 1.64
21 A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol 2004 1.59
22 FXR: a metabolic regulator and cell protector. Cell Res 2008 1.59
23 All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology 2014 1.59
24 Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A 2005 1.57
25 Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol 2009 1.49
26 Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 2004 1.46
27 Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem 2001 1.46
28 Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One 2010 1.45
29 Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem 2003 1.44
30 The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 2004 1.38
31 Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res 2007 1.38
32 Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol 2004 1.36
33 Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem 2001 1.34
34 Liver receptor homolog-1, an emerging metabolic modulator. Front Biosci 2008 1.32
35 Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem 2006 1.29
36 Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology 2008 1.28
37 Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology 2010 1.27
38 Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Res 2007 1.25
39 Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Mol Pharmacol 2008 1.24
40 Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol 2013 1.22
41 C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology 2008 1.22
42 GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr 2003 1.21
43 CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem 2002 1.20
44 Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest 2010 1.17
45 Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem 2001 1.13
46 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. J Biol Chem 2005 1.11
47 Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets 2011 1.09
48 The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos 2008 1.08
49 Circadian dysregulation disrupts bile acid homeostasis. PLoS One 2009 1.07
50 Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology 2006 1.06
51 Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicol Appl Pharmacol 2012 1.06
52 Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol 2008 1.05
53 Retracted Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol 2006 1.03
54 The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol 2007 1.01
55 Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. J Nutr Biochem 2005 1.01
56 Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor. Gastroenterology 2002 0.99
57 The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Toxicol Sci 2007 0.97
58 Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology 2012 0.97
59 Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos 2003 0.97
60 Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Mol Nutr Food Res 2009 0.96
61 Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. Am J Physiol Gastrointest Liver Physiol 2011 0.96
62 Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res 2011 0.95
63 MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. J Clin Invest 2015 0.95
64 Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta 2009 0.94
65 FOR, a novel orphan nuclear receptor related to farnesoid X receptor. J Biol Chem 2002 0.93
66 Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Mol Nutr Food Res 2008 0.91
67 Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. J Lipid Res 2008 0.90
68 Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology 2009 0.87
69 Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes. Hepatology 2012 0.87
70 Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife 2014 0.86
71 Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. Toxicol Appl Pharmacol 2008 0.86
72 Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr 2009 0.86
73 Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR. Nucl Recept 2003 0.86
74 Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α. Mol Endocrinol 2011 0.85
75 Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos 2013 0.84
76 Endoplasmic reticulum stress and glucose homeostasis. Curr Opin Clin Nutr Metab Care 2011 0.83
77 DamIP: a novel method to identify DNA binding sites in vivo. Nucl Recept Signal 2010 0.83
78 Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest 2015 0.81
79 Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2011 0.81
80 Research resource: The estrogen receptor α cistrome defined by DamIP. Mol Endocrinol 2011 0.79
81 Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Hepatol Res 2013 0.78
82 Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice. Pharmacol Biochem Behav 2004 0.78
83 FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway. Pflugers Arch 2013 0.77
84 Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo. J Virol 2011 0.77
85 DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo. Curr Protoc Mol Biol 2011 0.77
86 Correction: Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife 2015 0.77
87 Gender dictates the nuclear receptor-mediated regulation of CYP3A44. Drug Metab Dispos 2006 0.77
88 Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes. Toxicol Appl Pharmacol 2011 0.76
89 Chemical approaches to nuclear receptors in metabolism. Sci Signal 2009 0.75
90 Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. J Clin Invest 2017 0.75
91 Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis. Liver Int 2014 0.75
92 The orphan receptor SHP and the three-hybrid interference assay. Methods Enzymol 2003 0.75
93 Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor α. Dig Dis 2017 0.75
94 Endocrine Society 2014 Laureate Awards. Horm Cancer 2014 0.75