Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
2
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
3
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
4
|
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
|
N Engl J Med
|
2014
|
5.47
|
5
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
6
|
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
|
Nat Genet
|
2009
|
4.56
|
7
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
8
|
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
|
PLoS Genet
|
2009
|
3.18
|
9
|
Association of adolescent obesity with risk of severe obesity in adulthood.
|
JAMA
|
2010
|
3.10
|
10
|
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
|
Nat Genet
|
2011
|
3.03
|
11
|
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study.
|
Am J Epidemiol
|
2011
|
2.98
|
12
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
13
|
FTO genotype is associated with phenotypic variability of body mass index.
|
Nature
|
2012
|
2.77
|
14
|
Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal.
|
Hepatology
|
2003
|
2.51
|
15
|
Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Clin Nutr
|
2010
|
2.40
|
16
|
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
|
Am J Hum Genet
|
2010
|
2.15
|
17
|
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.
|
PLoS Genet
|
2011
|
2.13
|
18
|
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
Diabetes
|
2011
|
2.09
|
19
|
Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study.
|
PLoS Biol
|
2013
|
2.08
|
20
|
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
Nat Genet
|
2013
|
1.85
|
21
|
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
|
Nat Genet
|
2013
|
1.82
|
22
|
Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.
|
Hum Mol Genet
|
2006
|
1.74
|
23
|
TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.
|
J Am Soc Nephrol
|
2008
|
1.71
|
24
|
Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study.
|
PLoS One
|
2012
|
1.65
|
25
|
Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study.
|
Nephrol Dial Transplant
|
2006
|
1.59
|
26
|
Linkage analysis of glomerular filtration rate in American Indians.
|
Kidney Int
|
2008
|
1.59
|
27
|
IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women.
|
Cancer Epidemiol Biomarkers Prev
|
2009
|
1.58
|
28
|
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
|
PLoS Genet
|
2013
|
1.57
|
29
|
Irritable bowel syndrome: a co-twin control analysis.
|
Am J Gastroenterol
|
2007
|
1.56
|
30
|
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
|
PLoS Genet
|
2012
|
1.52
|
31
|
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
|
Am J Respir Crit Care Med
|
2012
|
1.49
|
32
|
Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study.
|
Atherosclerosis
|
2013
|
1.48
|
33
|
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
|
PLoS Genet
|
2011
|
1.47
|
34
|
Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative.
|
Genet Epidemiol
|
2012
|
1.42
|
35
|
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
|
Am J Clin Nutr
|
2013
|
1.35
|
36
|
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
|
PLoS Genet
|
2011
|
1.35
|
37
|
Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium.
|
Diabetes
|
2012
|
1.31
|
38
|
Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart Study.
|
J Hypertens
|
2004
|
1.30
|
39
|
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
|
Am J Hum Genet
|
2012
|
1.29
|
40
|
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study.
|
Obesity (Silver Spring)
|
2013
|
1.28
|
41
|
Fine Mapping and Identification of BMI Loci in African Americans.
|
Am J Hum Genet
|
2013
|
1.27
|
42
|
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.
|
Circ Cardiovasc Genet
|
2011
|
1.26
|
43
|
Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Diabetes
|
2003
|
1.24
|
44
|
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
|
PLoS Genet
|
2013
|
1.24
|
45
|
Meta-analysis of gene-level associations for rare variants based on single-variant statistics.
|
Am J Hum Genet
|
2013
|
1.24
|
46
|
NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review.
|
Genet Med
|
2006
|
1.23
|
47
|
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
|
Hum Mol Genet
|
2013
|
1.23
|
48
|
Body mass index gain, fast food, and physical activity: effects of shared environments over time.
|
Obesity (Silver Spring)
|
2006
|
1.23
|
49
|
Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|
Hum Mol Genet
|
2013
|
1.23
|
50
|
A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
|
PLoS Genet
|
2013
|
1.21
|
51
|
Genome-wide association study of lung function decline in adults with and without asthma.
|
J Allergy Clin Immunol
|
2012
|
1.20
|
52
|
Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) Study.
|
Obesity (Silver Spring)
|
2009
|
1.17
|
53
|
Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the Strong Heart Study.
|
Circulation
|
2004
|
1.16
|
54
|
DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas.
|
Neuroepidemiology
|
2007
|
1.15
|
55
|
Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study.
|
J Lipid Res
|
2009
|
1.15
|
56
|
Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study.
|
Hum Genet
|
2007
|
1.12
|
57
|
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.
|
Hum Mol Genet
|
2011
|
1.07
|
58
|
Imputation of coding variants in African Americans: better performance using data from the exome sequencing project.
|
Bioinformatics
|
2013
|
1.05
|
59
|
Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.
|
Circ Cardiovasc Genet
|
2011
|
1.05
|
60
|
The association of diabetes with breast cancer incidence and mortality in the Long Island Breast Cancer Study Project.
|
Cancer Causes Control
|
2012
|
1.05
|
61
|
Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.
|
PLoS One
|
2010
|
1.03
|
62
|
Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study.
|
Am J Epidemiol
|
2013
|
1.03
|
63
|
COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States).
|
Cancer Causes Control
|
2006
|
1.01
|
64
|
Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study.
|
Diabetes
|
2008
|
1.01
|
65
|
Serum adiponectin in relation to body mass index and other correlates in black and white women.
|
Ann Epidemiol
|
2010
|
1.01
|
66
|
Genetic influences on aortic root size in American Indians: the Strong Heart Study .
|
Arterioscler Thromb Vasc Biol
|
2002
|
1.01
|
67
|
Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review.
|
Genet Med
|
2008
|
1.00
|
68
|
Race- and sex-specific associations of obesity measures with ischemic stroke incidence in the Atherosclerosis Risk in Communities (ARIC) study.
|
Stroke
|
2010
|
1.00
|
69
|
Phenotypic, genetic, and genome-wide structure in the metabolic syndrome.
|
BMC Genet
|
2003
|
1.00
|
70
|
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
|
Pharmacogenet Genomics
|
2007
|
1.00
|
71
|
Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study.
|
BMC Cardiovasc Disord
|
2007
|
1.00
|
72
|
ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women.
|
Obesity (Silver Spring)
|
2011
|
0.98
|
73
|
Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study.
|
J Hypertens
|
2008
|
0.97
|
74
|
The genetics of obesity and the metabolic syndrome.
|
Endocr Metab Immune Disord Drug Targets
|
2010
|
0.97
|
75
|
Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: the ARIC study.
|
Obesity (Silver Spring)
|
2011
|
0.97
|
76
|
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
|
Circ Cardiovasc Genet
|
2012
|
0.97
|
77
|
The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study.
|
Hum Genet
|
2010
|
0.96
|
78
|
Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer.
|
Cancer Epidemiol Biomarkers Prev
|
2011
|
0.95
|
79
|
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
|
PLoS One
|
2011
|
0.95
|
80
|
Obesity and diabetes genetic variants associated with gestational weight gain.
|
Am J Obstet Gynecol
|
2010
|
0.94
|
81
|
Impact of ancestry and common genetic variants on QT interval in African Americans.
|
Circ Cardiovasc Genet
|
2012
|
0.94
|
82
|
Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study.
|
Am J Epidemiol
|
2013
|
0.94
|
83
|
Linkage study of fibrinogen levels: the Strong Heart Family Study.
|
BMC Med Genet
|
2008
|
0.94
|
84
|
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
|
Hum Genet
|
2012
|
0.93
|
85
|
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
|
Am J Epidemiol
|
2013
|
0.93
|
86
|
Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study.
|
Atherosclerosis
|
2005
|
0.93
|
87
|
Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites.
|
Am J Epidemiol
|
2005
|
0.92
|
88
|
Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study.
|
Clin Nutr
|
2010
|
0.92
|
89
|
Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urine.
|
Environ Health Perspect
|
2013
|
0.92
|
90
|
NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities study.
|
Pharmacogenet Genomics
|
2006
|
0.92
|
91
|
Genetic determination of acute phase reactant levels: the strong heart study.
|
Hum Hered
|
2004
|
0.91
|
92
|
Body mass, DRD4, physical activity, sedentary behavior, and family socioeconomic status: the add health study.
|
Obesity (Silver Spring)
|
2007
|
0.91
|
93
|
GSTM1 and GSTT1 polymorphisms, cigarette smoking, and risk of colon cancer: a population-based case-control study in North Carolina (United States).
|
Cancer Causes Control
|
2006
|
0.90
|
94
|
Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Clin Nutr
|
2013
|
0.89
|
95
|
Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci.
|
BMC Proc
|
2007
|
0.89
|
96
|
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.
|
PLoS One
|
2007
|
0.88
|
97
|
Linkage analysis of albuminuria.
|
J Am Soc Nephrol
|
2009
|
0.88
|
98
|
Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.
|
J Nutr
|
2013
|
0.88
|
99
|
Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study.
|
J Epidemiol
|
2010
|
0.88
|
100
|
The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.
|
Diabetes
|
2013
|
0.87
|
101
|
The association of genetic variants of type 2 diabetes with kidney function.
|
Kidney Int
|
2012
|
0.87
|
102
|
Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study.
|
Am J Hypertens
|
2008
|
0.87
|
103
|
Accuracy of haplotype estimation in a region of low linkage disequilibrium.
|
BMC Genet
|
2005
|
0.87
|
104
|
Relation of albuminuria to left ventricular mass (from the HyperGEN Study).
|
Am J Cardiol
|
2008
|
0.87
|
105
|
The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study.
|
Atherosclerosis
|
2012
|
0.87
|
106
|
Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
|
Genet Epidemiol
|
2013
|
0.87
|
107
|
A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study.
|
Hypertension
|
2006
|
0.87
|
108
|
Fine-mapping and initial characterization of QT interval loci in African Americans.
|
PLoS Genet
|
2012
|
0.86
|
109
|
A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypes.
|
Hypertension
|
2005
|
0.86
|
110
|
Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study.
|
Carcinogenesis
|
2008
|
0.86
|
111
|
Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13.
|
Genet Epidemiol
|
2003
|
0.86
|
112
|
Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15.
|
Genet Epidemiol
|
2007
|
0.86
|
113
|
Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.
|
BMC Genet
|
2013
|
0.86
|
114
|
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
|
Diabetes
|
2012
|
0.86
|
115
|
Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study.
|
BMC Med Genet
|
2013
|
0.85
|
116
|
Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study.
|
Genet Epidemiol
|
2008
|
0.85
|
117
|
Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia.
|
J Natl Cancer Inst
|
2014
|
0.85
|
118
|
QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study.
|
BMC Med Genet
|
2008
|
0.85
|
119
|
The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis.
|
Am J Med Genet B Neuropsychiatr Genet
|
2010
|
0.85
|
120
|
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study.
|
BMC Med Genet
|
2008
|
0.85
|
121
|
Use of longitudinal data in genetic studies in the genome-wide association studies era: summary of Group 14.
|
Genet Epidemiol
|
2009
|
0.85
|
122
|
Genome-wide linkage scan for plasma high density lipoprotein cholesterol, apolipoprotein A-1 and triglyceride variation among American Indian populations: the Strong Heart Family Study.
|
J Med Genet
|
2009
|
0.84
|
123
|
A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.
|
Am J Med Genet B Neuropsychiatr Genet
|
2010
|
0.84
|
124
|
Genetic association studies and the effect of misclassification and selection bias in putative confounders.
|
BMC Proc
|
2009
|
0.84
|
125
|
Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) study.
|
Diabetes Metab Res Rev
|
2010
|
0.84
|
126
|
Longitudinal age-dependent effect on systolic blood pressure.
|
BMC Proc
|
2009
|
0.84
|
127
|
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.
|
Hum Mol Genet
|
2013
|
0.84
|
128
|
Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
|
BMC Med Genet
|
2013
|
0.84
|
129
|
Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study.
|
Circ Cardiovasc Genet
|
2009
|
0.84
|
130
|
Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study.
|
Neurology
|
2012
|
0.83
|
131
|
Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis.
|
Cancer Epidemiol Biomarkers Prev
|
2010
|
0.83
|
132
|
Identification of Obesity and Cardiovascular Risk in Ethnically and Racially Diverse Populations: A Scientific Statement From the American Heart Association.
|
Circulation
|
2015
|
0.83
|
133
|
Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study.
|
BMC Med Genet
|
2009
|
0.82
|
134
|
Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study.
|
Diabetes
|
2004
|
0.82
|
135
|
Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
|
BMC Proc
|
2009
|
0.82
|
136
|
Sex-influenced association of nonalcoholic fatty liver disease with coronary heart disease.
|
Atherosclerosis
|
2013
|
0.82
|
137
|
Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata.
|
Reprod Sci
|
2007
|
0.82
|
138
|
Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study.
|
Hum Genet
|
2004
|
0.82
|
139
|
Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk.
|
Int J Cancer
|
2013
|
0.81
|
140
|
Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.
|
Circ Cardiovasc Genet
|
2014
|
0.81
|
141
|
A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium.
|
Hum Mol Genet
|
2011
|
0.81
|
142
|
Evidence of heterogeneity by race/ethnicity in genetic determinants of QT interval.
|
Epidemiology
|
2014
|
0.81
|
143
|
Comparison of genome-wide variation between Malawians and African ancestry HapMap populations.
|
J Hum Genet
|
2010
|
0.81
|
144
|
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