Published in PLoS One on September 24, 2013
Is There Potential for Repurposing Statins as Novel Antimicrobials? Antimicrob Agents Chemother (2016) 0.93
Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent. Sci Rep (2015) 0.89
Statin-Conferred Enhanced Cellular Resistance against Bacterial Pore-Forming Toxins in Airway Epithelial Cells. Am J Respir Cell Mol Biol (2015) 0.79
The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection. PLoS One (2014) 0.79
Statin Decreases Helicobacter pylori Burden in Macrophages by Promoting Autophagy. Front Cell Infect Microbiol (2017) 0.77
Interactions between Autophagy and Bacterial Toxins: Targets for Therapy? Toxins (Basel) (2015) 0.77
Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation. Respir Res (2015) 0.77
Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth. Front Microbiol (2016) 0.76
An Emerging Approach for Parallel Quantification of Intracellular Protozoan Parasites and Host Cell Characterization Using TissueFAXS Cytometry. PLoS One (2015) 0.75
Current and Emerging Uses of Statins in Clinical Therapeutics: A Review. Lipid Insights (2016) 0.75
Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. Sci Rep (2016) 0.75
Enzymatic determination of total serum cholesterol. Clin Chem (1974) 20.65
Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch Intern Med (2010) 7.49
Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation. Infect Immun (1989) 5.04
Statins as a newly recognized type of immunomodulator. Nat Med (2000) 5.00
Essential role for cholesterol in entry of mycobacteria into macrophages. Science (2000) 3.36
MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J Immunol Methods (1990) 3.24
The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. J Cell Biol (2002) 3.01
Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe (2010) 2.28
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest (1980) 2.26
Statin use and mortality within 180 days after bacteremia: a population-based cohort study. Crit Care Med (2006) 2.16
Statins reduce the risk of lung cancer in humans: a large case-control study of US veterans. Chest (2007) 2.15
GILT is a critical host factor for Listeria monocytogenes infection. Nature (2008) 2.12
Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur J Immunol (2000) 2.00
CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol (2009) 1.80
Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci (1998) 1.78
Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol (2006) 1.76
Cholesterol biosynthesis modulation regulates dengue viral replication. Virology (2009) 1.64
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A (2007) 1.57
The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis (2008) 1.52
Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mol Genet Metab (1999) 1.48
Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest (2002) 1.46
Salmonella-containing vacuoles: directing traffic and nesting to grow. Traffic (2008) 1.45
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44
Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells. J Cell Biol (2004) 1.42
The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55. Cell Microbiol (2002) 1.42
Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem (2002) 1.39
Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation. Infect Immun (2004) 1.36
IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes. Int Immunol (1999) 1.18
Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. Biochim Biophys Acta (1997) 1.15
Simvastatin reduces the association of NMDA receptors to lipid rafts: a cholesterol-mediated effect in neuroprotection. Stroke (2008) 1.12
Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection. Microb Pathog (1994) 1.11
Cholesterol is required for Leishmania donovani infection: implications in leishmaniasis. Mol Biochem Parasitol (2004) 1.10
Identification of novel Listeria monocytogenes secreted virulence factors following mutational activation of the central virulence regulator, PrfA. Infect Immun (2007) 1.09
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. BMC Cancer (2008) 1.09
Statins for atherosclerosis--as good as it gets? N Engl J Med (2005) 1.08
Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A (2004) 1.06
Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. J Immunol (2004) 1.06
Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice. Vaccine (2010) 1.05
Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. Arterioscler Thromb Vasc Biol (2004) 1.01
What is a relevant statin concentration in cell experiments claiming pleiotropic effects? Br J Clin Pharmacol (2011) 1.00
Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages. Infect Immun (2011) 0.97
Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice. Antimicrob Agents Chemother (2005) 0.96
Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol (2005) 0.96
Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice? Atherosclerosis (1998) 0.95
Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proc Natl Acad Sci U S A (2007) 0.91
Human tumor necrosis factor increases the resistance against Listeria infection in mice. Med Microbiol Immunol (1989) 0.91
Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. Protein Sci (2004) 0.90
Labeling of cholesterol with filipin in cellular membranes of parenchymatous organs. Standardization of incubation conditions. Histochemistry (1987) 0.89
Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes. Atherosclerosis (2004) 0.84
Hydrophobic but not hydrophilic statins enhance phagocytosis and decrease apoptosis of human peripheral blood cells in vitro. Biomed Pharmacother (2007) 0.84
Effect of pravastatin, simvastatin and atorvastatin on the phagocytic activity of mouse peritoneal macrophages. Exp Mol Pathol (2005) 0.82
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med (2008) 14.01
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest (2006) 6.61
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity (2004) 6.46
A promoter-level mammalian expression atlas. Nature (2014) 6.25
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
The regulated retrotransposon transcriptome of mammalian cells. Nat Genet (2009) 5.79
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res (2005) 4.86
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature (2011) 4.71
Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38
Tiny RNAs associated with transcription start sites in animals. Nat Genet (2009) 4.19
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol (2002) 3.89
Complex Loci in human and mouse genomes. PLoS Genet (2006) 3.74
IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol (2007) 3.25
A comprehensive survey of 3' animal miRNA modification events and a possible role for 3' adenylation in modulating miRNA targeting effectiveness. Genome Res (2010) 2.87
IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol (2007) 2.48
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol (2004) 2.30
Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin. RNA Biol (2011) 2.18
The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis (2006) 1.99
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med (2009) 1.97
Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet (2006) 1.95
Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response. Arterioscler Thromb Vasc Biol (2005) 1.91
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection. J Immunol (2005) 1.86
Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol (2006) 1.76
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med (2007) 1.75
A genome-wide and nonredundant mouse transcription factor database. Biochem Biophys Res Commun (2004) 1.75
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med (2003) 1.75
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med (2013) 1.73
Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries. Genome Res (2010) 1.73
The global cardiovascular diseases risk pattern in a peri-urban working-class community in South Africa. The Mamre study. Ethn Dis (2004) 1.73
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc Natl Acad Sci U S A (2012) 1.72
Transcriptional network dynamics in macrophage activation. Genomics (2006) 1.72
Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics (2009) 1.71
CDS annotation in full-length cDNA sequence. Genome Res (2003) 1.70
Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. J Allergy Clin Immunol (2006) 1.70
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61
Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. Biotechniques (2008) 1.61
The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biol (2009) 1.60
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat Commun (2013) 1.58
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J (2006) 1.51
Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy. Circulation (2011) 1.51
Interaction generality, a measurement to assess the reliability of a protein-protein interaction. Nucleic Acids Res (2002) 1.50
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet (2015) 1.50
Colesevelam hydrochloride: efficacy and safety in pediatric subjects with heterozygous familial hypercholesterolemia. J Pediatr (2009) 1.49
IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. J Immunol (2009) 1.48
Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions. Blood (2006) 1.43
Transcriptional features of genomic regulatory blocks. Genome Biol (2009) 1.37
Host-directed drug targeting of factors hijacked by pathogens. Sci Signal (2008) 1.36
The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem (2003) 1.32
FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions. Genome Biol (2009) 1.32
Construction of reliable protein-protein interaction networks with a new interaction generality measure. Bioinformatics (2003) 1.31
Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity. Infect Immun (2003) 1.28
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol (2005) 1.28
IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. Eur J Immunol (2010) 1.27
IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis. Am J Pathol (2009) 1.27
The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. J Biol Chem (2012) 1.27
Transmembrane TNF induces an efficient cell-mediated immunity and resistance to Mycobacterium bovis bacillus Calmette-Guérin infection in the absence of secreted TNF and lymphotoxin-alpha. J Immunol (2002) 1.27
Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation. J Infect Dis (2013) 1.26
Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial. J Pediatr (2003) 1.23
The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol (2005) 1.23
Contribution of transmembrane tumor necrosis factor to host defense against Mycobacterium bovis bacillus Calmette-guerin and Mycobacterium tuberculosis infections. Am J Pathol (2005) 1.21
Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. Int J Cancer (2006) 1.16
Genome-wide investigation of in vivo EGR-1 binding sites in monocytic differentiation. Genome Biol (2009) 1.14
Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation. BMC Genomics (2009) 1.14
A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis. J Immunol (2007) 1.13
Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis. Genomics (2004) 1.13
Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. J Exp Med (2011) 1.13
Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia. J Cereb Blood Flow Metab (2003) 1.13
Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Med Microbiol Immunol (2002) 1.13
Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis (2006) 1.12
Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog (2007) 1.12
Transcription and enhancer profiling in human monocyte subsets. Blood (2014) 1.12
The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog (2008) 1.09
Innate immunity mediates follicular transport of particulate but not soluble protein antigen. J Immunol (2012) 1.09
Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLoS Pathog (2007) 1.09
P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. J Infect Dis (2004) 1.08
Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Res (2010) 1.08
Familial hypercholesterolaemia: the Cape Town experience. S Afr Med J (2008) 1.08
The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood (2014) 1.08
Solution structure of a BolA-like protein from Mus musculus. Protein Sci (2004) 1.07
Gemin2 plays an important role in stabilizing the survival of motor neuron complex. J Biol Chem (2007) 1.07
Reduction of non-insert sequence reads by dimer eliminator LNA oligonucleotide for small RNA deep sequencing. Biotechniques (2010) 1.07