Published in Small GTPases on October 02, 2013
Insights into the biological functions of Dock family guanine nucleotide exchange factors. Genes Dev (2014) 1.15
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc Natl Acad Sci U S A (2014) 1.02
Rho GTPases: Anti- or pro-neoplastic targets? Oncogene (2016) 0.84
Redox regulation of Rac1 by thiol oxidation. Free Radic Biol Med (2014) 0.83
Lamellipodia are crucial for haptotactic sensing and response. J Cell Sci (2016) 0.81
Updates of reactive oxygen species in melanoma etiology and progression. Arch Biochem Biophys (2014) 0.81
Endothelial Rac1 is essential for hematogenous metastasis to the lung. Oncotarget (2015) 0.78
Rho GTPases: Regulation and roles in cancer cell biology. Small GTPases (2016) 0.78
Reversing synapse loss in Alzheimer's disease: Rho-guanosine triphosphatases and insights from other brain disorders. Neurotherapeutics (2015) 0.77
The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. J Biol Chem (2016) 0.76
14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIα. Mol Cell Biol (2014) 0.76
Deregulation of Rho GTPases in cancer. Small GTPases (2016) 0.76
LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer. BMC Bioinformatics (2016) 0.75
Coevolution of RAC Small GTPases and their Regulators GEF Proteins. Evol Bioinform Online (2016) 0.75
Tools for Live Imaging of Active Rho GTPases in Xenopus. Genesis (2017) 0.75
DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells. Leukemia (2016) 0.75
De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones. Elife (2017) 0.75
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. PLoS Comput Biol (2017) 0.75
Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions. Sci Rep (2017) 0.75
Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen. J Physiol (2015) 0.75
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55
Rho GTPases in cell biology. Nature (2002) 22.81
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol (2005) 16.77
A landscape of driver mutations in melanoma. Cell (2012) 12.61
RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61
GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet (2012) 7.00
The Ras superfamily at a glance. J Cell Sci (2005) 4.83
GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol (2005) 4.13
Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell (1993) 3.70
Rho GTPases are over-expressed in human tumors. Int J Cancer (1999) 3.70
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell (1994) 3.57
Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci (2004) 3.27
Ras in cancer and developmental diseases. Genes Cancer (2011) 2.68
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol (2000) 2.58
RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res (2000) 2.48
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38
Rho GTPases have diverse effects on the organization of the actin filament system. Biochem J (2004) 2.23
Role of a new Rho family member in cell migration and axon guidance in C. elegans. Cell (1997) 2.18
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development (2001) 2.16
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol (2004) 1.87
Rho proteins and cancer. Breast Cancer Res Treat (2004) 1.77
Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res (2003) 1.76
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene (2009) 1.76
Expression of seven main Rho family members in gastric carcinoma. Biochem Biophys Res Commun (2004) 1.63
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res (2004) 1.58
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem (2003) 1.55
Androgen axis in prostate cancer. J Cell Biochem (2006) 1.48
Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics (2002) 1.31
The Rho GTPase family: a Racs to Wrchs story. J Cell Sci (2002) 1.29
Motility-related proteins as markers for head and neck squamous cell cancer. Laryngoscope (2001) 1.28
Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour. BJU Int (2001) 1.26
Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration. Genetics (2005) 1.19
Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma. Blood (2003) 1.19
Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. Cancer (1999) 1.18
The expression of rho proteins decreases with human brain tumor progression: potential tumor markers. Clin Exp Metastasis (2002) 1.16
p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. Genes Dev (2003) 1.16
Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer. J Proteome Res (2008) 1.15
The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance. Genetics (2008) 1.12
Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Oncogene (2000) 1.10
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene (2009) 1.07
Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma. FEBS J (2010) 0.99
RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer. BJU Int (2003) 0.96
The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance. PLoS Genet (2012) 0.95
RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis. Small GTPases (2011) 0.89
Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein. Breast Cancer Res (2010) 0.86
Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma. J Oral Maxillofac Surg (2004) 0.85
Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. Int J Oncol (2002) 0.84
Rac2 expression and mutation in human brain tumors. Acta Neurochir (Wien) (2005) 0.83
Expression of the Rho-family GTPase gene RHOF in lymphocyte subsets and malignant lymphomas. Br J Haematol (2005) 0.81