Published in Biochem J on January 15, 2004
The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Cell (2009) 4.26
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Cell biology and pathology of podocytes. Annu Rev Physiol (2011) 2.42
Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol Biol Cell (2006) 2.36
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol (2006) 1.96
Vascular endothelial growth factors and vascular permeability. Cardiovasc Res (2010) 1.89
Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal (2010) 1.70
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. Mol Biol Cell (2005) 1.66
MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PLoS One (2011) 1.61
Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem (2007) 1.61
Src activates Abl to augment Robo1 expression in order to promote tumor cell migration. Oncotarget (2010) 1.52
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell (2011) 1.39
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. Mol Biol Cell (2005) 1.36
RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. Cell (2009) 1.23
Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arterioscler Thromb Vasc Biol (2008) 1.21
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. Cancer Res (2009) 1.21
Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria. J Cell Biol (2006) 1.20
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proc Natl Acad Sci U S A (2007) 1.19
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
RhoC expression and head and neck cancer metastasis. Mol Cancer Res (2009) 1.16
B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol Biol Cell (2007) 1.15
Functional interdependence between septin and actin cytoskeleton. BMC Cell Biol (2004) 1.13
Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation. Am J Physiol Cell Physiol (2006) 1.12
Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J Am Soc Nephrol (2011) 1.11
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation. J Cell Sci (2013) 1.08
CAAX-box protein, prenylation process and carcinogenesis. Am J Transl Res (2009) 1.07
The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization. Infect Immun (2009) 1.07
Salmonella enterica serovar typhimurium invades fibroblasts by multiple routes differing from the entry into epithelial cells. Infect Immun (2010) 1.05
Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer (2008) 1.03
Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS One (2011) 1.02
Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders. Exp Cell Res (2013) 1.01
Mutationally activated Rho GTPases in cancer. Small GTPases (2013) 1.01
Oxygen free radicals and redox biology of organelles. Histochem Cell Biol (2004) 1.00
Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism. Exp Cell Res (2008) 0.99
Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB. Mol Biol Cell (2004) 0.99
Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii. Infect Immun (2009) 0.99
The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol Cell Biol (2008) 0.98
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem (2008) 0.97
The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J Cell Sci (2010) 0.95
GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration. Mol Biol Cell (2011) 0.95
Importance of RhoGTPases in formation, characteristics, and functions of invadosomes. Small GTPases (2014) 0.90
Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. J Cancer Res Clin Oncol (2005) 0.90
Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration. Oncogene (2012) 0.89
Mesenchymal migration as a therapeutic target in glioblastoma. J Oncol (2010) 0.89
The small GTPase Rif is dispensable for platelet filopodia generation in mice. PLoS One (2013) 0.89
Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem (2009) 0.89
SRC points the way to biomarkers and chemotherapeutic targets. Genes Cancer (2012) 0.88
Lymphatic endothelial cells adapt their barrier function in response to changes in shear stress. Lymphat Res Biol (2009) 0.87
Rho GTPases in hematopoietic stem cell functions. Curr Opin Hematol (2009) 0.87
The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. Mol Cell Biol (2007) 0.86
Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity. Mol Biol Cell (2006) 0.86
A CULLINary ride across the secretory pathway: more than just secretion. Trends Cell Biol (2014) 0.86
Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-beta signaling. Cells Tissues Organs (2007) 0.85
RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly. J Cell Sci (2014) 0.85
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. Mol Carcinog (2013) 0.84
Platelet Rho GTPases-a focus on novel players, roles and relationships. Biochem J (2015) 0.84
RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Mol Biol Cell (2012) 0.84
From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PLoS One (2014) 0.83
Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis. PLoS One (2011) 0.82
PleiotRHOpic: Rho pathways are essential for all stages of Neural Crest development. Small GTPases (2014) 0.81
Atypical RhoV and RhoU GTPases control development of the neural crest. Small GTPases (2011) 0.80
Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.80
Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol (2011) 0.79
Yersinia enterocolitica YopT and Clostridium difficile toxin B induce expression of GILZ in epithelial cells. PLoS One (2012) 0.79
Maturation of filopodia shaft adhesions is upregulated by local cycles of lamellipodia advancements and retractions. PLoS One (2014) 0.79
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma. Oncotarget (2016) 0.78
Rho GTPases: Regulation and roles in cancer cell biology. Small GTPases (2016) 0.78
Rhof promotes murine marginal zone B cell development. Nagoya J Med Sci (2014) 0.78
Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231. BMC Cancer (2012) 0.78
Rho'ing in and out of cells: viral interactions with Rho GTPase signaling. Small GTPases (2014) 0.78
Pathophysiological Functions of Rnd3/RhoE. Compr Physiol (2015) 0.77
Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans. Small GTPases (2013) 0.77
RhoGTPases and p53 are involved in the morphological appearance and interferon-alpha response of hairy cells. Am J Pathol (2006) 0.77
Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells. Biol Open (2015) 0.77
Cdc42 Effector Protein 2 (XCEP2) is required for normal gastrulation and contributes to cellular adhesion in Xenopus laevis. BMC Dev Biol (2004) 0.76
Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK. PLoS One (2015) 0.76
Optimization and stabilization of Rho small GTPase proteins for solution NMR studies: The case of Rnd1. Small GTPases (2011) 0.75
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. Sci Rep (2017) 0.75
Atypical RhoV and RhoU GTPases control development of the neural crest. Small GTPases (2015) 0.75
Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep (2016) 0.75
The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B. BMC Cancer (2017) 0.75
Taking a lipidation-dependent path toward endolysosomes. Commun Integr Biol (2015) 0.75
Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo. Oncotarget (2017) 0.75
Retracted Adseverin knockdown inhibits osteoclastogenesis in RAW264.7 cells. Int J Mol Med (2014) 0.75
The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis. PLoS One (2015) 0.75
TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region. J Biol Chem (2016) 0.75
The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology. Biomed Res Int (2016) 0.75
RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. Am J Hum Genet (2017) 0.75
Adrenomedullin ameliorates podocyte injury induced by puromycin aminonucleoside in vitro and in vivo through modulation of Rho GTPases. Int Urol Nephrol (2017) 0.75
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99
Rho GTPases in cell biology. Nature (2002) 22.81
ras genes. Annu Rev Biochem (1987) 22.59
Small GTP-binding proteins. Physiol Rev (2001) 9.52
Rho GTPases and their effector proteins. Biochem J (2000) 8.89
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev (2002) 6.54
A novel ras-related gene family. Cell (1985) 5.81
Rho GTPases and cell migration. J Cell Sci (2001) 5.66
Rho family proteins: coordinating cell responses. Trends Cell Biol (2001) 3.98
Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker. J Cell Biol (1993) 3.96
Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol (2000) 3.86
Rho GTPase-activating proteins in cell regulation. Trends Cell Biol (2003) 3.44
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol (1996) 3.13
Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal (1999) 3.00
Regulation of receptor-mediated endocytosis by Rho and Rac. Nature (1996) 2.84
Structure, mechanism and function of prenyltransferases. Eur J Biochem (2002) 2.63
All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol Cell Biol (2001) 2.56
Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem (2002) 2.56
ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Annu Rev Cell Dev Biol (2000) 2.53
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol (1998) 2.36
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell (2002) 2.27
A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. Curr Biol (1997) 2.03
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. Immunity (2001) 1.93
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase. Nat Cell Biol (2003) 1.92
Endosome dynamics regulated by a Rho protein. Nature (1996) 1.90
A novel Cdc42Hs mutant induces cellular transformation. Curr Biol (1997) 1.87
PDGF alpha- and beta-receptors activate unique and common signal transduction pathways. EMBO J (1992) 1.85
RhoE regulates actin cytoskeleton organization and cell migration. Mol Cell Biol (1998) 1.80
Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. Curr Biol (1999) 1.71
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. Mol Biol Cell (1998) 1.66
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev (2001) 1.49
Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. Curr Biol (1998) 1.49
The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control. Biochem Biophys Res Commun (1998) 1.44
Distinct cellular effects and interactions of the Rho-family GTPase TC10. Curr Biol (1998) 1.37
Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem (2000) 1.32
The Rho GTPase family: a Racs to Wrchs story. J Cell Sci (2002) 1.29
Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J Cell Sci (2003) 1.21
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol (2002) 1.20
The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. Curr Biol (2000) 1.13
Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Oncogene (2000) 1.10
TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene (1995) 1.10
Regulation of Wiskott-Aldrich syndrome protein and related molecules. Curr Opin Cell Biol (2002) 1.05
Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Gene (2002) 1.01
The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. J Neurosci (2000) 0.98
Transposition of RhoA to the murine Y chromosome. Genomics (1998) 0.81
Crucial role of TCL/TC10beta L, a subfamily of Rho GTPase, in adipocyte differentiation. J Biol Chem (2003) 0.80
Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron (2009) 3.49
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc Natl Acad Sci U S A (2008) 3.04
The Miro GTPases: at the heart of the mitochondrial transport machinery. FEBS Lett (2009) 1.10
RICH-1 has a BIN/Amphiphysin/Rvsp domain responsible for binding to membrane lipids and tubulation of liposomes. Biochem Biophys Res Commun (2004) 1.05
Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem (2008) 0.96
Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton. Trends Biochem Sci (2006) 0.93
Obestatin/ghrelin cells in normal mucosa and endocrine tumours of the stomach. Eur J Endocrinol (2009) 0.85
Expression of tyrosine kinase receptors in malignant midgut carcinoid tumors. Neuroendocrinology (2006) 0.79
Neuroendocrine markers are expressed in human mammary glands. Regul Pept (2009) 0.77