Published in Small GTPases on April 22, 2016
Rho GTPases: Anti- or pro-neoplastic targets? Oncogene (2016) 0.84
Rho GTPases: Regulation and roles in cancer cell biology. Small GTPases (2016) 0.78
Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms. Small GTPases (2016) 0.77
GEFs: Dual regulation of Rac1 signaling. Small GTPases (2016) 0.77
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation. PLoS One (2016) 0.75
The Rac GTPase in cancer: from old concepts to new paradigms. Cancer Res (2017) 0.75
Rho GTPases as therapeutic targets in cancer (Review). Int J Oncol (2017) 0.75
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov (2012) 26.98
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54
Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol (2005) 16.77
A landscape of driver mutations in melanoma. Cell (2012) 12.61
Comprehensive molecular characterization of gastric adenocarcinoma. Nature (2014) 11.93
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
Comprehensive molecular characterization of urothelial bladder carcinoma. Nature (2014) 8.48
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A (2004) 7.24
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet (2012) 7.00
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature (2001) 6.70
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med (1999) 3.76
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov (2013) 3.71
Rho GTPases are over-expressed in human tumors. Int J Cancer (1999) 3.70
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer (2010) 3.59
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell (1994) 3.57
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell (2012) 3.10
Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev (2013) 3.07
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature (2002) 2.79
Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene (2000) 2.71
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol (2010) 2.61
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev (2008) 2.60
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev (2005) 2.59
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science (2009) 2.51
The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol (2011) 2.39
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet (2014) 2.36
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet (2014) 2.34
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet (2014) 2.34
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. EMBO J (1998) 2.22
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
IntOGen-mutations identifies cancer drivers across tumor types. Nat Methods (2013) 2.10
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet (2012) 2.07
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol Cell Biol (2001) 1.99
Early requirement of Rac1 in a mouse model of pancreatic cancer. Gastroenterology (2011) 1.98
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci U S A (2000) 1.97
SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol (2010) 1.95
Rho family GTPases. Biochem Soc Trans (2012) 1.85
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol (2005) 1.84
Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res (2007) 1.80
ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res (2007) 1.77
Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res (2003) 1.76
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol (2006) 1.76
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene (2009) 1.76
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells. Biochem Biophys Res Commun (2000) 1.73
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell (2007) 1.72
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci U S A (2000) 1.69
Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med (2012) 1.67
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep (2012) 1.66
Expression of seven main Rho family members in gastric carcinoma. Biochem Biophys Res Commun (2004) 1.63
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res (2004) 1.58
Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res (2004) 1.56
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem (2003) 1.55
The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops. PLoS Biol (2013) 1.50
Loss of RhoB expression in human lung cancer progression. Clin Cancer Res (2004) 1.50
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene (2013) 1.44
Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. J Biol Chem (2003) 1.39
The diverse roles of Rac signaling in tumorigenesis. Cell Cycle (2011) 1.38
Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene (2010) 1.35
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem (2005) 1.33
Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem (2001) 1.30
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul (2009) 1.28
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J Biol Chem (2003) 1.28
Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma. Br J Dermatol (2007) 1.23
The role of ubiquitylation and degradation in RhoGTPase signalling. J Cell Sci (2010) 1.22
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis. Leukemia (2008) 1.20
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Int J Oncol (2008) 1.19
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol (2008) 1.18
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer (2009) 1.17
The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci Signal (2012) 1.17
A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One (2013) 1.17
p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. Genes Dev (2003) 1.16
Rho GTPases: masters of cell migration. Small GTPases (2014) 1.14
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis. Oncogene (2012) 1.13
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Oncogene (2000) 1.10
Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther (2009) 1.09
Prognostic relevance of increased Rac GTPase expression in prostate carcinomas. Endocr Relat Cancer (2007) 1.08
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF. Cancer Res (2014) 1.08
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene (2009) 1.07
Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A (2013) 1.07
The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas. J Pathol (2003) 1.06
RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci U S A (2013) 1.05
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A (2013) 1.05
Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma. Ann Surg Oncol (2007) 1.03
Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver. Gastroenterology (2008) 1.02
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. Oncogene (2012) 1.02
RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. Int J Cancer (2007) 1.01
Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol (2005) 1.01
Mutationally activated Rho GTPases in cancer. Small GTPases (2013) 1.01
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma. Proc Natl Acad Sci U S A (2016) 1.00
A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer. Oncogene (2011) 1.00
Direct modifications of Rho proteins: deconstructing GTPase regulation. Biol Cell (2010) 0.99
Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols. Genes Chromosomes Cancer (2014) 0.99
Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion. Hepatology (2012) 0.97
The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer. Int Semin Surg Oncol (2008) 0.97
Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci Signal (2012) 0.96
Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors. Cell Cycle (2016) 0.75