Published in J Clin Pharm Ther on October 05, 2013
Comparison of intravenous and subcutaneous exposure supporting dose selection of subcutaneous belimumab systemic lupus erythematosus Phase 3 program. Lupus (2016) 0.79
Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects. Clin Pharmacol Drug Dev (2015) 0.78
Pharmacokinetics and safety of single doses of tabalumab in subjects with rheumatoid arthritis or systemic lupus erythematosus. Br J Clin Pharmacol (2016) 0.75
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
Qualitative and Quantitative Analyses of Gibberellins in Vegetative Shoots of Normal, dwarf-1, dwarf-2, dwarf-3, and dwarf-5 Seedlings of Zea mays L. Plant Physiol (1988) 8.05
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev (1999) 7.69
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93
Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. Nucleic Acids Res (1980) 5.20
Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene. Cell (1979) 5.04
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02
Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant Physiol (1990) 4.71
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40
The dominant non-gibberellin-responding dwarf mutant (D8) of maize accumulates native gibberellins. Proc Natl Acad Sci U S A (1988) 4.28
Modulation of osteoclast differentiation. Endocr Rev (1992) 4.27
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. J Biol Chem (1978) 3.97
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell (1982) 3.72
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci U S A (1980) 3.70
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol (1998) 3.39
A gamma-ray burst at a redshift of z approximately 8.2. Nature (2009) 3.29
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A (1993) 3.29
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A (1997) 3.26
Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. Proc Natl Acad Sci U S A (1983) 3.07
Complete amino acid sequence of human plasma beta 2-glycoprotein I. Proc Natl Acad Sci U S A (1984) 3.06
The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates. EMBO J (1990) 3.04
Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA. Nature (1980) 2.97
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res (1996) 2.86
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology (1989) 2.83
Giant T wave inversion as a manifestation of asymmetrical apical hypertrophy (AAH) of the left ventricle. Echocardiographic and ultrasono-cardiotomographic study. Jpn Heart J (1976) 2.80
Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol (1999) 2.75
Proposed procedure for the allocation of trivial names to the gibberellins. Nature (1968) 2.72
Identification of Vibrio parahaemolyticus strains at the species level by PCR targeted to the toxR gene. J Clin Microbiol (1999) 2.71
Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proc Natl Acad Sci U S A (1985) 2.64
ICRP Publication 116. Conversion coefficients for radiological protection quantities for external radiation exposures. Ann ICRP (2012) 2.59
Evolutionary pattern of the hemagglutinin gene of influenza B viruses isolated in Japan: cocirculating lineages in the same epidemic season. J Virol (1990) 2.54
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest (1993) 2.52
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A (1999) 2.48
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem (1999) 2.47
Mechanism of action of the antifugal agent polyoxin D. J Bacteriol (1970) 2.44
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. J Antibiot (Tokyo) (1976) 2.42
Therapeutic effects of ML-236B in primary hypercholesterolemia. Atherosclerosis (1980) 2.35
An N-linked high-mannose type oligosaccharide, expressed at the major outer membrane protein of Chlamydia trachomatis, mediates attachment and infectivity of the microorganism to HeLa cells. J Clin Invest (1996) 2.35
Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell (1982) 2.32
A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol (1996) 2.29
Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell (1987) 2.29
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature (1981) 2.28
Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A (1998) 2.22
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet (1997) 2.20
Relativistic jet activity from the tidal disruption of a star by a massive black hole. Nature (2011) 2.12
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science (1999) 2.06
Mechanism of acid-induced folding of proteins. Biochemistry (1990) 2.06
Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res (1999) 2.06
The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J (2001) 2.05
Imaging of nontraumatic hemorrhage of the adrenal gland. Radiographics (1999) 2.03
Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell (1985) 2.02
Mitochondrial mutation in fatal infantile cardiomyopathy. Lancet (1990) 1.98
Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell (1985) 1.98
Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol (1999) 1.96
Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. J Clin Invest (1998) 1.96
Endogenous Gibberellins from Sporophytes of Two Tree Ferns, Cibotium glaucum and Dicksonia antarctica. Plant Physiol (1988) 1.95
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction. Neuroscience (2003) 1.92
Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist. Arthritis Rheum (2005) 1.91
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism. Proc Natl Acad Sci U S A (1981) 1.91
Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease. Circulation (1999) 1.89
Clinical features of prognosis of Japanese patients with anomalous origin of the coronary artery. Jpn Circ J (1996) 1.89
Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension (1998) 1.88
Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Eur J Biochem (1978) 1.86
Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum (2001) 1.85
The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides. Proc Natl Acad Sci U S A (1986) 1.85
Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. Proc Natl Acad Sci U S A (1988) 1.82
Role of 1 alpha,25-dihydroxyvitamin D3 in osteoclast differentiation and function. Methods Enzymol (1997) 1.81
A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells. J Biol Chem (1995) 1.81
A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapy. Am J Transplant (2009) 1.81
High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Trop (2003) 1.80
Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis (2002) 1.79
Cloning of human immunoglobulin mu gene and comparison with mouse mu gene. Nucleic Acids Res (1980) 1.79
Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res (1995) 1.75
Flagellar hook protein from Salmonella SJ25. J Bacteriol (1976) 1.74
Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides. Biochem Biophys Res Commun (1978) 1.74
Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report. Am J Hum Genet (1988) 1.74
Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta. Proc Natl Acad Sci U S A (1986) 1.73
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ (2012) 1.72
Spectrum of CT findings in nonmalignant disease of the adrenal gland. Radiographics (1998) 1.71
Preparation and characterization of a mouse osteoclast-like multinucleated cell population. J Bone Miner Res (1992) 1.71
Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule. Proc Natl Acad Sci U S A (1984) 1.71
Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy. Biochem Biophys Res Commun (1991) 1.70
Nonsurgical correction of congenital auricular deformities in the early neonate: a preliminary report. Plast Reconstr Surg (1984) 1.69
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem (1995) 1.69
Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death. J Membr Biol (2006) 1.68
Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds. Nature (1999) 1.68
Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev (2000) 1.66
Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand. Endocrinology (2001) 1.66
Tbx5 and the retinotectum projection. Science (2000) 1.65
Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease. Eur Respir J (2001) 1.65
Protein variants in Hiroshima and Nagasaki: tales of two cities. Am J Hum Genet (1988) 1.63
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem Biophys Res Commun (1998) 1.63
Gastrointestinal tract perforation: CT diagnosis of presence, site, and cause. Abdom Imaging (2005) 1.63
Analyses of N-linked oligosaccharides using a two-dimensional mapping technique. Anal Biochem (1988) 1.62
Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci (2003) 1.62
Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J Biol Chem (1990) 1.61
Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology (2000) 1.61
Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med (1995) 1.60