Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

PubWeight™: 1.96‹?› | Rank: Top 2%

🔗 View Article (PMC 508629)

Published in J Clin Invest on February 15, 1998

Authors

A Calderone1, C M Thaik, N Takahashi, D L Chang, W S Colucci

Author Affiliations

1: Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA.

Articles citing this

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2002) 3.27

cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev (2010) 3.27

Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J Clin Invest (2005) 3.22

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. J Clin Invest (2003) 2.37

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J Clin Invest (2001) 2.19

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest (2001) 2.03

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci U S A (2002) 1.88

Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition. Circulation (2016) 1.87

Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest (2006) 1.81

Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest (2005) 1.70

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol (2009) 1.60

The prevention of cardiovascular disease in cancer survivors. Tex Heart Inst J (2012) 1.57

A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions. J Am Coll Cardiol (2009) 1.53

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. J Clin Invest (2009) 1.51

Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity. Circ Res (2008) 1.49

Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2006) 1.48

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proc Natl Acad Sci U S A (2010) 1.33

A friend within the heart: natriuretic peptide receptor signaling. J Clin Invest (2003) 1.16

Regulation of cardiac remodeling by nitric oxide: focus on cardiac myocyte hypertrophy and apoptosis. Heart Fail Rev (2002) 1.11

Progressive cardiac hypertrophy and dysfunction in atrial natriuretic peptide receptor (GC-A) deficient mice. Heart (2002) 1.11

Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. Am J Physiol Heart Circ Physiol (2002) 1.10

Matrix metalloproteinases: pathways of induction by bioactive molecules. Heart Fail Rev (2004) 1.10

Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) (2009) 1.09

Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice. Nitric Oxide (2006) 1.08

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet (2011) 1.05

Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res (2014) 1.03

Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T. BMC Pharmacol (2005) 1.01

Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo. J Am Heart Assoc (2012) 0.99

Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart. Curr Cardiol Rev (2009) 0.96

Inhibition of DNA synthesis in cultured hepatocytes by endotoxin-conditioned medium of activated stellate cells is transforming growth factor-beta and nitric oxide-independent. Br J Pharmacol (2001) 0.93

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res Cardiol (2011) 0.92

KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways. Br J Pharmacol (2010) 0.92

Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks. Hypertension (2012) 0.91

Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation. J Mol Cell Cardiol (2008) 0.87

The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment. Clin Sci (Lond) (2016) 0.87

Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. PLoS One (2013) 0.86

Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I. Br J Pharmacol (2003) 0.86

Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A. Peptides (2006) 0.85

The role of nitric oxide in the failing heart. Heart Fail Rev (2001) 0.85

Nitric oxide-cyclic GMP signaling in stem cell differentiation. Free Radic Biol Med (2011) 0.85

Endothelial dysfunction is associated with left ventricular mass (assessed using MRI) in an adult population (MESA). J Hum Hypertens (2010) 0.84

The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy. PLoS One (2012) 0.84

Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. Oxid Med Cell Longev (2015) 0.84

Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca(2+) release, and activation of protein kinase C. Front Mol Neurosci (2014) 0.82

Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1/endothelin receptor A cascade. Heart Vessels (2013) 0.82

Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). Free Radic Biol Med (2014) 0.81

Csk mediates G-protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity. Biochemistry (2006) 0.80

Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury. Mol Med Rep (2017) 0.79

LU135252, an endothelin(A) receptor antagonist did not prevent pulmonary vascular remodelling or lung fibrosis in a rat model of myocardial infarction. Br J Pharmacol (2000) 0.79

Tadalafil-induced improvement in left ventricular diastolic function in resistant hypertension. Eur J Clin Pharmacol (2013) 0.79

Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects. Circ Heart Fail (2013) 0.78

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events. J Am Heart Assoc (2015) 0.78

Role of nitric oxide in the pathophysiology of heart failure. Heart Fail Rev (2003) 0.78

Breakthrough in heart failure with preserved ejection fraction: are we there yet? Korean J Intern Med (2015) 0.78

FGF2 modulates cardiac remodeling in an isoform- and sex-specific manner. Physiol Rep (2013) 0.77

Genetically altered mutant mouse models of guanylyl cyclase/natriuretic peptide receptor-A exhibit the cardiac expression of proinflammatory mediators in a gene-dose-dependent manner. Endocrinology (2014) 0.77

Oxytocin: Old Hormone, New Drug. Pharmaceuticals (Basel) (2009) 0.77

Control of left ventricular mass by moxonidine involves reduced DNA synthesis and enhanced DNA fragmentation. Br J Pharmacol (2007) 0.76

Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload. Cardiovasc Pathol (2014) 0.76

Waon therapy attenuates cardiac hypertrophy and promotes myocardial capillary growth in hypertensive rats: a comparative study with fluvastatin. Heart Vessels (2015) 0.76

Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice. Physiol Genomics (2016) 0.75

Human Endomyocardial Biopsy Specimen-Derived Stromal Cells Modulate Angiotensin II-Induced Cardiac Remodeling. Stem Cells Transl Med (2016) 0.75

Periodontitis and myocardial hypertrophy. Hypertens Res (2016) 0.75

Regulation of cardiac angiotensin-converting enzyme and angiotensin AT1 receptor gene expression in Npr1 gene-disrupted mice. Clin Exp Pharmacol Physiol (2009) 0.75

Docosahexaenoic acid inhibits protein kinase C translocation/activation and cardiac hypertrophy in rat cardiomyocytes. J Mol Genet Med (2005) 0.75

Modulating the nitric oxide - cyclic GMP pathway in the pressure-overloaded left ventricle and group II pulmonary hypertension. Int J Clin Pract Suppl (2010) 0.75

Articles cited by this

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest (1989) 5.01

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res (1993) 3.87

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci U S A (1993) 2.32

Expression of inducible nitric oxide synthase in human heart failure. Circulation (1996) 2.26

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. J Clin Invest (1983) 2.23

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc Natl Acad Sci U S A (1991) 2.15

Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium. Br J Pharmacol (1992) 2.09

cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway. Circulation (1997) 1.93

The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem (1993) 1.68

Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol (1993) 1.62

Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ Res (1995) 1.42

Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts. Circ Res (1993) 1.40

Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase. Am J Physiol (1995) 1.39

Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes. J Biol Chem (1997) 1.37

Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes. J Clin Invest (1994) 1.36

Natriuretic peptides inhibit DNA synthesis in cardiac fibroblasts. Hypertension (1995) 1.29

Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes. J Clin Invest (1995) 1.25

Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Circ Res (1994) 1.25

Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest (1995) 1.24

The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways. J Biol Chem (1991) 1.16

Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy. Proc Natl Acad Sci U S A (1991) 1.13

Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs. Circulation (1995) 1.05

Cyclic GMP-mediated inhibition of L-type Ca2+ channel activity by human natriuretic peptide in rabbit heart cells. Br J Pharmacol (1995) 0.99

Natriuretic peptide receptor mRNAs in the rat and human heart. J Clin Invest (1992) 0.98

Gene expression of natriuretic peptide receptors in myocardial cells. Circ Res (1995) 0.97

Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth. J Clin Invest (1994) 0.96

Effects of interleukin-1 beta and nitric oxide on cardiac myocytes. Hypertension (1995) 0.95

Effect of atriopeptin II on Ca influx, contractile behavior and cyclic nucleotide content of cultured neonatal rat myocardial cells. J Mol Cell Cardiol (1990) 0.92

Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells. Proc Natl Acad Sci U S A (1990) 0.92

Involvement of protein kianse C and Ca2+ in angiotensin II-induced mitogenesis of cardiac fibroblasts. Am J Physiol (1994) 0.92

Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium. J Mol Cell Cardiol (1993) 0.89

Chronic L-arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats. Hypertension (1996) 0.89

Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol (1991) 0.88

Extracellular ATP inhibits adrenergic agonist-induced hypertrophy of neonatal cardiac myocytes. Circ Res (1996) 0.87

Effect of norepinephrine on myocardial collagen gene expression and response of cardiac fibroblasts after norepinephrine treatment. Am J Pathol (1991) 0.86

Clearance receptor-binding atrial natriuretic peptides inhibit mitogenesis and proliferation of rat aortic smooth muscle cells. Biochem Biophys Res Commun (1991) 0.84

The L-type calcium channel current is increased by alpha-1 adrenoceptor activation in neonatal rat ventricular cells. J Pharmacol Exp Ther (1994) 0.83

Cyclic GMP inhibits the inotropic response to alpha 1-adrenoceptors in the papillary muscle of the ferret. Cardioscience (1992) 0.80

Transforming growth factor beta-1 modulates the number of beta-adrenergic receptors in cardiac fibroblasts. J Mol Cell Cardiol (1994) 0.80

Regulation of rat ventricular myosin heavy chain expression by serum and contractile activity. Am J Physiol (1994) 0.80

Interaction of PDGF and natriuretic peptides on mesangial cell proliferation and endothelin secretion. Am J Physiol (1993) 0.79

Articles by these authors

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med (1996) 12.77

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61

Qualitative and Quantitative Analyses of Gibberellins in Vegetative Shoots of Normal, dwarf-1, dwarf-2, dwarf-3, and dwarf-5 Seedlings of Zea mays L. Plant Physiol (1988) 8.05

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev (1999) 7.69

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93

Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. Nucleic Acids Res (1980) 5.20

Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene. Cell (1979) 5.04

Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02

Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant Physiol (1990) 4.71

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40

The dominant non-gibberellin-responding dwarf mutant (D8) of maize accumulates native gibberellins. Proc Natl Acad Sci U S A (1988) 4.28

Modulation of osteoclast differentiation. Endocr Rev (1992) 4.27

Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure. The PRECISE Trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise. Circulation (1996) 3.98

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell (1982) 3.72

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci U S A (1980) 3.70

Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure. N Engl J Med (2001) 3.44

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol (1998) 3.39

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A (1993) 3.29

Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A (1997) 3.26

Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. Proc Natl Acad Sci U S A (1983) 3.07

Complete amino acid sequence of human plasma beta 2-glycoprotein I. Proc Natl Acad Sci U S A (1984) 3.06

The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates. EMBO J (1990) 3.04

Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA. Nature (1980) 2.97

Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation (1998) 2.91

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res (1996) 2.86

The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology (1989) 2.83

Proposed procedure for the allocation of trivial names to the gibberellins. Nature (1968) 2.72

Identification of Vibrio parahaemolyticus strains at the species level by PCR targeted to the toxR gene. J Clin Microbiol (1999) 2.71

Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proc Natl Acad Sci U S A (1985) 2.64

Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest (1993) 2.52

Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. Circulation (1999) 2.50

The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A (1999) 2.48

Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circ Res (2000) 2.36

An N-linked high-mannose type oligosaccharide, expressed at the major outer membrane protein of Chlamydia trachomatis, mediates attachment and infectivity of the microorganism to HeLa cells. J Clin Invest (1996) 2.35

Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell (1982) 2.32

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol (1996) 2.29

Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell (1987) 2.29

Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol Cell Physiol (2001) 2.28

Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature (1981) 2.28

Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am J Cardiol (1988) 2.25

Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A (1998) 2.22

Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure. N Engl J Med (1980) 2.15

Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science (1999) 2.06

Mechanism of acid-induced folding of proteins. Biochemistry (1990) 2.06

Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res (1999) 2.06

The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J (2001) 2.05

Imaging of nontraumatic hemorrhage of the adrenal gland. Radiographics (1999) 2.03

Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell (1985) 2.02

Functional significance of presynaptic alpha-adrenergic receptors in failing and nonfailing human left ventricle. Circulation (1995) 2.00

Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research. Circulation (1997) 2.00

Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell (1985) 1.98

Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ Res (2001) 1.97

Decreased lymphocyte beta-adrenergic-receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist pirbuterol. N Engl J Med (1981) 1.97

Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol (1999) 1.96

Endogenous Gibberellins from Sporophytes of Two Tree Ferns, Cibotium glaucum and Dicksonia antarctica. Plant Physiol (1988) 1.95

Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist. Arthritis Rheum (2005) 1.91

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism. Proc Natl Acad Sci U S A (1981) 1.91

Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure. Circulation (1981) 1.90

Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension (1998) 1.88

The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides. Proc Natl Acad Sci U S A (1986) 1.85

Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum (2001) 1.85

Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. Proc Natl Acad Sci U S A (1988) 1.82

Role of 1 alpha,25-dihydroxyvitamin D3 in osteoclast differentiation and function. Methods Enzymol (1997) 1.81

A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells. J Biol Chem (1995) 1.81

Right ventricular ejection fraction: an indicator of increased mortality in patients with congestive heart failure associated with coronary artery disease. J Am Coll Cardiol (1983) 1.81

A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapy. Am J Transplant (2009) 1.81

Modulation of cardiac autonomic activity during and immediately after exercise. Am J Physiol (1989) 1.81

High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Trop (2003) 1.80

Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis (2002) 1.79

Cloning of human immunoglobulin mu gene and comparison with mouse mu gene. Nucleic Acids Res (1980) 1.79

Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res (1995) 1.75

Flagellar hook protein from Salmonella SJ25. J Bacteriol (1976) 1.74

Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides. Biochem Biophys Res Commun (1978) 1.74

Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report. Am J Hum Genet (1988) 1.74

Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta. Proc Natl Acad Sci U S A (1986) 1.73

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ (2012) 1.72

Spectrum of CT findings in nonmalignant disease of the adrenal gland. Radiographics (1998) 1.71

Preparation and characterization of a mouse osteoclast-like multinucleated cell population. J Bone Miner Res (1992) 1.71

Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule. Proc Natl Acad Sci U S A (1984) 1.71

Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res (2001) 1.70

Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure. Circulation (2000) 1.69

Nonsurgical correction of congenital auricular deformities in the early neonate: a preliminary report. Plast Reconstr Surg (1984) 1.69

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem (1995) 1.69

New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2. N Engl J Med (1986) 1.69

Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death. J Membr Biol (2006) 1.68

Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds. Nature (1999) 1.68

Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev (2000) 1.66

Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand. Endocrinology (2001) 1.66

Tbx5 and the retinotectum projection. Science (2000) 1.65

Protein variants in Hiroshima and Nagasaki: tales of two cities. Am J Hum Genet (1988) 1.63

Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem Biophys Res Commun (1998) 1.63

Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators. Circulation (2000) 1.63

Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand. Bone (1999) 1.62

Analyses of N-linked oligosaccharides using a two-dimensional mapping technique. Anal Biochem (1988) 1.62

Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci (2003) 1.62

Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology (2000) 1.61