Published in Biol Cell on November 26, 2013
Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization. Mol Biol Cell (2014) 0.93
Kinesin-5 is a microtubule polymerase. Nat Commun (2015) 0.83
Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proc Natl Acad Sci U S A (2016) 0.78
Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase. Cell Mol Life Sci (2017) 0.76
Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics. Mol Biol Cell (2016) 0.75
Novel allosteric pathway of Eg5 regulation identified through multivariate statistical analysis of HX-MS ligand screening data. Mol Cell Proteomics (2017) 0.75
Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis. Sci Rep (2016) 0.75
Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. ACS Chem Biol (2016) 0.75
The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner. J Biol Chem (2017) 0.75
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (1999) 12.52
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell (1987) 8.76
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
The way things move: looking under the hood of molecular motor proteins. Science (2000) 7.28
A structural change in the kinesin motor protein that drives motility. Nature (1999) 6.92
Direct observation of single kinesin molecules moving along microtubules. Nature (1996) 5.77
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol (2000) 5.75
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell (1995) 5.68
Mitosis in living budding yeast: anaphase A but no metaphase plate. Science (1997) 5.15
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J Cell Biol (2003) 5.12
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature (2005) 4.63
The design plan of kinesin motors. Annu Rev Cell Dev Biol (1997) 3.79
Monastrol inhibition of the mitotic kinesin Eg5. J Biol Chem (2005) 3.49
A bipolar kinesin. Nature (1996) 3.39
Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell (2008) 3.02
TPX2, A novel xenopus MAP involved in spindle pole organization. J Cell Biol (2000) 3.01
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5. Biochemistry (2004) 2.95
Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc Natl Acad Sci U S A (1995) 2.82
HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol (2006) 2.74
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro. Nat Cell Biol (2006) 2.73
Cell cycle regulation of human WEE1. EMBO J (1995) 2.56
Kinesin-5 acts as a brake in anaphase spindle elongation. Curr Biol (2007) 2.51
Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors. Mol Biol Cell (1997) 2.42
Role of the kinesin neck linker and catalytic core in microtubule-based motility. Curr Biol (2000) 2.34
Proteome analysis of the human mitotic spindle. Mol Cell Proteomics (2004) 2.31
Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150. J Biol Chem (1997) 2.13
Directional switching of the kinesin Cin8 through motor coupling. Science (2011) 2.06
Antitumor activity of a kinesin inhibitor. Cancer Res (2004) 1.93
An atomic-level mechanism for activation of the kinesin molecular motors. Proc Natl Acad Sci U S A (2010) 1.93
Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J (2002) 1.91
Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell (2005) 1.89
Microtubule cross-linking triggers the directional motility of kinesin-5. J Cell Biol (2008) 1.83
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J (2008) 1.81
Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array. J Cell Biol (2007) 1.73
ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism. J Biol Chem (2009) 1.64
A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature (2005) 1.64
Influence of the kinesin neck domain on dimerization and ATPase kinetics. J Biol Chem (1997) 1.60
Mitosis-targeted anti-cancer therapies: where they stand. Cell Death Dis (2012) 1.60
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol (2002) 1.58
Kinesin's cover-neck bundle folds forward to generate force. Proc Natl Acad Sci U S A (2008) 1.57
Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis. Mol Biol Cell (2009) 1.57
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function. Nature (2012) 1.56
Mechanism of microtubule kinesin ATPase. Biochemistry (1995) 1.55
A computational model predicts Xenopus meiotic spindle organization. J Cell Biol (2010) 1.53
A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding. Curr Biol (2011) 1.45
Kinesin: switch I & II and the motor mechanism. J Cell Sci (2002) 1.40
Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation. EMBO J (2012) 1.34
Targeting the kinesin spindle protein: basic principles and clinical implications. Clin Cancer Res (2008) 1.33
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci (2008) 1.32
Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. PLoS One (2008) 1.28
Spindle pole regulation by a discrete Eg5-interacting domain in TPX2. Curr Biol (2008) 1.26
Interhead tension determines processivity across diverse N-terminal kinesins. Proc Natl Acad Sci U S A (2011) 1.20
Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol (2006) 1.19
TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle. J Cell Biol (2011) 1.17
A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. J Cell Sci (2008) 1.15
The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1. Curr Biol (2013) 1.14
Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry. EMBO J (2011) 1.13
The nucleotide-binding state of microtubules modulates kinesin processivity and the ability of Tau to inhibit kinesin-mediated transport. J Biol Chem (2011) 1.11
Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration. Mol Biol Cell (2011) 1.10
Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem (2007) 1.08
Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Mol Biol Cell (2010) 1.08
The kinesin-related protein Kip1p of Saccharomyces cerevisiae is bipolar. J Biol Chem (1999) 1.07
Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins. J Cell Sci (1998) 1.07
Crystal structure of kinesin regulated by Ca(2+)-calmodulin. J Biol Chem (2004) 1.07
Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core. J Biol Chem (2010) 1.07
The structural basis of force generation by the mitotic motor kinesin-5. J Biol Chem (2012) 1.06
Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis. J Biol Chem (2006) 1.05
Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2. Mol Biol Cell (2012) 1.05
The bipolar assembly domain of the mitotic motor kinesin-5. Nat Commun (2013) 1.03
Phospho-regulation of kinesin-5 during anaphase spindle elongation. J Cell Sci (2011) 1.00
Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents. J Mol Biol (2006) 0.96
Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5. J Neurosci (2012) 0.94
Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A. J Cell Biol (2009) 0.94
Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell (2011) 0.92
Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers. Biophys J (2009) 0.92
Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity. Curr Biol (2009) 0.91
Modular aspects of kinesin force generation machinery. Biophys J (2013) 0.90
Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. J Cell Sci (2013) 0.89
B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast. PLoS Genet (2010) 0.89
The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5. Biophys J (2011) 0.87
Neck-linker length dependence of processive Kinesin-5 motility. J Mol Biol (2012) 0.85
Structural insights into a unique inhibitor binding pocket in kinesin spindle protein. J Am Chem Soc (2013) 0.85
A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility. Biophys J (2013) 0.83
The origin of minus-end directionality and mechanochemistry of Ncd motors. PLoS Comput Biol (2012) 0.83
Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment. Biochem J (2013) 0.77
Opposite-polarity motors activate one another to trigger cargo transport in live cells. J Cell Biol (2009) 2.00
Optical traps to study properties of molecular motors. Cold Spring Harb Protoc (2011) 1.79
The kinesin-1 motor protein is regulated by a direct interaction of its head and tail. Proc Natl Acad Sci U S A (2008) 1.63
The optical trapping dumbbell assay for nonprocessive motors or motors that turn around filaments. Cold Spring Harb Protoc (2011) 1.30
Attachment of anti-GFP antibodies to microspheres for optical trapping experiments. Cold Spring Harb Protoc (2011) 1.18
Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. J Biol Chem (2010) 1.17
The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5. Biophys J (2010) 1.11
Mechanism of cooperative behaviour in systems of slow and fast molecular motors. Phys Chem Chem Phys (2009) 1.02
The Kinesin-1 tail conformationally restricts the nucleotide pocket. Biophys J (2009) 0.99
Kinesin's light chains inhibit the head- and microtubule-binding activity of its tail. Proc Natl Acad Sci U S A (2010) 0.99
Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proc Natl Acad Sci U S A (2010) 0.98
Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro. EMBO Rep (2013) 0.88
Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects. Proteins (2014) 0.88
The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5. Biophys J (2011) 0.87
Kinesin tail domains are intrinsically disordered. Proteins (2012) 0.82
Analysis of the interaction of the Eg5 Loop5 with the nucleotide site. J Theor Biol (2011) 0.79
Intrinsic Disorder in the Kinesin Superfamily. Biophys Rev (2013) 0.78
Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. PLoS One (2013) 0.77
X-ray diffraction from intact tau aggregates in human brain tissue. Nucl Instrum Methods Phys Res A (2011) 0.77
Temperature dependence of myosin-II tail fragment assembly. J Muscle Res Cell Motil (2008) 0.75