Published in J Cell Sci on November 11, 2008
Traffic control: regulation of kinesin motors. Nat Rev Mol Cell Biol (2009) 2.87
Cell cycle regulation by the NEK family of protein kinases. J Cell Sci (2012) 1.64
The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol (2009) 1.55
Breaking the ties that bind: new advances in centrosome biology. J Cell Biol (2012) 1.41
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
Cancer biomarker discovery: the entropic hallmark. PLoS One (2010) 1.26
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. Mol Cell (2009) 1.12
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. Am J Hum Genet (2012) 1.10
On the molecular mechanisms of mitotic kinase activation. Open Biol (2012) 1.08
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol (2015) 0.98
A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One (2011) 0.94
The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. J Cell Sci (2009) 0.94
Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. J Biol Chem (2010) 0.94
Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell (2011) 0.92
Kinesin-5: cross-bridging mechanism to targeted clinical therapy. Gene (2013) 0.92
Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. J Biol Chem (2013) 0.91
Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity. Curr Biol (2009) 0.91
"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases. World J Biol Chem (2014) 0.91
Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle. Biol Cell (2013) 0.87
NEK9-dependent proliferation of cancer cells lacking functional p53. Sci Rep (2014) 0.87
Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis. Cell Cycle (2012) 0.87
Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies. Mol Biol Cell (2013) 0.87
Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res (2014) 0.85
DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. J Biol Chem (2011) 0.84
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nat Commun (2016) 0.84
Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer. Chromosome Res (2016) 0.84
Apoptosis signal-regulating kinase 1 promotes Ochratoxin A-induced renal cytotoxicity. Sci Rep (2015) 0.79
No evidence of locus heterogeneity in familial microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndrome. Orphanet J Rare Dis (2015) 0.78
Intrinsic Disorder in the Kinesin Superfamily. Biophys Rev (2013) 0.78
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization. Nat Commun (2015) 0.76
C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting. Dev Biol (2014) 0.76
Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases. Mol Cell Oncol (2015) 0.76
Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5. Cell Rep (2016) 0.75
A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase. J Cell Biol (2017) 0.75
Mitotic spindle organization by a plus-end-directed microtubule motor. Nature (1992) 6.52
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell (1995) 5.68
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature (2005) 4.63
Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A (2006) 3.56
A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol (1998) 3.42
The kinesin-like protein KLP61F is essential for mitosis in Drosophila. J Cell Biol (1993) 3.32
Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc Natl Acad Sci U S A (1995) 2.82
Caught Nek-ing: cilia and centrioles. J Cell Sci (2005) 2.33
The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem (2003) 2.18
Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol (2003) 2.13
Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150. J Biol Chem (1997) 2.13
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol (2004) 2.06
The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. J Biol Chem (1999) 2.04
Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein. Mol Cell Biol (1991) 1.95
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol (2001) 1.82
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
Nek2 kinase in chromosome instability and cancer. Cancer Lett (2005) 1.75
Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells. Biotechniques (2002) 1.52
The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles. Mol Biol Cell (2004) 1.31
Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Lett (2006) 1.27
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell (2005) 1.17
Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. J Biol Chem (2002) 1.08
Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics (2000) 1.01
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell (2002) 11.50
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol (2002) 3.89
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev (2012) 3.62
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem (2001) 3.08
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J (2004) 2.78
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem (2007) 2.77
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A (2011) 2.54
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol (2002) 2.51
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J (2007) 2.21
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells (2004) 2.06
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene (2002) 1.96
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One (2012) 1.74
A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J (2007) 1.69
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol (2008) 1.61
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem (2005) 1.59
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair. J Cell Biol (2011) 1.43
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem (2002) 1.41
Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases. Oncogene (2004) 1.35
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
Characterization of ubiquilin 1, an mTOR-interacting protein. Biochim Biophys Acta (2002) 1.32
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene (2002) 1.29
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med (2012) 1.25
The where, when and how of microtubule nucleation - one ring to rule them all. J Cell Sci (2012) 1.24
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev (2011) 1.21
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem (2010) 1.20
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell (2005) 1.17
TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology (2012) 1.17
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol (2008) 1.15
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem (2004) 1.13
The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. Mol Biol Cell (2010) 1.13
Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. EMBO J (2003) 1.11
Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Mol Biol Cell (2009) 1.11
Selective roles of MAPKs during the macrophage response to IFN-gamma. J Immunol (2008) 1.08
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem (2013) 1.04
JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation. J Biol Chem (2007) 1.03
Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken) (2012) 1.02
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01
Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome. Curr Biol (2012) 0.97
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J Biol Chem (2011) 0.94
CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation. Eur J Immunol (2009) 0.93
Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. J Biol Chem (2013) 0.91
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1. J Biol Chem (2007) 0.91
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell (2005) 0.91
Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin. J Cell Sci (2012) 0.90
IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation. Blood (2008) 0.90
Hypoglycemic action of thiazolidinediones/peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway. Diabetes (2007) 0.89
Hippo pathway in intestinal homeostasis and tumorigenesis. Protein Cell (2012) 0.88
Nek9, Nek6, Nek7 and the separation of centrosomes. Cell Cycle (2011) 0.88
mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev (2013) 0.87
Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 binding. Mol Biol Cell (2011) 0.86
Characterization of two Mst1-deficient mouse models. Dev Dyn (2008) 0.85
DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. J Biol Chem (2011) 0.84
In vivo JNK activation in pancreatic β-cells leads to glucose intolerance caused by insulin resistance in pancreas. Diabetes (2013) 0.83
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis. Neuropharmacology (2003) 0.81
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney. J Cell Biochem (2013) 0.79
A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation. Methods Mol Biol (2012) 0.78
Involvement of the cellular phosphatase DUSP1 in vaccinia virus infection. PLoS Pathog (2013) 0.77
Over-expression of muscle glycogen synthase in human diabetic nephropathy. Histochem Cell Biol (2014) 0.76
pTOM, a vector for expressing two proteins in mammalian cells. Anal Biochem (2009) 0.75
Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin. J Cell Sci (2016) 0.75
[Probable levetiracetam-induced psychosis]. Med Clin (Barc) (2007) 0.75