Published in Science on July 25, 1997
Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J Cell Biol (1998) 7.34
The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol (1998) 5.87
The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev (1999) 4.69
Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol (1998) 4.08
The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae. Nat Cell Biol (2000) 3.76
Budding yeast chromosome structure and dynamics during mitosis. J Cell Biol (2001) 3.39
High-voltage electron tomography of spindle pole bodies and early mitotic spindles in the yeast Saccharomyces cerevisiae. Mol Biol Cell (1999) 3.23
Endocytosis of nanomedicines. J Control Release (2010) 3.23
Yeast Bim1p promotes the G1-specific dynamics of microtubules. J Cell Biol (1999) 3.20
Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin. Mol Biol Cell (2001) 3.15
Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Nature (2010) 2.99
Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J Cell Biol (1998) 2.97
Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Mol Biol Cell (1998) 2.79
Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae. J Cell Biol (2000) 2.72
Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation. EMBO J (2002) 2.68
The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol (2003) 2.65
A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae. J Cell Biol (2001) 2.64
Using movies to analyse gene circuit dynamics in single cells. Nat Rev Microbiol (2009) 2.44
Yeast nuclei display prominent centromere clustering that is reduced in nondividing cells and in meiotic prophase. J Cell Biol (1998) 2.44
The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. J Cell Biol (2003) 2.39
Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex. J Cell Biol (2001) 2.38
Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. J Cell Biol (1999) 2.38
Pericentric chromatin is organized into an intramolecular loop in mitosis. Curr Biol (2008) 2.33
Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J Cell Biol (1999) 2.32
Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Mol Biol Cell (2002) 2.26
A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Nature (1998) 2.18
CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint. Genes Dev (1998) 2.18
Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol Biol Cell (2001) 2.16
Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution. J Cell Biol (1998) 2.14
Pericentric chromatin is an elastic component of the mitotic spindle. Curr Biol (2007) 2.10
Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature (2005) 2.09
Cdc14-regulated midzone assembly controls anaphase B. J Cell Biol (2007) 2.09
Positive feedback sharpens the anaphase switch. Nature (2008) 2.07
Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. J Cell Biol (1999) 2.04
Cell-cycle-coupled structural oscillation of centromeric nucleosomes in yeast. Cell (2012) 2.02
The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly. J Cell Biol (2003) 1.99
A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1. J Cell Biol (2001) 1.95
Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophys J (2003) 1.93
The cortical protein Num1p is essential for dynein-dependent interactions of microtubules with the cortex. J Cell Biol (2000) 1.87
Stu2 promotes mitotic spindle elongation in anaphase. J Cell Biol (2001) 1.81
Pds1p of budding yeast has dual roles: inhibition of anaphase initiation and regulation of mitotic exit. Genes Dev (1999) 1.79
Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell (2000) 1.76
Microtubule capture by the cleavage apparatus is required for proper spindle positioning in yeast. Genes Dev (2002) 1.76
Kip3, the yeast kinesin-8, is required for clustering of kinetochores at metaphase. Cell Cycle (2010) 1.75
Kinetochore microtubule interaction during S phase in Saccharomyces cerevisiae. Genes Dev (2007) 1.72
Somatic pairing of homologs in budding yeast: existence and modulation. Genes Dev (1999) 1.71
Analysis of kinesin motor function at budding yeast kinetochores. J Cell Biol (2006) 1.67
A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis. J Cell Biol (2001) 1.63
Yeast Dam1p is required to maintain spindle integrity during mitosis and interacts with the Mps1p kinase. Mol Biol Cell (1999) 1.62
Microtubule dynamics from mating through the first zygotic division in the budding yeast Saccharomyces cerevisiae. J Cell Biol (1999) 1.62
Polyploids require Bik1 for kinetochore-microtubule attachment. J Cell Biol (2001) 1.60
PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae. J Cell Biol (1999) 1.58
MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell (2001) 1.58
Visualization of parental HSV-1 genomes and replication compartments in association with ND10 in live infected cells. EMBO J (2002) 1.57
Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol (2006) 1.57
The surveillance mechanism of the spindle position checkpoint in yeast. J Cell Biol (2001) 1.53
Chromosome arm length and nuclear constraints determine the dynamic relationship of yeast subtelomeres. Proc Natl Acad Sci U S A (2010) 1.50
The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit. Mol Biol Cell (2004) 1.49
Cell cycle-regulated trafficking of Chs2 controls actomyosin ring stability during cytokinesis. Mol Biol Cell (2005) 1.49
Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Mol Biol Cell (2003) 1.45
Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. Mol Cell Biol (2003) 1.44
Fluorescent proteins: a cell biologist's user guide. Trends Cell Biol (2009) 1.40
The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation? J Cell Biol (2002) 1.38
The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle. J Cell Biol (2008) 1.37
beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast. Mol Biol Cell (2002) 1.37
Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control. Mol Cell Biol (2001) 1.35
The kinetochore protein Ndc10p is required for spindle stability and cytokinesis in yeast. Proc Natl Acad Sci U S A (2005) 1.34
Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II. Mol Biol Cell (2003) 1.32
Short tetracysteine tags to beta-tubulin demonstrate the significance of small labels for live cell imaging. Mol Biol Cell (2004) 1.31
Time-lapse video microscopy analysis reveals astral microtubule detachment in the yeast spindle pole mutant cnm67. Mol Biol Cell (2000) 1.29
Biophysics of mitosis. Q Rev Biophys (2012) 1.26
Basic mechanism of eukaryotic chromosome segregation. Philos Trans R Soc Lond B Biol Sci (2005) 1.26
A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination. EMBO J (2001) 1.26
Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell (2002) 1.26
Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.25
Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res (2003) 1.23
Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. Mol Cell Biol (1999) 1.22
Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores. J Cell Biol (2009) 1.20
Cell polarity determinants establish asymmetry in MEN signaling. Dev Cell (2009) 1.20
Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae. J Cell Biol (1998) 1.19
Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Genes Dev (2008) 1.16
Dynamic localization of protein phosphatase type 1 in the mitotic cell cycle of Saccharomyces cerevisiae. J Cell Biol (2000) 1.16
A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response. J Cell Biol (2007) 1.15
The two alpha-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro. EMBO Rep (2003) 1.15
Coordinated spindle assembly and orientation requires Clb5p-dependent kinase in budding yeast. J Cell Biol (2000) 1.14
Nuclear congression is driven by cytoplasmic microtubule plus end interactions in S. cerevisiae. J Cell Biol (2005) 1.13
Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. Genes Dev (1999) 1.13
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol (2007) 1.13
Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequences of nuclear reorganization. PLoS Biol (2005) 1.12
Bud6 directs sequential microtubule interactions with the bud tip and bud neck during spindle morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell (2000) 1.12
The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea. Mol Cell Biol (2004) 1.11
Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation. EMBO Rep (2009) 1.07
Design features of a mitotic spindle: balancing tension and compression at a single microtubule kinetochore interface in budding yeast. Annu Rev Genet (2008) 1.07
Differential contribution of Bud6p and Kar9p to microtubule capture and spindle orientation in S. cerevisiae. J Cell Biol (2004) 1.07
A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin. Genes Dev (2006) 1.07
Nuclear and spindle dynamics in budding yeast. Mol Biol Cell (1998) 1.07
NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function. EMBO J (2013) 1.06
Gamma-tubulin is required for proper recruitment and assembly of Kar9-Bim1 complexes in budding yeast. Mol Biol Cell (2006) 1.05
Dynein-dependent movements of the mitotic spindle in Saccharomyces cerevisiae Do not require filamentous actin. Mol Biol Cell (2000) 1.05
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. PLoS Genet (2013) 1.04
From molecular to modular cell biology. Nature (1999) 23.51
Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93
Feedback control of mitosis in budding yeast. Cell (1991) 12.39
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell (1993) 6.84
Fluorescence microscopy in three dimensions. Methods Cell Biol (1989) 6.70
Budding yeast Cdc20: a target of the spindle checkpoint. Science (1998) 6.59
Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol (1998) 6.49
GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion. Curr Biol (1996) 6.49
Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science (1996) 6.10
Fluorescence microscopy: reduced photobleaching of rhodamine and fluorescein protein conjugates by n-propyl gallate. Science (1982) 5.92
Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol Biol Cell (1997) 5.47
Interphase chromosomes undergo constrained diffusional motion in living cells. Curr Biol (1997) 5.00
I5M: 3D widefield light microscopy with better than 100 nm axial resolution. J Microsc (1999) 4.84
The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev (2001) 4.82
Perturbation of nuclear architecture by long-distance chromosome interactions. Cell (1996) 4.73
The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev (1999) 4.69
Pedigree analysis of plasmid segregation in yeast. Cell (1983) 4.65
Direct evidence of a role for heterochromatin in meiotic chromosome segregation. Cell (1996) 4.53
Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science (1996) 4.47
Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J Cell Biol (2000) 4.26
Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. Nature (1995) 4.24
Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis. Mol Cell Biol (1985) 4.14
Construction of artificial chromosomes in yeast. Nature (1983) 4.10
Chromosome and low copy plasmid segregation in E. coli: visual evidence for distinct mechanisms. Cell (1997) 4.06
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell (1994) 4.05
Integrating genetic approaches into the discovery of anticancer drugs. Science (1997) 3.99
The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell (2000) 3.95
The spindle assembly checkpoint. Curr Opin Cell Biol (1996) 3.84
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity (2001) 3.84
Three-dimensional architecture of a polytene nucleus. Nature (1983) 3.82
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J Cell Biol (1998) 3.77
Determination of the nucleotide sequence of a fragment of bacteriophage phiX 174 DNA. Nat New Biol (1973) 3.74
Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J Cell Biol (1995) 3.67
S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature (1992) 3.56
Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol (1999) 3.45
Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. Biophys J (1990) 3.44
Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J Cell Biol (1998) 3.37
MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p. J Cell Biol (2000) 3.31
Structure of the DNA of bacteriophage phiX174. VII. Methylation. J Mol Biol (1970) 3.23
Chromosome segregation in mitosis and meiosis. Annu Rev Cell Biol (1985) 3.14
Detection of Babesia microti by polymerase chain reaction. J Clin Microbiol (1992) 3.03
Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J Cell Biol (1998) 2.97
Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J Cell Biol (2000) 2.84
Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis. Science (2000) 2.83
The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol Biol Cell (1999) 2.75
Chromosome length controls mitotic chromosome segregation in yeast. Cell (1986) 2.73
Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Curr Biol (1996) 2.71
Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro. Chromosoma (1989) 2.66
Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nat Cell Biol (1999) 2.65
Block in anaphase chromosome separation caused by a telomerase template mutation. Science (1997) 2.65
The use of a charge-coupled device for quantitative optical microscopy of biological structures. Science (1987) 2.64
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell (1999) 2.61
Inhibition of 5'-nucleotidase from Ehrlich ascites-tumour cells by nucleoside triphosphates. Biochem J (1969) 2.55
Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase. J Cell Biol (1992) 2.52
Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. Semin Cell Biol (1991) 2.43
Lack of tension at kinetochores activates the spindle checkpoint in budding yeast. Curr Biol (2001) 2.42
Three-dimensional structural characterization of centrosomes from early Drosophila embryos. J Cell Biol (1995) 2.41
Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster. J Cell Biol (1986) 2.39
Multiple regimes of constrained chromosome motion are regulated in the interphase Drosophila nucleus. Curr Biol (2001) 2.37
Meiotic chromosome pairing in maize is associated with a novel chromatin organization. Cell (1994) 2.34
Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Mol Biol Cell (1996) 2.32
Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery. Cell (1990) 2.32
The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. J Cell Biol (1993) 2.26
A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization. J Cell Biol (1987) 2.26
Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J Cell Biol (1997) 2.17
Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations. J Cell Biol (1998) 2.16
An alternative pathway for meiotic chromosome segregation in yeast. Science (1986) 2.13
IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. J Struct Biol (1996) 2.12
Members of the NAP/SET family of proteins interact specifically with B-type cyclins. J Cell Biol (1995) 2.09
Cloning regulated yeast genes from a pool of lacZ fusions. Methods Enzymol (1983) 2.06
Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast. J Cell Biol (1996) 1.99
The biological significance of purine salvage. Annu Rev Biochem (1971) 1.99
Phase-retrieved pupil functions in wide-field fluorescence microscopy. J Microsc (2004) 1.96
Fractionation of nucleic acid on benzoylated-naphthoylated DEAE cellulose. J Mol Biol (1967) 1.92
Computational adaptive optics for live three-dimensional biological imaging. Proc Natl Acad Sci U S A (2001) 1.91
Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics (2001) 1.89
Dispersion, aberration and deconvolution in multi-wavelength fluorescence images. J Microsc (1996) 1.89
Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell (1993) 1.87
The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon. J Cell Biol (1994) 1.84
NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast. J Cell Biol (1995) 1.83
Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos. J Cell Biol (1990) 1.80
Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.71
High resolution multimode digital imaging system for mitosis studies in vivo and in vitro. Biol Bull (1994) 1.66
Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. J Cell Biol (1988) 1.59
Three-dimensional organization of Drosophila melanogaster interphase nuclei. II. Chromosome spatial organization and gene regulation. J Cell Biol (1987) 1.58
The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase. Nature (1993) 1.57
Detection of Epstein-Barr virus by polymerase chain reaction. J Clin Microbiol (1990) 1.57
Automated microscopy for electron tomography. Ultramicroscopy (1992) 1.56
A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis. Mol Biol Cell (1997) 1.52
Mapping three-dimensional chromosome architecture in situ. Methods Cell Biol (1998) 1.51
Genetic selection of peptide inhibitors of biological pathways. Science (1999) 1.51
Purine metabolism in germinating wheat embryos. Biochem J (1969) 1.51
A novel 3D wavelet-based filter for visualizing features in noisy biological data. J Microsc (2005) 1.50