Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.

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Published in Inorg Chem on October 21, 2013

Authors

Christopher M Lemon1, Peter N Curtin, Rebecca C Somers, Andrew B Greytak, Ryan M Lanning, Rakesh K Jain, Moungi G Bawendi, Daniel G Nocera

Author Affiliations

1: Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

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On the origin of cancer cells. Science (1956) 49.55

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med (2004) 49.02

Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36

Angiogenesis in cancer and other diseases. Nature (2000) 28.28

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 23.44

Quantum dots for live cells, in vivo imaging, and diagnostics. Science (2005) 21.62

In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol (2004) 17.47

Semiconductor nanocrystals as fluorescent biological labels. Science (1998) 16.68

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell (2009) 16.06

Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44

Angiogenesis in life, disease and medicine. Nature (2005) 15.36

Tumour stem cells and drug resistance. Nat Rev Cancer (2005) 15.21

Deep tissue two-photon microscopy. Nat Methods (2005) 14.95

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med (2003) 14.59

Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science (1998) 14.44

Nonlinear magic: multiphoton microscopy in the biosciences. Nat Biotechnol (2003) 13.29

Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater (2005) 12.97

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res (1989) 12.85

Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov (2007) 11.46

Fluorescence spectroscopy of single biomolecules. Science (1999) 10.67

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med (2001) 10.37

In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science (2002) 8.80

Lysyl oxidase is essential for hypoxia-induced metastasis. Nature (2006) 8.28

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl (2009) 8.15

Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol (2002) 7.92

Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science (2003) 7.33

Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science (2003) 6.92

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med (1997) 6.86

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell (2003) 6.59

Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96

Multiphoton fluorescence excitation: new spectral windows for biological nonlinear microscopy. Proc Natl Acad Sci U S A (1996) 5.78

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov (2011) 5.59

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med (2001) 5.54

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A (1996) 5.04

Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell (2010) 4.98

Signaling Recognition Events with Fluorescent Sensors and Switches. Chem Rev (1997) 4.65

Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat Mater (2003) 4.19

Multiphoton microscopy in life sciences. J Microsc (2000) 4.12

Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism. Proc Natl Acad Sci U S A (1999) 4.05

Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer (2002) 3.96

Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem (2008) 3.93

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res (1994) 3.84

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res (1992) 3.77

Electrochemical glucose biosensors. Chem Rev (2007) 3.67

Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res (2007) 3.64

Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Förster distance dependence and subpopulations. Proc Natl Acad Sci U S A (1999) 3.61

Normal stem cells and cancer stem cells: the niche matters. Cancer Res (2006) 3.60

Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability. Nat Biotechnol (1999) 3.44

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res (2000) 3.39

Design of organic molecules with large two-photon absorption cross sections. Science (1998) 3.27

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A (2012) 3.21

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med (2005) 3.19

Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev (2008) 3.18

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res (2006) 3.10

Compact biocompatible quantum dots functionalized for cellular imaging. J Am Chem Soc (2008) 2.92

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res (1999) 2.91

Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. J Am Chem Soc (2005) 2.71

Oligomeric ligands for luminescent and stable nanocrystal quantum dots. J Am Chem Soc (2003) 2.68

Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem (2007) 2.67

Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl (2010) 2.57

HIF induces human embryonic stem cell markers in cancer cells. Cancer Res (2011) 2.46

Two-Photon Fluorescence Excitation Cross Sections of Biomolecular Probes from 690 to 960 nm. Appl Opt (1998) 2.31

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res (2002) 2.29

A ratiometric CdSe/ZnS nanocrystal pH sensor. J Am Chem Soc (2006) 2.27

A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol (2003) 2.23

Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng (2011) 2.17

Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol (2004) 2.12

Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. J Am Chem Soc (2007) 2.09

Advances in fluorescence imaging with quantum dot bio-probes. Biomaterials (2005) 1.96

Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding. J Biomed Opt (2002) 1.92

Fluorescence-based glucose sensors. Biosens Bioelectron (2004) 1.92

Noninvasive glucose sensing. Anal Chem (2005) 1.84

A nanoparticle size series for in vivo fluorescence imaging. Angew Chem Int Ed Engl (2010) 1.84

Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J Am Chem Soc (2010) 1.80

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Quantum dot-based resonance energy transfer and its growing application in biology. Phys Chem Chem Phys (2008) 1.67

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Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand. J Am Chem Soc (2010) 1.60

Concise review: Emerging concepts in clinical targeting of cancer stem cells. Stem Cells (2011) 1.45

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ (2011) 1.40

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Concanavalin A for in vivo glucose sensing: a biotoxicity review. Biosens Bioelectron (2006) 1.23

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Two steps forward in the treatment of colorectal cancer. N Engl J Med (2004) 1.12

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Luminescent quantum dots as platforms for probing in vitro and in vivo biological processes. Adv Drug Deliv Rev (2011) 1.08

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Luminescent CdSe/CdS core/shell nanocrystals in dendron boxes: superior chemical, photochemical and thermal stability. J Am Chem Soc (2003) 1.08

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Optical colorimetric sensor strip for direct readout glucose measurement. Biosens Bioelectron (2009) 1.05

Two-photon absorbing nanocrystal sensors for ratiometric detection of oxygen. J Am Chem Soc (2009) 1.05

Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res (2000) 1.03

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