Published in Organogenesis on October 25, 2013
Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer (2014) 0.89
Compartments within a compartment: what C. elegans can tell us about ciliary subdomain composition, biogenesis, function, and disease. Organogenesis (2014) 0.89
The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. PLoS Genet (2014) 0.81
ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size. PLoS Genet (2016) 0.80
The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat Rev Nephrol (2015) 0.79
Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet (2014) 0.77
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. Proc Natl Acad Sci U S A (2016) 0.75
Heterotrimeric G protein signaling in polycystic kidney disease. Physiol Genomics (2016) 0.75
Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP. G3 (Bethesda) (2017) 0.75
Planar cell polarity (PCP) proteins and spermatogenesis. Semin Cell Dev Biol (2016) 0.75
Bridging the gap: a Canadian perspective on translational kidney research. Can J Kidney Health Dis (2014) 0.75
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell (2007) 10.75
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet (2005) 6.67
An LDL-receptor-related protein mediates Wnt signalling in mice. Nature (2000) 6.34
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Towards an integrated view of Wnt signaling in development. Development (2009) 6.07
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature (2000) 5.52
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell (2005) 4.91
Polycystic kidney disease. Annu Rev Med (2009) 4.78
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet (2005) 4.76
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A (2003) 4.47
Defective planar cell polarity in polycystic kidney disease. Nat Genet (2005) 4.31
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet (2008) 4.28
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development (2000) 4.06
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nat Genet (2008) 3.84
Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet (2007) 3.79
Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol (2002) 3.55
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (2003) 3.52
PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet (2002) 3.21
Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proc Natl Acad Sci U S A (2004) 3.11
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science (2012) 3.01
Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol (2009) 2.99
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet (2009) 2.84
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet (2013) 2.71
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. Oncogene (2001) 2.63
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci U S A (2001) 2.62
The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem (1999) 2.37
Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci U S A (2002) 2.29
A transcriptional network in polycystic kidney disease. EMBO J (2004) 2.21
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol (2008) 2.20
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest (2002) 2.07
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol (2008) 2.04
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development (2011) 1.92
Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature (1998) 1.90
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol (2007) 1.82
Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol (2010) 1.81
Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J Am Soc Nephrol (2009) 1.79
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem (2004) 1.77
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene (2005) 1.73
Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development (2011) 1.71
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol (2008) 1.70
Identification of 99 novel mutations in a worldwide cohort of 1,056 patients with a nephronophthisis-related ciliopathy. Hum Genet (2013) 1.69
Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nat Genet (2012) 1.62
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet (2008) 1.62
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A (2009) 1.57
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling. J Am Soc Nephrol (2011) 1.55
Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy. J Bone Miner Res (2012) 1.55
Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem (2011) 1.51
Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet (2008) 1.46
Assembling a primary cilium. Curr Opin Cell Biol (2013) 1.45
Wnt5a enhances the response of CML cells to Imatinib Mesylate through JNK activation and γ-catenin inhibition. Leuk Res (2013) 1.43
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39
PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation. Development (2009) 1.36
The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men. Dev Dyn (2008) 1.36
Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia. Cytoskeleton (Hoboken) (2010) 1.32
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. J Biol Chem (2010) 1.28
Mouse models of polycystic kidney disease. Curr Top Dev Biol (2008) 1.27
Intraflagellar transport. Curr Biol (2002) 1.24
PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. EMBO J (2011) 1.24
Cystic disease of the kidney. Annu Rev Pathol (2007) 1.21
Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations. Hum Mol Genet (2006) 1.21
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development (2012) 1.19
Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol (2012) 1.16
Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol (2010) 1.13
Polycystins and renovascular mechanosensory transduction. Nat Rev Nephrol (2010) 1.13
The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet (2010) 1.10
Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression. Hum Mol Genet (2010) 1.10
Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling. J Am Soc Nephrol (2013) 1.09
Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. J Biochem (1996) 1.07
Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells. J Biol Chem (2012) 1.02
Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proc Natl Acad Sci U S A (2010) 1.02
Putative roles of cilia in polycystic kidney disease. Biochim Biophys Acta (2011) 0.99
Cystic kidney diseases and planar cell polarity signaling. Clin Genet (2009) 0.99
Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development. Development (2013) 0.98
Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney. Development (2011) 0.96
Defects in ciliary localization of Nek8 is associated with cystogenesis. Pediatr Nephrol (2008) 0.96
Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum Mol Genet (2011) 0.95
The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium. Mol Biol Cell (2013) 0.95
vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. Development (2010) 0.94
Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes. J Biol Chem (2013) 0.93
Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. PLoS One (2013) 0.92
Genetic variation of DKK3 may modify renal disease severity in ADPKD. J Am Soc Nephrol (2010) 0.91
Dishevelled: in vivo roles of a multifunctional gene family during development. Curr Top Dev Biol (2012) 0.90
Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One (2012) 0.90
Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function. PLoS One (2012) 0.89
Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol (2008) 0.89
The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice. Kidney Int (2011) 0.89
Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis. Biol Open (2012) 0.88
Expression of Wnt signaling components during Xenopus pronephros development. PLoS One (2011) 0.87
Ciliogenesis in normal human kidney development and post-natal life. Pediatr Nephrol (2011) 0.85
Planar cell polarity in kidney development and disease. Organogenesis (2011) 0.85
Non-canonical wnt signals antagonize and canonical wnt signals promote cell proliferation in early kidney development. Dev Dyn (2011) 0.84
Wnt5a attenuates Wnt/β-catenin signalling in human dermal papilla cells. Exp Dermatol (2013) 0.81
DAAM family members leading a novel path into formin research. Commun Integr Biol (2011) 0.79
Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling. J Biol Chem (2013) 0.78