Published in Toxicon on January 01, 1985
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J (1994) 2.64
Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures. J Gen Physiol (1987) 1.57
Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule. Biophys J (2003) 1.05
The tetrodotoxin binding site is within the outer vestibule of the sodium channel. Mar Drugs (2010) 1.04
Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects. Mar Drugs (2015) 0.77
Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmacol Rev (1966) 7.45
Blockage of sodium conductance increase in lobster giant axon by tarichatoxin (tetrodotoxin). J Gen Physiol (1966) 4.68
Actions of some anions on electrical properties and mechanical threshold of frog twitch muscle. J Physiol (1968) 2.68
The conserved B3 domain of VIVIPAROUS1 has a cooperative DNA binding activity. Plant Cell (1997) 2.55
Actions of saxitoxin on peripheral neuromuscular systems. J Physiol (1965) 2.00
Taxonomy of four marine bacterial strains that produce tetrodotoxin. Int J Syst Bacteriol (1990) 1.91
Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts. J AOAC Int (1995) 1.63
Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann N Y Acad Sci (1986) 1.57
Actions of some cations on the electrical properties and mechanical threshold of frog sartorius muscle fibers. J Gen Physiol (1970) 1.49
Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish. Toxicon (1987) 1.47
Maize VP1 complements Arabidopsis abi3 and confers a novel ABA/auxin interaction in roots. Plant J (2001) 1.43
Pharmacology of tetrodotoxin and saxitoxin. Fed Proc (1972) 1.38
Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. Nat Toxins (1999) 1.38
The structure elucidation and biological activities of high molecular weight algal toxins: maitotoxin, prymnesins and zooxanthellatoxins. Nat Prod Rep (2000) 1.31
New saxitoxin analogues from the freshwater filamentous cyanobacterium Lyngbya wollei. Nat Toxins (1997) 1.28
Ionic currents in the guinea-pig taenia coli. J Physiol (1976) 1.27
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon (2000) 1.23
Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe. Biosci Biotechnol Biochem (2001) 1.20
Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J Cell Biol (1987) 1.20
Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship. Biochem J (1992) 1.18
Maitotoxin, a Ca2+ channel activator candidate. J Biol Chem (1982) 1.18
First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus. Toxicon (1994) 1.17
A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels. Toxicon (1996) 1.16
Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice. Toxicon (2002) 1.16
Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A. J Biol Chem (2001) 1.14
Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon. J Physiol (1982) 1.14
Three new complementation groups of temperature-sensitive Chinese hamster ovary cell mutants defective in the endocytic pathway. Somat Cell Mol Genet (1988) 1.12
Ionic currents in the uterine smooth muscle. J Physiol (1975) 1.11
Origins of ciguatera fish poisoning: a new dinoflagellate, Gambierdiscus toxicus Adachi and Fukuyo, definitively involved as a causal agent. Toxicon (1980) 1.09
Dinoflagellate Gymnodinium catenatum as the source of paralytic shellfish toxins in Tasmanian shellfish. Toxicon (1987) 1.07
Electrospray ionization mass spectrometry of tetrodotoxin and its analogs: liquid chromatography/mass spectrometry, tandem mass spectrometry, and liquid chromatography/tandem mass spectrometry. Anal Biochem (2001) 1.07
Aplysiatoxin and debromoaplysiatoxin as the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii. Toxicon (1996) 1.06
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. Jpn J Cancer Res (1988) 1.06
Some chemical properties of maitotoxin, a putative calcium channel agonist isolated from a marine dinoflagellate. J Biochem (1988) 1.05
Potassium currents in freshly dissociated uterine myocytes from nonpregnant and late-pregnant rats. J Gen Physiol (1998) 1.05
Inward current in single smooth muscle cells of the guinea pig taenia coli. J Gen Physiol (1989) 1.04
Ca2+ channel activating function of maitotoxin, the most potent marine toxin known, in clonal rat pheochromocytoma cells. J Biol Chem (1983) 1.02
Preparation of monoclonal antibodies against okadaic acid prepared from the sponge Halichondria okadai. Toxicon (1989) 1.01
Outward current in single smooth muscle cells of the guinea pig taenia coli. J Gen Physiol (1989) 1.00
Sodium and calcium inward currents in freshly dissociated smooth myocytes of rat uterus. J Gen Physiol (1997) 1.00
Oral and intraperitoneal acute toxicity studies of yessotoxin and homoyessotoxins in mice. Toxicon (2003) 1.00
Short-term oral toxicity of homoyessotoxins, yessotoxin and okadaic acid in mice. Toxicon (2004) 0.99
Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand. Nat Toxins (1999) 0.99
Toxicologic evaluation of yessotoxin. Nat Toxins (1997) 0.99
Tetrodotoxin derivatives in puffer fish. Toxicon (1985) 0.99
Electrophysiological actions of oxytocin on the rabbit myometrium. J Gen Physiol (1969) 0.98
Identification of Protoceratium reticulatum as the biogenetic origin of yessotoxin. Nat Toxins (1997) 0.98
Actions of Ba++ on ionic currents of the guinea-pig taenia coli. J Pharmacol Exp Ther (1985) 0.97
Structure-activity relationship within a series of okadaic acid derivatives. Carcinogenesis (1990) 0.97
Effects of ciguatoxin and maitotoxin on the isolated guinea pig atria. Res Commun Chem Pathol Pharmacol (1979) 0.96
Affinity of okadaic acid to type-1 and type-2A protein phosphatases is markedly reduced by oxidation of its 27-hydroxyl group. Biochem J (1994) 0.96
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice. Cancer Res (1997) 0.96
Differentiation of the actions of tetrodotoxin and saxitoxin. Toxicon (1967) 0.95
Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts. Toxicon (1990) 0.95
Human fatality due to ingestion of the crab Demania reynaudii that contained a palytoxin-like toxin. Toxicon (1988) 0.94
Effects of specific modifications of several hydroxyls of tetrodotoxin on its affinity to rat brain membrane. J Pharmacol Exp Ther (1999) 0.94
The occurrence of paralytic shellfish toxins in two species of xanthid crab from Suva barrier reef, Fiji Islands. Toxicon (1983) 0.94
Identification of putative palytoxin as the cause of clupeotoxism. Toxicon (1999) 0.94
Histopathological studies on experimental marine toxin poisoning--5. The effects in mice of yessotoxin isolated from Patinopecten yessoensis and of a desulfated derivative. Toxicon (1990) 0.93
Actions of epimers of 12-(OH)-reduced saxitoxin and of 11-(OSO3)-saxitoxin on squid axon. Toxicon (1985) 0.93
Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin. J Physiol (1983) 0.92
Selective stimulation of Ca2+ flux in cells by maitotoxin. Eur J Pharmacol (1992) 0.92
Purification, characterization, and cDNA cloning of a novel soluble saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish, Fugu pardalis. Eur J Biochem (2001) 0.92
Permeation, selectivity, and blockade of the Ca2+-activated potassium channel of the guinea pig taenia coli myocyte. J Gen Physiol (1989) 0.92
Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels. Toxicon (1996) 0.92
Excitatory effect of the most potent marine toxin, maitotoxin, on the guinea-pig vas deferens. J Pharmacol Exp Ther (1983) 0.92
Actions of chiriquitoxin on frog skeletal muscle fibers and implications for the tetrodotoxin/saxitoxin receptor. J Gen Physiol (1992) 0.92
Ionic mechanisms of repolarization in the guinea-pig taenia coli as revealed by the actions of strontium. J Physiol (1979) 0.92
Quantitative determination of marine toxins associated with diarrhetic shellfish poisoning by liquid chromatography coupled with mass spectrometry. J Chromatogr A (2001) 0.91
Plasma-induced grafted polymerization of acrylic acid and subsequent grafting of collagen onto polymer film as biomaterials. Biomaterials (1996) 0.90
Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon (1998) 0.90
Manauealides, some of the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii. J Nat Prod (1997) 0.90
Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. Mol Biol Cell (1999) 0.90
Azaspiracid shellfish poisoning: unusual toxin dynamics in shellfish and the increased risk of acute human intoxications. Food Addit Contam (2002) 0.90
Clinical and laboratory findings implicating palytoxin as cause of ciguatera poisoning due to Decapterus macrosoma (mackerel). Toxicon (1989) 0.90
Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis. Biochem J (1992) 0.89
The Ca2+-activated K+ channel and its functional roles in smooth muscle cells of guinea pig taenia coli. J Gen Physiol (1989) 0.89
Binding properties of (3)H-PbTx-3 and (3)H-saxitoxin to brain membranes and to skeletal muscle membranes of puffer fish Fugu pardalis and the primary structure of a voltage-gated Na(+) channel alpha-subunit (fMNa1) from skeletal muscle of F. pardalis. Biochem Biophys Res Commun (2000) 0.89
Interspecies distribution and possible origin of tetrodotoxin. Ann N Y Acad Sci (1986) 0.89
A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry. Nat Toxins (1999) 0.88
Multiresidue method for determination of algal toxins in shellfish: single-laboratory validation and interlaboratory study. J AOAC Int (2005) 0.88
Toxicities and distribution of tetrodotoxin in the tissues of puffer fish found in the coast of the Baja California Peninsula, Mexico. Toxicon (2000) 0.88
Further report of the occurrence of tetrodotoxin in Atelopus species (family: Bufonidae). Toxicon (1995) 0.87
Ion concentrations and membrane potentials of myometrium during recovery from cold. Am J Physiol (1969) 0.87
Electrophysiological properties of splenic nerve in relation to norepinephrine overflow. J Pharmacol Exp Ther (1973) 0.86
The active guanidinium group of saxitoxin and neosaxitoxin identified by the effects of pH on their activities on squid axon. Pflugers Arch (1983) 0.86
Structure elucidation of ostreocin D, a palytoxin analog isolated from the dinoflagellate Ostreopsis siamensis. Biosci Biotechnol Biochem (2001) 0.86
In vitro assembly of the outer shell of bacteriophage phi 6 nucleocapsid. Virology (1988) 0.86
Vasomotor and respiratory depressant actions of tetrodotoxin and saxitoxin. Arch Int Pharmacodyn Ther (1967) 0.86
Maitotoxin stimulates hormonal release and calcium flux in rat anterior pituitary cells in vitro. Am J Physiol (1984) 0.86
New insights into maitotoxin action. Eur J Biochem (1988) 0.86
A fluorescent lipid analogue can be used to monitor secretory activity and for isolation of mammalian secretion mutants. Mol Biol Cell (1995) 0.86
Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. Mol Pharmacol (1992) 0.86
Confirmation of anatoxin-a(s), in the cyanobacterium Anabaena lemmermannii, as the cause of bird kills in Danish lakes. Toxicon (1997) 0.85
Maitotoxin-induced free Ca changes in single rat hepatocytes. Cell Signal (1999) 0.85
Impaired secretion and fluid-phase endocytosis in the End4 mutant of Chinese hamster ovary cells. J Biol Chem (1990) 0.85
Oligonucleotide-directed mutagenesis of antibody combining sites. Int Rev Immunol (1993) 0.85
Isolation and structural assignment of 5-deoxytetrodotoxin from the puffer fish Fugu poecilonotus. Biosci Biotechnol Biochem (1999) 0.85