Published in J Pharmacol Exp Ther on October 01, 1983
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Epoxide-opening cascades in the synthesis of polycyclic polyether natural products. Angew Chem Int Ed Engl (2009) 1.13
Maitotoxin-activated single calcium channels in guinea-pig cardiac cells. Br J Pharmacol (1987) 0.93
The mechanism of action of maitotoxin in relation to Ca2+ movements in guinea-pig and rat cardiac muscles. Br J Pharmacol (1985) 0.85
Interactions of maitotoxin with voltage-sensitive calcium channels in cultured neuronal cells. Proc Natl Acad Sci U S A (1984) 0.85
Ca(2+)-dependent aggregation of rabbit platelets induced by maitotoxin, a potent marine toxin, isolated from a dinoflagellate. Br J Pharmacol (1993) 0.84
Palytoxin-induced contraction and release of endogenous noradrenaline in rat tail artery. Br J Pharmacol (1988) 0.77
Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus. Mar Drugs (2017) 0.75
Taxonomy of four marine bacterial strains that produce tetrodotoxin. Int J Syst Bacteriol (1990) 1.91
Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts. J AOAC Int (1995) 1.63
Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish. Toxicon (1987) 1.47
Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. Nat Toxins (1999) 1.38
The structure elucidation and biological activities of high molecular weight algal toxins: maitotoxin, prymnesins and zooxanthellatoxins. Nat Prod Rep (2000) 1.31
Dual regulation of the skeletal muscle ryanodine receptor by triadin and calsequestrin. Biochemistry (1998) 1.29
New saxitoxin analogues from the freshwater filamentous cyanobacterium Lyngbya wollei. Nat Toxins (1997) 1.28
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon (2000) 1.23
Antiinflammatory principles of Aconitum roots. J Pharmacobiodyn (1980) 1.23
Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels. J Biol Chem (1991) 1.21
Cardiotonic principles of ginger (Zingiber officinale Roscoe). J Pharm Sci (1982) 1.21
Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe. Biosci Biotechnol Biochem (2001) 1.20
Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship. Biochem J (1992) 1.18
Maitotoxin, a Ca2+ channel activator candidate. J Biol Chem (1982) 1.18
First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus. Toxicon (1994) 1.17
A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels. Toxicon (1996) 1.16
Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice. Toxicon (2002) 1.16
A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia (1986) 1.13
Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiency. J Pharmacol Exp Ther (1982) 1.12
Cytotoxic macrolides from a cultured marine dinoflagellate of the genus Amphidinium. J Nat Prod (1990) 1.10
Origins of ciguatera fish poisoning: a new dinoflagellate, Gambierdiscus toxicus Adachi and Fukuyo, definitively involved as a causal agent. Toxicon (1980) 1.09
Cardiotonic action of [8]-gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum, in guinea pig atrial muscle. J Pharmacol Exp Ther (1988) 1.07
Dinoflagellate Gymnodinium catenatum as the source of paralytic shellfish toxins in Tasmanian shellfish. Toxicon (1987) 1.07
Electrospray ionization mass spectrometry of tetrodotoxin and its analogs: liquid chromatography/mass spectrometry, tandem mass spectrometry, and liquid chromatography/tandem mass spectrometry. Anal Biochem (2001) 1.07
The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom. FEBS Lett (1983) 1.06
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. Jpn J Cancer Res (1988) 1.06
Aplysiatoxin and debromoaplysiatoxin as the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii. Toxicon (1996) 1.06
Some chemical properties of maitotoxin, a putative calcium channel agonist isolated from a marine dinoflagellate. J Biochem (1988) 1.05
Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology (Berl) (2004) 1.05
Ca2+ channel activating function of maitotoxin, the most potent marine toxin known, in clonal rat pheochromocytoma cells. J Biol Chem (1983) 1.02
Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells. Eur J Pharmacol (2000) 1.01
Preparation of monoclonal antibodies against okadaic acid prepared from the sponge Halichondria okadai. Toxicon (1989) 1.01
Mode of the excitatory and inhibitory actions of ciguatoxin in the guinea-pig vas deferens. J Pharmacol Exp Ther (1981) 1.01
Mechanism of the excitatory action of palytoxin and N-acetylpalytoxin in the isolated guinea-pig vas deferens. J Pharmacol Exp Ther (1980) 1.01
Oral and intraperitoneal acute toxicity studies of yessotoxin and homoyessotoxins in mice. Toxicon (2003) 1.00
Short-term oral toxicity of homoyessotoxins, yessotoxin and okadaic acid in mice. Toxicon (2004) 0.99
Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand. Nat Toxins (1999) 0.99
Toxicologic evaluation of yessotoxin. Nat Toxins (1997) 0.99
Tetrodotoxin derivatives in puffer fish. Toxicon (1985) 0.99
Identification of Protoceratium reticulatum as the biogenetic origin of yessotoxin. Nat Toxins (1997) 0.98
Preoperative radio/chemo-radiotherapy in combination with intraoperative radiotherapy for T3-4Nx rectal cancer. Eur J Surg Oncol (2004) 0.98
Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker. J Biol Chem (1986) 0.97
Structure-activity relationship within a series of okadaic acid derivatives. Carcinogenesis (1990) 0.97
Affinity of okadaic acid to type-1 and type-2A protein phosphatases is markedly reduced by oxidation of its 27-hydroxyl group. Biochem J (1994) 0.96
Effects of ciguatoxin and maitotoxin on the isolated guinea pig atria. Res Commun Chem Pathol Pharmacol (1979) 0.96
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle. J Pharm Pharmacol (1984) 0.95
Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts. Toxicon (1990) 0.95
Human fatality due to ingestion of the crab Demania reynaudii that contained a palytoxin-like toxin. Toxicon (1988) 0.94
The occurrence of paralytic shellfish toxins in two species of xanthid crab from Suva barrier reef, Fiji Islands. Toxicon (1983) 0.94
Effects of specific modifications of several hydroxyls of tetrodotoxin on its affinity to rat brain membrane. J Pharmacol Exp Ther (1999) 0.94
Identification of putative palytoxin as the cause of clupeotoxism. Toxicon (1999) 0.94
Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-zeta. Mol Pharmacol (2001) 0.94
Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus. FEBS Lett (1990) 0.94
Histopathological studies on experimental marine toxin poisoning--5. The effects in mice of yessotoxin isolated from Patinopecten yessoensis and of a desulfated derivative. Toxicon (1990) 0.93
Maitotoxin-activated single calcium channels in guinea-pig cardiac cells. Br J Pharmacol (1987) 0.93
Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels. Toxicon (1996) 0.92
Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin. J Physiol (1983) 0.92
Selective stimulation of Ca2+ flux in cells by maitotoxin. Eur J Pharmacol (1992) 0.92
Pharmacological actions of aconitine alkaloids. Tohoku J Exp Med (1979) 0.92
Purification, characterization, and cDNA cloning of a novel soluble saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish, Fugu pardalis. Eur J Biochem (2001) 0.92
Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells. Br J Pharmacol (1994) 0.91
Quantitative determination of marine toxins associated with diarrhetic shellfish poisoning by liquid chromatography coupled with mass spectrometry. J Chromatogr A (2001) 0.91
Characteristics of Ca2+ release for activation of K+ current and contractile system in some smooth muscles. Am J Physiol (1996) 0.91
Azaspiracid shellfish poisoning: unusual toxin dynamics in shellfish and the increased risk of acute human intoxications. Food Addit Contam (2002) 0.90
Mode of the ciguatoxin-induced supersensitivity in the guinea-pig vas deferens. J Pharmacol Exp Ther (1982) 0.90
Manauealides, some of the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii. J Nat Prod (1997) 0.90
Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon (1998) 0.90
Isolation and amino acid compositions of geographutoxin I and II from the marine snail Conus geographus. Experientia (1983) 0.90
Clinical and laboratory findings implicating palytoxin as cause of ciguatera poisoning due to Decapterus macrosoma (mackerel). Toxicon (1989) 0.90
Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol (1996) 0.89
Interspecies distribution and possible origin of tetrodotoxin. Ann N Y Acad Sci (1986) 0.89
Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. Eur J Pharmacol (1999) 0.89
Possible mechanism of the dual action of the new polypeptide (anthopleurin-B) from sea anemone in the isolated ileum and taenia caeci of the guinea-pig. Br J Pharmacol (1981) 0.89
Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis. Biochem J (1992) 0.89
Binding properties of (3)H-PbTx-3 and (3)H-saxitoxin to brain membranes and to skeletal muscle membranes of puffer fish Fugu pardalis and the primary structure of a voltage-gated Na(+) channel alpha-subunit (fMNa1) from skeletal muscle of F. pardalis. Biochem Biophys Res Commun (2000) 0.89
Actions of 4-epitetrodotoxin and anhydrotetrodotoxin on the squid axon. Toxicon (1985) 0.89
Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis. J Nat Prod (2001) 0.89
Multiresidue method for determination of algal toxins in shellfish: single-laboratory validation and interlaboratory study. J AOAC Int (2005) 0.88
A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry. Nat Toxins (1999) 0.88
Toxicities and distribution of tetrodotoxin in the tissues of puffer fish found in the coast of the Baja California Peninsula, Mexico. Toxicon (2000) 0.88
9-methyl-7-bromoeudistomin D, a powerful radio-labelable Ca++ releaser having caffeine-like properties, acts on Ca(++)-induced Ca++ release channels of sarcoplasmic reticulum. J Pharmacol Exp Ther (1991) 0.87
Further report of the occurrence of tetrodotoxin in Atelopus species (family: Bufonidae). Toxicon (1995) 0.87
Effects of interferon-α-transduced tumor cell vaccines and blockade of programmed cell death-1 on the growth of established tumors. Cancer Gene Ther (2012) 0.87
Geographutoxin II, a novel peptide inhibitor of Na channels of skeletal muscles and autonomic nerves. J Pharmacol Exp Ther (1986) 0.87
Isolation of a New Alkaloid from Evodia rutaecarpa. J Nat Prod (1988) 0.87
New insights into maitotoxin action. Eur J Biochem (1988) 0.86
Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. Mol Pharmacol (1992) 0.86
Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: a quantitative study. Brain Res (1998) 0.86
Structure elucidation of ostreocin D, a palytoxin analog isolated from the dinoflagellate Ostreopsis siamensis. Biosci Biotechnol Biochem (2001) 0.86
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells. Am J Chin Med (1998) 0.86
Ca-dependent arrhythmogenic effects of maitotoxin, the most potent marine toxin known, on isolated rat cardiac muscle cells. Eur J Pharmacol (1985) 0.86
Maitotoxin stimulates hormonal release and calcium flux in rat anterior pituitary cells in vitro. Am J Physiol (1984) 0.86
Bromo-eudistomin D, a novel inducer of calcium release from fragmented sarcoplasmic reticulum that causes contractions of skinned muscle fibers. J Biol Chem (1986) 0.85