Published in Nucleic Acids Res on November 04, 2013
Repurposing the CRISPR-Cas9 system for targeted DNA methylation. Nucleic Acids Res (2016) 1.27
Editing the epigenome: technologies for programmable transcription and epigenetic modulation. Nat Methods (2016) 1.24
Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. Acc Chem Res (2014) 1.06
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet (2014) 1.06
Chromatin regulation at the frontier of synthetic biology. Nat Rev Genet (2015) 1.01
Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics (2015) 0.99
Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation. Nucleic Acids Res (2014) 0.95
CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter. Oncotarget (2016) 0.93
Epigenome engineering in cancer: fairytale or a realistic path to the clinic? Front Oncol (2015) 0.92
Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase. Epigenetics (2015) 0.91
Enabling functional genomics with genome engineering. Genome Res (2015) 0.90
P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis. Genome Biol (2015) 0.87
Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions. Nat Biotechnol (2016) 0.86
Directed evolution of improved zinc finger methyltransferases. PLoS One (2014) 0.85
Can genome engineering be used to target cancer-associated enhancers? Epigenomics (2014) 0.81
Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer. Breast Cancer Res (2014) 0.81
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner. Nat Commun (2016) 0.80
Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. Epigenetics (2015) 0.80
Strategies for precision modulation of gene expression by epigenome editing: an overview. Epigenetics Chromatin (2015) 0.79
A novel pax5-binding regulatory element in the igκ locus. Front Immunol (2014) 0.79
Re-expression of Selected Epigenetically Silenced Candidate Tumor Suppressor Genes in Cervical Cancer by TET2-directed Demethylation. Mol Ther (2015) 0.79
Longitudinal Study of DNA Methylation of Inflammatory Genes and Cancer Risk. Cancer Epidemiol Biomarkers Prev (2015) 0.78
The epigenome: the next substrate for engineering. Genome Biol (2016) 0.77
Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene. Gene (2015) 0.77
Back and forth in time: Directing age in iPSC-derived lineages. Brain Res (2015) 0.77
A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue. Schizophr Bull (2015) 0.77
The expanding scope and impact of epigenetic cytosine modifications. Curr Opin Chem Biol (2016) 0.77
Artificial Induction of Native Aquaporin-1 Expression in Human Salivary Cells. J Dent Res (2017) 0.77
CRISPR-Mediated Epigenome Editing. Yale J Biol Med (2016) 0.75
Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. Hum Reprod Update (2016) 0.75
Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain. Epigenetics (2017) 0.75
Methylation-dependent and independent regulatory regions in the Na,K-ATPase alpha4 (Atp1a4) gene may impact its testis-specific expression. Gene (2015) 0.75
Modern Genome Editing Technologies in Huntington's Disease Research. J Huntingtons Dis (2017) 0.75
Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will. Curr Genet Med Rep (2016) 0.75
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
A new pyrimidine base from bacteriophage nucleic acids. Nature (1952) 17.95
Eukaryotic cytosine methyltransferases. Annu Rev Biochem (2005) 15.45
Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
DNA methylation and human disease. Nat Rev Genet (2005) 12.00
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
Demethylation of the zygotic paternal genome. Nature (2000) 8.52
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10
Active demethylation of the paternal genome in the mouse zygote. Curr Biol (2000) 6.99
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80
Epigenetic reprogramming in mammals. Hum Mol Genet (2005) 6.73
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Epigenetic reprogramming in mouse primordial germ cells. Mech Dev (2002) 6.67
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38
Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet (2008) 5.67
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A (2011) 5.45
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res (2010) 4.91
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J Biol Chem (2011) 4.64
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet (2011) 4.25
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09
DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol (1999) 3.76
The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J (1972) 3.68
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A (2000) 2.98
TET2 promotes histone O-GlcNAcylation during gene transcription. Nature (2012) 2.92
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget (2011) 2.80
DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS One (2011) 2.80
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J (2013) 2.70
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes. Genome Res (2011) 2.15
GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14
5-Methylcytosine content in the vertebrate deoxyribonucleic acids: species specificity. J Mol Evol (1976) 2.01
DNA methylation and cellular reprogramming. Trends Cell Biol (2010) 1.77
Epigenetic reprogramming of cancer cells via targeted DNA methylation. Epigenetics (2012) 1.65
Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res (2012) 1.60
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. Nucleic Acids Res (2012) 1.40
DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory. Cancer Res (2012) 1.35
Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing. Angew Chem Int Ed Engl (2012) 1.34
Methylation of DNA in cancer. Adv Clin Chem (2010) 1.31
The human L1 promoter: variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity. Genome Res (2004) 1.31
Molecular biology. Demystifying DNA demethylation. Science (2011) 1.29
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. J Mol Biol (2012) 1.17
DNA methylation supports intrinsic epigenetic memory in mammalian cells. PLoS Genet (2006) 1.17
Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis. Cancer Res (2000) 1.13
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation. J Mol Biol (2004) 1.02
Reactivation of MASPIN in non-small cell lung carcinoma (NSCLC) cells by artificial transcription factors (ATFs). Epigenetics (2011) 1.00
Towards sustained silencing of HER2/neu in cancer by epigenetic editing. Mol Cancer Res (2013) 0.96
Recent advances in understanding of the immunological off-target effects of siRNA. Curr Gene Ther (2011) 0.90
Targeted DNA methylation by a DNA methyltransferase coupled to a triple helix forming oligonucleotide to down-regulate the epithelial cell adhesion molecule. Bioconjug Chem (2010) 0.88
Epigenetics in disease: leader or follower? Epigenetics (2011) 0.86
Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain. Epigenetics (2012) 0.85
Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors. Mol Oncol (2013) 0.84
Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes. Bioorg Med Chem (2012) 0.83
Histone H3 Arg2 methylation provides alternative directions for COMPASS. Nat Struct Mol Biol (2007) 0.82
Transcription factors and molecular epigenetic marks underlying EpCAM overexpression in ovarian cancer. Br J Cancer (2011) 0.82
Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer. Br J Cancer (2013) 0.81
Complementation between inactive fragments of SssI DNA methyltransferase. BMC Mol Biol (2012) 0.81
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell (2013) 3.13
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell (2013) 2.40
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
EpCAM in carcinogenesis: the good, the bad or the ugly. Carcinogenesis (2010) 2.13
Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. J Biol Chem (2004) 2.02
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc (2013) 1.90
Timing of establishment of paternal methylation imprints in the mouse. Genomics (2004) 1.84
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell (2012) 1.72
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol (2004) 1.68
Epigenetic reprogramming of cancer cells via targeted DNA methylation. Epigenetics (2012) 1.65
Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res (2012) 1.60
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities. Nucleic Acids Res (2003) 1.48
Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet (2013) 1.45
A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity. Clin Cancer Res (2004) 1.44
Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome. Genes Chromosomes Cancer (2009) 1.43
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res (2006) 1.40
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. Nucleic Acids Res (2012) 1.40
Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep (2011) 1.38
Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro. Am J Physiol Cell Physiol (2005) 1.32
Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages. J Gen Virol (2008) 1.26
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res (2011) 1.24
The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A (2009) 1.24
A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo. Hum Gene Ther (2004) 1.22
Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors. World J Gastroenterol (2007) 1.19
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. J Mol Biol (2012) 1.17
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. Blood (2009) 1.16
Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J Am Chem Soc (2014) 1.14
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet (2006) 1.05
Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development. Hum Mol Genet (2008) 1.00
Prognostic significance of overexpression of EZH2 and H3k27me3 proteins in gastric cancer. Asian Pac J Cancer Prev (2012) 0.96
Primary intestinal non-Hodgkin's lymphoma: a clinicopathologic analysis of 81 patients. World J Gastroenterol (2011) 0.96
The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. Am J Respir Cell Mol Biol (2003) 0.96
Towards sustained silencing of HER2/neu in cancer by epigenetic editing. Mol Cancer Res (2013) 0.96
Bio-molecule Surfaces Construction via a Higher-Order Level-Set Method. J Comput Sci Technol (2008) 0.94
Analysis of clinical effect of high-intensity focused ultrasound on liver cancer. World J Gastroenterol (2004) 0.92
Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. Int J Oncol (2009) 0.92
Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res (2013) 0.91
Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res (2013) 0.91
Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase. Epigenetics (2015) 0.91
A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism. Virology (2003) 0.91
Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. Phytomedicine (2012) 0.91
Engineering zinc finger protein transcription factors: the therapeutic relevance of switching endogenous gene expression on or off at command. J Mol Biol (2005) 0.90
Sequential chemoradiotherapy with gemcitabine and cisplatin for locoregionally advanced nasopharyngeal carcinoma. Int J Cancer (2012) 0.89
Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Mol Carcinog (2007) 0.89
Targeted DNA methylation by a DNA methyltransferase coupled to a triple helix forming oligonucleotide to down-regulate the epithelial cell adhesion molecule. Bioconjug Chem (2010) 0.88
RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Development (2008) 0.88
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development (2013) 0.88
Detection of micrometastatic breast cancer by means of real time quantitative RT-PCR and immunostaining in perioperative blood samples and sentinel nodes. Int J Cancer (2003) 0.87
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer (2008) 0.87
Selective targeting of adenovirus to alphavbeta3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies. Int J Pharm (2010) 0.87
Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2. J Control Release (2007) 0.86
Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells. J Control Release (2010) 0.86
PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Mol Pharm (2008) 0.85
Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study. J Control Release (2009) 0.85
Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene. Arthritis Res Ther (2006) 0.85
The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy. J Nucl Med (2005) 0.84
Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors. Mol Oncol (2013) 0.84
Step out of the groove: epigenetic gene control systems and engineered transcription factors. Adv Genet (2006) 0.84
Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells. Mol Pharm (2013) 0.84
Upregulation of endogenous ICAM-1 reduces ovarian cancer cell growth in the absence of immune cells. Int J Cancer (2013) 0.84
Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob. Cancer Gene Ther (2003) 0.83
Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells. Exp Cell Res (2009) 0.82
Establishment of protein delivery systems targeting podocytes. PLoS One (2010) 0.82
Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality. Mol Cell Biol (2010) 0.81
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor. Virology (2006) 0.81
Targeted siRNA delivery to diseased microvascular endothelial cells: cellular and molecular concepts. IUBMB Life (2011) 0.81
The role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma. J Int Med Res (2013) 0.81
Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer. Breast Cancer Res (2014) 0.81
Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma. Med Oncol (2013) 0.80
Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. Epigenetics (2015) 0.80
Use of the EGP-2/Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines. Cancer Gene Ther (2004) 0.80
Modulation of gene expression using zinc finger-based artificial transcription factors. Methods Mol Biol (2010) 0.79
Step into the groove: engineered transcription factors as modulators of gene expression. Adv Genet (2006) 0.78
[Experimental study of preventing postoperative stenosis by modifying artificial esophagus in dogs]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2006) 0.78
Efficient nuclear DNA cleavage in human cancer cells by synthetic bleomycin mimics. ACS Chem Biol (2014) 0.77
Efficient nontoxic delivery of PD-L1 and PD-L2 siRNA into dendritic cell vaccines using the cationic lipid SAINT-18. J Immunother (2015) 0.77
A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement. PLoS One (2013) 0.76
A rapid and sensitive assay for detection of replication-competent adenoviruses by a combination of microcarrier cell culture and quantitative PCR. J Virol Methods (2007) 0.75
[Application of endoscopic ultrasonography to preoperative clinical staging of esophageal cancer]. Ai Zheng (2005) 0.75
Relationship Between PD-L1 Expression and CD8+ T-cell Immune Responses in Hepatocellular Carcinoma. J Immunother (2017) 0.75
Protein C/S ratio, an accurate and simple tool to identify carriers of a protein C gene mutation. Br J Haematol (2002) 0.75
[Applications of stable isotope techniques in the studies of soil collembolan: a review]. Ying Yong Sheng Tai Xue Bao (2013) 0.75
Stem cell epigenetics: looking forward. Cell Stem Cell (2014) 0.75
Relationship Between PD-L1 Expression and CD8+ T-cell Immune Responses in Hepatocellular Carcinoma. J Immunother (2017) 0.75