Epigenetic reprogramming in mammals.

Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70

Effect of in utero and early-life conditions on adult health and disease. N Engl J Med (2008) 14.46

CpG islands and the regulation of transcription. Genes Dev (2011) 9.50

DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell (2008) 8.62

A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell (2008) 4.80

Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature (2008) 4.69

Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature (2007) 4.55

DNA demethylation in the Arabidopsis genome. Proc Natl Acad Sci U S A (2007) 4.55

Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet (2011) 3.99

Active DNA demethylation mediated by DNA glycosylases. Annu Rev Genet (2009) 3.66

DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A (2007) 3.24

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol (2009) 3.12

DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs. Cell Stem Cell (2011) 3.10

Human embryonic stem cells have a unique epigenetic signature. Genome Res (2006) 2.89

Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements. Nucleic Acids Res (2007) 2.80

Epigenetic gene regulation in the bacterial world. Microbiol Mol Biol Rev (2006) 2.66

Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A (2006) 2.63

Mammalian genomic imprinting. Cold Spring Harb Perspect Biol (2011) 2.59

Cytosine-5-methyltransferases add aldehydes to DNA. Nat Chem Biol (2009) 2.31

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. EMBO J (2010) 2.30

Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development (2011) 2.28

Genomic imprinting: employing and avoiding epigenetic processes. Genes Dev (2009) 2.26

Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15

DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma (2009) 2.13

Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. PLoS One (2008) 2.07

Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07

Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis. PLoS Biol (2008) 2.04

Epigenetics and human disease: translating basic biology into clinical applications. CMAJ (2006) 1.98

Genomic imprinting in mammals. Cold Spring Harb Perspect Biol (2014) 1.92

PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92

DNA methylation and demethylation in mammals. J Biol Chem (2011) 1.89

Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev (2014) 1.86

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev (2011) 1.86

A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res (2010) 1.83

What is an epigenetic transgenerational phenotype? F3 or F2. Reprod Toxicol (2007) 1.79

DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76

A subset of methylated CpG sites differentiate psoriatic from normal skin. J Invest Dermatol (2011) 1.73

Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Mol Cell Biol (2006) 1.71

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers. Philos Trans R Soc Lond B Biol Sci (2013) 1.70

Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev (2007) 1.69

Genome-wide, high-resolution DNA methylation profiling using bisulfite-mediated cytosine conversion. Genome Res (2008) 1.68

DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle (2009) 1.64

Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A (2010) 1.64

A survey of small RNAs in human sperm. Hum Reprod (2011) 1.62

Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective. Schizophr Res (2011) 1.57

Epigenetic determination of a cell-specific gene expression program by ATF-2 and the histone variant macroH2A. EMBO J (2006) 1.54

The TBP-PP2A mitotic complex bookmarks genes by preventing condensin action. Nat Cell Biol (2008) 1.50

Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. Nucleic Acids Res (2011) 1.49

Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies? Fertil Steril (2011) 1.47

Metabolic shifts in immunity and inflammation. J Immunol (2010) 1.45

Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans. PLoS Genet (2006) 1.42

Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Res (2007) 1.41

CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells. PLoS Genet (2006) 1.41

Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements. PLoS One (2011) 1.41

High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring. Nat Commun (2012) 1.35

The roles of Ca2+, downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development. Dev Biol (2008) 1.34

Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints. BMC Dev Biol (2008) 1.33

Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote. Chromosoma (2007) 1.33

Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming. Cell Res (2011) 1.33

Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice. Proc Natl Acad Sci U S A (2005) 1.31

Transgenerational epigenetic programming of the embryonic testis transcriptome. Genomics (2007) 1.30

Epigenetic transgenerational inheritance of somatic transcriptomes and epigenetic control regions. Genome Biol (2012) 1.29

Epigenetics and its role in male infertility. J Assist Reprod Genet (2012) 1.27

Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos. PLoS One (2010) 1.27

Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucleic Acids Res (2010) 1.27

Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy. Future Oncol (2010) 1.25

Can environmental conditions experienced in early life influence future generations? Proc Biol Sci (2014) 1.22

Developmental decoupling of alternative phenotypes: insights from the transcriptomes of horn-polyphenic beetles. Evolution (2010) 1.21

Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol (2010) 1.20

Control of the DNA methylation system component MBD2 by protein arginine methylation. Mol Cell Biol (2006) 1.18

Beyond genetics: epigenetic code in chronic kidney disease. Kidney Int (2010) 1.18

The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res (2012) 1.16

Epigenetics in acute myeloid leukemia. Semin Oncol (2008) 1.16

Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J Cell Biol (2006) 1.15

Epigenetic regulation in mammalian preimplantation embryo development. Reprod Biol Endocrinol (2009) 1.15

Epigenetic responses to environmental change and their evolutionary implications. Philos Trans R Soc Lond B Biol Sci (2009) 1.14

Grandma plays favourites: X-chromosome relatedness and sex-specific childhood mortality. Proc Biol Sci (2009) 1.13

Nuclear transfer to eggs and oocytes. Cold Spring Harb Perspect Biol (2011) 1.13

Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos. PLoS Genet (2011) 1.13

Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet (2007) 1.12

Epigenetic reprogramming and development: a unique heterochromatin organization in the preimplantation mouse embryo. Brief Funct Genomics (2010) 1.11

Interactions between epigenetics and metabolism in cancers. Front Oncol (2012) 1.11

The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update (2013) 1.11

Assisted reproduction treatment and epigenetic inheritance. Hum Reprod Update (2012) 1.11

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter. Nucleic Acids Res (2013) 1.10

The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics (2011) 1.08

RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. Mol Cell Biol (2012) 1.08

DNA methylation program during development. Front Biol (Beijing) (2012) 1.07

Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control. Nucleic Acids Res (2010) 1.07

Genomic RNA profiling and the programme controlling preimplantation mammalian development. Mol Hum Reprod (2008) 1.07

Active DNA demethylation in plants and animals. Cold Spring Harb Symp Quant Biol (2012) 1.07

Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription. J Biol Chem (2006) 1.06

DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem (2009) 1.06

A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity. PLoS Pathog (2010) 1.05

The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation. Mol Cell Biol (2011) 1.05

Epigenetic regulation of mammalian stem cells. Stem Cells Dev (2008) 1.04

Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet (2007) 1.04

Evolution and functions of long noncoding RNAs. Cell (2009) 17.54

Active genes dynamically colocalize to shared sites of ongoing transcription. Nat Genet (2004) 9.57

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature (2011) 9.33

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84

Epigenetic reprogramming in mouse primordial germ cells. Mech Dev (2002) 6.67

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95

Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol (2002) 5.86

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun (2011) 5.66

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis (2003) 5.19

Epigenetic reprogramming in plant and animal development. Science (2010) 5.18

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17

Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature (2002) 5.10

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J Biol Chem (2004) 4.86

The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol Cell (2012) 4.32

Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet (2011) 4.25

Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet (2003) 4.25

Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet (2008) 3.89

DNA demethylation by DNA repair. Trends Genet (2009) 3.49

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet (2004) 3.47

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25

BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol (2009) 3.12

FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell (2013) 2.79

Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nat Cell Biol (2008) 2.77

Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev (2009) 2.76

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol (2012) 2.73

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature (2013) 2.63

Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. Eur J Hum Genet (2005) 2.62

Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Dev Biol (2005) 2.51

Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet (2008) 2.20

Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol Cell (2011) 2.13

The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet (2004) 2.13

Resourceful imprinting. Nature (2004) 2.10

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J Physiol (2003) 2.01

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol (2012) 1.94

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A (2005) 1.90

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. Hum Mol Genet (2003) 1.85

Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark. Hum Mol Genet (2003) 1.80

Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions. Hum Mol Genet (2003) 1.73

Epigenetic reprogramming during early development in mammals. Reproduction (2004) 1.72

Methylome analysis using MeDIP-seq with low DNA concentrations. Nat Protoc (2012) 1.70

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers. Philos Trans R Soc Lond B Biol Sci (2013) 1.70

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development (2009) 1.69

Placental overgrowth in mice lacking the imprinted gene Ipl. Proc Natl Acad Sci U S A (2002) 1.67

Identification of novel imprinted genes in a genome-wide screen for maternal methylation. Genome Res (2003) 1.67

Germline mutation in NLRP2 (NALP2) in a familial imprinting disorder (Beckwith-Wiedemann Syndrome). PLoS Genet (2009) 1.64

Community mental health care for women with severe mental illness who are parents. Community Ment Health J (2002) 1.62

Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting. PLoS Genet (2009) 1.58

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline. Development (2012) 1.55

Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab (2012) 1.55

Mice deficient in APOBEC2 and APOBEC3. Mol Cell Biol (2005) 1.55

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat Protoc (2013) 1.54

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol (2013) 1.50

Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol Cell Biol (2003) 1.47

Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Semin Cell Dev Biol (2003) 1.44

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. J Clin Invest (2004) 1.44

Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci U S A (2013) 1.43

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development (2006) 1.38

Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote. Chromosoma (2007) 1.33

Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer. Stem Cells (2005) 1.33

Imprinted Nesp55 influences behavioral reactivity to novel environments. Mol Cell Biol (2005) 1.25

Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells. Curr Opin Cell Biol (2013) 1.25

Evidence that paternal expression of the epsilon-sarcoglycan gene accounts for reduced penetrance in myoclonus-dystonia. Am J Hum Genet (2002) 1.24

Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies. Hum Reprod (2008) 1.23

Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation. Biotechniques (2012) 1.18

Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet (2005) 1.14

Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer. Oncogene (2002) 1.10

DNA methylation in mammalian development and disease. Birth Defects Res C Embryo Today (2005) 1.06

Active demethylation in mouse zygotes involves cytosine deamination and base excision repair. Epigenetics Chromatin (2013) 1.06

The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Hum Mol Genet (2005) 1.02