Published in Mol Biol Cell on November 06, 2013
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron (2015) 2.82
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science (2016) 2.67
Novel roles for actin in mitochondrial fission. J Cell Sci (2014) 1.08
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. Elife (2014) 1.06
Mitochondrial division and fusion in metabolism. Curr Opin Cell Biol (2015) 1.03
A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell (2014) 0.97
Mitophagy mechanisms and role in human diseases. Int J Biochem Cell Biol (2014) 0.86
Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells. J Cell Sci (2015) 0.84
The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1. Mol Biol Cell (2015) 0.84
Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection. BMC Biol (2015) 0.83
The critical roles of mitophagy in cerebral ischemia. Protein Cell (2016) 0.77
Actin filaments as dynamic reservoirs for Drp1 recruitment. Mol Biol Cell (2016) 0.76
Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance. Front Mol Neurosci (2017) 0.75
SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death. Sci Rep (2017) 0.75
Mitochondrial Dynamics Decrease Prior to Axon Degeneration Induced by Vincristine and are Partially Rescued by Overexpressed cytNmnat1. Front Cell Neurosci (2016) 0.75
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiol Aging (2016) 0.75
The little big genome: the organization of mitochondrial DNA. Front Biosci (Landmark Ed) (2017) 0.75
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms. Trends Neurosci (2017) 0.75
Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities. Pharmacol Res (2016) 0.75
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. Elife (2016) 0.75
A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans. Front Neurosci (2017) 0.75
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells. Cell Metab (2017) 0.75
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09
Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell (2001) 9.67
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct (1998) 9.18
Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science (2003) 9.17
Heritable gene targeting in zebrafish using customized TALENs. Nat Biotechnol (2011) 8.34
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature (2007) 6.61
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat Cell Biol (1999) 6.26
C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell (1999) 6.14
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem (2007) 5.95
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol (2010) 5.94
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell (2004) 5.94
Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol (2000) 5.86
ER tubules mark sites of mitochondrial division. Science (2011) 5.45
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol (2003) 4.56
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet (2011) 4.41
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J Cell Biol (2000) 4.07
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol (2010) 3.91
hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem (2003) 3.84
Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol (2005) 3.75
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2008) 3.57
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature (2013) 3.57
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell (2010) 2.96
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J (2011) 2.71
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell (2007) 2.61
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J Cell Biol (2009) 2.45
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J Cell Biol (2005) 2.33
MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep (2011) 2.26
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell (2013) 2.21
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science (2013) 2.15
A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2005) 1.89
Improved methods for the generation of human gene knockout and knockin cell lines. Nucleic Acids Res (2005) 1.75
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab (2012) 1.66
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol Cell (2008) 1.61
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J (2010) 1.57
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochim Biophys Acta (2012) 1.54
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet (2010) 1.52
The subcellular distribution of calnexin is mediated by PACS-2. Mol Biol Cell (2008) 1.51
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo. Mol Biol Cell (2010) 1.49
Induction of macroautophagy by exogenously introduced calcium. Autophagy (2008) 1.48
High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta (2008) 1.44
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A (2013) 1.39
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell (2011) 1.39
Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. Exp Cell Res (2007) 1.37
Subcellular localization of SV2 and other secretory vesicle components in PC12 cells by an efficient method of preembedding EM immunocytochemistry for cell cultures. J Histochem Cytochem (1996) 1.20
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem (2013) 1.19
Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein. Biochem Biophys Res Commun (2005) 1.18
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Mol Biol Cell (2011) 1.12
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. J Cell Biol (2010) 1.10
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. J Cell Sci (2012) 1.00
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet (2009) 8.11
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
Mitochondrial fission, fusion, and stress. Science (2012) 7.45
Mitochondrial dynamics and apoptosis. Genes Dev (2008) 6.07
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol (2010) 5.94
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell (2004) 5.94
Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Neuron (2003) 5.38
Role of Bax and Bak in mitochondrial morphogenesis. Nature (2006) 5.25
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol (2002) 5.01
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell (2011) 4.91
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA (2006) 4.26
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol (2010) 3.91
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol (2007) 3.83
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy (2010) 3.68
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2008) 3.57
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol (2004) 3.55
The role of mitochondria in apoptosis*. Annu Rev Genet (2009) 3.44
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol (2011) 3.36
Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria. J Biol Chem (2004) 3.35
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol Cell (2004) 3.28
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell (2011) 3.23
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage. J Cell Biol (2007) 3.15
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann Neurol (2008) 2.95
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron (2003) 2.86
Composition and dynamics of human mitochondrial nucleoids. Mol Biol Cell (2003) 2.74
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci (2003) 2.68
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep (2012) 2.60
Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro. J Biol Chem (2005) 2.60
OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain (2008) 2.57
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell (2012) 2.52
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J Cell Biol (2009) 2.45
The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell (2011) 2.43
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol (2005) 2.31
Endophilin B1 is required for the maintenance of mitochondrial morphology. J Cell Biol (2004) 2.28
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nat Cell Biol (2012) 2.25
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem (2007) 2.22
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J (2003) 2.16
How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol (2006) 2.14
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A (2010) 2.10
LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res (2008) 2.09
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron (2007) 2.08
Genomic investigation of alpha-synuclein multiplication and parkinsonism. Ann Neurol (2008) 2.04
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. J Cell Biol (2013) 2.04
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Hum Mol Genet (2004) 2.02
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet (2012) 2.01
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep (2003) 2.01
Mutations for Gaucher disease confer high susceptibility to Parkinson disease. Arch Neurol (2009) 2.00
Control of mitochondrial permeability by Bcl-2 family members. Biochim Biophys Acta (2004) 2.00
Gradient echo T2*-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease. J Stroke Cerebrovasc Dis (2011) 1.99
Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology (2011) 1.95
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell (2008) 1.94
Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Dev Cell (2007) 1.91
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91
Parkin stabilizes PINK1 through direct interaction. Biochem Biophys Res Commun (2009) 1.89
PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci (2012) 1.89
Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci U S A (2004) 1.85
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum Mol Genet (2006) 1.83
Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy (2009) 1.82
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal (2011) 1.82
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy (2011) 1.81
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett (2010) 1.79
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J (2004) 1.77
Novel PINK1 mutations in early-onset parkinsonism. Ann Neurol (2004) 1.72
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol (2003) 1.70
Mechanism and treatment of dropped head syndrome associated with parkinsonism. Parkinsonism Relat Disord (2008) 1.68
Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection. Anal Chem (2007) 1.67
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann Neurol (2006) 1.66
Multiple pathways for mitochondrial protein traffic. Biol Chem (2009) 1.66
Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet (2007) 1.65
SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG. Development (2002) 1.65
PINK1 is degraded through the N-end rule pathway. Autophagy (2013) 1.63
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nat Methods (2012) 1.62
Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Curr Opin Cell Biol (2011) 1.62
Mechanisms of mitochondrial fission and fusion. Cold Spring Harb Perspect Biol (2013) 1.61
A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem (2005) 1.60
Bid, but not Bax, regulates VDAC channels. J Biol Chem (2004) 1.57
Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation (2008) 1.56
Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage, reversible posterior leukoencephalopathy, and cerebral infarction. Intern Med (2011) 1.55
UCHL1 is a Parkinson's disease susceptibility gene. Ann Neurol (2004) 1.54
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol (2002) 1.54
Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. J Biol Chem (2005) 1.54
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest (2011) 1.52
Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol (2006) 1.52