Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

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🔗 View Article (PMID 24226770)

Published in Nature on November 13, 2013

Authors

Yukihiro Furusawa1, Yuuki Obata2, Shinji Fukuda3, Takaho A Endo4, Gaku Nakato4, Daisuke Takahashi4, Yumiko Nakanishi5, Chikako Uetake4, Keiko Kato6, Tamotsu Kato4, Masumi Takahashi4, Noriko N Fukuda5, Shinnosuke Murakami5, Eiji Miyauchi4, Shingo Hino7, Koji Atarashi8, Satoshi Onawa4, Yumiko Fujimura9, Trevor Lockett10, Julie M Clarke10, David L Topping10, Masaru Tomita5, Shohei Hori4, Osamu Ohara4, Tatsuya Morita7, Haruhiko Koseki11, Jun Kikuchi12, Kenya Honda13, Koji Hase14, Hiroshi Ohno11

Author Affiliations

1: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan [3].
2: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan [3] Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan [4].
3: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan [3].
4: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan.
5: Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan.
6: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan.
7: Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan.
8: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.
9: The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
10: Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia.
11: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan [3] Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan.
12: 1] Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan [2] RIKEN Center for Sustainable Resource Science, Kanagawa 230-0045, Japan.
13: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan.
14: 1] RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan [2] The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan [3] PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan [4].

Associated clinical trials:

A Pilot Study Evaluating a Ketogenic Diet Concomitant to Nivolumab and Ipilimumab in Patients With Metastatic Renal Cell Carcinoma (KETOREIN) | NCT05119010

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