Published in Nature on July 06, 2016
Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc Natl Acad Sci U S A (2016) 1.50
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell (2017) 1.39
Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci (2017) 0.81
Transfusion as an Inflammation Hit: Knowns and Unknowns. Front Immunol (2016) 0.80
The metabolome 18 years on: a concept comes of age. Metabolomics (2016) 0.79
Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective. Front Immunol (2016) 0.79
The Influence of the Microbiome on Allergic Sensitization to Food. J Immunol (2017) 0.78
Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function. Gut Microbes (2016) 0.77
Gut Dysbiosis and Adaptive Immune Response in Diet-induced Obesity vs. Systemic Inflammation. Front Microbiol (2017) 0.77
The multiple pathways to autoimmunity. Nat Immunol (2017) 0.76
A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model. Clin Immunol (2016) 0.76
Mechanisms and consequences of intestinal dysbiosis. Cell Mol Life Sci (2017) 0.76
Regulation of inflammation by microbiota interactions with the host. Nat Immunol (2017) 0.75
Gut Microbiota Species Can Provoke both Inflammatory and Tolerogenic Immune Responses in Human Dendritic Cells Mediated by Retinoic Acid Receptor Alpha Ligation. Front Immunol (2017) 0.75
Grand Challenges in Immunological Memory. Front Immunol (2017) 0.75
Intestinal dysbiosis is common in systemic sclerosis and associated with gastrointestinal and extraintestinal features of disease. Arthritis Res Ther (2016) 0.75
Roles of the intestinal microbiota in pathogen protection. Clin Transl Immunology (2017) 0.75
Microbial Immuno-Communication in Neurodegenerative Diseases. Front Neurosci (2017) 0.75
Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model. Oncotarget (2016) 0.75
Host-microbial Cross-talk in Inflammatory Bowel Disease. Immune Netw (2017) 0.75
Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome (2017) 0.75
T Cells in Osteoarthritis: Alterations and Beyond. Front Immunol (2017) 0.75
Intestinal Dysbiosis Is Associated with Altered Short-Chain Fatty Acids and Serum-Free Fatty Acids in Systemic Lupus Erythematosus. Front Immunol (2017) 0.75
Striking a Balance with Help from our Little Friends - How the Gut Microbiota Contributes to Immune Homeostasis. Yale J Biol Med (2016) 0.75
Cats are not small dogs: is there an immunological explanation for why cats are less affected by arthropod-borne disease than dogs? Parasit Vectors (2016) 0.75
Pathophysiology of Intestinal Na(+)/H(+) exchange. Cell Mol Gastroenterol Hepatol (2017) 0.75
Metagenomic Sequencing for Surveillance of Food- and Waterborne Viral Diseases. Front Microbiol (2017) 0.75
Detection of Increased Plasma Interleukin-6 Levels and Prevalence of Prevotella copri and Bacteroides vulgatus in the Feces of Type 2 Diabetes Patients. Front Immunol (2017) 0.75
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system. Sci Rep (2017) 0.75
Collateral damage during antibiotic treatment of C. difficile infection in the aged host: insights into why recurrent disease happens. Gut Microbes (2017) 0.75
Investigation into the stability and culturability of Chinese enterotypes. Sci Rep (2017) 0.75
Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development. Front Immunol (2017) 0.75
Antigen-specific regulatory T-cell responses to intestinal microbiota. Mucosal Immunol (2017) 0.75
Anticancer effects of the microbiome and its products. Nat Rev Microbiol (2017) 0.75
The Bacterial Ecosystem of Mother's Milk and Infant's Mouth and Gut. Front Microbiol (2017) 0.75
Modulatory Influence of Segmented Filamentous Bacteria on Transcriptomic Response of Gnotobiotic Mice Exposed to TCDD. Front Microbiol (2017) 0.75
Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis. J Immunol Res (2017) 0.75
A gut feeling about multiple sclerosis. Proc Natl Acad Sci U S A (2017) 0.75
The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity. Front Immunol (2017) 0.75
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29
Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A (2008) 14.18
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 9.81
Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 9.75
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53
ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02
The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe (2014) 7.43
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell (2010) 6.79
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature (2013) 6.45
Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity (2009) 6.24
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science (2011) 6.19
Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98
Microbial exposure during early life has persistent effects on natural killer T cell function. Science (2012) 5.90
Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature (2012) 5.63
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature (2013) 5.47
Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A (2011) 5.44
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol (2011) 5.41
Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39
IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe (2007) 5.18
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 5.10
Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity (2011) 4.86
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature (2013) 4.74
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature (2013) 4.57
Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell (2014) 4.25
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science (2015) 4.23
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature (2003) 4.22
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity (2010) 4.19
Compartmentalized control of skin immunity by resident commensals. Science (2012) 4.19
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature (2011) 4.07
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55
Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science (2010) 3.53
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science (2014) 3.13
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science (2015) 3.12
The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature (2014) 3.10
Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05
Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect Immun (1999) 3.03
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol (2005) 3.00
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep (2012) 2.83
An enteric virus can replace the beneficial function of commensal bacteria. Nature (2014) 2.80
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A (2009) 2.77
Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu Rev Immunol (2012) 2.71
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity (2014) 2.69
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013) 2.69
Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med (2015) 2.64
Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis (2010) 2.62
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61
Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J Exp Med (2002) 2.60
Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science (2014) 2.59
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature (2015) 2.52
Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity (2014) 2.50
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med (2012) 2.49
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med (2013) 2.47
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. J Clin Invest (2011) 2.43
Outer membrane vesicles of a human commensal mediate immune regulation and disease protection. Cell Host Microbe (2012) 2.41
Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science (2016) 2.40
Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am J Respir Crit Care Med (2008) 2.39
MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells. Science (2015) 2.36
A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity (2015) 2.35
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity (2013) 2.27
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol (2013) 2.24
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med (2014) 2.13
Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice. Lab Anim (1985) 2.12
Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity (2015) 2.12
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med (2012) 2.11
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol (2013) 2.11
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med (2014) 2.09
Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell (2016) 2.06
Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science (2013) 2.03
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Immunity (2010) 2.02
Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A (2014) 2.02
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science (2012) 2.01
Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature (2016) 1.97
The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Science (2015) 1.95
Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity (2014) 1.94
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science (2015) 1.91
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity. Nat Immunol (2013) 1.86
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. Immunity (2015) 1.83
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature (2014) 1.81
New concepts in the generation and functions of IgA. Nat Rev Immunol (2012) 1.81
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol (2012) 1.80
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity (2014) 1.78
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. Cell (2015) 1.76
Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat Immunol (2016) 1.75