Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin-binding site.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 3873583)

Published in J Biol Chem on November 18, 2013

Authors

Payel Datta1, Guoyun Li, Bo Yang, Xue Zhao, Jong Youn Baik, Trent R Gemmill, Susan T Sharfstein, Robert J Linhardt

Author Affiliations

1: From the Departments of Biology.

Articles cited by this

Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem (2001) 7.87

Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A (1985) 6.00

Molecular diversity of heparan sulfate. J Clin Invest (2001) 5.40

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol (2011) 2.87

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature (1999) 2.82

Lessons learned from the contamination of heparin. Nat Prod Rep (2009) 2.81

Heparin is essential for the storage of specific granule proteases in mast cells. Nature (1999) 2.34

Inhibition of chondroitin and heparan sulfate biosynthesis in Chinese hamster ovary cell mutants defective in galactosyltransferase I. J Biol Chem (1987) 2.30

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation. J Biol Chem (2007) 1.70

E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor. Biotechnol Bioeng (2010) 1.65

Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. J Biol Chem (1999) 1.58

Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem (1999) 1.58

Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. J Biol Chem (2000) 1.54

Biosynthesis of heparin. Substrate specificity of heparosan N-sulfate D-glucuronosyl 5-epimerase. J Biol Chem (1984) 1.46

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. Proc Natl Acad Sci U S A (2008) 1.45

Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography-mass spectrometry. J Chromatogr A (2011) 1.42

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling. An Acad Bras Cienc (2009) 1.37

Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes. Biochim Biophys Acta (2002) 1.34

Influence of core protein sequence on glycosaminoglycan assembly. Curr Opin Struct Biol (1996) 1.29

Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem (2007) 1.27

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem (2000) 1.25

6-O-sulfotransferase-1 represents a critical enzyme in the anticoagulant heparan sulfate biosynthetic pathway. J Biol Chem (2001) 1.23

Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase. Biochemistry (2001) 1.22

Heparan sulfate core proteins in cell-cell signaling. Annu Rev Genet (2003) 1.16

Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase. J Biol Chem (1992) 1.15

The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate. J Biol Chem (2001) 1.14

Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proc Natl Acad Sci U S A (2012) 1.11

Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells. Nat Chem Biol (2006) 1.10

Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metab Eng (2012) 1.09

Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. J Biol Chem (1999) 1.08

Structural characterization of pharmaceutical heparins prepared from different animal tissues. J Pharm Sci (2013) 1.08

Structural characterization of heparins from different commercial sources. Anal Bioanal Chem (2011) 1.07

CHO glycosylation mutants: proteoglycans. Methods Enzymol (2006) 1.06

Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II. J Biol Chem (2006) 1.04

Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem (2004) 1.03

Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes. Glycoconj J (2003) 1.03

Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line. J Biol Chem (1994) 1.02

cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem (1994) 1.02

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases. Biochem J (2003) 1.02

An 'omics approach towards CHO cell engineering. Biotechnol Bioeng (2013) 1.01

2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. J Biol Chem (2008) 0.99

Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes. J Biol Chem (1998) 0.98

Anticoagulant heparan sulfate to not clot--or not? Prog Mol Biol Transl Sci (2010) 0.90

Synthesis of anticoagulantly active heparan sulfate proteoglycans by glomerular epithelial cells involves multiple 3-O-sulfotransferase isoforms and a limiting precursor pool. J Biol Chem (2005) 0.90

Characterization of the structure of antithrombin-binding heparan sulfate generated by heparan sulfate 3-O-sulfotransferase 5. Biochim Biophys Acta (2005) 0.88

Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases. J Immunol (2009) 0.87

Expression of the mouse mastocytoma glucosaminyl N-deacetylase/ N-sulfotransferase in human kidney 293 cells results in increased N-sulfation of heparan sulfate. Biochemistry (1996) 0.86

Heparin biosynthesis. Handb Exp Pharmacol (2012) 0.85

Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity. J Biol Chem (2003) 0.83

Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfoglucosamine residue. FEBS Lett (2011) 0.82

Stable heparin-producing cell lines derived from the Furth murine mastocytoma. Proc Natl Acad Sci U S A (1992) 0.82

Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin. J Biol Chem (2012) 0.82

Microscale separation of heparosan, heparan sulfate, and heparin. Anal Biochem (2012) 0.80

Articles by these authors

Heparin-protein interactions. Angew Chem Int Ed Engl (2002) 7.27

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (2008) 4.46

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol (2007) 3.73

Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J Biol Chem (2003) 2.94

Lessons learned from the contamination of heparin. Nat Prod Rep (2009) 2.81

Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins. Science (2011) 2.79

Preperitoneal single-port transvesical enucleation of the prostate (STEP) for large-volume BPH: one-year follow-up of Qmax, IPSS, and QoL. Urology (2012) 2.78

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology (2005) 2.46

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32

The proteoglycan bikunin has a defined sequence. Nat Chem Biol (2011) 2.14

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev (2005) 2.10

Solution structures of chemoenzymatically synthesized heparin and its precursors. J Am Chem Soc (2008) 2.02

Flexible energy storage devices based on nanocomposite paper. Proc Natl Acad Sci U S A (2007) 2.02

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle (2009) 1.97

Improvement of the survival of human autologous fat transplantation by using VEGF-transfected adipose-derived stem cells. Plast Reconstr Surg (2009) 1.93

Comparative proteomic analysis of NaCl stress-responsive proteins in Arabidopsis roots. J Exp Bot (2007) 1.93

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Hum Mol Genet (2004) 1.92

Electron detachment dissociation of glycosaminoglycan tetrasaccharides. J Am Soc Mass Spectrom (2006) 1.89

Enzymatic redesigning of biologically active heparan sulfate. J Biol Chem (2005) 1.89

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87

Novel robotic da Vinci instruments for laparoendoscopic single-site surgery. Urology (2010) 1.83

Management of forgotten ureteral stents with holmium laser. Lasers Med Sci (2008) 1.80

Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol (2002) 1.78

Robotic laparoendoscopic single-site radical prostatectomy: technique and early outcomes. Eur Urol (2010) 1.73

Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71

Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction. J Virol (2006) 1.71

Heparin-binding domains in vascular biology. Arterioscler Thromb Vasc Biol (2004) 1.71

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A (2004) 1.70

Distributed optimal consensus filter for target tracking in heterogeneous sensor networks. IEEE Trans Cybern (2013) 1.68

Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity. Hum Mol Genet (2003) 1.66

Registration Combining Wide and Narrow Baseline Feature Tracking Techniques for Markerless AR Systems. Sensors (Basel) (2009) 1.65

E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor. Biotechnol Bioeng (2010) 1.65

Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem (2010) 1.64

Quality of life and cost for patients with premature ventricular contractions by radiofrequency catheter ablation. Pacing Clin Electrophysiol (2006) 1.62

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med (2013) 1.61

Distinguishing glucuronic from iduronic acid in glycosaminoglycan tetrasaccharides by using electron detachment dissociation. Anal Chem (2007) 1.61

STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood (2007) 1.60

Retracted Predicting new molecular targets for rhein using network pharmacology. BMC Syst Biol (2012) 1.55

Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. J Biol Chem (2002) 1.53

Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides. J Biol Chem (2003) 1.51

Urological laparoendoscopic single site surgery: multi-institutional analysis of risk factors for conversion and postoperative complications. J Urol (2012) 1.50

L1, β-catenin, and E-cadherin expression in patients with colorectal cancer: correlation with clinicopathologic features and its prognostic significance. J Surg Oncol (2010) 1.50

Utility of a modality combining FISH and cytology in upper tract urothelial carcinoma detection in voided urine samples of Chinese patients. Urology (2011) 1.48

Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46

Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis. Biotechnol Bioeng (2009) 1.46

Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody. Cytometry A (2007) 1.45

Quantification of heparan sulfate disaccharides using ion-pairing reversed-phase microflow high-performance liquid chromatography with electrospray ionization trap mass spectrometry. Anal Chem (2009) 1.45

Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging system. J Clin Endocrinol Metab (2007) 1.44

Nonsteroidal Anti-inflammatory Drugs as Prophylaxis for Heterotopic Ossification after Total Hip Arthroplasty: A Systematic Review and Meta-Analysis. Medicine (Baltimore) (2015) 1.43

Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem (2004) 1.42

Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography-mass spectrometry. J Chromatogr A (2011) 1.42

Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem (2004) 1.41

Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci (2006) 1.41

Electron detachment dissociation of dermatan sulfate oligosaccharides. J Am Soc Mass Spectrom (2007) 1.40

[Robot assisted laparoscopic partial nephrectomy: techniques and outcomes]. Arch Esp Urol (2011) 1.40

Influence of charge state and sodium cationization on the electron detachment dissociation and infrared multiphoton dissociation of glycosaminoglycan oligosaccharides. J Am Soc Mass Spectrom (2008) 1.40

Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy (2009) 1.39

Negative electron transfer dissociation of glycosaminoglycans. Anal Chem (2010) 1.39

Perioperative outcomes and cosmesis analysis of patients undergoing laparoendoscopic single-site adrenalectomy: a comparison of transumbilical, transperitoneal subcostal, and retroperitoneal subcostal approaches. Urology (2013) 1.39

Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. J Biol Chem (2004) 1.38

Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells. J Biol Chem (2008) 1.38

Structural analysis of bikunin glycosaminoglycan. J Am Chem Soc (2008) 1.37

Orthogonal analytical approaches to detect potential contaminants in heparin. Proc Natl Acad Sci U S A (2009) 1.36

Beneficial effects of exercise and its molecular mechanisms on depression in rats. Behav Brain Res (2005) 1.36

Control of the heparosan N-deacetylation leads to an improved bioengineered heparin. Appl Microbiol Biotechnol (2011) 1.33

Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly. Biochemistry (2004) 1.33

Heparin accelerates gelsolin amyloidogenesis. Biochemistry (2006) 1.31

Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass. Biotechnol Bioeng (2011) 1.31

Analysis of E. coli K5 capsular polysaccharide heparosan. Anal Bioanal Chem (2010) 1.30

Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions. Biochem Biophys Res Commun (2005) 1.29

Ultra-performance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis. Anal Biochem (2011) 1.28

Microscale isolation and analysis of heparin from plasma using an anion-exchange spin column. Anal Biochem (2006) 1.27

Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. J Biol Chem (2011) 1.26

Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS. Anal Chem (2012) 1.26

Recent chemical and enzymatic approaches to the synthesis of glycosaminoglycan oligosaccharides. Curr Med Chem (2003) 1.25

Proteoglycomics: recent progress and future challenges. OMICS (2010) 1.25

Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet (2009) 1.25

Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin. J Med Chem (2010) 1.24

CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med (2012) 1.23

Electron-induced dissociation of glycosaminoglycan tetrasaccharides. J Am Soc Mass Spectrom (2008) 1.23

The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery. J Biol Chem (2004) 1.23

Adverse events following acupuncture: a systematic review of the Chinese literature for the years 1956-2010. J Altern Complement Med (2012) 1.23

Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification. Appl Microbiol Biotechnol (2005) 1.22

Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance. Biochim Biophys Acta (2005) 1.22

Preactivation-based, one-pot combinatorial synthesis of heparin-like hexasaccharides for the analysis of heparin-protein interactions. Chemistry (2010) 1.22

Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1. Biochemistry (2008) 1.21

Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively. Carbohydr Res (2002) 1.20

Diaqua-bis(1,10-phenanthroline-κN,N')zinc(II) 2-hydr-oxy-5-sulfonatobenzoate tetra-hydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.20

Image guided percutaneous probe ablation for renal tumors in 65 solitary kidneys: functional and oncological outcomes. J Urol (2011) 1.20

Preparation of biopolymer fibers by electrospinning from room temperature ionic liquids. Biomacromolecules (2006) 1.19

Engineering of routes to heparin and related polysaccharides. Appl Microbiol Biotechnol (2011) 1.19

Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach. J Proteomics (2011) 1.19

Structural characterization of human liver heparan sulfate. Biochim Biophys Acta (2004) 1.18

Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron (2012) 1.18

Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction. Am J Physiol Heart Circ Physiol (2007) 1.16

Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE. J Pharm Sci (2009) 1.16

Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome. Biol Open (2014) 1.16

Isolation and characterization of heparan sulfate from various murine tissues. Glycoconj J (2006) 1.15