Disease implications of the Hippo/YAP pathway.

Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45

Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1. PLoS One (2017) 1.39

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene (2016) 1.39

YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol (2015) 1.29

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev (2015) 1.13

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol (2016) 1.06

Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway. Mol Cancer Res (2015) 0.87

Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep (2016) 0.86

A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions. Sci Rep (2015) 0.83

The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol (2016) 0.82

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget (2016) 0.81

The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. J Mol Cell Cardiol (2015) 0.80

Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling. J Biol Chem (2016) 0.79

MicroRNA-15b/16 Attenuates Vascular Neointima Formation by Promoting the Contractile Phenotype of Vascular Smooth Muscle Through Targeting YAP. Arterioscler Thromb Vasc Biol (2015) 0.79

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3. Nat Commun (2016) 0.77

Stressing out the Hippo/YAP signaling pathway: toward a new role in Schwann cells. Cell Death Dis (2015) 0.77

Cell density regulates cancer metastasis via the Hippo pathway. Future Oncol (2015) 0.77

Activated Hippo/Yes-Associated Protein Pathway Promotes Cell Proliferation and Anti-apoptosis in Endometrial Stromal Cells of Endometriosis. J Clin Endocrinol Metab (2016) 0.77

Tumor suppressor Nf2/merlin drives Schwann cell changes following electromagnetic field exposure through Hippo-dependent mechanisms. Cell Death Discov (2015) 0.76

MECP2 impairs neuronal structure by regulating KIBRA. Neurobiol Dis (2016) 0.76

YAP-Mediated Mechanotransduction in Skeletal Muscle. Front Physiol (2016) 0.76

YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: "Hippo-thetical", new therapeutic targets? Cancer Biol Ther (2016) 0.75

MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad. Genes (Basel) (2017) 0.75

CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells. Cell Death Dis (2017) 0.75

Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells Int (2016) 0.75

Repression of YAP by NCTD disrupts NSCLC progression. Oncotarget (2016) 0.75

Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development. Genetics (2016) 0.75

A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Nat Commun (2016) 0.75

Regulation of Hippo signalling by p38 signalling. J Mol Cell Biol (2016) 0.75

Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell (2016) 0.75

The dynamic mechanism of RASSF5 and MST kinase activation by Ras. Phys Chem Chem Phys (2017) 0.75

Disruption of mechanical stress in extracellular matrix is related to Stanford type A aortic dissection through down-regulation of Yes-associated protein. Aging (Albany NY) (2016) 0.75

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ). J Biol Chem (2016) 0.75

Overexpression of TAZ promotes cell proliferation, migration and epithelial-mesenchymal transition in ovarian cancer. Oncol Lett (2016) 0.75

ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell (2016) 0.75

Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight (2017) 0.75

Mapping the STK4/Hippo signaling network in prostate cancer cell. PLoS One (2017) 0.75

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05

Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell (2005) 10.61

TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88

YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11

Mutations in GNA11 in uveal melanoma. N Engl J Med (2010) 7.52

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell (2002) 7.15

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell (2008) 5.58

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev (2001) 5.41

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet (1997) 5.11

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell (2011) 5.06

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol (2008) 5.02

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90

Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 4.55

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell (2010) 4.47

A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res (2008) 4.33

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 4.19

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene (2005) 3.64

Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature (2012) 3.54

In vivo regulation of Yorkie phosphorylation and localization. Development (2008) 3.51

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44

Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev (2007) 3.41

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell (2012) 3.33

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A (2010) 3.18

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev (2011) 3.15

Role of TAZ as mediator of Wnt signaling. Cell (2012) 3.05

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev (2010) 3.02

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development (2008) 2.98

Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell (2014) 2.70

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A (2011) 2.54

A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A (2005) 2.50

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell (2014) 2.50

Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem (2011) 2.47

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A (2007) 2.31

The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol (2008) 2.24

Hippo pathway activity influences liver cell fate. Cell (2014) 2.24

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med (2012) 2.24

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (2013) 2.16

Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci (2010) 2.04

Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers. Nat Med (2014) 2.03

Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ (2008) 2.03

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem (2011) 2.00

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell (2014) 1.96

Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem (2010) 1.95

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem (2012) 1.89

TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol (2007) 1.86

TAZ is a novel oncogene in non-small cell lung cancer. Oncogene (2011) 1.85

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85

Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene (2002) 1.82

Hippo signaling impedes adult heart regeneration. Development (2013) 1.81

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma. Sci Transl Med (2011) 1.79

Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell (2014) 1.79

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun (2013) 1.76

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. Mol Biol Cell (2011) 1.75

Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J (2006) 1.67

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res (2007) 1.66

Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice. Hepatology (2011) 1.61

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci Signal (2014) 1.61

A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Biochem Biophys Res Commun (2007) 1.59

Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (2009) 1.54

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biol (2009) 1.54

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br J Cancer (2010) 1.53

Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol (2014) 1.47

Merlin is a potent inhibitor of glioma growth. Cancer Res (2008) 1.47

Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer (2013) 1.45

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet (2013) 1.39

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene (2012) 1.36

Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology (2012) 1.34

LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res (2011) 1.32

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis. EMBO J (2014) 1.30

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev (2014) 1.30

The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res (2013) 1.30

The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis. Sci Signal (2013) 1.25

Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer. Eur J Cancer (2011) 1.24

The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP. Neoplasia (2008) 1.23

PTPN14 is required for the density-dependent control of YAP1. Genes Dev (2012) 1.23

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer Cell (2014) 1.22

Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol (2012) 1.21

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res (2014) 1.20

Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2010) 1.19

Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res (2013) 1.18

PTPN14 interacts with and negatively regulates the oncogenic function of YAP. Oncogene (2012) 1.17

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16

Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology (2012) 1.15

Bile acids activate YAP to promote liver carcinogenesis. Cell Rep (2013) 1.14

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun (2014) 1.12

Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth. J Neuropathol Exp Neurol (2011) 1.10

Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. PLoS One (2012) 1.02

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01