Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for IL-15Rα.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 3894449)

Published in Immunogenetics on November 26, 2013

Authors

Johannes M Dijkstra1, Fumio Takizawa, Uwe Fischer, Maik Friedrich, Veronica Soto-Lampe, Christophe Lefèvre, Matthias Lenk, Axel Karger, Taei Matsui, Keiichiro Hashimoto

Author Affiliations

1: Institute for Comprehensive Medical Science, Fujita Health University, Dengakugakubo 1-98, Toyoake, Aichi, 470-1192, Japan, dijkstra@fujita-hu.ac.jp.

Articles cited by this

A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 11.48

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med (2000) 9.78

Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on mammal diversification. Science (2011) 8.23

Structure and expression of a cloned cDNA for human interleukin-2. Nature (1983) 7.04

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science (1994) 6.65

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol (2006) 6.22

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity (2002) 6.10

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J (1994) 5.69

The biology of interleukin-2. Annu Rev Immunol (2008) 4.77

The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol (1999) 3.81

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J (1995) 3.59

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol (2002) 3.35

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol (1995) 3.34

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity (2013) 2.69

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol (1996) 2.50

IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med (2008) 2.33

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature (2012) 2.08

Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins. J Biol Chem (2005) 2.01

Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem (1995) 1.90

Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. Blood (2012) 1.90

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J Immunol (2004) 1.87

Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol (2002) 1.55

The structure of interleukin-2 complexed with its alpha receptor. Science (2005) 1.53

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell (1999) 1.48

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. J Biol Chem (2007) 1.47

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A (2006) 1.41

Structural comparisons among the short-chain helical cytokines. Structure (1994) 1.38

Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene (2002) 1.22

Novel human interleukin-15 agonists. J Immunol (2009) 1.15

Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans. Nat Immunol (2007) 1.14

Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish. Immunogenetics (2008) 1.13

Phylogeny and evolution of class-I helical cytokines. J Endocrinol (2006) 1.11

Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX. BMC Genomics (2008) 1.10

Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surface. Protein Sci (1996) 1.08

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation. J Biol Chem (2007) 1.07

Identification of Treg-like cells in Tetraodon: insight into the origin of regulatory T subsets during early vertebrate evolution. Cell Mol Life Sci (2010) 1.04

Interleukin-26: an IL-10-related cytokine produced by Th17 cells. Cytokine Growth Factor Rev (2010) 1.03

The interleukins of fish. Dev Comp Immunol (2011) 0.98

Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J Biol Chem (2012) 0.94

A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15. J Immunol (1997) 0.91

Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int J Cancer (2013) 0.90

Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. J Biol Chem (2004) 0.90

The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue. J Biol Chem (2007) 0.88

Characterization and expression analysis of an interleukin-7 homologue in the Japanese pufferfish, Takifugu rubripes. FEBS J (2008) 0.86

Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15. Immunogenetics (1999) 0.82

Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis. Mol Immunol (2010) 0.81

Distinct evolution process among type I interferon in mammals. Protein Cell (2013) 0.81

Two interleukin (IL)-15 homologues in fish from two distinct origins. Mol Immunol (2005) 0.80

Molecular and functional characterization of IL-15 in rainbow trout Oncorhynchus mykiss: a potent inducer of IFN-gamma expression in spleen leukocytes. J Immunol (2007) 0.79

Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny. Immunogenetics (2004) 0.78

Identification and characterization of an interleukin-15 homologue from Tetraodon nigroviridis. Comp Biochem Physiol B Biochem Mol Biol (2006) 0.77

Molecular cloning and characterization of IL-15R alpha gene in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol (2006) 0.77

Characterization of an interleukin-15 like (IL-15L) gene from zebrafish (Danio rerio). Fish Shellfish Immunol (2006) 0.77

Molecular and functional characterization of chicken IL-15. Dev Comp Immunol (1999) 0.76

IL26 gene inactivation in Equidae. Anim Genet (2013) 0.76

Articles by these authors

The pseudorabies virus UL11 protein is a virion component involved in secondary envelopment in the cytoplasm. J Virol (2003) 1.69

Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures. PLoS Pathog (2010) 1.59

Gadobenate dimeglumine-enhanced MRI of the breast: analysis of dose response and comparison with gadopentetate dimeglumine. AJR Am J Roentgenol (2003) 1.53

Replicative Capacity of MERS Coronavirus in Livestock Cell Lines. Emerg Infect Dis (2014) 1.42

Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope glycoprotein E. J Virol (2006) 1.41

Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts. Mol Cell Biol (2004) 1.39

A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J Cell Sci (2002) 1.37

Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development. J Bone Miner Res (2002) 1.19

p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. Nucleic Acids Res (2010) 1.19

Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish. Immunogenetics (2008) 1.13

A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes. Immunogenetics (2007) 1.13

Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals. Immunogenetics (2012) 1.10

Functional analysis of the pseudorabies virus UL51 protein. J Virol (2005) 1.08

Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation. J Cell Physiol (2010) 1.08

German Francisella tularensis isolates from European brown hares (Lepus europaeus) reveal genetic and phenotypic diversity. BMC Microbiol (2013) 1.03

Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7. J Immunol (2010) 1.02

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins. J Biol Chem (2003) 1.02

Resuscitation-induced gut edema and intestinal dysfunction. J Trauma (2005) 1.01

Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland. Funct Integr Genomics (2008) 0.98

Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo. Protein Sci (2005) 0.98

Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates. BMC Evol Biol (2013) 0.97

The expression of CD8α discriminates distinct T cell subsets in teleost fish. Dev Comp Immunol (2011) 0.97

Identification and characterization of a second CD4-like gene in teleost fish. Mol Immunol (2005) 0.96

Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution. BMC Biol (2008) 0.95

Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol (2010) 0.94

Summary of the animal homologue section of HLDA8. Cell Immunol (2005) 0.94

Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments. Mol Immunol (2011) 0.94

Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue. J Anat (2010) 0.94

Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome. Int J Hematol (2002) 0.92

Assessment of inactivated human rabies vaccines: biochemical characterization and genetic identification of virus strains. Vaccine (2012) 0.92

Identification, subviral localization, and functional characterization of the pseudorabies virus UL17 protein. J Virol (2005) 0.92

Relevance of the interaction between alphaherpesvirus UL3.5 and UL48 proteins for virion maturation and neuroinvasion. J Virol (2007) 0.90

Myristoylation-regulated direct interaction between calcium-bound calmodulin and N-terminal region of pp60v-src. J Mol Biol (2004) 0.90

1-Aminocyclopropane-1-carboxylic acid and abscisic acid during the germination of sugar beet (Beta vulgaris L.): a comparative study of fruits and seeds. J Exp Bot (2007) 0.90

miRNA_Targets: a database for miRNA target predictions in coding and non-coding regions of mRNAs. Genomics (2012) 0.89

Alloantigen-specific killing is mediated by CD8-positive T cells in fish. Dev Comp Immunol (2008) 0.89

Quantitative whole-cell proteome analysis of pseudorabies virus-infected cells. J Virol (2008) 0.89

Pseudorabies virus particles lacking tegument proteins pUL11 or pUL16 incorporate less full-length pUL36 than wild-type virus, but specifically accumulate a pUL36 N-terminal fragment. J Gen Virol (2006) 0.89

Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J Virol Methods (2009) 0.89

Efficient incorporation of tegument proteins pUL46, pUL49, and pUS3 into pseudorabies virus particles depends on the presence of pUL21. J Virol (2006) 0.88

Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish. Dev Comp Immunol (2011) 0.88

Molecular cloning of C4 gene and identification of the class III complement region in the shark MHC. J Immunol (2003) 0.88

Proteomics reveals potential biomarkers of seed vigor in sugarbeet. Proteomics (2011) 0.88

A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells. J Biol Chem (2012) 0.88

Classical MHC class I genes composed of highly divergent sequence lineages share a single locus in rainbow trout (Oncorhynchus mykiss). J Immunol (2002) 0.87

Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Biochim Biophys Acta (2010) 0.86

Association of MR1 protein, an MHC class I-related molecule, with beta(2)-microglobulin. Biochem Biophys Res Commun (2002) 0.85

Cell-mediated cytotoxicity in rainbow trout, Oncorhynchus mykiss, infected with viral haemorrhagic septicaemia virus. Fish Shellfish Immunol (2006) 0.85

Identification and transcript analysis of a novel wallaby (Macropus eugenii) basal-like breast cancer cell line. Mol Cancer (2008) 0.84

Characterization and localization of side population (SP) cells in zebrafish kidney hematopoietic tissue. Blood (2007) 0.84

A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes. Immunogenetics (2010) 0.84

Development of an oral vaccine for immunisation of rainbow trout (Oncorhynchus mykiss) against viral haemorrhagic septicaemia. Vaccine (2007) 0.84

Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii). Vet Immunol Immunopathol (2007) 0.84

Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants. Funct Integr Genomics (2009) 0.83

Characterization of twin toll-like receptors from rainbow trout (Oncorhynchus mykiss): evolutionary relationship and induced expression by Aeromonas salmonicida salmonicida. Dev Comp Immunol (2006) 0.83

Pigment-producing granulomatous myopathy in Atlantic salmon: a novel inflammatory response. Fish Shellfish Immunol (2012) 0.83

Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. Biochem J (2002) 0.83

Molecular evolution of monotreme and marsupial whey acidic protein genes. Evol Dev (2007) 0.83

A novel immunoglobulin-like transcript from rainbow trout with two Ig-like domains and two isoforms. Mol Immunol (2007) 0.83

Tollip, a negative regulator of TLR-signalling, is encoded by twin genes in salmonid fish. Fish Shellfish Immunol (2008) 0.82

Isoform-specific downregulation of peroxiredoxin in human failing myocardium. Life Sci (2007) 0.82

Isolation, purification, characterization and glycan-binding profile of a d-galactoside specific lectin from the marine sponge, Halichondria okadai. Comp Biochem Physiol B Biochem Mol Biol (2008) 0.82

Evaluation of baculovirus-derived recombinant 53-kDa protein of Trichinella spiralis for detection of Trichinella-specific antibodies in domestic pigs by ELISA. Parasitol Res (2006) 0.82

Cytotoxicity and glycan-binding profile of a D-galactose-binding lectin from the eggs of a Japanese sea hare (Aplysia kurodai). Protein J (2011) 0.81

EXP-PAC: providing comparative analysis and storage of next generation gene expression data. Genomics (2012) 0.81

Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937. Biochim Biophys Acta (2011) 0.81

Cell-mediated immune responses in rainbow trout after DNA immunization against the viral hemorrhagic septicemia virus. Dev Comp Immunol (2007) 0.80

Investigations on the ORF 167L of lymphocystis disease virus (Iridoviridae). Virus Genes (2004) 0.80

Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA. Vet Immunol Immunopathol (2009) 0.80

The MHC class I linkage group is a major determinant in the in vivo rejection of allogeneic erythrocytes in rainbow trout (Oncorhynchus mykiss). Immunogenetics (2003) 0.80

Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. Biochim Biophys Acta (2005) 0.79

Molecular cloning and preliminary expression analysis of banded dogfish (Triakis scyllia) TNF decoy receptor 3 (TNFRSF6B). Fish Shellfish Immunol (2007) 0.79

Developmental changes of gene expression after spinal cord injury in neonatal opossums. Brain Res (2010) 0.79

A novel porcine in vitro model of the blood-cerebrospinal fluid barrier with strong barrier function. PLoS One (2012) 0.79

Cytotoxicity and glycan-binding properties of an 18 kDa lectin isolated from the marine sponge Halichondria okadai. Toxins (Basel) (2012) 0.78

The C3 subtypes are differentially regulated after immunostimulation in rainbow trout, but head kidney macrophages do not contribute to C3 transcription. Vet Immunol Immunopathol (2007) 0.78

Contrasted TCRβ diversity of CD8+ and CD8- T cells in rainbow trout. PLoS One (2013) 0.78

Transcript profiles uncover temporal and stress-induced changes of metabolic pathways in germinating sugar beet seeds. BMC Plant Biol (2008) 0.78

Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase. Mol Immunol (2007) 0.77

The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol (2003) 0.77

The rainbow trout classical MHC class I molecule Onmy-UBA*501 is expressed in similar cell types as mammalian classical MHC class I molecules. Fish Shellfish Immunol (2003) 0.77

Glycomics of a novel type-2 N-acetyllactosamine-specific lectin purified from the feather star, Oxycomanthus japonicus (Pelmatozoa: Crinoidea). Comp Biochem Physiol B Biochem Mol Biol (2010) 0.77

MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after VHSV infection. Fish Shellfish Immunol (2011) 0.77

Identification and functional characterization of a novel monotreme- specific antibacterial protein expressed during lactation. PLoS One (2013) 0.77

Influence of insertion site of the avian influenza virus haemagglutinin (HA) gene within the Newcastle disease virus genome on HA expression. J Gen Virol (2010) 0.77

Gene expression profiling of Pseudorabies virus (PrV) infected bovine cells by combination of transcript analysis and quantitative proteomic techniques. Vet Microbiol (2010) 0.77

Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody. J Biochem (2010) 0.77

[Relationship between cytokine concentration and activities of daily living in rehabilitation patients with stroke]. Rinsho Byori (2007) 0.77

Molecular evolution of a novel marsupial S100 protein (S100A19) which is expressed at specific stages of mammary gland and gut development. Mol Phylogenet Evol (2013) 0.77

Contrast-enhanced high in-plane resolution dynamic MRI of the breast. Are there advantages in comparison to standard dynamic MRI? Clin Imaging (2002) 0.77

Zinc-dependent binding between peptides derived from rainbow trout CD8alpha and LCK. Fish Shellfish Immunol (2009) 0.76

A multicolour flow cytometry identifying defined leukocyte subsets of rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol (2013) 0.76

Amino acid sequence and characterization of C-type lectin purified from the snake venom of Crotalus ruber. Comp Biochem Physiol B Biochem Mol Biol (2006) 0.76

Acute involution in the tammar wallaby: identification of genes and putative novel milk proteins implicated in mammary gland function. Genomics (2011) 0.76

Keratin function and regulation in tissue homeostasis and pathogenesis. Biomol Concepts (2012) 0.76