Published in J Leukoc Biol on November 01, 2002
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood (2008) 3.52
Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut (2006) 1.47
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med (2013) 1.39
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses. J Exp Med (2006) 1.36
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med (2005) 1.35
New insights into the pathogenesis and genetics of psoriatic arthritis. Nat Clin Pract Rheumatol (2009) 1.35
A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis. J Interferon Cytokine Res (2011) 1.12
Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy. J Biomed Biotechnol (2011) 1.09
Genetic basis of alopecia areata: a roadmap for translational research. Dermatol Clin (2012) 1.03
Melanoma-restricted genes. J Transl Med (2004) 1.03
Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model. J Transl Med (2006) 1.02
Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for IL-15Rα. Immunogenetics (2013) 1.01
Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol (2005) 0.96
Cloning and characterization of deer mouse (Peromyscus maniculatus) cytokine and chemokine cDNAs. BMC Immunol (2004) 0.95
Generation of a novel regulatory NK cell subset from peripheral blood CD34+ progenitors promoted by membrane-bound IL-15. PLoS One (2008) 0.90
Role of IL-21 and IL-21 receptor on B cells in HIV infection. Crit Rev Immunol (2012) 0.90
Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells. Immunology (2011) 0.89
Role of interleukin-21 in HBV infection: friend or foe? Cell Mol Immunol (2014) 0.87
IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms. J Immunol (2012) 0.86
Persistent humoral immune responses in the CNS limit recovery of reactivated murine cytomegalovirus. PLoS One (2012) 0.86
Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection. Immunology (2007) 0.85
The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. PLoS One (2015) 0.84
Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study. J Immunother Cancer (2014) 0.83
CD28 is not directly involved in the response of human CD3- CD56+ natural killer cells to lipopolysaccharide: a role for T cells. Immunology (2004) 0.83
Interleukin-21 suppresses the differentiation and functions of T helper 2 cells. Immunology (2015) 0.83
The role of interleukin-21 in HIV infection. Cytokine Growth Factor Rev (2012) 0.81
Exclusion of IL-21 in the pathogenesis of OVA-induced asthma in mice. Int J Clin Exp Med (2014) 0.81
Elevated serum IL-21 levels in hantavirus-infected patients correlate with the severity of the disease. Inflammation (2014) 0.80
IL-21 receptor expression in human tendinopathy. Mediators Inflamm (2014) 0.79
Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R. Haematologica (2015) 0.79
Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility. World J Gastroenterol (2014) 0.79
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2. Nat Commun (2017) 0.79
Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny. Immunogenetics (2004) 0.78
Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells. Clin Exp Immunol (2013) 0.78
Cytokine crowdsourcing: multicellular production of TH17-associated cytokines. J Leukoc Biol (2014) 0.78
IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis. Mucosal Immunol (2016) 0.77
IL-21 does not involve in OVA-induced airway remodeling and chronic airway inflammation. Int J Clin Exp Med (2015) 0.77
Human peripheral neutrophils express functional IL-21 receptors. Inflammation (2014) 0.77
Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma. Oncol Lett (2014) 0.76
A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane. Genes Immun (2015) 0.76
IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol (2015) 0.76
Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL. Int J Mol Med (2016) 0.75
Serum IL-21 levels associated with chronic hepatitis B and hepatitis B-related liver failure. Exp Ther Med (2014) 0.75
Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis. Springerplus (2016) 0.75
Interleukin-21 overexpression dominates T cell response to Epstein-Barr virus in a fatal case of X-linked lymphoproliferative syndrome type 1. Clin Vaccine Immunol (2013) 0.75
Technical Considerations for the Generation of Adoptively Transferred T Cells in Cancer Immunotherapy. Cancers (Basel) (2016) 0.75
Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology (2006) 3.46
Interleukin-21 inhibits dendritic cell activation and maturation. Blood (2003) 2.00
Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem (2002) 1.89
A synthetic adjuvant to enhance and expand immune responses to influenza vaccines. PLoS One (2010) 1.57
IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J Immunol (2004) 1.56
Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood (2002) 1.50
Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J Invest Dermatol (2003) 1.10
Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost (2005) 1.10
Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model. J Transl Med (2006) 1.02
Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. Oncogene (2003) 1.02
Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. Immunology (2004) 0.88
Physiological and chemical inducers of tissue factor pathway inhibitor-2 in human glioma cells. Int J Oncol (2003) 0.83
Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. Oncogene (2002) 0.77