Published in Mol Microbiol on November 27, 2013
Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. FEMS Microbiol Rev (2016) 0.88
Biofilms formed by gram-negative bacteria undergo increased lipid a palmitoylation, enhancing in vivo survival. MBio (2014) 0.84
Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS two-component system. Mol Microbiol (2015) 0.84
Mutant Alleles of lptD Increase the Permeability of Pseudomonas aeruginosa and Define Determinants of Intrinsic Resistance to Antibiotics. Antimicrob Agents Chemother (2015) 0.82
Characterization of Pseudomonas aeruginosa LpxT reveals dual positional lipid A kinase activity and co-ordinated control of outer membrane modification. Mol Microbiol (2014) 0.82
Site-specific activity of the acyltransferases HtrB1 and HtrB2 in Pseudomonas aeruginosa lipid A biosynthesis. Pathog Dis (2015) 0.76
Polymorphic Regulation of Outer Membrane Lipid A Composition. MBio (2016) 0.75
Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship. Biochim Biophys Acta (2017) 0.75
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem (2010) 25.20
I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc (2010) 22.66
I-TASSER server for protein 3D structure prediction. BMC Bioinformatics (2008) 18.28
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature (2009) 8.99
Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem (2007) 8.60
A 10-min method for preparation of highly electrocompetent Pseudomonas aeruginosa cells: application for DNA fragment transfer between chromosomes and plasmid transformation. J Microbiol Methods (2005) 6.02
FFAS03: a server for profile--profile sequence alignments. Nucleic Acids Res (2005) 4.99
Cystic fibrosis. Am J Respir Crit Care Med (1996) 4.56
Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides. Cell (1998) 4.42
Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science (1999) 3.98
Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res (2001) 3.46
A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest (1996) 2.94
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol (2004) 2.80
Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des (2010) 2.67
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria. EMBO J (2000) 2.64
Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate. J Biol Chem (1999) 2.56
Detergent-accelerated hydrolysis of bacterial endotoxins and determination of the anomeric configuration of the glycosyl phosphate present in the "isolated lipid A" fragment of the Bordetella pertussis endotoxin. Carbohydr Res (1988) 2.55
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective. Nat Rev Microbiol (2012) 2.50
Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A (2002) 2.39
Variation in lipid A structure in the pathogenic yersiniae. Mol Microbiol (2004) 2.28
Diversity of endotoxin and its impact on pathogenesis. J Endotoxin Res (2006) 2.24
Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity. Microbes Infect (2001) 1.91
Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis. Nat Rev Microbiol (2013) 1.88
Isolation and characterization of eight lipid A precursors from a 3-deoxy-D-manno-octylosonic acid-deficient mutant of Salmonella typhimurium. J Biol Chem (1985) 1.67
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin. EMBO J (2004) 1.60
Position of ester groups in the lipid A backbone of lipopolysaccharides obtained from Salmonella typhimurium. J Biol Chem (1983) 1.57
Microextraction of bacterial lipid A: easy and rapid method for mass spectrometric characterization. J Lipid Res (2005) 1.53
Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection. Infect Immun (2001) 1.50
The lipid A palmitoyltransferase PagP: molecular mechanisms and role in bacterial pathogenesis. Mol Microbiol (2005) 1.49
Purification and mass spectrometry of six lipid A species from the bacterial endosymbiont Rhizobium etli. Demonstration of a conserved distal unit and a variable proximal portion. J Biol Chem (2000) 1.40
Biosynthesis, transport, and modification of lipid A. Biochem Cell Biol (2004) 1.40
The bordetellae: lessons from genomics. Nat Rev Microbiol (2004) 1.37
Induction of human interleukin 1 by bacterial and synthetic lipid A. Eur J Immunol (1986) 1.36
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients. Antimicrob Agents Chemother (2011) 1.33
PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients. Antimicrob Agents Chemother (2011) 1.32
Structural and functional analyses of bacterial lipopolysaccharides. Microbes Infect (2002) 1.30
Tandem mass spectrometry of glycolipids. Methods Enzymol (1990) 1.26
Characterization of lipopolysaccharide-deficient mutants of Pseudomonas aeruginosa derived from serotypes O3, O5, and O6. Infect Immun (1994) 1.24
A protocol for computer-based protein structure and function prediction. J Vis Exp (2011) 1.23
Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis. J Infect Dis (2007) 1.19
Salmonella-type heptaacylated lipid A is inactive and acts as an antagonist of lipopolysaccharide action on human line cells. J Immunol (2000) 1.19
Gauging a hydrocarbon ruler by an intrinsic exciton probe. Biochemistry (2007) 1.14
Induction of tumor necrosis factor-alpha release by lipopolysaccharide and defined lipopolysaccharide partial structures. Immunobiology (1989) 1.12
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. Structure (2010) 1.09
Associations of Escherichia coli K-12 OmpF trimers with rough and smooth lipopolysaccharides. J Bacteriol (1990) 1.05
Temperature-dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defenses. Infect Immun (2011) 1.02
The role of Pseudomonas lipopolysaccharide in cystic fibrosis airway infection. Subcell Biochem (2010) 0.99
Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4. J Endotoxin Res (2004) 0.98
Bacterial lipopolysaccharides--themes and variations. Prog Lipid Res (1996) 0.98
Comparison of the capacity of two lipid A precursor molecules to express the local Shwartzman phenomenon. Infect Immun (1985) 0.97
Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid (Kdo) core determines bacterial association of secreted toxins. J Biol Chem (2003) 0.94
Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant. Infect Immun (2011) 0.85
A thiolate anion buried within the hydrocarbon ruler perturbs PagP lipid acyl chain selection. Biochemistry (2010) 0.85
Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface. Proc Natl Acad Sci U S A (2012) 0.83
Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses. Mol Biosyst (2013) 0.80
Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation. Biochemistry (2010) 0.78
Characterization of protonated phospholipids as fragile ions in quadrupole ion trap mass spectrometry. Int J Mass Spectrom (2011) 0.76
Hybrid error correction and de novo assembly of single-molecule sequencing reads. Nat Biotechnol (2012) 10.31
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol (2006) 9.64
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A (2006) 8.85
Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem (2007) 8.60
Salmonellae interplay with host cells. Nat Rev Microbiol (2008) 5.26
LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol (2005) 5.25
Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species. PLoS Biol (2005) 5.22
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A (2005) 5.02
Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment. Nature (2004) 5.00
A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe (2010) 4.98
Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species. Nucleic Acids Res (2004) 4.97
Coordinate regulation of energy transduction modules in Halobacterium sp. analyzed by a global systems approach. Proc Natl Acad Sci U S A (2002) 4.96
Aminoglycoside antibiotics induce bacterial biofilm formation. Nature (2005) 4.93
Recognition of antimicrobial peptides by a bacterial sensor kinase. Cell (2005) 4.78
Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax. Proc Natl Acad Sci U S A (2004) 4.73
Assigning function to yeast proteins by integration of technologies. Mol Cell (2003) 4.58
Multiple antimicrobial resistance in plague: an emerging public health risk. PLoS One (2007) 4.21
Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat Immunol (2002) 3.56
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science (2013) 3.56
Automated prediction of CASP-5 structures using the Robetta server. Proteins (2003) 3.41
Genetic basis of proteome variation in yeast. Nat Genet (2007) 3.04
Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins (2007) 3.01
Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A (2008) 2.99
Anopheles NF-κB-regulated splicing factors direct pathogen-specific repertoires of the hypervariable pattern recognition receptor AgDscam. Cell Host Microbe (2012) 2.88
De novo prediction of three-dimensional structures for major protein families. J Mol Biol (2002) 2.88
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol (2007) 2.87
Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res (2006) 2.85
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res (2006) 2.84
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol (2004) 2.80
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol (2007) 2.68
Factors affecting the escape of Francisella tularensis from the phagolysosome. J Med Microbiol (2004) 2.57
Experimental protein mixture for validating tandem mass spectral analysis. OMICS (2002) 2.54
Cyclic di-GMP as a bacterial second messenger. Microbiology (2004) 2.54
Defining genomic islands and uropathogen-specific genes in uropathogenic Escherichia coli. J Bacteriol (2007) 2.50
The study of macromolecular complexes by quantitative proteomics. Nat Genet (2003) 2.44
Molecular mechanisms of enterotoxigenic Escherichia coli infection. Microbes Infect (2009) 2.39
Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A (2002) 2.39
Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Science (2012) 2.34
Variation in lipid A structure in the pathogenic yersiniae. Mol Microbiol (2004) 2.28
Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone. Mol Cell Proteomics (2004) 2.22
Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape. Gastroenterology (2005) 2.21
Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Cell Host Microbe (2008) 2.21
Structural characterization of the molecular platform for type III secretion system assembly. Nature (2005) 2.20
Mass spectrometry based targeted protein quantification: methods and applications. J Proteome Res (2009) 2.20
The Yeast Resource Center Public Data Repository. Nucleic Acids Res (2005) 2.19
Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol (2004) 2.19
Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun (2006) 2.18
A mouse macrophage lipidome. J Biol Chem (2010) 2.14
Formation and composition of the Bacillus anthracis endospore. J Bacteriol (2004) 2.12
Free modeling with Rosetta in CASP6. Proteins (2005) 2.10
Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol (2012) 2.10
A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe (2012) 2.08
Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol (2011) 2.08
Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence. Infect Immun (2009) 2.07
LPS remodeling is an evolved survival strategy for bacteria. Proc Natl Acad Sci U S A (2012) 2.05
Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis. Trends Microbiol (2011) 2.03
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Nat Struct Mol Biol (2009) 2.02
Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides. Mol Microbiol (2003) 2.01
Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division. Science (2010) 1.99
Activation of the bacterial sensor kinase PhoQ by acidic pH. Mol Cell (2007) 1.98
Precursor acquisition independent from ion count: how to dive deeper into the proteomics ocean. Anal Chem (2009) 1.96
Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2006) 1.95
Prediction of CASP6 structures using automated Robetta protocols. Proteins (2005) 1.94
Synthesis of novel substituted tetrazoles having antifungal activity. Eur J Med Chem (2004) 1.92
A comparative genomic analysis of diverse clonal types of enterotoxigenic Escherichia coli reveals pathovar-specific conservation. Infect Immun (2010) 1.92
openBIS: a flexible framework for managing and analyzing complex data in biology research. BMC Bioinformatics (2011) 1.91
Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One (2010) 1.90
Quantitative proteomic analysis of Myc oncoprotein function. EMBO J (2002) 1.89
A microcapillary trap cartridge-microcapillary high-performance liquid chromatography electrospray ionization emitter device capable of peptide tandem mass spectrometry at the attomole level on an ion trap mass spectrometer with automated routine operation. Rapid Commun Mass Spectrom (2003) 1.85
Type IV pili-mediated secretion modulates Francisella virulence. Mol Microbiol (2006) 1.83
Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Mol Cell (2008) 1.82
Comparative metaproteomics reveals ocean-scale shifts in microbial nutrient utilization and energy transduction. ISME J (2010) 1.80
The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis. BMC Genomics (2011) 1.79
Approaching complete peroxisome characterization by gas-phase fractionation. Electrophoresis (2002) 1.78
The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature (2013) 1.78
Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease. Inflamm Bowel Dis (2015) 1.74
Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. J Cyst Fibros (2008) 1.71
PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium. J Bacteriol (2007) 1.70
Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis. Environ Microbiol (2003) 1.68
3-O-deacylation of lipid A by PagL, a PhoP/PhoQ-regulated deacylase of Salmonella typhimurium, modulates signaling through Toll-like receptor 4. J Biol Chem (2004) 1.67
Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes. Infect Immun (2007) 1.66
Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes. Am J Respir Crit Care Med (2014) 1.66
Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activities. Cell Microbiol (2009) 1.66
Escherichia coli global gene expression in urine from women with urinary tract infection. PLoS Pathog (2010) 1.65