Published in Proc Natl Acad Sci U S A on November 01, 1986
Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc Natl Acad Sci U S A (1997) 2.48
Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes. J Gen Physiol (1989) 1.69
Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A (2004) 1.67
Control of daily transcript oscillations in Drosophila by light and the circadian clock. PLoS Genet (2006) 1.58
Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila. Genetics (2002) 1.34
Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endings. J Physiol (1999) 1.32
Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability. Genetics (2004) 1.20
A BK (Slo1) channel journey from molecule to physiology. Channels (Austin) (2013) 1.17
Regulation of synaptic transmission by presynaptic CaMKII and BK channels. Mol Neurobiol (2008) 1.15
Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics (1998) 1.14
Homeotic control in Drosophila; the scabrous gene is an in vivo target of Ultrabithorax proteins. EMBO J (1992) 1.12
A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce. Proc Natl Acad Sci U S A (1991) 1.10
Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD. Am J Physiol Renal Physiol (2011) 1.05
Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A (2007) 1.04
SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. PLoS Pathog (2011) 1.01
The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons. Neural Dev (2006) 1.00
BK channel opening involves side-chain reorientation of multiple deep-pore residues. Proc Natl Acad Sci U S A (2013) 0.95
SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics. Invert Neurosci (2007) 0.94
Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity. J Neurosci (2012) 0.93
The LIM-homeodomain protein islet dictates motor neuron electrical properties by regulating K(+) channel expression. Neuron (2012) 0.90
The fundamentals of flying: simple and inexpensive strategies for employing Drosophila genetics in neuroscience teaching laboratories. J Undergrad Neurosci Educ (2012) 0.89
In vivo role of a potassium channel-binding protein in regulating neuronal excitability and behavior. J Neurosci (2009) 0.89
Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila. J Neurosci (2010) 0.89
In vivo functional role of the Drosophila hyperkinetic beta subunit in gating and inactivation of Shaker K+ channels. Biophys J (1996) 0.88
Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. PLoS Genet (2010) 0.87
dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genet (2012) 0.84
BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart Circ Physiol (2014) 0.84
Segmental differences in firing properties and potassium currents in Drosophila larval motoneurons. J Neurophysiol (2011) 0.84
Effects of social isolation on neuromuscular excitability and aggressive behaviors in Drosophila: altered responses by Hk and gsts1, two mutations implicated in redox regulation. J Neurogenet (2009) 0.83
Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response. Dev Neurobiol (2013) 0.82
Blurring the boundaries: developmental and activity-dependent determinants of neural circuits. Trends Neurosci (2013) 0.81
Novel embryonic regulation of Ca(2+)-activated K+ channel expression in Drosophila. Invert Neurosci (1997) 0.81
Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside. PLoS Negl Trop Dis (2014) 0.81
SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila. PLoS One (2011) 0.81
An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron. Am J Physiol Cell Physiol (2015) 0.79
Slob, a Slowpoke channel-binding protein, modulates synaptic transmission. J Gen Physiol (2011) 0.79
Ways and means for left shifts in the MaxiK channel. Proc Natl Acad Sci U S A (1997) 0.79
An improved method for accurate and rapid measurement of flight performance in Drosophila. J Vis Exp (2014) 0.79
Potassium transport in the maturing kidney. Pediatr Nephrol (2007) 0.79
Effects of manipulating slowpoke calcium-dependent potassium channel expression on rhythmic locomotor activity in Drosophila larvae. PeerJ (2013) 0.78
Expression of Drosophila Shaker potassium channels in mammalian cells infected with recombinant vaccinia virus. Proc Natl Acad Sci U S A (1989) 0.78
Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. J Physiol (2015) 0.77
δ/ω-Plectoxin-Pt1a: an excitatory spider toxin with actions on both Ca(2+) and Na(+) channels. PLoS One (2013) 0.77
De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics (2016) 0.77
Effects of mutant Drosophila K+ channel subunits on habituation of the olfactory jump response. J Neurogenet (2007) 0.77
Cell-specific fine-tuning of neuronal excitability by differential expression of modulator protein isoforms. J Neurosci (2013) 0.76
The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits. PLoS Negl Trop Dis (2015) 0.76
Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ. J Neurophysiol (2014) 0.76
Sodium-dependent potassium channels in leech P neurons. J Membr Biol (2005) 0.76
Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP. Front Mol Neurosci (2017) 0.75
Profile of Barry Ganetzky. Proc Natl Acad Sci U S A (2007) 0.75
Cell-specific regulation of L-WNK1 by dietary K. Am J Physiol Renal Physiol (2015) 0.75
Functional upregulation of Ca(2+)-activated K(+) channels in the development of substantia nigra dopamine neurons. PLoS One (2012) 0.75
Cloning and distribution of Ca2+-activated K+ channels in lobster Panulirus interruptus. Neuroscience (2010) 0.75
Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic. eNeuro (2016) 0.75
S0, where is it? J Gen Physiol (2008) 0.75
Melatonin increases the regularity of cardiac rhythmicity in the Drosophila heart in both wild-type and strains bearing pathogenic mutations. J Comp Physiol B (2016) 0.75
Three pharmacologically distinct potassium channels in molluscan neurones. J Physiol (1977) 7.03
Classical conditioning and retention in normal and mutant Drosophila melanogaster. J Comp Physiol A (1985) 6.72
Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox. J Physiol (1975) 5.09
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature (1985) 4.95
Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones. Nature (1982) 4.57
Apamin blocks certain neurotransmitter-induced increases in potassium permeability. Nature (1979) 3.93
Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proc Natl Acad Sci U S A (1985) 3.66
Genetic dissection of behavior. Sci Am (1973) 2.93
Two mutations of synaptic transmission in Drosophila. Proc R Soc Lond B Biol Sci (1977) 2.60
Potassium current suppression by quinidine reveals additional calcium currents in neuroblastoma cells. Proc Natl Acad Sci U S A (1981) 2.45
Motor outputs of giant nerve fiber in Drosophila. J Neurophysiol (1980) 2.44
Action potential repolarization may involve a transient, Ca2+-sensitive outward current in a vertebrate neurone. Nature (1982) 2.36
Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet (1983) 1.91
Genetic modification of potassium channels in Drosophila Shaker mutants. Nature (1981) 1.89
Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants. J Neurosci (1985) 1.60
Abnormal action potentials associated with the Shaker complex locus of Drosophila. Proc Natl Acad Sci U S A (1981) 1.60
Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing. J Neurophysiol (1982) 1.58
A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc Natl Acad Sci U S A (1978) 1.57
Modulation of single Ca2+-dependent K+-channel activity by protein phosphorylation. Nature (1985) 1.55
Ca2+ -activated K+ conductance in internally perfused snail neurons is enhanced by protein phosphorylation. Proc Natl Acad Sci U S A (1982) 1.33
Restoration by calmodulin of a Ca2+-dependent K+ current missing in a mutant of Paramecium. Science (1986) 1.30
Ion currents in Drosophila flight muscles. J Physiol (1983) 1.22
Calcium and potassium currents in muscle fibres of an insect (Carausius morosus). J Physiol (1982) 1.21
Mutant analysis shows that the Ca2+-induced K+ current shuts off one type of excitation in Paramecium. Proc Natl Acad Sci U S A (1983) 1.19
Apamin, a neurotoxin specific for one class of Ca2+-dependent K+ channels. Cell Calcium (1983) 1.19
Drosophila mutants reveal two components of fast outward current. Nature (1983) 1.16
Genetic manipulation of motor output in shaker mutants of Drosophila. J Neurobiol (1973) 1.03
A 'TEA+-insensitive' mutant with increased potassium conductance in Paramecium aurelia. J Exp Biol (1976) 0.96
HERG, a human inward rectifier in the voltage-gated potassium channel family. Science (1995) 7.26
A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A (1994) 5.77
A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science (1991) 4.94
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J Comp Physiol A (1994) 4.24
Functional role of the beta subunit of high conductance calcium-activated potassium channels. Neuron (1995) 3.75
A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science (1991) 3.26
The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell (1991) 2.98
Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron (2000) 2.87
Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron (1998) 2.78
Molecular analysis of the para locus, a sodium channel gene in Drosophila. Cell (1989) 2.78
On the components of segregation distortion in Drosophila melanogaster. Genetics (1977) 2.56
Morphological plasticity of motor axons in Drosophila mutants with altered excitability. J Neurosci (1990) 2.48
DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli. J Bacteriol (2001) 2.40
Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Science (1999) 2.29
Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae. J Neurobiol (1993) 2.23
Arrhythmias and the "Holiday Heart": alcohol-associated cardiac rhythm disorders. Am Heart J (1978) 2.06
Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen Physiol (1997) 1.99
Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. Hum Mol Genet (1994) 1.99
Nuclear mislocalization of enzymatically active RanGAP causes segregation distortion in Drosophila. Dev Cell (2001) 1.99
Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron (1998) 1.96
Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER. Genetics (1982) 1.95
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Nature (1999) 1.93
Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet (1983) 1.91
The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing. Neuron (2000) 1.82
Potassium currents in Drosophila: different components affected by mutations of two genes. Science (1983) 1.76
Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell (1997) 1.75
Effects of kinesin mutations on neuronal functions. Science (1992) 1.69
Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels. Science (1991) 1.69
RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. Genetics (2000) 1.67
On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus. Genetics (1983) 1.63
Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science (1991) 1.62
Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants. J Neurosci (1985) 1.60
Factors influencing views of patients with gynecologic cancer about end-of-life decisions. Am J Obstet Gynecol (1997) 1.60
Alteration of four identified K+ currents in Drosophila muscle by mutations in eag. Science (1991) 1.59
Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing. J Neurophysiol (1982) 1.58
A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc Natl Acad Sci U S A (1978) 1.57
A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus. Proc Natl Acad Sci U S A (1995) 1.52
Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg (2000) 1.51
Altered habituation of an identified escape circuit in Drosophila memory mutants. J Neurosci (1996) 1.47
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. J Neurosci (2001) 1.45
On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster. Exp Gerontol (1978) 1.44
Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster. Nature (1980) 1.42
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Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade. J Neurosci (1992) 1.41
A Drosophila NSF mutant. Nature (1995) 1.39
Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies. Proc Natl Acad Sci U S A (1987) 1.37
Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila. Proc Natl Acad Sci U S A (1994) 1.36
Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes. Neuropharmacology (1996) 1.35
Genetic studies of membrane excitability in Drosophila: lethal interaction between two temperature-sensitive paralytic mutations. Genetics (1984) 1.33
Neurogenetics of membrane excitability in Drosophila. Annu Rev Genet (1986) 1.33
Modulation of different K+ currents in Drosophila: a hypothetical role for the Eag subunit in multimeric K+ channels. J Neurosci (1993) 1.32
Dissociated neurons from normal and mutant Drosophila larval central nervous system in cell culture. J Neurosci (1983) 1.30
Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. Neuron (2001) 1.30
On the components of segregation distortion in Drosophila melanogaster. IV. Construction and analysis of free duplications for the Responder locus. Genetics (1989) 1.30
Neurogenetic studies of ion channels in Drosophila. Ion Channels (1992) 1.30
The Drosophila erg K+ channel polypeptide is encoded by the seizure locus. J Neurosci (1997) 1.29
napts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription. Cell (1991) 1.29
Detection of Rsp and modifier variation in the meiotic drive system Segregation distorter (SD) of Drosophila melanogaster. Genetics (1986) 1.26
Reversible inhibition of endocytosis in cultured neurons from the Drosophila temperature-sensitive mutant shibirets1. J Neurogenet (1990) 1.25
Morphometric description of the wandering behavior in Drosophila larvae: aberrant locomotion in Na+ and K+ channel mutants revealed by computer-assisted motion analysis. J Neurogenet (1997) 1.24
Allelic interactions at the shibire locus of Drosophila: effects on behavior. J Neurogenet (1990) 1.23
Differential physiology and morphology of motor axons to ventral longitudinal muscles in larval Drosophila. J Comp Neurol (1994) 1.23
Reversible blockage of neurite development and growth cone formation in neuronal cultures of a temperature-sensitive mutant of Drosophila. J Neurosci (1987) 1.23
Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para. Genetics (1995) 1.22
Frequency characteristics in the visual system of Drosophila: genetic dissection of electroretinogram components. J Gen Physiol (1977) 1.21
Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability. Genetics (1990) 1.21
On the components of segregation distortion in Drosophila melanogaster. V. Molecular analysis of the Sd locus. Genetics (1991) 1.20
Spatial and temporal expression patterns of two sodium channel genes in Drosophila. J Neurosci (1994) 1.19
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion. Proc Natl Acad Sci U S A (2001) 1.19
Expression of ion channels and mutational effects in giant Drosophila neurons differentiated from cell division-arrested embryonic neuroblasts. J Neurosci (1991) 1.17
Functional analysis of a mouse brain Elk-type K+ channel. J Neurosci (1999) 1.17
Photoreceptor mutant of Drosophia: is protein involved in intermediate steps of phototransduction? Science (1976) 1.16
Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J Neurosci (1994) 1.15
Two-stage design of quantal response studies. Biometrics (1999) 1.15
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides. Mol Gen Genet (1997) 1.15
Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster. Genetics (1991) 1.13
Altered synaptic transmission in Drosophila hyperkinetic mutants. J Neurogenet (1989) 1.10
A novel leg-shaking Drosophila mutant defective in a voltage-gated K(+)current and hypersensitive to reactive oxygen species. J Neurosci (2000) 1.10
Altered branching of serotonin-containing neurons in Drosophila mutants unable to synthesize serotonin and dopamine. J Neurosci (1989) 1.09
Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants. J Neurosci (2000) 1.07
Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses. Neuron (1994) 1.07
Quantal basis of photoreceptor spectral sensitivity of Drosophila melanogaster. J Gen Physiol (1975) 1.06
Light-induced voltage noise in the photoreceptor of Drosophila melanogaster. J Gen Physiol (1978) 1.06
Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila. J Neurosci (1998) 1.06
A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila. J Neurosci (1990) 1.04
Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila. J Comp Physiol A (1992) 1.04
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3. J Neurosci (2001) 1.03
Heteromultimeric interactions among K+ channel subunits from Shaker and eag families in Xenopus oocytes. Neuron (1996) 1.03
Neuronal polymorphism among natural alleles of a cGMP-dependent kinase gene, foraging, in Drosophila. J Neurosci (1999) 1.03
Identification and characterization of inebriated, a gene affecting neuronal excitability in Drosophila. J Neurogenet (1992) 1.02
Evidence that the Drosophila olfactory mutant smellblind defines a novel class of sodium channel mutation. Genetics (1994) 1.02
The roles of potassium currents in Drosophila flight muscles. J Neurosci (1988) 0.99
HERG sequence correction. Science (1996) 0.99
Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog. J Biol Chem (1995) 0.98