Published in Genetics on July 01, 2000
RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem (2001) 9.66
Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A (2004) 3.58
Insect sodium channels and insecticide resistance. Invert Neurosci (2007) 2.06
Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res (2005) 2.02
Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J Neurosci (2002) 1.80
RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA (2003) 1.70
Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology (2003) 1.67
ADAR editing in double-stranded UTRs and other noncoding RNA sequences. Trends Biochem Sci (2010) 1.63
CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain. Mol Cell Biol (2001) 1.56
RNA editing generates tissue-specific sodium channels with distinct gating properties. J Biol Chem (2004) 1.50
Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Mol Cell (2012) 1.48
An ADAR that edits transcripts encoding ion channel subunits functions as a dimer. EMBO J (2003) 1.40
Tuning of RNA editing by ADAR is required in Drosophila. EMBO J (2005) 1.39
The ADAR protein family. Genome Biol (2012) 1.39
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J (2002) 1.38
Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem (2010) 1.34
Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons. J Neurosci (2008) 1.29
Molecular biology of insect sodium channels and pyrethroid resistance. Insect Biochem Mol Biol (2014) 1.28
ADAR proteins: double-stranded RNA and Z-DNA binding domains. Curr Top Microbiol Immunol (2012) 1.09
Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. Proc Natl Acad Sci U S A (2004) 1.08
Regulated RNA editing and functional epistasis in Shaker potassium channels. J Gen Physiol (2009) 1.07
Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest (2001) 1.07
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr Top Microbiol Immunol (2012) 1.01
Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. Nat Commun (2012) 0.99
Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem (2009) 0.99
Characterization of five RNA editing sites in Shab potassium channels. Channels (Austin) (2008) 0.98
Dark matter RNA: an intelligent scaffold for the dynamic regulation of the nuclear information landscape. Front Genet (2012) 0.88
Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes. PLoS One (2012) 0.87
A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels. Proc Natl Acad Sci U S A (2010) 0.87
Genetic mapping uncovers cis-regulatory landscape of RNA editing. Nat Commun (2015) 0.84
Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes. BMC Evol Biol (2009) 0.84
Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains. RNA (2013) 0.83
The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection. PLoS Genet (2016) 0.79
Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain. RNA Biol (2014) 0.77
RNAi-mediated knockdown of the voltage gated sodium ion channel TcNav causes mortality in Tribolium castaneum. Sci Rep (2016) 0.76
A molecular, phylogenetic and functional study of the dADAR mRNA truncated isoform during Drosophila embryonic development reveals an editing-independent function. Open J Anim Sci (2013) 0.76
Molecular characterization and alternative splicing of a sodium channel and DSC1 ortholog genes in Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae). Int J Biol Sci (2013) 0.75
Large-scale detection and analysis of adenosine-to-inosine RNA editing during development in Plutella xylostella. Mol Genet Genomics (2014) 0.75
Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing. PLoS Genet (2017) 0.75
Adaptation of A-to-I RNA editing in Drosophila. PLoS Genet (2017) 0.75
Acetylcholinesterase 1 in populations of organophosphate-resistant North American strains of the cattle tick, Rhipicephalus microplus (Acari: Ixodidae). Parasitol Res (2015) 0.75
Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem (1991) 8.03
Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature (1997) 7.92
Protein kinase recognition sequence motifs. Trends Biochem Sci (1990) 7.49
An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell (1988) 5.93
RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21
Molecular evolution in Drosophila and the higher Diptera II. A time scale for fly evolution. J Mol Evol (1984) 3.98
A mammalian RNA editing enzyme. Nature (1996) 3.90
Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase. EMBO J (1994) 3.75
A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs. Proc Natl Acad Sci U S A (1989) 3.23
Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron (1993) 3.08
Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science (1995) 2.78
RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J Biol Chem (1996) 2.64
Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA. J Virol (1995) 2.54
RNA editing and hypermutation by adenosine deamination. Trends Biochem Sci (1997) 2.51
A standardized nomenclature for adenosine deaminases that act on RNA. RNA (1997) 2.50
Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts. Proc Natl Acad Sci U S A (1997) 2.33
Substrate specificity of the dsRNA unwinding/modifying activity. EMBO J (1991) 2.18
Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. Proc Natl Acad Sci U S A (1999) 2.08
Structural requirements for RNA editing in glutamate receptor pre-mRNAs by recombinant double-stranded RNA adenosine deaminase. J Biol Chem (1996) 2.06
The importance of internal loops within RNA substrates of ADAR1. J Mol Biol (1999) 1.98
Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc Natl Acad Sci U S A (1996) 1.92
RNA editing generates a diverse array of transcripts encoding squid Kv2 K+ channels with altered functional properties. Neuron (1997) 1.71
Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase. Science (1993) 1.64
Detection of inosine in messenger RNA by inosine-specific cleavage. Biochemistry (1997) 1.62
A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci (1996) 1.57
RNA editing. Annu Rev Neurosci (1996) 1.42
Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila. Proc Natl Acad Sci U S A (1999) 1.37
Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. J Neurosci (1997) 1.30
Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications. J Neurochem (1999) 1.25
Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para. Genetics (1995) 1.22
Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence. Proc Natl Acad Sci U S A (1994) 1.21
A minor fraction of basic fibroblast growth factor mRNA is deaminated in Xenopus stage VI and matured oocytes. RNA (1999) 1.16
Deamination of mammalian glutamate receptor RNA by Xenopus dsRNA adenosine deaminase: similarities to in vivo RNA editing. RNA (1995) 1.13
Sodium current density correlates with expression of specific alternatively spliced sodium channel mRNAs in single neurons. J Neurosci (1995) 1.11
cAMP-dependent phosphorylation of two sites in the alpha subunit of the cardiac sodium channel. J Biol Chem (1996) 1.10
Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes. J Neurosci (1996) 1.05
Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Proc Natl Acad Sci U S A (1996) 1.03
A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. Dev Biol (1997) 0.94
Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer. Nucleic Acids Res (1995) 0.92
RNA editing and alternative splicing generate mRNA transcript diversity from the Drosophila 4f-rnp locus. Gene (1997) 0.91
RNA editing. The long and the short of it. Nature (1996) 0.88
A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs. Mech Dev (1997) 0.85
HERG, a human inward rectifier in the voltage-gated potassium channel family. Science (1995) 7.26
A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A (1994) 5.77
A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science (1991) 4.94
Extended life-span conferred by cotransporter gene mutations in Drosophila. Science (2000) 4.62
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell (2000) 3.86
Functional role of the beta subunit of high conductance calcium-activated potassium channels. Neuron (1995) 3.75
Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics (1994) 3.52
A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science (1991) 3.26
The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell (1991) 2.98
Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron (2000) 2.87
Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron (1998) 2.78
Molecular analysis of the para locus, a sodium channel gene in Drosophila. Cell (1989) 2.78
On the components of segregation distortion in Drosophila melanogaster. Genetics (1977) 2.56
Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Science (1999) 2.29
Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen Physiol (1997) 1.99
Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. Hum Mol Genet (1994) 1.99
Nuclear mislocalization of enzymatically active RanGAP causes segregation distortion in Drosophila. Dev Cell (2001) 1.99
Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron (1998) 1.96
dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. RNA (2000) 1.95
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Nature (1999) 1.93
Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet (1983) 1.91
The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing. Neuron (2000) 1.82
Potassium currents in Drosophila: different components affected by mutations of two genes. Science (1983) 1.76
Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell (1997) 1.75
Effects of kinesin mutations on neuronal functions. Science (1992) 1.69
Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels. Science (1991) 1.69
A Drosophila mutation that eliminates a calcium-dependent potassium current. Proc Natl Acad Sci U S A (1986) 1.66
On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus. Genetics (1983) 1.63
Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing. J Neurophysiol (1982) 1.58
A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc Natl Acad Sci U S A (1978) 1.57
A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus. Proc Natl Acad Sci U S A (1995) 1.52
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. J Neurosci (2001) 1.45
On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster. Exp Gerontol (1978) 1.44
Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster. Nature (1980) 1.42
On the components of segregation distortion in Drosophila melanogaster. III. Nature of enhancer of SD. Genetics (1984) 1.41
A Drosophila NSF mutant. Nature (1995) 1.39
Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes. Neuropharmacology (1996) 1.35
Genetic studies of membrane excitability in Drosophila: lethal interaction between two temperature-sensitive paralytic mutations. Genetics (1984) 1.33
Neurogenetics of membrane excitability in Drosophila. Annu Rev Genet (1986) 1.33
Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. Neuron (2001) 1.30
On the components of segregation distortion in Drosophila melanogaster. IV. Construction and analysis of free duplications for the Responder locus. Genetics (1989) 1.30
Neurogenetic studies of ion channels in Drosophila. Ion Channels (1992) 1.30
The Drosophila erg K+ channel polypeptide is encoded by the seizure locus. J Neurosci (1997) 1.29
napts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription. Cell (1991) 1.29
Detection of Rsp and modifier variation in the meiotic drive system Segregation distorter (SD) of Drosophila melanogaster. Genetics (1986) 1.26
Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para. Genetics (1995) 1.22
Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability. Genetics (1990) 1.21
On the components of segregation distortion in Drosophila melanogaster. V. Molecular analysis of the Sd locus. Genetics (1991) 1.20
Spatial and temporal expression patterns of two sodium channel genes in Drosophila. J Neurosci (1994) 1.19
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion. Proc Natl Acad Sci U S A (2001) 1.19
Functional analysis of a mouse brain Elk-type K+ channel. J Neurosci (1999) 1.17
Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J Neurosci (1994) 1.15
Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta (2006) 1.15
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides. Mol Gen Genet (1997) 1.15
Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster. Genetics (1991) 1.13
Altered synaptic transmission in Drosophila hyperkinetic mutants. J Neurogenet (1989) 1.10
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3. J Neurosci (2001) 1.03
Identification and characterization of inebriated, a gene affecting neuronal excitability in Drosophila. J Neurogenet (1992) 1.02
Evidence that the Drosophila olfactory mutant smellblind defines a novel class of sodium channel mutation. Genetics (1994) 1.02
The roles of potassium currents in Drosophila flight muscles. J Neurosci (1988) 0.99
HERG sequence correction. Science (1996) 0.99
Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog. J Biol Chem (1995) 0.98
Conduction in the giant nerve fiber pathway in temperature-sensitive paralytic mutants of Drosophila. J Neurogenet (1990) 0.97
Neurogenetic analysis of Drosophila mutations affecting sodium channels: synergistic effects on viability and nerve conduction in double mutants involving tip-E. J Neurogenet (1986) 0.97
Interaction of the K channel beta subunit, Hyperkinetic, with eag family members. J Biol Chem (1998) 0.97
Molecular characterization of neurally expressing genes in the para sodium channel gene cluster of drosophila. Genetics (1996) 0.97
Analysis of repolarization of presynaptic motor terminals in Drosophila larvae using potassium-channel-blocking drugs and mutations. J Exp Biol (1992) 0.96
Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins. Proc Natl Acad Sci U S A (1994) 0.94
A Drosophila melanogaster gene encodes a protein homologous to the mouse t complex polypeptide 1. Gene (1988) 0.93
A glial-neuronal signaling pathway revealed by mutations in a neurexin-related protein. Science (1999) 0.92
Functional identification of the Segregation distorter locus of Drosophila melanogaster by germline transformation. Genetics (1994) 0.87
Tailoring uniform coats for synaptic vesicles during endocytosis. Neuron (1999) 0.85
Genetic modifiers of the Kv beta2-null phenotype in mice. Genes Brain Behav (2005) 0.83
A TPR domain in the SNAP secretory proteins. Trends Biochem Sci (1994) 0.82
RNA editing of a Drosophila sodium channel gene. Ann N Y Acad Sci (1999) 0.82
Molecular and genetic characterization of the Drosophila melanogaster 87E actin gene region. Genetics (1988) 0.80
Mechanisms of neurotransmitter release. Int Rev Neurobiol (1999) 0.79
Evidence for voltage-gated potassium channel beta-subunits with oxidoreductase motifs in human and rodent pancreatic beta cells. Receptors Channels (2000) 0.79
Analysis of mutations affecting sodium channels in Drosophila. Ann N Y Acad Sci (1986) 0.78
HERG sequence correction. Science (1996) 0.77
Searching for molecules mediating glial-neuronal communication. Mol Psychiatry (1999) 0.76
The 1997 Thomas Hunt Morgan Medal. Oliver Evans Nelson, Jr. Genetics (1998) 0.75
Properties of potassium channels altered by mutations of two genes in Drosophila. Biophys J (1984) 0.75
Biochemical aspects of oögenesis in Drosophila melanogaster. J Insect Physiol (1971) 0.75