Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 3951242)

Published in Arterioscler Thromb Vasc Biol on December 05, 2013

Authors

Dafina Pruthi1, Amy McCurley, Mark Aronovitz, Carol Galayda, S Ananth Karumanchi, Iris Z Jaffe

Author Affiliations

1: From the Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (D.P., A.M., M.A., C.G., I.Z.J.); and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA (S.A.K.).

Articles citing this

Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function. Endocrinology (2014) 2.17

Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23

Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension (2015) 0.92

Effects of aldosterone on insulin sensitivity and secretion. Steroids (2014) 0.83

Myeloid mineralocorticoid receptor deficiency inhibits aortic constriction-induced cardiac hypertrophy in mice. PLoS One (2014) 0.81

Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications. Curr Hypertens Rep (2014) 0.80

The involvement of aldosterone on vascular insulin resistance: implications in obesity and type 2 diabetes. Diabetol Metab Syndr (2014) 0.80

Is there a new dawn for selective mineralocorticoid receptor antagonism? Curr Opin Nephrol Hypertens (2014) 0.78

Arterial smooth muscle. Arterioscler Thromb Vasc Biol (2014) 0.78

Brain mineralocorticoid receptors in cognition and cardiovascular homeostasis. Steroids (2014) 0.78

Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease. J Diabetes Res (2016) 0.78

Role of smooth muscle cell mineralocorticoid receptor in vascular tone. Pflugers Arch (2014) 0.77

Hypotensive and Angiotensin-Converting Enzyme Inhibitory Activities of Eisenia fetida Extract in Spontaneously Hypertensive Rats. Evid Based Complement Alternat Med (2015) 0.75

Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis. Biomarkers (2015) 0.75

Aldosterone in vascular and metabolic dysfunction. Curr Opin Nephrol Hypertens (2016) 0.75

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor. Sci Rep (2014) 0.75

The orphan nuclear receptor Nur77 inhibits low shear stress-induced carotid artery remodeling in mice. Int J Mol Med (2015) 0.75

Primary aldosteronism: a common cause of resistant hypertension. CMAJ (2017) 0.75

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature. J Endocrinol (2017) 0.75

5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77. Inflammation (2017) 0.75

Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced Hypertension. Hypertension (2017) 0.75

The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury. PLoS One (2017) 0.75

Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure. J Am Heart Assoc (2017) 0.75

Articles cited by this

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med (1999) 29.32

Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med (2010) 14.43

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med (2003) 13.25

Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation (2008) 5.26

Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol (2005) 4.20

Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation (2003) 3.49

Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol (2002) 2.94

Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res (2005) 2.79

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med (2012) 2.59

Biology of vascular endothelial growth factors. FEBS Lett (2006) 2.26

Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure. Eur Heart J (2011) 1.93

Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J Clin Endocrinol Metab (2007) 1.78

Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res (2008) 1.76

A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib. J Natl Cancer Inst (2008) 1.63

Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology (2002) 1.45

Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol (2011) 1.38

Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment. Heart (2004) 1.22

Mineralocorticoid receptor activation promotes vascular cell calcification. Arterioscler Thromb Vasc Biol (2007) 1.21

Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest (2010) 1.17

Mechanisms of post-intervention arterial remodelling. Cardiovasc Res (2012) 1.13

Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1. Circ Res (1997) 1.13

Distinguishing the antihypertensive and electrolyte effects of eplerenone. J Clin Endocrinol Metab (2004) 1.09

Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol (2003) 1.07

Mineralocorticoid action. Steroids (2000) 1.05

Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways. Arterioscler Thromb Vasc Biol (2011) 1.04

Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. J Am Heart Assoc (2013) 1.02

Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. Circulation (2001) 0.99

Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1. Cardiovasc Res (2002) 0.96

Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension (2005) 0.92

The importance of reendothelialization after arterial injury. Curr Pharm Des (2007) 0.92

Neointimal thickening after balloon denudation is enhanced by aldosterone and inhibited by spironolactone, and aldosterone antagonist. Cardiovasc Res (1995) 0.90

Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice. J Thorac Cardiovasc Surg (2012) 0.81

Articles by these authors

Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med (2004) 14.00

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest (2003) 13.72

Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med (2013) 9.87

Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med (2006) 7.06

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35

Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med (2006) 6.21

Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med (2006) 3.72

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med (2008) 3.39

Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation (2011) 3.33

Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia. Hypertension (2007) 2.77

Urinary placental growth factor and risk of preeclampsia. JAMA (2005) 2.76

Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med (2006) 2.75

Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int (2012) 2.74

Vascular endothelial growth factor-A and aldosterone: relevance to normal pregnancy and preeclampsia. Hypertension (2013) 2.70

Pathogenesis of preeclampsia. Annu Rev Pathol (2010) 2.66

Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia. Hypertension (2007) 2.62

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med (2012) 2.59

Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res (2011) 2.55

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation (2011) 2.55

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33

Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem (2005) 2.33

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32

Vitamin D deficiency and cardiovascular events in patients with coronary heart disease: data from the Heart and Soul Study. Am J Epidemiol (2014) 2.30

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature (2012) 2.27

Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci U S A (2007) 2.25

c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ Res (2005) 2.23

Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. Hypertens Pregnancy (2013) 2.22

Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension (2005) 2.22

Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function. Endocrinology (2014) 2.17

Early outcomes among those initiating chronic dialysis in the United States. Clin J Am Soc Nephrol (2011) 2.17

First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab (2004) 2.11

Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda) (2009) 2.10

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol (2009) 2.09

Preeclampsia and angiogenic imbalance. Annu Rev Med (2008) 2.05

Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res (2002) 2.05

Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies. Am J Obstet Gynecol (2005) 2.03

Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension (2006) 2.02

Molecular mechanisms of preeclampsia. Microvasc Res (2007) 1.90

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest (2011) 1.88

Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation (2012) 1.88

Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension (2012) 1.86

Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension. Hypertension (2009) 1.82

Diagnostic utility of soluble fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy. Am J Obstet Gynecol (2007) 1.80

Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatr Res (2005) 1.78

Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res (2008) 1.76

Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. Placenta (2005) 1.74

Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens (2004) 1.71

Pathophysiology of the clinical manifestations of preeclampsia. Clin J Am Soc Nephrol (2007) 1.69

Pre-eclampsia: clinical manifestations and molecular mechanisms. Nephron Clin Pract (2007) 1.67

Cytomegalovirus-induced mirror syndrome associated with elevated levels of circulating antiangiogenic factors. Obstet Gynecol (2007) 1.67

Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia. Arthritis Rheumatol (2015) 1.61

Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study. BMJ (2009) 1.59

Angiogenic factors and preeclampsia. Semin Nephrol (2011) 1.58

VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med (2008) 1.54

Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chem (2002) 1.51

The glomerular injury of preeclampsia. J Am Soc Nephrol (2007) 1.50

High blood pressure arising from a defect in vascular function. Proc Natl Acad Sci U S A (2008) 1.50

Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model. J Natl Cancer Inst (2006) 1.49

Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species. Mol Endocrinol (2007) 1.47

Familial factors in the association between preeclampsia and later ESRD. Clin J Am Soc Nephrol (2012) 1.47

Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes (2013) 1.45

Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int (2004) 1.42

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol (2006) 1.41

First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension (2010) 1.39

Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol (2011) 1.38

Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem (2005) 1.36

Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol (2002) 1.34

Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab (2004) 1.34

Hypoxia and sFlt-1 in preeclampsia: the "chicken-and-egg" question. Endocrinology (2004) 1.33

Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy. Diabetes Care (2007) 1.32

Vascular endothelial growth factor induces branching morphogenesis/tubulogenesis in renal epithelial cells in a neuropilin-dependent fashion. Mol Cell Biol (2005) 1.29

Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol (2006) 1.28

Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J (2007) 1.27

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol (2011) 1.25

Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med (2013) 1.25

Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review. Obstet Gynecol (2007) 1.20

Breathing life into the lifecourse approach: pregnancy history and cardiovascular disease in women. Hypertension (2010) 1.20

The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice. J Clin Invest (2012) 1.18

Increased sensitivity to angiotensin II is present postpartum in women with a history of hypertensive pregnancy. Hypertension (2010) 1.18

New aspects in the pathophysiology of preeclampsia. J Am Soc Nephrol (2004) 1.17

Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia? Am J Obstet Gynecol (2008) 1.17

Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest (2010) 1.17

Rapid recruitment of temporally distinct vascular gene sets by estrogen. Mol Endocrinol (2008) 1.16

Plasma gelsolin and circulating actin correlate with hemodialysis mortality. J Am Soc Nephrol (2009) 1.16

Circulating angiogenic factors and placental abruption. Obstet Gynecol (2006) 1.15

Circulating angiogenic factors in preeclampsia. Clin Obstet Gynecol (2005) 1.12

Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation (2012) 1.12

Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarker. Semin Nephrol (2010) 1.11

Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am (2010) 1.11

Angiogenic factors in diagnosis, management, and research in preeclampsia. Hypertension (2013) 1.11

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol (2011) 1.10

Pre-eclampsia and cardiovascular disease. Cardiovasc Res (2014) 1.10

Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med (2014) 1.08

Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors. J Immunol (2013) 1.07

Soluble Fms-like tyrosine kinase associated with preeclampsia in pregnancy in systemic lupus erythematosus. J Rheumatol (2008) 1.05

Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension (2010) 1.05