Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

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Published in J Med Chem on February 05, 2014

Authors

Daqing Sun1, Zhihong Li, Yosup Rew, Michael Gribble, Michael D Bartberger, Hilary P Beck, Jude Canon, Ada Chen, Xiaoqi Chen, David Chow, Jeffrey Deignan, Jason Duquette, John Eksterowicz, Benjamin Fisher, Brian M Fox, Jiasheng Fu, Ana Z Gonzalez, Felix Gonzalez-Lopez De Turiso, Jonathan B Houze, Xin Huang, Min Jiang, Lixia Jin, Frank Kayser, Jiwen Jim Liu, Mei-Chu Lo, Alexander M Long, Brian Lucas, Lawrence R McGee, Joel McIntosh, Jeff Mihalic, Jonathan D Oliner, Tao Osgood, Matthew L Peterson, Philip Roveto, Anne Y Saiki, Paul Shaffer, Maria Toteva, Yingcai Wang, Yu Chung Wang, Sarah Wortman, Peter Yakowec, Xuelei Yan, Qiuping Ye, Dongyin Yu, Ming Yu, Xiaoning Zhao, Jing Zhou, Jiang Zhu, Steven H Olson, Julio C Medina

Author Affiliations

1: Departments of Therapeutic Discovery, ‡Pharmaceutics, and §Pharmacokinetics and Drug Metabolism, Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California, 94080, United States.

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