De novo mutations in schizophrenia implicate synaptic networks.

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Published in Nature on January 22, 2014

Authors

Menachem Fromer1, Andrew J Pocklington2, David H Kavanagh2, Hywel J Williams2, Sarah Dwyer2, Padhraig Gormley3, Lyudmila Georgieva2, Elliott Rees2, Priit Palta4, Douglas M Ruderfer5, Noa Carrera2, Isla Humphreys2, Jessica S Johnson6, Panos Roussos6, Douglas D Barker7, Eric Banks8, Vihra Milanova9, Seth G Grant10, Eilis Hannon2, Samuel A Rose7, Kimberly Chambert7, Milind Mahajan6, Edward M Scolnick7, Jennifer L Moran7, George Kirov2, Aarno Palotie11, Steven A McCarroll12, Peter Holmans2, Pamela Sklar13, Michael J Owen2, Shaun M Purcell14, Michael C O'Donovan2

Author Affiliations

1: 1] Division of Psychiatric Genomics in the Department of Psychiatry, and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
2: Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK.
3: 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK [2] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
4: 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK [2] Department of Bioinformatics, Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia [3] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.
5: 1] Division of Psychiatric Genomics in the Department of Psychiatry, and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK.
6: Division of Psychiatric Genomics in the Department of Psychiatry, and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
7: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
8: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
9: Department of Psychiatry, Medical University, Sofia 1431, Bulgaria.
10: Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK.
11: 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK [2] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [3] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.
12: 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
13: 1] Division of Psychiatric Genomics in the Department of Psychiatry, and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
14: 1] Division of Psychiatric Genomics in the Department of Psychiatry, and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [3] Analytic and Translational Genetics Unit, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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