Published in J Invest Dermatol on February 03, 2014
Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell (2015) 1.66
Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Cell Biol (2015) 0.79
Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence. J Invest Dermatol (2015) 0.76
Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling. J Biol Chem (2016) 0.75
Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer. Cell Rep (2016) 0.75
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06
Dual roles for patched in sequestering and transducing Hedgehog. Cell (1996) 4.10
Basal cell carcinomas in mice overexpressing sonic hedgehog. Science (1997) 3.84
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature (1997) 3.64
Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet (2011) 2.93
Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet (2000) 2.82
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci U S A (2000) 2.73
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature (2000) 2.41
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. J Clin Invest (1999) 2.02
Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A (1997) 1.97
Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med (1997) 1.93
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A (2011) 1.89
The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J (2003) 1.72
Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A (2011) 1.68
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest (2011) 1.65
Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res (2006) 1.56
Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol (2000) 1.56
Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prev Res (Phila) (2010) 1.55
Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A (1998) 1.38
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat Genet (1998) 1.38
The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev (2006) 1.32
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31
Patched 1 conditional null allele in mice. Genesis (2003) 1.31
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development (2004) 1.30
Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development (2012) 1.28
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol (2012) 1.22
Gene duplications, robustness and evolutionary innovations. Bioessays (2008) 1.21
Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res (2006) 1.16
Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. Cancer Res (2002) 1.15
Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Dev Biol (2008) 1.12
Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J (2004) 1.08
Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Mech Dev (2004) 1.08
Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem (2002) 1.03
Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett (1997) 0.96
PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Cancer Res (1999) 0.94
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. Mol Cell Biol (2006) 0.93
Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J Biol Chem (2008) 0.89
Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development (2010) 0.88
Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. J Neurobiol (2006) 0.82
Co-localization of patched and activated sonic hedgehog to lysosomes in neurons. Neuroreport (2000) 0.81