Published in Mol Biol Cell on February 05, 2014
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Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev (2008) 2.40
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell (2004) 2.29
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem (2006) 1.96
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol (2006) 1.87
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int (2002) 1.77
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum (2009) 1.65
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. FASEB J (2002) 1.64
CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res (2006) 1.57
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts. Respir Res (2004) 1.55
β1 integrin-extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function. Lab Invest (2012) 1.53
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem (2004) 1.52
Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J (2011) 1.47
CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum (2011) 1.46
Retracted GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest (2008) 1.46
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix Biol (2007) 1.46
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum (2007) 1.45
The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res Ther (2006) 1.33
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts. Arthritis Rheum (2006) 1.30
The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol (2008) 1.25
Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Arthritis Rheum (2009) 1.25
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The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J Cell Commun Signal (2008) 1.21
Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci (2010) 1.21
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Mol Biol Cell (2007) 1.19
Retracted Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest (2008) 1.15
Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal (2007) 1.13
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum (2009) 1.11
Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci (2012) 1.09
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum (2012) 1.06
Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor. J Hepatol (2010) 1.05
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol (2009) 1.03
Skin progenitor cells contribute to bleomycin-induced skin fibrosis. Arthritis Rheumatol (2014) 1.02
Optimizing RNA extraction yield from whole blood for microarray gene expression analysis. Clin Biochem (2004) 1.02
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis Rheum (2008) 1.02
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Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. Arthritis Rheum (2009) 0.99
Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal (2009) 0.97
Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism. PLoS One (2011) 0.97
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Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. Rheumatology (Oxford) (2009) 0.96
CCN2 expression by fibroblasts is not required for cutaneous tissue repair. Wound Repair Regen (2014) 0.96
Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling. Arthritis Res Ther (2009) 0.96
Rac inhibition reverses the phenotype of fibrotic fibroblasts. PLoS One (2009) 0.94
Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum (2013) 0.94
LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias. J Lipid Res (2014) 0.93
Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol (2008) 0.93
Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis. J Crit Care (2011) 0.93
Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2. Arthritis Rheum (2013) 0.91
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k). J Biol Chem (2005) 0.91
Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice. Arthritis Rheum (2008) 0.89
Pericytes display increased CCN2 expression upon culturing. J Cell Commun Signal (2009) 0.88
Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair? PLoS One (2011) 0.88
Differentiation and injury-repair signals modulate the interaction of E2F and pRB proteins with novel target genes in keratinocytes. Cell Cycle (2006) 0.87
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. Arthritis Res Ther (2011) 0.87
Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice. Hepatology (2015) 0.86
Integrin β1 is required for dermal homeostasis. J Invest Dermatol (2012) 0.86
Conditional knockout of CTGF affects corneal wound healing. Invest Ophthalmol Vis Sci (2014) 0.85
Yin and Yang Part Deux: CCN5 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal (2010) 0.85
TAK1 is required for dermal wound healing and homeostasis. J Invest Dermatol (2013) 0.85
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. Rheumatology (Oxford) (2012) 0.85
TGF-b signaling in cartilage homeostasis and osteoarthritis. Front Biosci (Schol Ed) (2012) 0.85
Src kinase inhibition promotes the chondrocyte phenotype. Arthritis Res Ther (2007) 0.84
CCN2 is not required for skin development. J Cell Commun Signal (2011) 0.82
Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes. PLoS One (2012) 0.82
Integrin β1 is required for maintenance of vascular tone in postnatal mice. J Cell Commun Signal (2012) 0.81
An analysis of the myocardial transcriptome in a mouse model of cardiac dysfunction with decreased cholinergic neurotransmission. PLoS One (2012) 0.81
Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology (2005) 0.80
CCN2 expression and localization in melanoma cells. J Cell Commun Signal (2011) 0.80
RanBPM expression regulates transcriptional pathways involved in development and tumorigenesis. Am J Cancer Res (2012) 0.80
Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element. J Cell Commun Signal (2009) 0.79
Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues. Fibrogenesis Tissue Repair (2011) 0.79
Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling. PLoS One (2012) 0.79
CCN2 modulates hair follicle cycling in mice. Mol Biol Cell (2013) 0.78
Ceramide inhibits CCN2 expression in fibroblasts. J Cell Commun Signal (2008) 0.78
Integrin β1 is necessary for the maintenance of corneal structural integrity. Invest Ophthalmol Vis Sci (2011) 0.78
Monitoring collagen synthesis in fibroblasts using fluorescently labeled tRNA pairs. J Cell Physiol (2014) 0.78
Lefty contributes to the remodeling of extracellular matrix by inhibition of connective tissue growth factor and collagen mRNA expression and increased proteolytic activity in a fibrosarcoma model. J Biol Chem (2001) 0.78
ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts. J Cell Commun Signal (2014) 0.78
Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes. Matrix Biol (2009) 0.78
Loss of PPARγ expression by fibroblasts enhances dermal wound closure. Fibrogenesis Tissue Repair (2012) 0.77
Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice. Exp Biol Med (Maywood) (2013) 0.76
Report on the 6th international workshop of the CCN family of genes. J Cell Commun Signal (2011) 0.75