Comprehensive immunophenotyping of cerebrospinal fluid cells in patients with neuroimmunological diseases.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 4045479)

Published in J Immunol on February 07, 2014

Authors

Sungpil Han1, Yen Chih Lin, Tianxia Wu, Alan D Salgado, Ina Mexhitaj, Simone C Wuest, Elena Romm, Joan Ohayon, Raphaela Goldbach-Mansky, Adeline Vanderver, Adriana Marques, Camilo Toro, Peter Williamson, Irene Cortese, Bibiana Bielekova

Author Affiliations

1: Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892;

Associated clinical trials:

Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases) | NCT00059748

Articles citing this

Insufficient disease inhibition by intrathecal rituximab in progressive multiple sclerosis. Ann Clin Transl Neurol (2016) 1.08

Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis. Ann Clin Transl Neurol (2015) 0.96

Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis. PLoS Pathog (2015) 0.87

Natural killer cell subsets in cerebrospinal fluid of patients with multiple sclerosis. Clin Exp Immunol (2015) 0.83

A complex role of herpes viruses in the disease process of multiple sclerosis. PLoS One (2014) 0.82

Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections. MBio (2016) 0.81

Patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination. Neurol Neuroimmunol Neuroinflamm (2016) 0.81

Immune and Epstein-Barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis. J Neuroinflammation (2015) 0.79

CSF cytokines correlate with aseptic meningitis and blood brain barrier function in Neonatal-Onset Multisystem Inflammatory Disease (NOMID). Arthritis Rheumatol (2017) 0.76

Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes. Ann Clin Transl Neurol (2015) 0.76

Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. Clin Infect Dis (2016) 0.75

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis. Front Immunol (2016) 0.75

Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation. Clin Exp Immunol (2017) 0.75

Articles cited by this

Why most published research findings are false. PLoS Med (2005) 41.68

Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol (2011) 25.66

A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med (2008) 12.90

Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med (2007) 6.13

Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A (2006) 4.26

Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Annu Rev Immunol (2007) 4.14

Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med (2000) 3.84

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci (2013) 3.59

Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol (2009) 3.35

Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol (2011) 3.32

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity. Hum Mol Genet (2009) 3.07

Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell (2012) 2.91

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature (2008) 2.87

Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest (2006) 2.75

Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch Neurol (2006) 2.62

Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med (2005) 2.54

Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain Pathol (1996) 2.41

Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest (2006) 2.32

Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain (2005) 2.17

BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med (2005) 1.92

Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain (2005) 1.92

Primary-progressive multiple sclerosis. Lancet Neurol (2007) 1.81

Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain (2001) 1.78

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol (2010) 1.69

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain (2011) 1.61

Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology (2009) 1.59

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression. Neurobiol Dis (2005) 1.57

B cells and antibodies in CNS demyelinating disease. J Neuroimmunol (2001) 1.50

Cerebrospinal fluid neopterin is brain-derived and not associated with blood-CSF barrier dysfunction in non-inflammatory affective and schizophrenic spectrum disorders. J Psychiatr Res (2013) 1.50

Monogenic autoinflammatory diseases: concept and clinical manifestations. Clin Immunol (2013) 1.40

B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest (2012) 1.35

Patterns of cerebrospinal fluid pathology correlate with disease progression in multiple sclerosis. Brain (2001) 1.30

CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation. J Neuroinflammation (2012) 1.29

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain (2012) 1.27

Aicardi-Goutières syndrome. Handb Clin Neurol (2013) 1.27

Review: Mitochondria and disease progression in multiple sclerosis. Neuropathol Appl Neurobiol (2008) 1.25

Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection. J Virol (2008) 1.24

Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis. PLoS One (2008) 1.14

IL-18 in inflammatory and autoimmune disease. Cell Mol Life Sci (2013) 1.06

Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study. Brain (2005) 1.02

CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. J Virol (2007) 1.01

Central memory CD4+ T cells dominate the normal cerebrospinal fluid. Cytometry B Clin Cytom (2011) 0.99

Herpes simplex virus antigens directly activate NK cells via TLR2, thus facilitating their presentation to CD4 T lymphocytes. J Immunol (2012) 0.95

Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients. PLoS One (2011) 0.93

Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation. PLoS One (2012) 0.87

Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords. Ann Neurol (2010) 0.87

Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse. J Neuroinflammation (2011) 0.87

Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. Eur J Immunol (1989) 0.86

Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiol Dis (2007) 0.83

T-cell phenotypic profiles in the cerebrospinal fluid and peripheral blood of multiple sclerosis patients. J Neurol Sci (1992) 0.82

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy. J Neuroinflammation (2013) 0.81

The pathology of primary progressive multiple sclerosis. Mult Scler (2004) 0.81

Activation of immune responses to brain antigens after stroke. J Neurochem (2012) 0.80

Immunophenotypic patterns of T-cell activation in neuroinflammatory diseases. Acta Neurol Scand (2006) 0.77

Effector and regulatory T cells in patients with acute optic neuritis. Neuroimmunomodulation (2012) 0.76

Articles by these authors

Toward discovery science of human brain function. Proc Natl Acad Sci U S A (2010) 15.22

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet (2009) 5.84

Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis--United States, 1988-1994 and 1999-2002. MMWR Surveill Summ (2005) 5.40

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med (2009) 4.97

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother (2013) 4.80

Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood (2006) 4.63

Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull (2007) 3.61

Non-European doctors and change in UK policy: ten thousand international medical graduates may be affected. BMJ (2006) 3.54

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38

The National Institutes of Health Undiagnosed Diseases Program: insights into rare diseases. Genet Med (2011) 3.14

Autoinflammatory disease reloaded: a clinical perspective. Cell (2010) 3.04

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature (2012) 2.87

Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet (2007) 2.81

Treatment trials for post-Lyme disease symptoms revisited. Am J Med (2013) 2.75

A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy. Nat Med (2011) 2.69

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol (2013) 2.58

Evolution of the blood-brain barrier in newly forming multiple sclerosis lesions. Ann Neurol (2011) 2.43

A de novo mutation in the β-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum. Am J Hum Genet (2013) 2.42

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41

Magnetic resonance imaging in the evaluation of bone damage in rheumatoid arthritis: a more precise image or just a more expensive one? Arthritis Rheum (2003) 2.37

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta. Proc Natl Acad Sci U S A (2004) 2.37

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36

Magnetic resonance imaging pattern recognition in hypomyelinating disorders. Brain (2010) 2.19

Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis. Sci Transl Med (2012) 2.14

Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial. Ann Intern Med (2011) 2.11

PSORS2 is due to mutations in CARD14. Am J Hum Genet (2012) 2.10

Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol (2009) 2.06

Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat (2008) 2.04

Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet (2012) 1.88

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity. Arthritis Rheum (2012) 1.87

Detecting false-positive signals in exome sequencing. Hum Mutat (2012) 1.87

Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology (2007) 1.80

IL-1 family nomenclature. Nat Immunol (2010) 1.79

Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. Anesthesiology (2004) 1.78

Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood (2011) 1.72

Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders. Brain (2003) 1.71

Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy. Am J Hum Genet (2011) 1.67

Practice parameter: temporal lobe and localized neocortical resections for epilepsy. Epilepsia (2003) 1.66

High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: results of an International Multicenter Collaborative Study. Arthritis Rheum (2011) 1.61

Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum Mol Genet (2003) 1.59

Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism. J Med Genet (2013) 1.59

Long-term natural history of neurofibromatosis Type 2-associated intracranial tumors. J Neurosurg (2012) 1.59

Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study. Lancet Neurol (2013) 1.58

Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Can J Anaesth (2008) 1.57

An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol (2010) 1.57

Heterogeneity in response to interferon beta in patients with multiple sclerosis: a 3-year monthly imaging study. Arch Neurol (2008) 1.56

Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. PLoS Genet (2011) 1.54

Chediak-Higashi syndrome presenting as young-onset levodopa-responsive parkinsonism. Mov Disord (2013) 1.51

Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus. Psychiatry Clin Neurosci (2009) 1.50

Validation of digital spiral analysis as outcome parameter for clinical trials in essential tremor. Mov Disord (2011) 1.47

Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. Am J Hum Genet (2013) 1.46

A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophr Res (2004) 1.46

Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease. Diagn Microbiol Infect Dis (2012) 1.45

Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders. Arthritis Rheum (2003) 1.41

Monogenic autoinflammatory diseases: concept and clinical manifestations. Clin Immunol (2013) 1.40

Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes. Arthritis Rheum (2012) 1.40

Mutations of POLR3A encoding a catalytic subunit of RNA polymerase Pol III cause a recessive hypomyelinating leukodystrophy. Am J Hum Genet (2011) 1.38

Vesicular transport across the fungal cell wall. Trends Microbiol (2009) 1.36

Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci U S A (2011) 1.33

S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin. Arthritis Rheum (2008) 1.33

Analysis of DNA sequence variants detected by high-throughput sequencing. Hum Mutat (2012) 1.28

Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. Arthritis Res Ther (2009) 1.27

Rapid, simple, quantitative, and highly sensitive antibody detection for lyme disease. Clin Vaccine Immunol (2010) 1.25

Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis. Curr Opin Rheumatol (2010) 1.23

Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification of viral mutations. J Neurovirol (2014) 1.22

Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis. J Immunol (2011) 1.18

Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol (2006) 1.17

Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1. Am J Med Genet A (2015) 1.17

Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99.9% statistical confidence by massively parallel sequencing. DNA Res (2012) 1.16

Evidence for cortical dysfunction in autism: a proton magnetic resonance spectroscopic imaging study. Biol Psychiatry (2007) 1.11

IL-1 blockade in autoinflammatory syndromes. Annu Rev Med (2014) 1.10

Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling. Annu Rev Immunol (2015) 1.08

VAR-MD: a tool to analyze whole exome-genome variants in small human pedigrees with mendelian inheritance. Hum Mutat (2012) 1.08

Default mode network connectivity: effects of age, sex, and analytic approach. Neuroreport (2008) 1.08

Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. J Biol Chem (2005) 1.08

Brain magnetic resonance imaging (MRI) pattern recognition in Pol III-related leukodystrophies. J Child Neurol (2013) 1.07

Hypomyelinating leukodystrophies: translational research progress and prospects. Ann Neurol (2014) 1.06

Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens. Clin Immunol (2008) 1.06

Tremor-ataxia with central hypomyelination (TACH) leukodystrophy maps to chromosome 10q22.3-10q23.31. Neurogenetics (2010) 1.06

Interferon-beta1a therapy in human T-lymphotropic virus type I-associated neurologic disease. Ann Neurol (2005) 1.05

A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil. Arthritis Rheum (2011) 1.04

Changes in salivary proteome following allogeneic hematopoietic stem cell transplantation. Exp Hematol (2007) 1.04

Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers. J Virol (2009) 1.03

Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma. J Oral Maxillofac Surg (2007) 1.03

Translocator protein PET imaging for glial activation in multiple sclerosis. J Neuroimmune Pharmacol (2010) 1.03

Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. Cancer Sci (2009) 1.02

Time series proteome profiling to study endoplasmic reticulum stress response. J Proteome Res (2008) 1.02

Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors. Hum Mol Genet (2010) 1.02

A clinical genetic method to identify mechanisms by which pain causes depression and anxiety. Mol Pain (2006) 0.99

Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS). Clin Proteomics (2012) 0.98

Novel infantile-onset leukoencephalopathy with high lactate level and slow improvement. Arch Neurol (2012) 0.98